Inhibition of transforming growth factor β1/Smad3 signaling decreases hypoxia-inducible factor-1α protein stability by inducing prolyl hydroxylase 2 expression in human periodontal ligament cells

Journal of Periodontology

Volumn 84, Issue 9, 2013, Pages 1346-1352

  Watanabe, Teppei ^a   Yasue, Akihiro ^a   Tanaka, Eiji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Alpha subunit; Hypoxia inducible factor 1; Transforming growth factor beta1

Indexed keywords

6,7 DIMETHYL 2 (2E) 3 (1 METHYL 2 PHENYL 1H PYRROLO(2,3 B)PYRIDIN 3 YL PROP 2 ENOYL) 1,2,3,4 TETRAHYDROISOQUINOLINE HYDROCHLORIDE; 6,7-DIMETHYL-2-(2E)-3-(1-METHYL-2-PHENYL-1H-PYRROLO(2,3-B)PYRIDIN-3-YL-PROP-2-ENOYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE; CYCLOHEXIMIDE; EGLN1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; ISOQUINOLINE DERIVATIVE; PROTEIN SYNTHESIS INHIBITOR; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA1;

ADOLESCENT; ARTICLE; CELL CULTURE; CHRONIC PERIODONTITIS; CULTURE TECHNIQUE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; HUMAN; MALE; METABOLISM; PATHOLOGY; PERIODONTAL LIGAMENT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME;

ADOLESCENT; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHRONIC PERIODONTITIS; CYCLOHEXIMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; ISOQUINOLINES; MALE; PERIODONTAL LIGAMENT; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; PYRIDINES; PYRROLES; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84878391134     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2012.120373     Document Type: Article

References (25)

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