Folate-based inhibitors of thymidylate synthase: Synthesis and antitumor activity of γ-linked sterically hindered dipeptide analogues of 2-desamino- 2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Journal of Medicinal Chemistry

Volumn 40, Issue 10, 1997, Pages 1495-1510

  Bavetsias, Vassilios ^a   Jackman, Ann L ^a   Marriott, Jonathan H ^a   Kimbell, Rosemary ^a   Gibson, William ^a   Boyle, F Thomas ^b   Bisset, Graham M F ^a,c  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Unit 1   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEAMINO 2 METHYL 10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; AMIDE; DIPEPTIDE; FOLIC ACID; METHYL GROUP; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N PROP 2 YNYLAMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] N ETHYLGLUTAMIC ACID; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N PROP 2 YNYLAMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] N METHYLGLUTAMIC ACID; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N PROP 2 YNYLAMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] N PROP 2 YNYLGLUTAMIC ACID; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CROSS RESISTANCE; DRUG POTENCY; DRUG SYNTHESIS; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DIPEPTIDES; ENZYME INHIBITORS; FOLIC ACID; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; THYMIDYLATE SYNTHASE;

EID: 0030943914     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960878u     Document Type: Article

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