Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor

Biosensors and Bioelectronics

Volumn 48, Issue , 2013, Pages 230-237

  Jensen, Pia W ^a,b   Falconi, Mattia ^c   Kristoffersen, Emil L ^b   Simonsen, Anita T ^a,b   Cifuentes, Jèssica B ^a,b   Marcussen, Lærke B ^b   Frøhlich, Rikke ^b   Vagner, Josephine ^a   Harmsen, Charlotte ^b   Juul, Sissel ^b   Ho, Yi Ping ^b   Withers, Marjorie A ^d   Lupski, James R ^d,e   Koch, Jørn ^a   Desideri, Alessandro ^c   Knudsen, Birgitta R ^b   Stougaard, Magnus ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Biosensor; Enzyme activity; Fluorophore quencher; Real time measurement; Tyrosyl DNA phosphodiesterase 1 (TDP1)

Indexed keywords

ENZYMATIC ACTIVITIES; FLUOROPHORE-QUENCHER; FUNDAMENTAL STUDIES; PHOSPHODIESTERASES; REAL TIME MEASUREMENTS; SECONDARY STRUCTURES; SIGNAL AMPLIFICATIONS; SINGLE-STRAND BREAK REPAIRS;

DNA; ENZYME ACTIVITY; ENZYME INHIBITION; ESTERS; FLUOROPHORES; OLIGONUCLEOTIDES; REPAIR; SIGNAL DETECTION;

BIOSENSORS;

PHOSPHODIESTERASE I; TYROSYL DNA PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG;

ARTICLE; BIOSENSOR; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FLUOROPHORE QUENCHER COUPLED DNA BIOSENSOR; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; LIMIT OF DETECTION; PROCESS OPTIMIZATION; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

BIOSENSING TECHNIQUES; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; DNA; ENZYME ASSAYS; FLUORESCENT DYES; HUMANS; OLIGONUCLEOTIDES; PHOSPHORIC DIESTER HYDROLASES; SENSITIVITY AND SPECIFICITY;

EID: 84878140292     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2013.04.019     Document Type: Article

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