Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro

Neuropharmacology

Volumn 71, Issue , 2013, Pages 19-26

  Rehni, Ashish K ^a   Singh, Thakur Gurjeet ^a  

^a CHITKARA UNIVERSITY   (India)

Author keywords

Farnesyltransferase; FTI 276; Geranylgeranyl transferase; GGTI 2133; Morphine dependence; Withdrawal syndrome

Indexed keywords

FARNESYLTRANSFERASE I; GERANYLGERANYLTRANSFERASE; GGTI 2133; MORPHINE SULFATE; N [[4 (IMIDAZOL 4 YL)METHYLAMINO] 2 (1 NAPHTHYL)BENZOYL]LEUCINE TRIFLUOROACETATE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; NALOXONE; TRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; JUMPING; MALE; MORPHINE ADDICTION; MOUSE; NONHUMAN; OPIOID WITHDRAWAL; PRIORITY JOURNAL; REARING; SCORING SYSTEM; WITHDRAWAL SYNDROME;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FEMALE; ILEUM; IMIDAZOLES; LEUCINE; MALE; METHIONINE; MICE; MORPHINE DEPENDENCE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NAPHTHALENES; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84878140393     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.01.022     Document Type: Article

References (66)

1. T. Avidor-Reiss, I. Nevo, R. Levy, T. Pfeuffer, and Z. Vogel Chronic opioid treatment induces adenylyl cyclase v superactivation involvement of Gβγ J. Biol. Chem. 271 35 1996 21309 21315
2. J.M. Baeyens, E. Esposito, G. Ossowska, and R. Samanin Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats Eur. J. Pharmacol. 137 1 1987 9 13
3. A. Capasso, and A. Gallo Molecules acting on CB1 receptor and their effects on morphine withdrawal in vitro Open Biochem. J. 3 2009 78 84
4. A. Capasso, and L. Sorrentino Differential influence of D1 and D2 dopamine receptors on acute opiate withdrawal in guinea-pig isolated ileum Br. J. Pharmacol. 120 1997 1001 1006
5. G. Cassella, and R.L. Burger Statistical Inference second ed. 2002 Duxbury Pacific Grove, CA p. 243
6. W.J. Chen, D.A. Andres, J.L. Goldstein, and M.S. Brown Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase Proc. Natl. Acad. Sci. U. S. A. 88 24 1991 11368 11372
7. B. Cuellar, A.P. Fernández, I. Lizasoain, M.A. Moro, P. Lorenzo, M.L. Bentura, J. Rodrigo, and J.C. Leza Up-regulation of neuronal NO synthase immunoreactivity in opiate dependence and withdrawal Psychopharmacol. (Berl) 148 2000 66 73
8. F.E. D'Amour, and D.L. Smith A method for determining loss of pain sensation J. Pharmacol. Exp. Ther. 72 1941 74 79
9. C. Deraeve, Z. Guo, R.S. Bon, W. Blankenfeldt, R. DiLucrezia, and A. Wolf Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase J. Am. Chem. Soc. 134 17 2012 7384 7391
10. W.A. Falls, and J.E. Kelsey Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal Behav. Neurosci. 103 1989 842 849
11. T. Fan, G. Varghese, T. Nguyen, R. Tse, B.F. O'Dowd, and S.R. George A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers J. Biol. Chem. 280 2005 38478 38488
12. B. Gay, S. Suarez, G. Caravatti, P. Furet, T. Meyer, and J. Schoepfer Selective GRB2 SH2 inhibitors as anti-Ras therapy Int. J. Cancer 83 2 1999 235 241
13. S.R. George, T. Fan, Z. Xie, R. Tse, V. Tam, G. Varghese, and B.F. O'Dowd Oligomerization of mu- and delta-opioid receptors. generation of novel functional properties J. Biol. Chem. 275 2000 26128 26135
14. D. Georgescu, V. Zachariou, M. Barrot, M. Mieda, J.T. Willie, A.J. Eisch, M. Yanagisawa, E.J. Nestler, and R.J. DiLeone Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal J. Neurosci. 23 2003 3106 3111
15. J.L. Goldstein, M.S. Brown, S.J. Stradley, Y. Reiss, and L.M. Geirasch Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase J. Biol. Chem. 266 1991 15575 15578
16. S. Hao, S. Liu, X. Zheng, W. Zheng, H. Ouyang, M. Mata, and D.J. Fink The role of TNFa in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats Neuropsychopharmacology 36 2011 664 676
17. G.P. Hooff, N. Patel, W.G. Wood, W.E. Müller, G.P. Eckert, and D.A. Volmer A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS Anal. Bioanal. Chem. 398 4 2010 1801 1808
18. P.A. Iredale, J.D. Alvaro, Y. Lee, R. Terwilliger, Y.P.L. Chen, and R.S. Duman Role of corticotropin-releasing factor receptor-1 in opiate withdrawal J. Neurochem. 74 2000 199 208
19. A. Joly, G. Popjak, and P.A. Edwards In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues J. Biol. Chem. 266 1991 13495 13496
20. B.T. Kinsella, and W.A. Maltese Rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-Carbon isoprenoids J. Biol. Chem. 267 6 1992 3940 3945
21. P.A. Konstantinopoulos, M.V. Karamouzis, and A.G. Papavassiliou Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets Nat. Rev. Drug Discov. 6 7 2007 541 555
22. M.J. Krantz, and P.S. Mehler Treating opioid dependence growing implications for primary care Arch. Intern. Med. 164 2004 277 288
23. K.T. Lane, and L.S. Beese Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I J. Lipid Res. 47 2006 681 699
24. E.C. Lerner, Y. Qian, M.A. Blaskovich, R.D. Fossum, A. Vogt, and J. Sun Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes J. Biol. Chem. 270 45 1995 26802 26806
25. K.F. Leung, R. Baron, and M.C. Seabra Geranylgeranylation of Rab GTPases J. Lipid Res. 47 2006 467 475
26. J. Lewis, A. Mansour, H. Khachaturian, S.J. Watson, and H. Akil Opioids and pain regulation H. Akil, J.W. Lewis, Pain and Headache, Neurotransmitters and Pain Control 1987 S. Karger Basel 129 159
27. J.G. Liu, and K.J. Anand Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence Brain Res. Brain Res. Rev. 38 2001 1 19
28. Z. Liu, J.F. Zheng, L.Q. Yang, L. Yi, and B. Hu Effects of sinomenine on NO/nNOS system in cerebellum and spinal cord of morphine-dependent and withdrawal mice Sheng Li Xue Bao 59 2007 285 292
29. L. Lou, T. Zhou, P. Wang, and G. Pei Modulation of Ca21/Calmodulin- dependent protein kinase II activity by acute and chronic morphine administration in rat hippocampus: differential regulation of α and β isoforms Mol. Pharmacol. 55 1999 557 563
30. F.C. Luo, Y.M. Feng, L. Zhao, K. Li, S.D. Wang, J.Y. Song, and J. Bai Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells Neurosci. Lett. 523 1 2012 50 55
31. J. Marshall, and D.G. Graham-Smith Evidence against a role of brain 5 hydroxytryptamine in the development of physical dependence upon morphine in mice J. Pharmacol. Exp. Ther. 173 1971 634 641
32. H.E. Moon, D.S. Bahia, A. Cavalli, M. Hoffmann, and G. Milligan Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface Neuropharmacology 41 3 2001 321 330
33. T. Mori, S. Ito, K. Matsubayashi, and T. Sawaguchi Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome Behav. Pharmacol. 18 8 2007 725 729
34. U. Mühlhäuser, O. Zolk, T. Rau, F. Münzel, T. Wieland, and T. Eschenhagen Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits FASEB J. 20 6 2006 785 787
35. T. Mulligan, H. Blasér, E. Raz, and S.A. Farber Prenylation deficient G protein gamma subunits disrupt GPCR signalling in the zebrafish Cell. Signal. 22 2 2010 221 233
36. E.J. Nestler Historical review: molecular and cellular mechanisms of opiate and cocaine addiction Trends Pharmacol. Sci. 25 2004 210 218
37. J. Pan, E. Song, C. Cheng, M.H. Lee, and S.C. Yeung Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms? Autophagy 5 1 2009 129 131
38. Y. Qian, A. Vogt, A. Vasudevan, S.M. Sebti, and A.D. Hamilton Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics Bioorg. Med. Chem. 6 3 1998 293 299
39. A.K. Rehni, and N. Singh Modulation of src-kinase attenuates naloxone-precipitated opioid withdrawal syndrome in mice Behav. Pharmacol. 22 2 2011 182 190
40. A.K. Rehni, and N. Singh Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuates opioid withdrawal in vivo and in vitro Psychopharmacol. (Berl) 220 2012 427 438
41. A.K. Rehni, and N. Singh Potential involvement of tyrosine phosphatase and calpain-related pathways in opioid withdrawal syndrome in mice Behav. Pharmacol. 23 3 2012 302 309
42. A.K. Rehni, P. Bhateja, T.G. Singh, and N. Singh Nuclear factor-kappa-B inhibitor modulates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome Behav. Pharmacol. 19 3 2008 265 269
43. A.K. Rehni, I. Singh, N. Singh, N. Bansal, S. Bansal, and M. Kumar Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome Eur. J. Pharmacol. 598 1-3 2008 51 56
44. A.K. Rehni, N. Singh, M. Rachamalla, and K. Tikoo Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome Naunyn Schmiedebergs Arch. Pharmacol. 385 6 2012 605 619
45. Y.J.L. Reiss, M.C. Goldstein, P.J.C. Seabra, and M.S. Brown Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides Cell 62 1990 81 88
46. P.J. Roberts, and C.J. Der Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 2007 3291 3310
47. A. Ruocco, M. Santillo, M. Cicale, R. Serù, G. Cuda, J. Anrather, C. Iadecola, A. Postiglione, E.V. Avvedimento, and R. Paternò Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway Eur. J. Neurosci. 26 11 2007 3261 3266
48. Z. Saidak, K. Blake-Palmer, D.L. Hay, J.K. Northup, and M. Glass Differential activation of G-proteins by μ-opioid receptor agonists Br. J. Pharmacol. 147 2006 671 680
49. K.S. Sharma, W.A. Klee, and M. Nirenberg Opiate-dependent modulation of adenylate cyclase Proc. Natl. Acad. Sci. U. S. A. 74 1977 3365 3369
50. Y. Shoji, J. Delfs, and J.T. Williams Presynaptic inhibition of GABAB-mediated synaptic potentials in the ventral tegmental area during morphine withdrawal J. Neurosci. 19 6 1999 2347 2355
51. L.S. Steelman, W.H. Chappell, S.L. Abrams, C.R. Kempf, J. Long, and P. Laidler Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging Aging (Albany NY.) 3 3 2011 192 222
52. L. Stella, V. De Novellis, M.R. Vitelli, A. Capuano, F. Mazzeo, and L. Berrino Interactive role of adenosine and dopamine in the opiate withdrawal syndrome Naunyn Schmiedebergs Arch. Pharmacol. 368 2 2003 113 118
53. E.B. Stubbs, and C.L. Von Zee Prenylation of Rho G-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells Mol. Neurobiol. 46 1 2012 28 40
54. R.J. Tallarida, F. Porreca, and A. Cowan Statistical analysis of drug-drug and site-site interactions with isobolograms Life Sci. 45 1989 947 961
55. H. Teramoto, O.A. Coso, H. Miyata, T. Igishi, T. Miki, and J.S. Gutkind Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family J. Biol. Chem. 271 44 1996 27225 27228
56. G.K. Tiong, T.L. Pierce, and J.E. Olley Sub-chronic exposure to opiates in the rat: effects on brain levels of substance P and calcitonin gene related peptide during dependence and withdrawal J. Neurosci. Res. 32 1992 569 575
57. M. Torrecilla, C.L. Marker, S.C. Cintora, M. Stoffel, J.T. Williams, and K. Wickman G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons J. Neurosci. 22 2002 4328 4334
58. T. Trang, M. Sutak, R. Quirion, and K. Jhamandas The role of spinal neuropeptides and prostaglandins in opioid physical dependence Br. J. Pharmacol. 136 2002 37 48
59. K.A. Trujillo, and H. Akil Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801 Science 251 1991 85 87
60. E.L. Way, H.H. Loh, and F.H. Shen Simultaneous quantitative assessment of morphine tolerance and physical dependence J. Pharmacol. Exp. Ther. 167 1 1969 1 8
61. J.T. Williams, M.J. Christie, and O. Manzoni Cellular and synaptic adaptations mediating opioid dependence Physiol. Rev. 81 2001 299 343
62. W. Xu, C. Chen, P. Huang, J. Li, J.K. de Riel, J.A. Javitch, and L.Y. Liu-Chen The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors Biochemistry 39 45 2000 13904 13915
63. K.C. Yeung, D.W. Rose, A.S. Dhillon, D. Yaros, M. Gustafsson, and D. Chatterjee Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation Mol. Cell. Biol. 21 21 2001 7207 7217
64. K. Yokoyama, G.W. Goodwin, F. Ghomashchi, J.A. Glomset, and M.H. Gelb A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity Proc. Natl. Acad. Sci. U. S. A. 88 12 1991 5302 5306
65. F.L. Zhang, and P.J. Casey Protein prenylation: molecular mechanisms and functional consequences Annu. Rev. Biochem. 65 1996 241 269
66. B.S. Zuckerbraun, J.E. Barbato, A. Hamilton, S. Sebti, and E. Tzeng Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production J. Surg. Res. 124 2 2005 256 263