Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 Å and 1.05 Å resolution

Journal of Molecular Biology

Volumn 320, Issue 3, 2002, Pages 677-693

  Klon, Anthony E ^a   Héroux, Annie ^b   Ross, Larry J ^b   Pathak, Vibha ^b   Johnson, Cheryl A ^b   Piper, James R ^b   Borhani, David W ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Distorted geometry; Inhibitor selectivity; Lipophilic antifolates

Indexed keywords

6 [(5 QUINOLYLAMINO)METHYL] 2,4 DIAMINO 5 METHYLPYRIDO[2,3 D]PYRIMIDINE; 6 [2 (2,5 DIMETHOXYPHENYL)ETHEN 1 YL] 2,4 DIAMINO 5 METHYLPYRIDOL[2,3 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SRI 9439; SRI 9662; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

TOXOPLASMA GONDII;

EID: 0036311129     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00469-2     Document Type: Article

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