-
1
-
-
0024592086
-
α-monoamides of methotrexate as potential prodrugs
-
Antonjuk, D. J., Boadle, D. K., Cheung, H. T. A., Friedlander, M.L., Gregory, P.M., Tattersall, M. H. N. (1989) α-Monoamides of methotrexate as potential prodrugs. Arzneim. Forsch. Drug Res. 39: 12-15
-
(1989)
Arzneim. Forsch. Drug Res.
, vol.39
, pp. 12-15
-
-
Antonjuk, D.J.1
Boadle, D.K.2
Cheung, H.T.A.3
Friedlander, M.L.4
Gregory, P.M.5
Tattersall, M.H.N.6
-
2
-
-
0028139958
-
Effects of epidermal/dermal separation methods and ester chain configuration on the bioconversion of a homologous series of methotrexate dialkyl esters in dermal and epidermal homogenates of hairless mouse skin
-
Fort, J. J., Mitra, A. K. (1994) Effects of epidermal/dermal separation methods and ester chain configuration on the bioconversion of a homologous series of methotrexate dialkyl esters in dermal and epidermal homogenates of hairless mouse skin. Int. J. Pharm. 102: 241-247
-
(1994)
Int. J. Pharm.
, vol.102
, pp. 241-247
-
-
Fort, J.J.1
Mitra, A.K.2
-
3
-
-
0345678344
-
Design of antitumor prodrugs: Substrates for antibody targeted enzymes
-
Jungheim, L. N., Shepherd, T. A. (1994) Design of antitumor prodrugs: substrates for antibody targeted enzymes. Chem. Rev. 94: 1553-1566
-
(1994)
Chem. Rev.
, vol.94
, pp. 1553-1566
-
-
Jungheim, L.N.1
Shepherd, T.A.2
-
4
-
-
0024583590
-
Carboxypeptidase-mediated release of methotrexate from methotrexate α-peptides
-
Kuefner, U., Lohrmann, U., Montejano, Y. D., Vitols, K. S., Huennekens, F. M. (1989) Carboxypeptidase-mediated release of methotrexate from methotrexate α-peptides. Biochemistry 28: 2288-2297
-
(1989)
Biochemistry
, vol.28
, pp. 2288-2297
-
-
Kuefner, U.1
Lohrmann, U.2
Montejano, Y.D.3
Vitols, K.S.4
Huennekens, F.M.5
-
6
-
-
0013473782
-
Reductases
-
Hansch, C., Sammes, P. G., Taylor, J. B. (eds) Pergamon, Oxford
-
McCormack, J. J. (1990) Reductases. In: Hansch, C., Sammes, P. G., Taylor, J. B. (eds) Comprehensive Medicinal Chemistry, Vol. 2. Pergamon, Oxford, pp 271-298
-
(1990)
Comprehensive Medicinal Chemistry
, vol.2
, pp. 271-298
-
-
McCormack, J.J.1
-
7
-
-
0016762575
-
Bovine liver dihydrofolate reductase: Purification and properties of the enzyme
-
Peterson, D. L., Gleisner, J. M., Blakley, R. L. (1975) Bovine liver dihydrofolate reductase: purification and properties of the enzyme. Biochemistry 14: 5261-5266
-
(1975)
Biochemistry
, vol.14
, pp. 5261-5266
-
-
Peterson, D.L.1
Gleisner, J.M.2
Blakley, R.L.3
-
8
-
-
0029977393
-
Synthesis and preliminary in-vitro screening of lipophilic α,γ-bis(amides) as potential prodrugs of methotrexate
-
Pignatello, R., Sorrenti, V., Spampinato, G., Pecora, T., Fresta, M., Panico, A., Di Giacomo, C., Vanella, A., Puglisi, G. (1996) Synthesis and preliminary in-vitro screening of lipophilic α,γ-bis(amides) as potential prodrugs of methotrexate. Anticancer Drug Des. 11: 253-264
-
(1996)
Anticancer Drug Des.
, vol.11
, pp. 253-264
-
-
Pignatello, R.1
Sorrenti, V.2
Spampinato, G.3
Pecora, T.4
Fresta, M.5
Panico, A.6
Di Giacomo, C.7
Vanella, A.8
Puglisi, G.9
-
9
-
-
0031900337
-
Lipoamino acid conjugates of methotrexate with antitumor activity
-
Pignatello, R., Jansen, G., Kathmann, I., Puglisi, G., Toth, I. (1998) Lipoamino acid conjugates of methotrexate with antitumor activity. J. Pharm. Sci. 87: 367-371
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 367-371
-
-
Pignatello, R.1
Jansen, G.2
Kathmann, I.3
Puglisi, G.4
Toth, I.5
-
10
-
-
0020037138
-
Syntheses of α- and γ-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism
-
Piper, J. R., Montgomery, J. A., Sirotnak, F. M., Chello, P. L. (1982) Syntheses of α- and γ-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism. J. Med. Chem. 25: 182-187
-
(1982)
J. Med. Chem.
, vol.25
, pp. 182-187
-
-
Piper, J.R.1
Montgomery, J.A.2
Sirotnak, F.M.3
Chello, P.L.4
-
11
-
-
0004766703
-
Interaction of methotrexate α,γ-bis(amides) with DPPC biomembranes
-
Puglisi, G., Fresta, M., Pignatello, R. (1998) Interaction of methotrexate α,γ-bis(amides) with DPPC biomembranes. Drug Dev. Res. 44: 162-169
-
(1998)
Drug Dev. Res.
, vol.44
, pp. 162-169
-
-
Puglisi, G.1
Fresta, M.2
Pignatello, R.3
-
12
-
-
0023857756
-
The chemistry of methotrexate and its analogues
-
Rahman, L. K. A., Chhabra, S. R. (1988) The chemistry of methotrexate and its analogues. Med. Res. Rev. 8: 95-156
-
(1988)
Med. Res. Rev.
, vol.8
, pp. 95-156
-
-
Rahman, L.K.A.1
Chhabra, S.R.2
-
13
-
-
0007919865
-
Proteins involved in the transport of folates and antifolates by normal and neoplastic cells
-
Picciano, M. F., Stokstad, E. L. R., Gregory, J. F. (eds) Wiley-Liss
-
Ratnam, M., Freisheim, J. H. (1990) Proteins involved in the transport of folates and antifolates by normal and neoplastic cells. In: Picciano, M. F., Stokstad, E. L. R., Gregory, J. F. (eds) Folic Acid Metabolism in Health and Disease. Wiley-Liss, pp 91-120
-
(1990)
Folic Acid Metabolism in Health and Disease
, pp. 91-120
-
-
Ratnam, M.1
Freisheim, J.H.2
-
14
-
-
0015901102
-
Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3′,5′-dichloromethotrexate by direct esterification
-
Rosowsky, A. (1973) Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3′,5′-dichloromethotrexate by direct esterification. J. Med. Chem. 16: 1190-1193
-
(1973)
J. Med. Chem.
, vol.16
, pp. 1190-1193
-
-
Rosowsky, A.1
-
15
-
-
0020601794
-
Methotrexate analogues. 18. Enhancement of the antitumor effect of methotrexate and 3′-5′-dichloromethotrexate by the use of lipid-soluble diesters
-
Rosowsky, A., Yu, C. -S. (1983) Methotrexate analogues. 18. Enhancement of the antitumor effect of methotrexate and 3′-5′-dichloromethotrexate by the use of lipid-soluble diesters. J. Med. Chem. 26: 1448-1452
-
(1983)
J. Med. Chem.
, vol.26
, pp. 1448-1452
-
-
Rosowsky, A.1
Yu, C.-S.2
-
16
-
-
0017374443
-
Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs
-
Rosowsky, A., Ensminger, W. D., Lazarus, H., Yu, C. -S. (1977) Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs. J. Med. Chem. 20: 925-930
-
(1977)
J. Med. Chem.
, vol.20
, pp. 925-930
-
-
Rosowsky, A.1
Ensminger, W.D.2
Lazarus, H.3
Yu, C.-S.4
-
17
-
-
0019860179
-
Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide and hydroxamic acid derivatives of the glutamate side chain
-
Rosowsky, A., Yu, C. -S., Uren, J., Lazarus, H., Wick, M. (1981a) Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide and hydroxamic acid derivatives of the glutamate side chain. J. Med. Chem. 24: 559-567
-
(1981)
J. Med. Chem.
, vol.24
, pp. 559-567
-
-
Rosowsky, A.1
Yu, C.-S.2
Uren, J.3
Lazarus, H.4
Wick, M.5
-
18
-
-
0019839154
-
Methotrexate analogues. 4. Synthesis of new γ-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents
-
Rosowsky, A., Forsch, R., Uren, J., Wick, M. (1981b) Methotrexate analogues. 4. Synthesis of new γ-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents. J. Med. Chem. 24: 1450-1455
-
(1981)
J. Med. Chem.
, vol.24
, pp. 1450-1455
-
-
Rosowsky, A.1
Forsch, R.2
Uren, J.3
Wick, M.4
-
19
-
-
0021354218
-
Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters
-
Rosowsky, A., Forsch, R. A., Yu, C. -S., Lazarus, H., Beardsley, G. P. (1984) Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters. J. Med. Chem. 27: 605-609
-
(1984)
J. Med. Chem.
, vol.27
, pp. 605-609
-
-
Rosowsky, A.1
Forsch, R.A.2
Yu, C.-S.3
Lazarus, H.4
Beardsley, G.P.5
-
20
-
-
0022922474
-
Methotrexate analogues. 28. Synthesis and biological evaluation of new γ-monoamides of aminopterin and methotrexate
-
Rosowsky, A., Bader, H., Radike-Smith, M., Cucchi, C. A., Wick, M. M., Freisheim, J. H. (1986) Methotrexate analogues. 28. Synthesis and biological evaluation of new γ-monoamides of aminopterin and methotrexate. J. Med. Chem. 29: 1703-1709
-
(1986)
J. Med. Chem.
, vol.29
, pp. 1703-1709
-
-
Rosowsky, A.1
Bader, H.2
Radike-Smith, M.3
Cucchi, C.A.4
Wick, M.M.5
Freisheim, J.H.6
-
21
-
-
0023471363
-
Determinants of resistance to antifolates: Biochemical phenotypes, their frequency of occurrence and circumvention
-
Sirotnak, F. M. (1987) Determinants of resistance to antifolates: biochemical phenotypes, their frequency of occurrence and circumvention. Natl Cancer Inst. Monogr. 5: 27-35
-
(1987)
Natl Cancer Inst. Monogr.
, vol.5
, pp. 27-35
-
-
Sirotnak, F.M.1
-
22
-
-
0028985514
-
Methotrexate-α-phenylalanine: Optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody-conjugate
-
Vitols, K. S., Haag-Zeino, B., Baer, T., Montejano, Y. D., Huennekens, F. M. (1995) Methotrexate-α-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody-conjugate. Cancer Res. 55: 478-481
-
(1995)
Cancer Res.
, vol.55
, pp. 478-481
-
-
Vitols, K.S.1
Haag-Zeino, B.2
Baer, T.3
Montejano, Y.D.4
Huennekens, F.M.5
-
23
-
-
0029118446
-
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: Correlates of molecular structure and biological activity
-
Westerhof, G. R., Schornagel, J. H., Kathmann, I., Jackman, A. L., Rosowsky, A., Forsch, R. A., Hynes, J. B., Boyle, F. T., Peters, G. J., Pinedo, H. M., Jansen, G. (1995) Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular structure and biological activity. Mol. Pharmacol. 48: 459-471
-
(1995)
Mol. Pharmacol.
, vol.48
, pp. 459-471
-
-
Westerhof, G.R.1
Schornagel, J.H.2
Kathmann, I.3
Jackman, A.L.4
Rosowsky, A.5
Forsch, R.A.6
Hynes, J.B.7
Boyle, F.T.8
Peters, G.J.9
Pinedo, H.M.10
Jansen, G.11
|