The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia

Biochemical and Biophysical Research Communications

Volumn 434, Issue 4, 2013, Pages 722-727

  Park, Seong Joon ^a,b   Kim, Joong Gook ^a   Son, Tae Gen ^a   Yi, Joo Mi ^a   Kim, Nam Deuk ^b   Yang, Kwangmo ^a,c,d   Heo, Kyu ^a  

^a Dongnam Institute of Radiological and Medical Science   (South Korea)

^b Pusan National University   (South Korea)

^c Dongnam Institute of Radiological and Medical Science   (South Korea)

^d Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

ADM; Cell proliferation; Histone modification; Hypoxia; JMJD1A

Indexed keywords

ADRENOMEDULLIN; HISTONE DEMETHYLASE; JMJD1A PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE SILENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADRENOMEDULLIN; ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878189918     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.091     Document Type: Article

References (32)

1. Semenza G.L. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin. Cancer Biol. 2009, 19:12-16.
2. Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2002, 2:38-47.
3. Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 2002, 8:S62-7.
4. Lu X., Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin. Cancer Res. 2010, 16:5928-5935.
5. Ruan K., Song G., Ouyang G. Role of hypoxia in the hallmarks of human cancer. J. Cell. Biochem. 2009, 107:1053-1062.
6. Maxwell P.H., Pugh C.W., Ratcliffe P.J. Activation of the HIF pathway in cancer. Curr. Opin. Genet. Dev. 2001, 11:293-299.
7. Powis G., Kirkpatrick L. Hypoxia inducible factor-1alpha as a cancer drug target. Mol. Cancer Ther. 2004, 3:647-654.
8. Johnson A.B., Denko N., Barton M.C. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat. Res. 2008, 640:174-179.
9. Kim J.G., Yi J.M., Park S.J., Kim J.S., Son T.G., Yang K., Yoo M.A., Heo K. Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell. Biochim. Biophys. Acta 1819, 2012:1200-1207.
10. Klose R.J., Kallin E.M., Zhang Y. JmjC-domain-containing proteins and histone demethylation. Nat. Rev. Genet. 2006, 7:715-727.
11. Yamane K., Toumazou C., Tsukada Y., Erdjument-Bromage H., Tempst P., Wong J., Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006, 125:483-495.
12. Okada Y., Scott G., Ray M.K., Mishina Y., Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 2007, 450:119-123.
13. Tateishi K., Okada Y., Kallin E.M., Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009, 458:757-761.
14. Inagaki T., Tachibana M., Magoori K., Kudo H., Tanaka T., Okamura M., Naito M., Kodama T., Shinkai Y., Sakai J. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells 2009, 14:991-1001.
15. Chen H., Kluz T., Zhang R., Costa M. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis 2010, 31:2136-2144.
16. Wellmann S., Bettkober M., Zelmer A., Seeger K., Faigle M., Eltzschig H.K., Buhrer C. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem. Biophys. Res. Commun. 2008, 372:892-897.
17. Pollard P.J., Loenarz C., Mole D.R., McDonough M.A., Gleadle J.M., Schofield C.J., Ratcliffe P.J. Regulation of jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem. J. 2008, 416:387-394.
18. Beyer S., Kristensen M.M., Jensen K.S., Johansen J.V., Staller P. The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J. Biol. Chem. 2008, 283:36542-36552.
19. Sar A., Ponjevic D., Nguyen M., Box A.H., Demetrick D.J. Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia. Cell Tissue Res. 2009, 337:223-234.
20. Krieg A.J., Rankin E.B., Chan D., Razorenova O., Fernandez S., Giaccia A.J. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol. Cell. Biol. 2010, 30:344-353.
21. Barlev N.A., Liu L., Chehab N.H., Mansfield K., Harris K.G., Halazonetis T.D., Berger S.L. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 2001, 8:1243-1254.
22. Rotili D., Mai A. Targeting histone demethylases: a new avenue for the fight against cancer. Genes Cancer 2011, 2:663-679.
23. Miller M.J., Martinez A., Unsworth E.J., Thiele C.J., Moody T.W., Elsasser T., Cuttitta F. Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor. J. Biol. Chem. 1996, 271:23345-23351.
24. Garayoa M., Martinez A., Lee S., Pio R., An W.G., Neckers L., Trepel J., Montuenga L.M., Ryan H., Johnson R., Gassmann M., Cuttitta F. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol. Endocrinol. 2000, 14:848-862.
25. Ogita T., Hashimoto E., Yamasaki M., Nakaoka T., Matsuoka R., Kira Y., Fujita T. Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells. J. Hypertens. 2001, 19:603-608.
26. Ouafik L., Sauze S., Boudouresque F., Chinot O., Delfino C., Fina F., Vuaroqueaux V., Dussert C., Palmari J., Dufour H., Grisoli F., Casellas P., Brunner N., Martin P.M. Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Am. J. Pathol. 2002, 160:1279-1292.
27. Martinez A., Vos M., Guedez L., Kaur G., Chen Z., Garayoa M., Pio R., Moody T., Stetler-Stevenson W.G., Kleinman H.K., Cuttitta F. The effects of adrenomedullin overexpression in breast tumor cells. J. Natl. Cancer Inst. 2002, 94:1226-1237.
28. Ishikawa T., Chen J., Wang J., Okada F., Sugiyama T., Kobayashi T., Shindo M., Higashino F., Katoh H., Asaka M., Kondo T., Hosokawa M., Kobayashi M. Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis. Oncogene 2003, 22:1238-1242.
29. Deville J.L., Bartoli C., Berenguer C., Fernandez-Sauze S., Kaafarani I., Delfino C., Fina F., Salas S., Muracciole X., Mancini J., Lechevallier E., Martin P.M., Figarella-Branger D., Ouafik L., Daniel L. Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. Int. J. Cancer 2009, 125:2307-2315.
30. Oehler M.K., Norbury C., Hague S., Rees M.C., Bicknell R. Adrenomedullin inhibits hypoxic cell death by upregulation of bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oncogene 2001, 20:2937-2945.
31. Lachner M., O'Sullivan R.J., Jenuwein T. An epigenetic road map for histone lysine methylation. J. Cell Sci. 2003, 116:2117-2124.
32. Nottke A., Colaiacovo M.P., Shi Y. Developmental roles of the histone lysine demethylases. Development 2009, 136:879-889.