Evaluation of delivery conditions for cutaneous plasmid electrotransfer using a multielectrode array

Gene Therapy

Volumn 18, Issue 5, 2011, Pages 496-500

  Ferraro, B ^a   Heller, L C ^b   Cruz, Y L ^a   Guo, S ^b   Donate, A ^a   Heller, R ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b OLD DOMINION UNIVERSITY   (United States)

Author keywords

electrode design; electrotransfer; in vivo electroporation

Indexed keywords

DNA VACCINE; LUCIFERASE; LUCIFERIN; PLASMID DNA;

ANIMAL EXPERIMENT; ARTICLE; DNA IMMUNIZATION; DOSE RESPONSE; ELECTRIC FIELD; ELECTRODE; ELECTROPORATION; ELECTROTRANSFER; GENE EXPRESSION; GUINEA PIG; MULTIELECTRODE ARRAY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; REPORTER GENE; SKIN; TRANSGENE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ELECTRODES; ELECTROPORATION; FEMALE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GUINEA PIGS; LUCIFERASES; PLASMIDS; TRANSGENES;

CAVIA;

EID: 79955940970     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.171     Document Type: Article

References (42)

1. Vogel JC. Nonviral skin gene therapy. Hum Gene Ther 2000; 11: 2253-2259.
2. Sersa G, Cemazar M, Semrov D, Miklavcic D. Changing electrode orientation improves the efficacy of electrochemotherapy of solid tumors in mice. Bioelectrochem Bioenerg 1996; 39: 61-66. (Pubitemid 26050126)
3. Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim Biophys Acta 1997; 1334: 9-14. (Pubitemid 27063940)
4. Faurie C, Phez E, Golzio M, Vossen C, Lesbordes JC, Delteil C et al. Effect of electric field vectoriality on electrically mediated gene delivery in mammalian cells. Biochim Biophys Acta 2004; 1665: 92-100. (Pubitemid 39303574)
5. Heller LC, Jaroszeski MJ, Coppola D, Mccray AN, Hickey J, Heller R. Optimization of cutaneous electrically mediated plasmid DNA delivery using novel electrode. Gene Therapy 2007; 14: 275-280. (Pubitemid 46152631)
6. Heller LC, Jaroszeski MJ, Coppola D, Heller R. Comparison of electrically mediated and liposome-complexed plasmid DNA delivery to the skin. Genet Vaccines Ther 2008; 6: 16-23.
7. Ferraro B, Cruz YL, Coppola D, Heller R. Intradermal delivery of plasmid VEGF(165) by electroporation promotes wound healing. Mol Ther 2009; 17: 651-657.
8. Heller R, Cruz Y, Heller LC, Gilbert RA, Jaroszeski MJ. Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array. Hum Gene Ther 2010; 21: 357-362.
9. Ferraro B, Cruz YL, Baldwin M, Coppola D, Heller R. Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by non-invasive electroporation. Gene Therapy 2010; 17: 763-769.
10. Mershon MM, Mitcheltree LW, Petrali JP, Braue EH, Wade JV. Hairless guinea pig bioassay model for vesicant vapor exposures. Fundam Appl Toxicol 1990; 15: 622-630. (Pubitemid 20362407)
11. Sueki H, Gammal C, Kudoh K, Kligman AM. Hairless guinea pig skin: anatomical basis for studies of cutaneous biology. Eur J Dermatol 2000; 10: 357-364.
12. Lin W, Cormier M, Samiee A, Griffin A, Johnson B, Teng CL et al. Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux) technology. Pharm Res 2001; 18: 1789-1793. (Pubitemid 34020438)
13. Heller R, Jaroszeski M, Atkin A, Moradpour D, Gilbert R, Wands J et al. In vivo gene electroinjection and expression in rat liver. FEBS Lett 1996; 389: 225-228. (Pubitemid 26251823)
14. Nishi T, Yoshizato K, Yamashiro S, Takeshima H, Sato K, Hamada K et al. High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res 1996; 56: 1050-1055. (Pubitemid 26065399)
15. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870. (Pubitemid 28405859)
16. Heller LC, Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 2006; 17: 890-897. (Pubitemid 46076749)
17. Bodles-Brakhop AM, Heller R, Draghia-Akli R. Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments. Mol Ther 2009; 17: 585-592.
18. Gothelf A, Gehl J. Gene electrotransfer to skin; review of existing literature and clinical perspectives. Curr Gene Ther 2010; 10: 287-299.
19. Glasspool-Malone J, Somiari S, Drabick JJ, Malone RW. Efficient nonviral cutaneous transfection. Mol Ther 2000; 2: 140-146.
20. Drabick JJ, Glasspool-Malone J, King A, Malone RW. Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Mol Ther 2001; 3: 249-255. (Pubitemid 32509828)
21. Heller R, Schultz J, Lucas ML, Jaroszeski MJ, Heller LC, Gilbert RA et al. Intradermal delivery of interleukin-12 plasmid DNA by in vivo electroporation. DNA Cell Biol 2001; 20: 381.
22. Zhang L, Nolan E, Kreitschitz S, Rabussay DP. Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biochimica et BIOPHYSICA Acta-Gen Subj 2002; 1572: 1-9. (Pubitemid 35229983)
23. Babiuk S, Baca-Estrada ME, Foldvari M, Baizer L, Stout R, Storms M et al. Needle-free topical electroporation improves gene expression from plasmids administered in porcine skin. Mol Ther 2003; 8: 992-998. (Pubitemid 38072312)
24. Marti G, Ferguson M, Wang J, Byrnes C, Dieb R, Qaiser R et al. Electroporative transfection with KGF-1 DNA improves wound healing in a diabetic mouse model. Gene Therapy 2004; 11: 1780-1785. (Pubitemid 40028539)
25. Medi BM, Hoselton S, Marepalli RB, Singh J. Skin targeted DNA vaccine delivery using electroporation in rabbits. I: efficacy. Int J Pharm 2005; 294: 53-63. (Pubitemid 40462322)
26. Roos AK, Moreno S, Leder C, Pavlenko M, King A, Pisa P. Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation. Mol Ther 2006; 13: 320-327. (Pubitemid 43056897)
27. Hooper JW, Golden JW, Ferro AM, King AD. Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge. Vaccine 2007; 25: 1814-1823. (Pubitemid 46176327)
28. Vandermeulen G, Staes E, Vanderhaeghen ML, Bureau MF, Scherman D, Preat V. Optimisation of intradermal DNA electrotransfer for immunisation. J Control Release 2007; 124: 81-87. (Pubitemid 350088207)
29. Gao Z, Wu X, Song N, Cao Y, Liu W. Electroporation-mediated plasmid gene transfer in rat incisional wound. J Dermatol Sci 2007; 47: 161-164. (Pubitemid 46881111)
30. Hirao LA, Wu L, Khan AS, Satishchandran A, Draghia-Akli R, Weiner DB. Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques. Vaccine 2008; 26: 440-448.
31. Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV et al. Age-dependent impairment of HIF-1alpha expression in diabetic mice: correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 2008; 217: 319-327.
32. Andre F, Gehl J, Sersa G, Preat V, Hojman P, Eriksen J et al. Efficiency of high and low voltage pulse combinations for gene electrotransfer in muscle, liver, tumor and skin. Hum Gene Ther 2008; 19: 1261-1272.
33. Draghia-Akli R, Khan AS, Brown PA, Pope MA, Wu L, Hirao L et al. Parameters for DNA vaccination using adaptive constant-current electroporation in mouse and pig models. Vaccine 2008; 26: 5230-5237.
34. Martinon F, Kaldma K, Sikut R, Culina S, Romain G, Tuomela M et al. Persistent immune responses induced by a human immunodeficiency virus DNA vaccine delivered in association with electroporation in the skin of nonhuman primates. Hum Gene Ther 2009; 20: 1291-1307.
35. Vandermeulen G, Richiardi H, Escriou V, Ni J, Fournier P, Schirrmacher V et al. Skin-specific promoters for genetic immunisation by DNA electroporation. Vaccine 2009; 27: 4272-4277.
36. Roos AK, Eriksson F, Timmons JA, Gerhardt J, Nyman U, Gudmundsdotter L et al. Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment. PLoS One 2009; 4: e7226.
37. Roos AK, Eriksson F, Walters DC, Pisa P, King AD. Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patients. Mol Ther 2009; 17: 1637-1642.
38. Gothelf A, Hojman P, Gehl J. Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice. Gene Therapy 2010; 17: 1077-1084.
39. Daugimont L, Baron N, Vandermeulen G, Pavselj N, Miklavcic D, Jullien MC et al. Hollow microneedle arrays for intradermal drug delivery and DNA electroporation. J Membr Biol 2010; 236: 117-125.
40. Hengge UR, Walker PS, Vogel JC. Expression of naked DNA in human, pig, and mouse skin. J Clin Invest 1996; 97: 2911-2916. (Pubitemid 26197107)
41. Heller L, Jaroszeski MJ, Coppola D, Pottinger C, Gilbert R, Heller R. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Therapy 2000; 7: 826-829. (Pubitemid 30303578)
42. Contag CH, Spilman SD, Contag PR, Oshiro M, Eames B, Dennery P et al. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem Photobiol 1997; 66: 523-531. (Pubitemid 127470201)