-
1
-
-
47749141560
-
ATR: an essential regulator of genome integrity
-
Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 2008; 9: 616-27.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
2
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434: 605-11.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
3
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
4
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri A, Falck J, Lukas C, et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006; 8: 37-45.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
-
5
-
-
41149094512
-
Regulation of DNA repair throughout the cell cycle
-
Branzei D, Foiani M. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 2008; 9: 297-308.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 297-308
-
-
Branzei, D.1
Foiani, M.2
-
6
-
-
33748089029
-
DNA-PK autophosphorylation facilitates Artemis endonuclease activity
-
Goodarzi AA, Yu Y, Riballo E, et al. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J 2006; 25: 3880-9.
-
(2006)
EMBO J
, vol.25
, pp. 3880-3889
-
-
Goodarzi, A.A.1
Yu, Y.2
Riballo, E.3
-
7
-
-
20644463916
-
The Artemis: DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
-
Ma Y, Schwarz K, Lieber MR. The Artemis: DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst) 2005; 4: 845-51.
-
(2005)
DNA Repair (Amst)
, vol.4
, pp. 845-851
-
-
Ma, Y.1
Schwarz, K.2
Lieber, M.R.3
-
8
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
Riballo E, Kuhne M, Rief N, et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 2004; 16: 715-24.
-
(2004)
Mol Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
-
9
-
-
0037809601
-
Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families
-
Kobayashi N, Agematsu K, Sugita K, et al. Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families. Hum Genet 2003; 112: 348-52.
-
(2003)
Hum Genet
, vol.112
, pp. 348-352
-
-
Kobayashi, N.1
Agematsu, K.2
Sugita, K.3
-
10
-
-
33845715977
-
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
-
Stiff T, Walker SA, Cerosaletti K, et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 2006; 25: 5775-82.
-
(2006)
EMBO J
, vol.25
, pp. 5775-5782
-
-
Stiff, T.1
Walker, S.A.2
Cerosaletti, K.3
-
11
-
-
33645789832
-
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks
-
Sakasai R, Shinohe K, Ichijima Y, et al. Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells 2006; 11: 237-46.
-
(2006)
Genes Cells
, vol.11
, pp. 237-246
-
-
Sakasai, R.1
Shinohe, K.2
Ichijima, Y.3
-
12
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14: 397-402.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
13
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21: 4129-39.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
14
-
-
33746948393
-
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
-
Liu S, Bekker-Jensen S, Mailand N, Lukas C, Bartek J, Lukas J. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol 2006; 26: 6056-64.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6056-6064
-
-
Liu, S.1
Bekker-Jensen, S.2
Mailand, N.3
Lukas, C.4
Bartek, J.5
Lukas, J.6
-
15
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 2000; 97: 10389-94.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.J.6
-
16
-
-
26444553297
-
Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?
-
Takahashi A, Ohnishi T. Does gammaH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett 2005; 229: 171-9.
-
(2005)
Cancer Lett
, vol.229
, pp. 171-179
-
-
Takahashi, A.1
Ohnishi, T.2
-
17
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001; 276: 47759-62.
-
(2001)
J Biol Chem
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
18
-
-
16844384184
-
DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci
-
Robison JG, Lu L, Dixon K, Bissler JJ. DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. J Biol Chem 2005; 280: 12927-34.
-
(2005)
J Biol Chem
, vol.280
, pp. 12927-12934
-
-
Robison, J.G.1
Lu, L.2
Dixon, K.3
Bissler, J.J.4
-
19
-
-
35848930133
-
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
-
Hanada K, Budzowska M, Davies SL, et al. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol 2007; 14: 1096-104.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1096-1104
-
-
Hanada, K.1
Budzowska, M.2
Davies, S.L.3
-
20
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
Furuta T, Takemura H, Liao ZY, et al. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem 2003; 278: 20303-12.
-
(2003)
J Biol Chem
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
-
21
-
-
77953932126
-
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
-
Shi W, Feng Z, Zhang J, et al. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis 2010; 31: 994-1002.
-
(2010)
Carcinogenesis
, vol.31
, pp. 994-1002
-
-
Shi, W.1
Feng, Z.2
Zhang, J.3
-
22
-
-
0037106180
-
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
-
Chan DW, Chen BP, Prithivirajsingh S, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002; 16: 2333-8.
-
(2002)
Genes Dev
, vol.16
, pp. 2333-2338
-
-
Chan, D.W.1
Chen, B.P.2
Prithivirajsingh, S.3
-
23
-
-
17644384427
-
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
-
Chen BP, Chan DW, Kobayashi J, et al. Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem 2005; 280: 14709-15.
-
(2005)
J Biol Chem
, vol.280
, pp. 14709-14715
-
-
Chen, B.P.1
Chan, D.W.2
Kobayashi, J.3
-
24
-
-
0031930488
-
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
-
Hammarsten O, Chu G. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc Natl Acad Sci USA 1998; 95: 525-30.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 525-530
-
-
Hammarsten, O.1
Chu, G.2
-
25
-
-
0037169516
-
DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends
-
Martensson S, Hammarsten O. DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends. J Biol Chem 2002; 277: 3020-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 3020-3029
-
-
Martensson, S.1
Hammarsten, O.2
-
26
-
-
0028286463
-
DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
-
Morozov VE, Falzon M, Anderson CW, Kuff EL. DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J Biol Chem 1994; 269: 16684-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 16684-16688
-
-
Morozov, V.E.1
Falzon, M.2
Anderson, C.W.3
Kuff, E.L.4
-
27
-
-
0027156140
-
EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
-
Falzon M, Fewell JW, Kuff EL. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem 1993; 268: 10546-52.
-
(1993)
J Biol Chem
, vol.268
, pp. 10546-10552
-
-
Falzon, M.1
Fewell, J.W.2
Kuff, E.L.3
-
28
-
-
33747352774
-
The Bloom's syndrome helicase can promote the regression of a model replication fork
-
Ralf C, Hickson ID, Wu L. The Bloom's syndrome helicase can promote the regression of a model replication fork. J Biol Chem 2006; 281: 22839-46.
-
(2006)
J Biol Chem
, vol.281
, pp. 22839-22846
-
-
Ralf, C.1
Hickson, I.D.2
Wu, L.3
-
29
-
-
50649091340
-
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links
-
Bae JB, Mukhopadhyay SS, Liu L, et al. Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene 2008; 27: 5045-56.
-
(2008)
Oncogene
, vol.27
, pp. 5045-5056
-
-
Bae, J.B.1
Mukhopadhyay, S.S.2
Liu, L.3
-
30
-
-
50649091874
-
Structural and functional relationships of the XPF/MUS81 family of proteins
-
Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem 2008; 77: 259-87.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 259-287
-
-
Ciccia, A.1
McDonald, N.2
West, S.C.3
-
31
-
-
77953278318
-
Secondary structure formation and DNA instability at fragile site FRA16B
-
Burrow AA, Marullo A, Holder LR, Wang YH. Secondary structure formation and DNA instability at fragile site FRA16B. Nucleic Acids Res 2010; 38: 2865-77.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2865-2877
-
-
Burrow, A.A.1
Marullo, A.2
Holder, L.R.3
Wang, Y.H.4
-
32
-
-
48249141027
-
Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins
-
Voineagu I, Narayanan V, Lobachev KS, Mirkin SM. Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins. Proc Natl Acad Sci USA 2008; 105: 9936-41.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9936-9941
-
-
Voineagu, I.1
Narayanan, V.2
Lobachev, K.S.3
Mirkin, S.M.4
-
33
-
-
0043133778
-
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
-
Ding Q, Reddy YV, Wang W, et al. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol 2003; 23: 5836-48.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5836-5848
-
-
Ding, Q.1
Reddy, Y.V.2
Wang, W.3
-
34
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434: 864-70.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
35
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434: 907-13.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
-
36
-
-
84878177965
-
Artemis-dependent cell death by prolonged replication fork stalling
-
Unno J. Artemis-dependent cell death by prolonged replication fork stalling. Jpn J Pediatr Hematol. 2011; 25: 86-90.
-
(2011)
Jpn J Pediatr Hematol
, vol.25
, pp. 86-90
-
-
Unno, J.1
-
37
-
-
52149121819
-
KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation
-
Abe T, Ishiai M, Hosono Y, et al. KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Cell Signal 2008; 20: 1978-85.
-
(2008)
Cell Signal
, vol.20
, pp. 1978-1985
-
-
Abe, T.1
Ishiai, M.2
Hosono, Y.3
|