Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

Endocrinology

Volumn 140, Issue 7, 1999, Pages 2954-2961

  Hentunen, Teuvo A ^a   Jackson, Sharon H ^a,b   Chung, Hoyeon ^a   Reddy, Sakamuri V ^a   Lorenzo, Joseph ^c   Choi, Sun Jin ^a   David Roodman, G ^a,d  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CD11B ANTIGEN; CD86 ANTIGEN; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; FC RECEPTOR; GELATINASE B; INTERLEUKIN 1 RECEPTOR; ISOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL LINEAGE; CELL SURFACE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033305156     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.7.6867     Document Type: Article

References (19)

1. Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation anti apoptosis of osteoclasts
2. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
3. bcl-x, a bcl-2-related gene that functions as dominant regulator of apoptotic cell death
4. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
5. Bcl-XL displays a restricted expression during thymic development and inhibits multiple forms of apoptosis but not clonal deletion
6. Bcl-XL exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice
7. Development of an osteoclast cell line by targeting Bcl-XL and simian virus 40 large T antigen to the osteoclast lineage in transgenic mice
8. Postmitotic osteoclast precursors are mononuclear cells which express macrophage-associated pheotypes
9. Development of a monoclonal antibody to osteoclasts formed in vitro which recognizes mononuclear osteoclast precursors in the marrow
10. A comparative study of disaggregated chick and rat osteoclasts in vitro: Effect of calcitonin and prostaglandins
11. Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone
12. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures
13. The bone-marrow-derived stromal cell lines MC3T3G2/PA6 and ST2 support osteoclast-like cell differentiation
14. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
15. Establishment and characterization of an immortal marcrophage-like cell line inducible to differentiate to osteoclasts
16. In vitro differentiation of the murine macrophage cell line BDM-1 into osteoclast-like cells
17. Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse
18. Generation of mouse osteoclastogenic cell lines immortalized with SV40 large T antigen
19. Resorption-cycle-dependent polarization of mRNAs for different subunits of V-ATPase in bone-resorbing osteoclasts