Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress

Journal of Neurochemistry

Volumn 119, Issue 6, 2011, Pages 1262-1270

  Lee, Young Joo ^a   Park, Hyun Hee ^a   Koh, Seong Ho ^a,b   Choi, Na Young ^b   Lee, Kyu Yong ^a  

^a Hanyang University Guri Hospital   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

amlodipine besylate; amlodipine camsylate; calcium channel blocker; neuroprotection; oxidative stress; phosphatidylinositol 3 kinase

Indexed keywords

AMLODIPINE BESYLATE; AMLODIPINE CAMSYLATE; CALCIUM ANTAGONIST; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; HYDROGEN PEROXIDE; NIFEDIPINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME PHOSPHORYLATION; FETUS; INTRACELLULAR SIGNALING; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

AMLODIPINE; ANALYSIS OF VARIANCE; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; INDOLES; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION;

EID: 82955247593     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07529.x     Document Type: Article

References (39)

1. Arrowsmith J. E., Campbell S. F., Cross P. E., Stubbs J. K., Burges R. A., Gardiner D. G., and, Blackburn K. J., (1986) Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents. J. Med. Chem. 29, 1696-1702. (Pubitemid 16018197)
2. Cantley L. C., (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657. (Pubitemid 34579158)
3. Cantrell D. A., (2001) Phosphoinositide 3-kinase signalling pathways. J. Cell Sci. 114, 1439-1445. (Pubitemid 32427831)
4. de Champlain J., Wu R., Girouard H., Karas M., A E. L. M., Laplante M. A., and, Wu L., (2004) Oxidative stress in hypertension. Clin. Exp. Hypertens. 26, 593-601. (Pubitemid 40129747)
5. Coyle J. T., and, Puttfarcken P., (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695. (Pubitemid 23350687)
6. Crossthwaite A. J., Hasan S., and, Williams R. J., (2002) Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase. J. Neurochem. 80, 24-35. (Pubitemid 34614574)
7. Filomeni G., Aquilano K., Rotilio G., and, Ciriolo M. R., (2003) Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res. 63, 5940-5949. (Pubitemid 37187495)
8. Fogelholm R., Erila T., Palomaki H., Murros K., and, Kaste M., (2000) Effect of nimodipine on final infarct volume after acute ischemic stroke. Cerebrovasc. Dis. 10, 189-193. (Pubitemid 30219245)
9. Frame S., Cohen P., and, Biondi R. M., (2001) A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7, 1321-1327. (Pubitemid 32607364)
10. Gelmers H. J., Gorter K., de Weerdt C. J., and, Wiezer H. J., (1988) A controlled trial of nimodipine in acute ischemic stroke. N. Engl. J. Med. 318, 203-207. (Pubitemid 18035663)
11. Hajnoczky G., Csordas G., Das S., Garcia-Perez C., Saotome M., Sinha Roy S., and, Yi M., (2006) Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 40, 553-560. (Pubitemid 44660721)
12. Halliwell B., (2006) Oxidative stress and neurodegeneration: where are we now? J. Neurochem. 97, 1634-1658. (Pubitemid 43873658)
13. Horn J., and, Limburg M., (2001) Calcium antagonists for ischemic stroke: a systematic review. Stroke 32, 570-576. (Pubitemid 32155253)
14. Hoyt K. R., Gallagher A. J., Hastings T. G., and, Reynolds I. J., (1997) Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons. Neurochem. Res. 22, 333-340. (Pubitemid 27091824)
15. Jiang Q., Gu Z., Zhang G., and, Jing G., (2000) Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons. Brain Res. 857, 71-77. (Pubitemid 30107792)
16. Kawai H., Deguchi S., Deguchi K., et al. (2011) Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat. Brain Res. 1382, 308-314.
17. Kim J. S., Kang D. W., and, Kwon S. U., (2005) Intracranial atherosclerosis: incidence, diagnosis and treatment. J. Clin. Neurol. 1, 1-7. (Pubitemid 40470499)
18. Kitiyakara C., and, Wilcox C. S., (1998) Antioxidants for hypertension. Curr. Opin. Nephrol. Hypertens. 7, 531-538. (Pubitemid 28475292)
19. Kovacs R., Schuchmann S., Gabriel S., Kann O., Kardos J., and, Heinemann U., (2002) Free radical-mediated cell damage after experimental status epilepticus in hippocampal slice cultures. J. Neurophysiol. 88, 2909-2918. (Pubitemid 35448678)
20. Lee Y. J., Park K. H., Park H. H., Kim Y. J., Lee K. Y., Kim S. H., and, Koh S. H., (2009) Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway. J. Neurochem. 111, 90-100.
21. Lukic-Panin V., Kamiya T., Zhang H., Hayashi T., Tsuchiya A., Sehara Y., Deguchi K., Yamashita T., and, Abe K., (2007) Prevention of neuronal damage by calcium channel blockers with antioxidative effects after transient focal ischemia in rats. Brain Res. 1176, 143-150. (Pubitemid 47553120)
22. Martinez-Vila E., Guillen F., Villanueva J. A., Matias-Guiu J., Bigorra J., Gil P., Carbonell A., and, Martinez-Lage J. M., (1990) Placebo-controlled trial of nimodipine in the treatment of acute ischemic cerebral infarction. Stroke 21, 1023-1028. (Pubitemid 20218165)
23. Naziroglu M., (2007) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem. Res. 32, 1990-2001. (Pubitemid 47497894)
24. Naziroglu M., (2009) Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem. Res. 34, 2181-2191.
25. Naziroglu M., (2011) TRPM2 cation channels, oxidative stress and neurological diseases: where are we now? Neurochem. Res. 36, 355-366.
26. Noh M. Y., Koh S. H., Kim Y., Kim H. Y., Cho G. W., and, Kim S. H., (2009) Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J. Neurochem. 108, 1116-1125.
27. Pap M., and, Cooper G. M., (2002) Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Mol. Cell. Biol. 22, 578-586. (Pubitemid 34027502)
28. Park J. Y., Kim K. A., Lee G. S., Park P. W., Kim S. L., Lee Y. S., Lee Y. W., and, Shin E. K., (2004a) Randomized, open-label, two-period crossover comparison of the pharmacokinetic and pharmacodynamic properties of two amlodipine formulations in healthy adult male Korean subjects. Clin. Ther. 26, 715-723.
29. Park J. Y., Kim K. A., Park P. W., Suh K. H., and, Lee G. S., (2004b) Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover study. Clin. Ther. 26, 2092-2101. (Pubitemid 40353619)
30. Simonson S. G., Zhang J., Canada Jr A. T., Su Y. F., Benveniste H., and, Piantadosi C. A., (1993) Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. J. Cereb. Blood Flow Metab. 13, 125-134. (Pubitemid 23016609)
31. Smith M. A., Perry G., Richey P. L., Sayre L. M., Anderson V. E., Beal M. F., and, Kowall N., (1996) Oxidative damage in Alzheimer's. Nature 382, 120-121.
32. Starkov A. A., Polster B. M., and, Fiskum G., (2002) Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83, 220-228.
33. Uguz A. C., Naziroglu M., Espino J., Bejarano I., Gonzalez D., Rodriguez A. B., and, Pariente J. A., (2009) Selenium modulates oxidative stress-induced cell apoptosis in human myeloid HL-60 cells through regulation of calcium release and caspase-3 and -9 activities. J. Membr. Biol. 232, 15-23.
34. Vanhaesebroeck B., and, Waterfield M. D., (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253, 239-254.
35. Weiss J. H., Hartley D. M., Koh J., and, Choi D. W., (1990) The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science 247, 1474-1477.
36. Williams R. J., Spencer J. P., Goni F. M., and, Rice-Evans C. A., (2004) Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neurosci. Lett. 371, 106-110. (Pubitemid 39440754)
37. Yoshii T., Iwai M., Li Z., et al. (2006) Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions. Hypertens. Res. 29, 457-466. (Pubitemid 44109037)
38. Zhu D., Lipsky R. H., and, Marini A. M., (2002) Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons. Amino Acids 23, 11-17.
39. Zhuang Z. Y., Xu H., Clapham D. E., and, Ji R. R., (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J. Neurosci. 24, 8300-8309. (Pubitemid 39280809)