Synthesis and biological screening of some new substituted-3H-quinazolin-4- one analogs as antimicrobial agents

Saudi Pharmaceutical Journal

Volumn 12, Issue 2-3, 2004, Pages 63-71

  Al Omar, Mohamed A ^a   Abdel Hamide, Sami G ^a   Al Khamees, Hamad A ^a   El Subbagh, Hussein I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

3H quinazolin 4 one; Antimicrobial screening; Synthesis

Indexed keywords

2 (3 NITRO 2 PYRIDYL)THIO 3 BENZYL 6 METHYL 3H QUINAZOLIN 4 ONE; 2 ACETYLMETHYLTHIO 3 BENZYL 6 NITRO 3H QUINAZOLIN 4 ONE; 3H QUINAZOLIN 4 ONE DERIVATIVE; AMPICILLIN; ANTIINFECTIVE AGENT; NYSTATIN; QUINAZOLINONE DERIVATIVE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PHYSICAL CHEMISTRY; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 3543000497     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Misra HK, Sen Gupta AK. Synthesis and evaluation of substituted 4(3H)-quinazoline derivatives for antimicrobial and antiacetylcholinestrase activity. Pharmazie 1982, 37: 254-256.
2. El-Zhory MF, Ahmed AA, Omar FA, Abdalla MA. Synthesis and antibacterial activity of certain quinoline and quinazoline derivatives containing sulfide and sulfone moieties. J Chem Technol Biotechnol 1992, 53: 329-336.
3. Pandeya SN, Sriram D, Nath G, De Clereq E. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with quinazoline-4(3H)-one. Pharm Acta Helv 1999, 74: 11-17.
4. Atta FM. Synthesis and antibacterial activity of thioglycolic amino acid derivatives and dipeptides containing the 2-methyl-3,4-dihydroquinazoline-4- moiety. J Chem Technol Biotechnol 1994, 61: 225-229.
5. El-Ablak FS, Etman HA, Metwally MA. Synthesis and antimicrobial activity of some new carbazoles, indazoles, quinolines, quinazolines and naphthalenes. Boll Chim Farm 1995, 134: 77-79.
6. Abdel-Hamide SG. Synthesis and antimicrobial activity of some new substituted quinazolne derivatives. Saudi Pharm J 2001, 9: 72-84.
7. Abdel-Gawad SM, El-Gaby MS, Ghorab MM. Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thizolo[2,3-b]quinazolines. IL Farmaco 2000, 55: 287-282.
8. Karali N, Ilhan E, Gursoy A, Kiraz M. New cyclohexylidinehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of 3-phenyl-4(3H)-quinazolines. IL Farmaco 1998, 53: 346-349.
9. Rosenblatt JE. Antiparasitic agents. Mayo Clin Proc 1992, 67: 276-287.
10. Klepser ME, Klepser TB. Drug treatment of HIV-related apportunistic infections. Drugs 1997, 53: 40-73.
11. Rosowsky A, Papoulis T, Forsch RA, Queener SF. Synthesis and antiparasitic, antitumor activity of piritrexim analogs. J Med Chem 1999, 42: 1007-1017.
12. Levine SJ. Pneumocystis carinii. Clinics in chest. Med 1996, 17: 665-695.
13. Abdel-Hamide SG, Youssif KM, El-Shafie FS, El-Subbagh HI. Synthesis and antitumor activity of some new quinazoline analogs. Unpublished data.
14. Kunes J, Bazant J, Pour M, Waisser K, Slosarek M, Janata J. Quinazoline derivatives with antitubercular activity. IL Farmaco 2000, 55: 725-729.
15. th ed, Churchill Livingstone, London, UK.
16. El-Subbagh HI, El-Naggar WA, Badria FA. Synthesis and biological testing of 2,4-disubstituted thiazole derivatives as potential antitumor antibiotics. Med Chem Res 1994, 3: 503-516.
17. Shehata IA, Nasr MN, El-Subbagh HI, Gineinah MM, Kheira SM. Synthesis and Biological testing of certain 1,3,4-oxadiazole and 1,2,4-triazole derivatives as potential antimicrobial agents. Sci Pharm 1996, 64: 133-143.
18. Del Giudice MR, Borioni A, Mustazza C, Gatta F. Synthesis of Pyrido[3,2-e] and [4,3-e][1,2,4]triazolo[1,5-e]pyrimidine derivatives. J Heterocyclic Chem 1994, 31: 1503.