Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis

Oncogene

Volumn 22, Issue 8, 2003, Pages 1238-1242

  Ishikawa, Takahisa ^a,b   Chen, Jian ^a   Wang, Jingxin ^a   Okada, Futoshi ^a   Sugiyama, Toshiro ^b   Kobayashi, Takahiko ^b   Shindo, Masanobu ^a   Higashino, Fumihiro ^a   Katoh, Hiroyuki ^b   Asaka, Masahiro ^b   Kondo, Takeshi ^b   Hosokawa, Masuo ^a   Kobayashi, Masanobu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenomedullin; Adrenomedullin antagonist; Angiogenesis; Hypoxia; Pancreatic cancer

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN ANTAGONIST; ANGIOGENESIS INHIBITOR; CYCLINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; SCID MOUSE;

ADRENOMEDULLIN; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, SCID; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PEPTIDE FRAGMENTS; PEPTIDES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA;

EID: 0037468266     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206207     Document Type: Article

References (26)

1. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura K, Hosokawa M and Asaka M. (2001). Cancer Res., 61, 6548-6554.
2. Browder T, Folkman J and Pirie-Shepherd S. (2000). J Biol. Chem., 275, 1521-1524.
3. Carmeliet P. (2000). Nat. Med., 6, 389-395.
4. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxell P, Koch CJ, Ratcliffe P, Moons F, Jain RK, Collen D and Keshet E. (1998). Nature, 394, 485-490.
5. Choi S, Kobayashi M, Wang J, Habellhah H, Okada F, Hamada J, Moriuchi T, Totsuka Y and Hosokawa M. (2000). Clin. Exp. Metast., 18, 45-50.
6. Cormier-Regard S, Nguyen SV and Claycomb WC. (1998). J. Biol. Chem., 273, 1787-1792.
7. Drake CJ and Little CD. (1995). Proc. Natl. Acad. Sci. USA, 92, 7657-7661.
8. Eguchi S, Hirata Y, Iwasaki H, Sato K, Watanabe TX, Inui T, Nakajima K, Sakakibara S and Marumo F. (1994). Endocrinology, 135, 2454-2458.
9. Folkman J. (1995). Nat. Med., 1, 27-31.
10. Garayoa M, Martinez A, Lee S, Pio R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M and Cuttitta F. (2000). Mol. Endocrinol., 14, 848-862.
11. Hayakawa H, Hirata Y, Kakoki M, Suzuki Y, Nishimatsu H, Nagata D, Suzuki E, Kikuchi K, Nagano T, Kangawa K, Matsuo H, Sugimoto T and Omata M. (1999). Hypertension, 33, 689-693.
12. Kato H, Shichiri M, Marumo F and Hirata Y. (1997). Endocrinology, 138, 2615-2620.
13. Kerbel RS. (2000). Carcinogenesis, 21, 505-515.
14. Miller MJ, Martinez A, Unsworth EJ, Thiele CJ, Moody TW, Elsasser T and Cuttitta F. (1996). J Biol. Chem., 271, 23345-23351
15. Muff R, Born W and Fischer JA. (2001). Peptides, 22, 1765-1772.
16. Nakayama M, Takahashi K, Murakami O, Shirato K and Shibahara S. (1998). Biochem. Biophys. Res. Commun., 243, 514-517.
17. Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada J, Seth P, Katoh H, Watanabe H, Raz A and Hosokawa M. (2002). Br. J. Cancer, 86, 1914-1919.
18. Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kangawa K, Eto T and Wada A. (1993). Biochem. Biophys. Res. Commun., 196, 245-251.
19. Oehler MK, Hague S, Rees MC and Bicknell R. (2002). Oncogene, 21, 2815-2821.
20. Oehler MK, Norbury C, Hague S, Rees MC and Bicknell R. (2001). Oncogene, 20, 2937-2945.
21. Ouafik L, Sauze S, Boudouresque F, Chinot O, Delfino C, Fina F, Vuaroqueaux V, Dussert C, Palmari J, Dufour H, Grisoli F, Casellas P, Brunner N and Martin PM. (2002). Am. J. Pathol., 160, 1279-1292.
22. Rocchi P, Boudouresque F, Zamora AJ, Muracciole X, Lechevallier E, Martin PM and Ouafik L. (2001). Cancer Res., 61, 1196-1206.
23. Suri C, McClain J, Thurston G, McDonald DM, Zhou H, Oldmixon EH, Sato TN and Yancopoulos GD. (1998). Science, 282, 468-471.
24. Watanabe TX, Itahara Y, Inui T, Yoshizawa-Kumagaye K, Nakajima K and Sakakibara S. (1996). Biochem. Biophys. Res. Commun., 219, 59-63.
25. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ and Holash J. (2000). Nature, 407, 242-248.
26. Zhao L, Brown LA, Owji AA, Nunez DJ, Smith DM, Ghatei MA, Bloom SR and Wilkins MR. (1996). Am. J. Physiol., 271, 622-629.