G-Protein-Gated Potassium Channels Containing Kir3.2 and Kir3.3 Subunits Mediate the Acute Inhibitory Effects of Opioids on Locus Ceruleus Neurons

Journal of Neuroscience

Volumn 22, Issue 11, 2002, Pages 4328-4334

  Torrecilla, Maria ^a   Marker, Cheryl L ^b   Cintora, Stephanie C ^b   Stoffel, Markus ^c   Williams, John T ^a   Wickman, Kevin ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Addiction; GIRK; Kir3.0; Locus ceruleus; Met enkephalin; Mouse knock out; Opioid receptor; Potassium channel blockers; Tolerance; Whole cell recording

Indexed keywords

BARIUM; CATION; CESIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; METENKEPHALIN; OPIATE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN SUBUNIT; CALCIUM; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ9 PROTEIN, MOUSE; NARCOTIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEPOLARIZATION; EMBRYO; G PROTEIN GATED POTASSIUM CHANNEL; HYPERPOLARIZATION; ION CONDUCTANCE; KNOCKOUT MOUSE; LOCUS CERULEUS; MEMBRANE CURRENT; MOUSE; MOUSE STRAIN; NERVE CELL MEMBRANE; NERVE FIBER MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; WILD TYPE; ANIMAL; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; MALE; METABOLISM; MOUSE MUTANT; NERVE CELL; NERVE CELL INHIBITION; PATCH CLAMP; PHYSIOLOGY;

ANIMALS; BARIUM; CALCIUM; ENKEPHALIN, METHIONINE; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEINS; HETEROZYGOTE; HOMOZYGOTE; ION CHANNEL GATING; LOCUS COERULEUS; MALE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; NARCOTICS; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN SUBUNITS;

EID: 0036616477     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-11-04328.2002     Document Type: Article

References (37)

1. Aghajanian G, Wang Y-Y (1986) Pertussis toxin blocks the outward currents evoked by opiate and alpha(2)-agonists in locus coeruleus neurons. Brain Res 371:390-394.
2. Alreja M, Aghajanian G (1993) Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus ceruleus neurons. J Neurosci 13:3525-3532.
3. Alreja M, Aghajanian G (1994) QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons. Brain Res 639:320-324.
4. Alreja M, Aghajanian G (1995) Use of the whole-cell patch-clamp method in studies on the role of cAMP in regulating the spontaneous firing of locus coeruleus neurons. J Neurosci Methods 59:67-75.
5. Barry PH (1994) JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements. J Neurosci Methods 51:107-116.
6. Chen SC, Ehrhard P, Goldowitz D, Smeyne RJ (1997) Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Brain Res 778:251-264.
7. + channels. Cell Signal 9:551-573.
8. KACh currents in oocytes. Neuron 16:423-429.
9. Ivanov A, Aston-Jones G (2001) Local opiate withdrawal in locus coeruleus neurons in vitro. J Neurophysiol 85:2388-2397.
10. + (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem 275:36211-36216.
11. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 16:3559-3570.
12. Kogan JH, Nestler EJ, Aghajanian GK (1992) Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. Eur J Pharmacol 211:47-53.
13. +-channel proteins. Nature 374:135-141.
14. Lane-Ladd S, Pineda J, Boundy V, Pfeuffer T, Krupinski J, Aghajanian G, Nestler E (1997) CREB (cAM P response element-binding protein) in the locus ceruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J Neurosci 17:7890-7901.
15. Law P-Y, Wong Y, Loh H (2000) Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 40:389-430.
16. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron [Erratum (1997) 19:following 945] 19:687-695.
17. Nestler EJ (2001) Molecular neurobiology of addiction. Am J Addict 10:201-217.
18. North RA, Williams JT (1985) On the potassium conductance increased by opioids in rat locus coeruleus neurones. J Physiol (Lond) 364:265-280.
19. Oleskevich S, Clements JD, Williams JT (1993) Opioid-glutamate interactions in rat locus coeruleus neurons. J Neurophysiol 70:931-937.
20. Osborne PB, Williams JT (1996) Forskolin enhancement of opioid currents in rat locus coeruleus neurons. J Neurophysiol 76:1559-1565.
21. Pepper C, Henderson G (1980) Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro. Science 209:394.
22. Picciotto MR, Wickman K (1998) Using knockout and transgenic mice to study neurophysiology and behavior. Physiol Rev 78:1131-1163.
23. Ressler KJ, Nemeroff CB (1999) Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry 46:1219-1233.
24. + channel GIRK2. Proc Natl Acad Sci USA 94:923-927.
25. + currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc Natl Acad Sci USA 94:12210-12217.
26. Travagli R, Dunwiddie T, Williams J (1995) Opioid inhibition in locus coeruleus. J Neurophysiol 74:519-528.
27. Travagli R, Wessendorf M, Williams JT (1996) Dendritic arbor of locus coeruleus neurons contributes to opioid inhibition. J Neurophysiol 75:2029-2035.
28. + channel in rat brain neurons. Proc Natl Acad Sci USA 92:1590-1594.
29. Wang Y, Aghajanian G (1987) Excitation of locus coeruleus neurons by an adenosine 3′,5′-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices. Synapse 1:481-487.
30. Wickman K, Nemec J, Gendler SJ, Clapham DE (1998) Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 20:103-114.
31. + channel subunit, GIRK4. J Neurosci 20:5608-5615.
32. Wickman K, Pu W, Clapham D (2002) Structural characterization of the mouse Girk genes. Gene 284:241-250.
33. Williams JT, North RA (1984) Opiate-receptor interactions on single locus coeruleus neurones. Mol Pharmacol 26:489-497.
34. Williams J, Egan T, North R (1982) Enkephalin opens potassium channels on mammalian central neurones. Nature 299:74-77.
35. Williams JT, North RA, Tokimasa T (1988) Inward rectification of resting and opiate-activated potassium currents in rat locus ceruleus neurons. J Neurosci 8:4299-4306.
36. Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343.
37. Wimpey T, Chavkin C (1991) Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation. Neuron 6:281-289.