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Volumn 46, Issue 1, 2012, Pages 28-40

Prenylation of Rho G-proteins: A novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells

Author keywords

G proteins; Isoprenoids; Rho; Trabecular meshwork

Indexed keywords

DITERPENE; ISOPRENOID; PROTEASOME; PROTEIN FARNESYLTRANSFERASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SESQUITERPENE DERIVATIVE;

EID: 84868126101     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8249-x     Document Type: Article
Times cited : (24)

References (58)
  • 1
    • 3242785011 scopus 로고    scopus 로고
    • Isoprenoids: Remarkable diversity of form and function
    • DOI 10.1007/s11745-004-1233-3
    • Holstein SA, Hohl RJ (2004) Isoprenoids: remarkable diversity of form and function. Lipids 39:293-309 (Pubitemid 38971743)
    • (2004) Lipids , vol.39 , Issue.4 , pp. 293-309
    • Holstein, S.A.1    Hohl, R.J.2
  • 2
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang FL, Casey PJ (1996) Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem 65:241-269 (Pubitemid 26250610)
    • (1996) Annual Review of Biochemistry , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 3
    • 0030801368 scopus 로고    scopus 로고
    • Isolation and characterization of a prenylcysteine lyase from bovine brain
    • DOI 10.1074/jbc.272.37.23354
    • Zhang L, Tschantz WR, Casey PJ (1997) Isolation and characterization of a prenylcysteine lyase from bovine brain. J Biol Chem 272:23354-23359 (Pubitemid 27392475)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.37 , pp. 23354-23359
    • Zhang, L.1    Tschantz, W.R.2    Casey, P.J.3
  • 4
    • 77953470577 scopus 로고    scopus 로고
    • CAAX-box protein, prenylation process and carcinogenesis
    • Gao J, Liao J, Yang GY (2009) CAAX-box protein, prenylation process and carcinogenesis. Am J Transl Res 1:312-325
    • (2009) Am J Transl Res , vol.1 , pp. 312-325
    • Gao, J.1    Liao, J.2    Yang, G.Y.3
  • 5
    • 33646777423 scopus 로고    scopus 로고
    • Thematic review series: Lipid posttranslational modifications. CAAX modification and membrane targeting of Ras
    • Wright LP, Philips MR (2006) Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J Lipid Res 47:883-891
    • (2006) J Lipid Res , vol.47 , pp. 883-891
    • Wright, L.P.1    Philips, M.R.2
  • 6
    • 0842281652 scopus 로고    scopus 로고
    • Rho and rac take center stage
    • DOI 10.1016/S0092-8674(04)00003-0
    • Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116:167-179 (Pubitemid 38167310)
    • (2004) Cell , vol.116 , Issue.2 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 8
    • 6344231714 scopus 로고    scopus 로고
    • Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    • DOI 10.1016/j.yexcr.2004.08.012, PII S0014482704004793
    • Wheeler AP, Ridley AJ (2004) Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 301:43-49 (Pubitemid 39388895)
    • (2004) Experimental Cell Research , vol.301 , Issue.1 , pp. 43-49
    • Wheeler, A.P.1    Ridley, A.J.2
  • 9
    • 54449089270 scopus 로고    scopus 로고
    • Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification
    • Roberts PJ, Mitin N, Keller PJ et al (2008) Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem 283:25150-25163
    • (2008) J Biol Chem , vol.283 , pp. 25150-25163
    • Roberts, P.J.1    Mitin, N.2    Keller, P.J.3
  • 10
    • 10044268365 scopus 로고    scopus 로고
    • On the mechanism of protein palmitoylation
    • DOI 10.1038/sj.embor.7400277
    • Dietrich LE, Ungermann C (2004) On the mechanism of protein palmitoylation. EMBO Rep 5:1053-1057 (Pubitemid 39600203)
    • (2004) EMBO Reports , vol.5 , Issue.11 , pp. 1053-1057
    • Dietrich, L.E.P.1    Ungermann, C.2
  • 11
    • 3543099503 scopus 로고    scopus 로고
    • Palmitoylation of Intracellular Signaling Proteins: Regulation and function
    • DOI 10.1146/annurev.biochem.73.011303.073954
    • Smotrys JE, Linder ME (2004) Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73:559-587 (Pubitemid 39050380)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 559-587
    • Smotrys, J.E.1    Linder, M.E.2
  • 12
    • 64249083215 scopus 로고    scopus 로고
    • Uveoscleral outflow-A review
    • Alm A, Nilsson SF (2009) Uveoscleral outflow-A review. Exp Eye Res 88:760-768
    • (2009) Exp Eye Res , vol.88 , pp. 760-768
    • Alm, A.1    Nilsson, S.F.2
  • 13
    • 64249129112 scopus 로고    scopus 로고
    • The role of the actomyosin system in regulating trabecular fluid outflow
    • Tian B, Gabelt BT, Geiger B, Kaufman PL (2009) The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res 88:713-717
    • (2009) Exp Eye Res , vol.88 , pp. 713-717
    • Tian, B.1    Gabelt, B.T.2    Geiger, B.3    Kaufman, P.L.4
  • 14
    • 39749107230 scopus 로고    scopus 로고
    • Forskolin induces myosin light chain dephosphorylation in bovine trabecular meshwork cells
    • DOI 10.1080/02713680701837067, PII 790777191
    • Ramachandran C, Satpathy M, Mehta D, Srinivas SP (2008) Forskolin induces myosin light chain dephosphorylation in bovine trabecular meshwork cells. Curr Eye Res 33:169-176 (Pubitemid 351302199)
    • (2008) Current Eye Research , vol.33 , Issue.2 , pp. 169-176
    • Ramachandran, C.1    Satpathy, M.2    Mehta, D.3    Srinivas, S.P.4
  • 15
    • 38049186811 scopus 로고    scopus 로고
    • Rho GTPase and cAMP/protein kinase A signaling mediates myocilininduced alterations in cultured human trabecular meshwork cells
    • Shen X, Koga T, Park BC, SundarRaj N, Yue BY (2008) Rho GTPase and cAMP/protein kinase A signaling mediates myocilininduced alterations in cultured human trabecular meshwork cells. J Biol Chem 283:603-612
    • (2008) J Biol Chem , vol.283 , pp. 603-612
    • Shen, X.1    Koga, T.2    Park, B.C.3    Sundarraj, N.4    Yue, B.Y.5
  • 16
    • 34249694646 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma
    • DOI 10.2165/00063030-200721030-00004
    • Rao VP, Epstein DL (2007) Rho GTPase/Rho kinase inhibition Abstract: A novel target for the treatment of glaucoma. BioDrugs 21:167-177 (Pubitemid 46827850)
    • (2007) BioDrugs , vol.21 , Issue.3 , pp. 167-177
    • Rao, V.P.1    Epstein, D.L.2
  • 18
    • 29244491953 scopus 로고    scopus 로고
    • The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes
    • Liu X, Hu Y, Filla MS, Gabelt BT, Peters DM, Brandt CR, Kaufman PL (2005) The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes. Mol Vis 11:1112-1121 (Pubitemid 41819512)
    • (2005) Molecular Vision , vol.11 , pp. 1112-1121
    • Liu, X.1    Hu, Y.2    Filla, M.S.3    Gabelt, B.T.4    Peters, D.M.5    Brandt, C.R.6    Kaufman, P.L.7
  • 20
    • 24144445945 scopus 로고    scopus 로고
    • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow
    • Rao PV, Deng P, Maddala R, Epstein DL, Li CY, Shimokawa H (2005) Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. Mol Vis 11:288-297 (Pubitemid 41358280)
    • (2005) Molecular Vision , vol.11 , pp. 288-297
    • Rao, P.V.1    Deng, P.2    Maddala, R.3    Epstein, D.L.4    Li, C.-Y.5    Shimokawa, H.6
  • 23
  • 24
    • 40849130917 scopus 로고    scopus 로고
    • Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers
    • DOI 10.1001/archophthalmol.2007.76
    • Tanihara H, Inatani M, Honjo M, Tokushige H, Azuma J, Araie M (2008) Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch Ophthalmol 126:309-315 (Pubitemid 351398453)
    • (2008) Archives of Ophthalmology , vol.126 , Issue.3 , pp. 309-315
    • Tanihara, H.1    Inatani, M.2    Honjo, M.3    Tokushige, H.4    Azuma, J.5    Araie, M.6
  • 25
    • 0346101770 scopus 로고    scopus 로고
    • Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol
    • DOI 10.1074/jbc.M310053200
    • Sever N, Song BL, Yabe D, Goldstein JL, BrownMS, DeBose-Boyd RA (2003) Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3- methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem 278:52479-52490 (Pubitemid 38035841)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.52 , pp. 52479-52490
    • Sever, N.1    Song, B.-L.2    Yabe, D.3    Goldstein, J.L.4    Brown, M.S.5    DeBose-Boydb, R.A.6
  • 26
    • 0037137175 scopus 로고    scopus 로고
    • Isoprenoids influence expression of Ras and Ras-related proteins
    • DOI 10.1021/bi026251x
    • Holstein SA, Wohlford-Lenane CL, Hohl RJ (2002) Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry 41:13698-13704 (Pubitemid 35332707)
    • (2002) Biochemistry , vol.41 , Issue.46 , pp. 13698-13704
    • Holstein, S.A.1    Wohlford-Lenane, C.L.2    Hohl, R.J.3
  • 27
    • 0037155865 scopus 로고    scopus 로고
    • Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB
    • DOI 10.1074/jbc.M111369200
    • Holstein SA, Wohlford-Lenane CL, Hohl RJ (2002) Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. J Biol Chem 277:10678-10682 (Pubitemid 34968195)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.12 , pp. 10678-10682
    • Holstein, S.A.1    Wohlford-Lenane, C.L.2    Hohl, R.J.3
  • 29
    • 79955929398 scopus 로고    scopus 로고
    • Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells
    • Von Zee CL, Stubbs EB Jr (2011) Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 52:1676-1683
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1676-1683
    • Von Zee, C.L.1    Stubbs Jr., E.B.2
  • 31
    • 0034730812 scopus 로고    scopus 로고
    • Targeting Rho in cardiovascular disease
    • Laufs U, Liao JK (2000) Targeting Rho in cardiovascular disease. Circ Res 87:526-528
    • (2000) Circ Res , vol.87 , pp. 526-528
    • Laufs, U.1    Liao, J.K.2
  • 33
    • 0028920240 scopus 로고
    • CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB
    • Armstrong SA, Hannah VC, Goldstein JL, Brown MS (1995) CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J Biol Chem 270:7864-7868
    • (1995) J Biol Chem , vol.270 , pp. 7864-7868
    • Armstrong, S.A.1    Hannah, V.C.2    Goldstein, J.L.3    Brown, M.S.4
  • 34
    • 0030910236 scopus 로고    scopus 로고
    • Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription
    • DOI 10.1074/jbc.272.26.16093
    • Lebowitz PF, Du W, Prendergast GC (1997) Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription. J Biol Chem 272:16093-16095 (Pubitemid 27276421)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.26 , pp. 16093-16095
    • Lebowitz, P.F.1    Du, W.2    Prendergast, G.C.3
  • 35
    • 0034613286 scopus 로고    scopus 로고
    • RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription
    • Allal C, Favre G, Couderc B, Salicio S, Sixou S, Hamilton AD, Sebti SM, Lajoie-Mazenc I, Pradines A (2000) RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription. J Biol Chem 275:31001-31008
    • (2000) J Biol Chem , vol.275 , pp. 31001-31008
    • Allal, C.1    Favre, G.2    Couderc, B.3    Salicio, S.4    Sixou, S.5    Hamilton, A.D.6    Sebti, S.M.7    Lajoie-Mazenc, I.8    Pradines, A.9
  • 36
    • 33646137779 scopus 로고    scopus 로고
    • Isoprenoids and Alzheimer's disease: A complex relationship
    • Cole SL, Vassar R (2006) Isoprenoids and Alzheimer's disease: A complex relationship. Neurobiol Dis 22:209-222
    • (2006) Neurobiol Dis , vol.22 , pp. 209-222
    • Cole, S.L.1    Vassar, R.2
  • 38
    • 80155191187 scopus 로고    scopus 로고
    • Statins: The role in the treatment and prevention of Alzheimer's neurodegeneration
    • Pac-Soo C, Lloyd DG, Vizcaychipi MP, Ma D (2011) Statins: the role in the treatment and prevention of Alzheimer's neurodegeneration. J Alzheimers Dis 27:1-10
    • (2011) J Alzheimers Dis , vol.27 , pp. 1-10
    • Pac-Soo, C.1    Lloyd, D.G.2    Vizcaychipi, M.P.3    Ma, D.4
  • 40
    • 33846048569 scopus 로고    scopus 로고
    • Simvastatin enhances learning and memory independent of amyloid load in mice
    • DOI 10.1002/ana.21053
    • Li L, Cao D, Kim H, Lester R, Fukuchi K (2006) Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60:729-739 (Pubitemid 46061359)
    • (2006) Annals of Neurology , vol.60 , Issue.6 , pp. 729-739
    • Li, L.1    Cao, D.2    Kim, H.3    Lester, R.4    Fukuchi, K.-I.5
  • 41
    • 77951887071 scopus 로고    scopus 로고
    • Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice
    • Mans RA, Chowdhury N, Cao D, McMahon LL, Li L (2010) Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. Neuroscience 166:435-444
    • (2010) Neuroscience , vol.166 , pp. 435-444
    • Mans, R.A.1    Chowdhury, N.2    Cao, D.3    McMahon, L.L.4    Li, L.5
  • 42
    • 0025122034 scopus 로고
    • Ascorbic acid modulates the production of fibronectin and laminin by cells from an eye tissue-trabecular meshwork
    • Yue BY, Higginbotham EJ, Chang IL (1990) Ascorbic acid modulates the production of fibronectin and laminin by cells from an eye tissue-trabecular meshwork. Exp Cell Res 187:65-68
    • (1990) Exp Cell Res , vol.187 , pp. 65-68
    • Yue, B.Y.1    Higginbotham, E.J.2    Chang, I.L.3
  • 43
    • 0034687606 scopus 로고    scopus 로고
    • Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    • Laufs U, Endres M, Custodis F, Gertz K, Nickenig G, Liao JK, Bohm M (2000) Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 102:3104-3110
    • (2000) Circulation , vol.102 , pp. 3104-3110
    • Laufs, U.1    Endres, M.2    Custodis, F.3    Gertz, K.4    Nickenig, G.5    Liao, J.K.6    Bohm, M.7
  • 44
    • 0028307290 scopus 로고
    • Identification of farnesol Abstract: The non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3- methylglutaryl-coenzyme A reductase
    • Correll CC, Ng L, Edwards PA (1994) Identification of farnesol Abstract: the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 269:17390-17393
    • (1994) J Biol Chem , vol.269 , pp. 17390-17393
    • Correll, C.C.1    Ng, L.2    Edwards, P.A.3
  • 45
    • 0037147207 scopus 로고    scopus 로고
    • Isoprenylation of RhoB is necessary for its degradation: A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway
    • DOI 10.1074/jbc.M204049200
    • Stamatakis K, Cernuda-Morollon E, Hernandez-Perera O, Perez- Sala D (2002) Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. J Biol Chem 277:49389-49396 (Pubitemid 36014371)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.51 , pp. 49389-49396
    • Stamatakis, K.1    Cernuda-Morollon, E.2    Hernandez-Perera, O.3    Perez-Sala, D.4
  • 46
    • 0028123512 scopus 로고
    • Preliminary characterization of a transformed cell strain derived from human trabecular meshwork
    • Pang IH, Shade DL, Clark AF, Steely HT, DeSantis L (1994) Preliminary characterization of a transformed cell strain derived from human trabecular meshwork. Curr Eye Res 13:51-63 (Pubitemid 24053155)
    • (1994) Current Eye Research , vol.13 , Issue.1 , pp. 51-63
    • Pang, I.-H.1    Shade, D.L.2    Clark, A.F.3    Steely, H.T.4    DeSantis, L.5
  • 47
    • 20444480169 scopus 로고    scopus 로고
    • Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome- mediated degradation in vascular smooth muscle cells
    • DOI 10.1161/01.RES.0000170084.88780.ea
    • Rolli-Derkinderen M, Sauzeau V, Boyer L, Lemichez E, Baron C, Henrion D, Loirand G, Pacaud P (2005) Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Circ Res 96:1152-1160 (Pubitemid 40827690)
    • (2005) Circulation Research , vol.96 , Issue.11 , pp. 1152-1160
    • Rolli-Derkinderen, M.1    Sauzeau, V.2    Boyer, L.3    Lemichez, E.4    Baron, C.5    Henrion, D.6    Loirand, G.7    Pacaud, P.8
  • 48
    • 64249133695 scopus 로고    scopus 로고
    • The role of proteolytic cellular systems in trabecular meshwork homeostasis
    • Liton PB, Gonzalez P, Epstein DL (2009) The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res 88:724-728
    • (2009) Exp Eye Res , vol.88 , pp. 724-728
    • Liton, P.B.1    Gonzalez, P.2    Epstein, D.L.3
  • 49
    • 34249864120 scopus 로고    scopus 로고
    • A proteasome for all occasions
    • DOI 10.1016/j.febslet.2007.03.053, PII S0014579307003262, Vienna Special Issue: Molecular Machines
    • Hanna J, Finley D (2007) A proteasome for all occasions. FEBS Lett 581:2854-2861 (Pubitemid 46874384)
    • (2007) FEBS Letters , vol.581 , Issue.15 , pp. 2854-2861
    • Hanna, J.1    Finley, D.2
  • 51
    • 70349168448 scopus 로고    scopus 로고
    • Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement
    • Chen Y, Yang Z, Meng M et al (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell 35:841-855
    • (2009) Mol Cell , vol.35 , pp. 841-855
    • Chen, Y.1    Yang, Z.2    Meng, M.3
  • 52
    • 40149100476 scopus 로고    scopus 로고
    • Regulation of proteasome-mediated protein degradation during oxidative stress and aging
    • DOI 10.1515/BC.2008.029
    • Breusing N, Grune T (2008) Regulation of proteasome-mediated protein degradation during oxidative stress and aging. Biol Chem 389:203-209 (Pubitemid 351329027)
    • (2008) Biological Chemistry , vol.389 , Issue.3 , pp. 203-209
    • Breusing, N.1    Grune, T.2
  • 53
    • 77949524142 scopus 로고    scopus 로고
    • The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway
    • Perez-Sala D, Boya P, Ramos I, Herrera M, Stamatakis K (2009) The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway. PLoS One 4:e8117
    • (2009) PLoS One , vol.4
    • Perez-Sala, D.1    Boya, P.2    Ramos, I.3    Herrera, M.4    Stamatakis, K.5
  • 54
    • 0031048791 scopus 로고    scopus 로고
    • Formation of actin stress fibers and focal adhesions enhanced by Rho- kinase
    • DOI 10.1126/science.275.5304.1308
    • Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275:1308-1311 (Pubitemid 27114159)
    • (1997) Science , vol.275 , Issue.5304 , pp. 1308-1311
    • Amano, M.1    Chihara, K.2    Kimura, K.3    Fukata, Y.4    Nakamura, N.5    Matsuura, Y.6    Kaibuchi, K.7
  • 55
    • 0035726683 scopus 로고    scopus 로고
    • Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase
    • DOI 10.1076/ceyr.22.6.470.5489
    • Waki M, Yoshida Y, Oka T, Azuma M (2001) Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase. Curr Eye Res 22:470-474 (Pubitemid 34253206)
    • (2001) Current Eye Research , vol.22 , Issue.6 , pp. 470-474
    • Waki, M.1    Yoshida, Y.2    Oka, T.3    Azuma, M.4
  • 57
    • 0036974434 scopus 로고    scopus 로고
    • Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures
    • Vittitow JL, Garg R, Rowlette LL, Epstein DL, O'Brien ET, Borras T (2002) Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol Vis 8:32-44 (Pubitemid 36153588)
    • (2002) Molecular Vision , vol.8 , pp. 32-44
    • Vittitow, J.L.1    Garg, R.2    Rowlette, L.-L.S.3    Epstein, D.L.4    O'Brien, E.T.5    Borras, T.6
  • 58
    • 2942624365 scopus 로고    scopus 로고
    • Statins and other cholesterol-lowering medications and the presence of glaucoma
    • DOI 10.1001/archopht.122.6.822
    • McGwin G Jr, McNeal S, Owsley C, Girkin C, Epstein D, Lee PP (2004) Statins and other cholesterol-lowering medications and the presence of glaucoma. Arch Ophthalmol 122:822-826 (Pubitemid 38736240)
    • (2004) Archives of Ophthalmology , vol.122 , Issue.6 , pp. 822-826
    • McGwin Jr., G.1    McNeal, S.2    Owsley, C.3    Girkin, C.4    Epstein, D.5    Lee, P.P.6


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