The early activation of PI3K strongly enhances the resistance of cortical neurons to hypoxic injury via the activation of downstream targets of the PI3K pathway and the normalization of the levels of PARP activity, ATP, and NAD+.

Molecular neurobiology

Volumn 47, Issue 2, 2013, Pages 757-769

  Noh, Min Young ^a   Kim, Young Seo ^b   Lee, Kyu Yong ^b   Lee, Young Joo ^b   Kim, Seung H ^b   Yu, Hyun Jeung ^b   Koh, Seong Ho ^b  

^a Hanyang University College of Medicine   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL HYPOXIA; DOWN REGULATION; ENZYME ACTIVATION; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL HYPOXIA; CELLS, CULTURED; CEREBRAL CORTEX; DOWN-REGULATION; ENZYME ACTIVATION; NAD; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84878432026     PISSN: None     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8382-6     Document Type: Article

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