Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 33-45

  Al Omary, Fatmah A M ^a   Hassan, Ghada S ^a,b   El Messery, Shahenda M ^b   Nagi, Mahmoud N ^a   Habib, El Sayed E ^c   El Subbagh, Hussein I ^d  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b University of Mansoura   (Egypt)

^c TAIBAH UNIVERSITY   (Saudi Arabia)

^d FUTURE UNIVERSITY IN EGYPT   (Egypt)

Author keywords

Antimicrobial testing; Antitumor screening; DHFR inhibition; Molecular modeling study; Quinazolin 4 ones; Synthesis

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; QUINAZOLINONE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR MODEL;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FOLIC ACID ANTAGONISTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HL-60 CELLS; HUMANS; MCF-7 CELLS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84878538953     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.061     Document Type: Article

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