메뉴 건너뛰기




Volumn 37, Issue 5, 2013, Pages 406-414

Intestinal stem cells - types and markers

Author keywords

Active intestinal stem cells (A ISCs); Bmi1; Colorectal cancer; Intestinal stem cells (ISCs); Lgr5; Quiescent intestinal stem cells (Q ISCs)

Indexed keywords

B LYMPHOMA MO MLV INSERTION REGION 1; CELL MARKER; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; LEUCINE RICH REPEATS AND IMMUNOGLOBULIN LIKE DOMAIN 1; PLECKSTRIN HOMOLOGYLIKE DOMAIN PROTEIN; UNCLASSIFIED DRUG;

EID: 84878139409     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10049     Document Type: Review
Times cited : (14)

References (90)
  • 6
    • 44849111911 scopus 로고    scopus 로고
    • How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer
    • Boman BM, Fields JZ, Cavanaugh KL, Guetter A, Runquist OA (2008) How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer. Cancer Res 68: 3304-13.
    • (2008) Cancer Res , vol.68 , pp. 3304-3313
    • Boman, B.M.1    Fields, J.Z.2    Cavanaugh, K.L.3    Guetter, A.4    Runquist, O.A.5
  • 7
    • 34249041688 scopus 로고    scopus 로고
    • Symmetric division of cancer stem cells - a key mechanism in tumor growth that should be targeted in future therapeutic approaches
    • Boman BM,Wicha MS, Fields JZ, Runquist OA (2007) Symmetric division of cancer stem cells - a key mechanism in tumor growth that should be targeted in future therapeutic approaches. Clin Pharmacol Ther 81: 893-8.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 893-898
    • Boman, B.M.1    Wicha, M.S.2    Fields, J.Z.3    Runquist, O.A.4
  • 8
    • 58449088387 scopus 로고    scopus 로고
    • Gastrointestinal stem cells in development and cancer
    • Brabletz S, SchmalhoferO, Brabletz T (2009) Gastrointestinal stem cells in development and cancer. J Pathol 217: 307-17.
    • (2009) J Pathol , vol.217 , pp. 307-317
    • Brabletz, S.1    Schmalhofer, O.2    Brabletz, T.3
  • 9
    • 80054974211 scopus 로고    scopus 로고
    • Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target
    • Buczacki S, Davies RJ, Winton DJ (2011) Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target. Br J Cancer 105: 1253-9.
    • (2011) Br J Cancer , vol.105 , pp. 1253-1259
    • Buczacki, S.1    Davies, R.J.2    Winton, D.J.3
  • 10
    • 80053030114 scopus 로고    scopus 로고
    • The cancer stem cell niche - there goes the neighborhood
    • Cabarcas SM, Mathews LA, Farrar WL (2011) The cancer stem cell niche - there goes the neighborhood? Int J Cancer 129: 2315-27
    • (2011) Int J Cancer , vol.129 , pp. 2315-2327
    • Cabarcas, S.M.1    Mathews, L.A.2    Farrar, W.L.3
  • 11
    • 79952343462 scopus 로고    scopus 로고
    • Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy
    • Carlone DL, Breault DT (2011) Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. Cell Cycle 10: 723-4.
    • (2011) Cell Cycle , vol.10 , pp. 723-724
    • Carlone, D.L.1    Breault, D.T.2
  • 12
    • 84855482447 scopus 로고    scopus 로고
    • Tales from the crypt: the expanding role of slow cycling intestinal stem cells
    • Carlone DL, Breault DT (2012) Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell 10: 2-4.
    • (2012) Cell Stem Cell , vol.10 , pp. 2-4
    • Carlone, D.L.1    Breault, D.T.2
  • 14
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: models and concepts
    • Dalerba P, Cho RW, Clarke MF (2007) Cancer stem cells: models and concepts. Annu Rev Med 58: 267-84.
    • (2007) Annu Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 15
    • 84858750992 scopus 로고    scopus 로고
    • Regulation of the human catalytic subunit of telomerase (hTERT)
    • Daniel M, Peek GW, Tollefsbol TO (2012) Regulation of the human catalytic subunit of telomerase (hTERT). Gene 498: 135-46.
    • (2012) Gene , vol.498 , pp. 135-146
    • Daniel, M.1    Peek, G.W.2    Tollefsbol, T.O.3
  • 18
    • 84861868600 scopus 로고    scopus 로고
    • Intestinal stem cells: no longer immortal but ever so clever
    • Edgar BA (2012) Intestinal stem cells: no longer immortal but ever so clever. EMBO J 31: 2441-3.
    • (2012) EMBO J , vol.31 , pp. 2441-2443
    • Edgar, B.A.1
  • 20
    • 65849401051 scopus 로고    scopus 로고
    • The tortoise and the hair: slow-cycling cells in the stem cell race
    • Fuchs E (2009) The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 137: 811-9.
    • (2009) Cell , vol.137 , pp. 811-819
    • Fuchs, E.1
  • 21
    • 70849127062 scopus 로고    scopus 로고
    • DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium
    • author reply 2180-81
    • Gerbe F, Brulin B, Makrini L, Legraverend C, Jay P (2009) DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium. Gastroenterology 137: 2179-80; author reply 2180-1.
    • (2009) Gastroenterology , vol.137 , pp. 2179-2180
    • Gerbe, F.1    Brulin, B.2    Makrini, L.3    Legraverend, C.4    Jay, P.5
  • 22
    • 33746257301 scopus 로고    scopus 로고
    • Expression of mTert in primary murine cells links the growthpromoting effects of telomerase to transforming growth factorb signaling
    • Geserick C, Tejera A, González-Suárez E, Klatt P, Blasco MA (2006) Expression of mTert in primary murine cells links the growthpromoting effects of telomerase to transforming growth factorb signaling. Oncogene 25: 4310-9.
    • (2006) Oncogene , vol.25 , pp. 4310-4319
    • Geserick, C.1    Tejera, A.2    González-Suárez, E.3    Klatt, P.4    Blasco, M.A.5
  • 23
    • 77956960212 scopus 로고    scopus 로고
    • The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness
    • Hawiger D, Wan YY, Eynon EE, Flavell RA (2010) The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness. Nat Immunol 11: 962-8.
    • (2010) Nat Immunol , vol.11 , pp. 962-968
    • Hawiger, D.1    Wan, Y.Y.2    Eynon, E.E.3    Flavell, R.A.4
  • 25
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM (2009) Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69: 3382-9.
    • (2009) Cancer Res , vol.69 , pp. 3382-3389
    • Huang, E.H.1    Hynes, M.J.2    Zhang, T.3    Ginestier, C.4    Dontu, G.5    Appelman, H.6    Fields, J.Z.7    Wicha, M.S.8    Boman, B.M.9
  • 26
    • 84855469835 scopus 로고    scopus 로고
    • Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients
    • Huang MY, Wang HM, Chang HJ, Hsiao CP, Wang JY, Lin SR (2012) Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients. DNA Cell Biol 31: 43-9.
    • (2012) DNA Cell Biol , vol.31 , pp. 43-49
    • Huang, M.Y.1    Wang, H.M.2    Chang, H.J.3    Hsiao, C.P.4    Wang, J.Y.5    Lin, S.R.6
  • 27
    • 33747047561 scopus 로고    scopus 로고
    • Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
    • Jensen KB, Watt FM (2006) Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci USA 103: 11958-63.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11958-11963
    • Jensen, K.B.1    Watt, F.M.2
  • 28
    • 79961152605 scopus 로고    scopus 로고
    • PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer
    • Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K (2011) PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer. J Cell Sci 124: 2711-22.
    • (2011) J Cell Sci , vol.124 , pp. 2711-2722
    • Johnson, E.O.1    Chang, K.H.2    de Pablo, Y.3    Ghosh, S.4    Mehta, R.5    Badve, S.6    Shah, K.7
  • 31
    • 80051603461 scopus 로고    scopus 로고
    • Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer
    • Kleist B, Xu L, Li G, Kersten C (2011) Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Int J Clin Exp Pathol 4: 327-35.
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 327-335
    • Kleist, B.1    Xu, L.2    Li, G.3    Kersten, C.4
  • 32
    • 84862640587 scopus 로고    scopus 로고
    • Oncogenic challenges in stem cells and the link to cancer initiation
    • Lee JS, Bae GY, Lee MO, Cha HJ (2012) Oncogenic challenges in stem cells and the link to cancer initiation. Arch Pharm Res 35: 235-44.
    • (2012) Arch Pharm Res , vol.35 , pp. 235-244
    • Lee, J.S.1    Bae, G.Y.2    Lee, M.O.3    Cha, H.J.4
  • 34
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L Clevers H (2010) Coexistence of quiescent and active adult stem cells in mammals. Science 327: 542-5.
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 35
    • 84859170707 scopus 로고    scopus 로고
    • Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells
    • Liu RH, Yang MH, Xiang H, Bao LM, Yang HA, Yue LW, Jiang X, Ang N, Wu LY, Huang Y (2012) Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells. J Biomed Sci 19: 38.
    • (2012) J Biomed Sci , vol.19 , pp. 38
    • Liu, R.H.1    Yang, M.H.2    Xiang, H.3    Bao, L.M.4    Yang, H.A.5    Yue, L.W.6    Jiang, X.7    Ang, N.8    Wu, L.Y.9    Huang, Y.10
  • 37
    • 80053216016 scopus 로고    scopus 로고
    • Expression of a putative stem cell marker Musashi-1 in endometrium
    • Lu X, Lin F, Fang H, Yang X, Qin L (2011) Expression of a putative stem cell marker Musashi-1 in endometrium. Histol Histopathol 26: 1127-33.
    • (2011) Histol Histopathol , vol.26 , pp. 1127-1133
    • Lu, X.1    Lin, F.2    Fang, H.3    Yang, X.4    Qin, L.5
  • 38
    • 80054767272 scopus 로고    scopus 로고
    • OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer
    • Luo Z, Zhang Q, Zhao Z, Li B, Chen J, Wang Y (2011) OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer. J Cancer Res Clin Oncol 137: 1713-20.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1713-1720
    • Luo, Z.1    Zhang, Q.2    Zhao, Z.3    Li, B.4    Chen, J.5    Wang, Y.6
  • 39
    • 43049128928 scopus 로고    scopus 로고
    • Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    • May R, Riehl TE, Hunt C, Sureban SM, Anant S, Houchen CW (2008) Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 26: 630-7.
    • (2008) Stem Cells , vol.26 , pp. 630-637
    • May, R.1    Riehl, T.E.2    Hunt, C.3    Sureban, S.M.4    Anant, S.5    Houchen, C.W.6
  • 40
    • 70350239859 scopus 로고    scopus 로고
    • Doublecortin and CaM kinase-like-1 and leucine-rich-repeatcontaining G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively
    • May R, Sureban SM, Hoang N, Riehl TE, Lightfoot SA, Ramanujam R, Wyche JH, Anant S, Houchen CW (2009) Doublecortin and CaM kinase-like-1 and leucine-rich-repeatcontaining G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells 27: 2571-9.
    • (2009) Stem Cells , vol.27 , pp. 2571-2579
    • May, R.1    Sureban, S.M.2    Hoang, N.3    Riehl, T.E.4    Lightfoot, S.A.5    Ramanujam, R.6    Wyche, J.H.7    Anant, S.8    Houchen, C.W.9
  • 41
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP, Vermeulen L (2011) Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474: 318-26.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 42
    • 0035940437 scopus 로고    scopus 로고
    • The intestinal stem cell niche: there grows the neighborhood
    • Mills JC, Gordon JI (2001) The intestinal stem cell niche: there grows the neighborhood. Proc Natl Acad Sci USA 98: 12334-6.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12334-12336
    • Mills, J.C.1    Gordon, J.I.2
  • 48
    • 0037108860 scopus 로고    scopus 로고
    • Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation
    • Neef R, Kuske MA, Pröls E, Johnson JP (2002) Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. Cancer Res 62: 5920-9.
    • (2002) Cancer Res , vol.62 , pp. 5920-5929
    • Neef, R.1    Kuske, M.A.2    Pröls, E.3    Johnson, J.P.4
  • 49
    • 84865069589 scopus 로고    scopus 로고
    • Stem cells in epithelial renewal and cancer of the intestine
    • Nq A, Barker N (2011) Stem cells in epithelial renewal and cancer of the intestine. Eur Gastroenterol Hepatol Rev 7: 154-9.
    • (2011) Eur Gastroenterol Hepatol Rev , vol.7 , pp. 154-159
    • Nq, A.1    Barker, N.2
  • 53
    • 84866058761 scopus 로고    scopus 로고
    • Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice
    • Reed KR, Tunster SJ, Young M, Carrico A, John RM, Clarke AR (2011) Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61: 1435-8.
    • (2011) Gut , vol.61 , pp. 1435-1438
    • Reed, K.R.1    Tunster, S.J.2    Young, M.3    Carrico, A.4    John, R.M.5    Clarke, A.R.6
  • 54
    • 77956934167 scopus 로고    scopus 로고
    • The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation
    • Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M (2010) The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J Cell Sci 123.
    • (2010) J Cell Sci , pp. 123
    • Rezza, A.1    Skah, S.2    Roche, C.3    Nadjar, J.4    Samarut, J.5    Plateroti, M.6
  • 56
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi E, Capecchi MR (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-20.
    • (2008) Nat Genet , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 57
    • 66349132211 scopus 로고    scopus 로고
    • Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis
    • Sangiorgi E, Capecchi MR (2009) Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. Proc Natl Acad Sci USA 106: 7101-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7101-7106
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 58
    • 79952751557 scopus 로고    scopus 로고
    • Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes
    • Schepers AG, Vries R, van den Born M, van de Wetering M, Clevers H (2011) Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J 30: 1104-9.
    • (2011) EMBO J , vol.30 , pp. 1104-1109
    • Schepers, A.G.1    Vries, R.2    van den Born, M.3    van de Wetering, M.4    Clevers, H.5
  • 59
    • 39749092525 scopus 로고    scopus 로고
    • Current view: intestinal stem cells and signaling
    • Scoville DH, Sato T, He XC, Li L (2008) Current view: intestinal stem cells and signaling. Gastroenterology 134: 849-64.
    • (2008) Gastroenterology , vol.134 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 60
    • 78650467887 scopus 로고    scopus 로고
    • PHLDA1 (TDAG51) is a follicular stem cell marker and differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma
    • Sellheyer K, Krahl D (2011) PHLDA1 (TDAG51) is a follicular stem cell marker and differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma. Br J Dermatol 164: 141-7.
    • (2011) Br J Dermatol , vol.164 , pp. 141-147
    • Sellheyer, K.1    Krahl, D.2
  • 61
    • 79959244922 scopus 로고    scopus 로고
    • Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens
    • Sellheyer K, Nelson P (2011) Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens. J Cutan Pathol 38: 542-50.
    • (2011) J Cutan Pathol , vol.38 , pp. 542-550
    • Sellheyer, K.1    Nelson, P.2
  • 62
    • 77956234910 scopus 로고    scopus 로고
    • Intestinal stem cells and epithelial- mesenchymal interactions in the crypt and stem cell niche
    • Shaker A, Rubin DC (2010) Intestinal stem cells and epithelial- mesenchymal interactions in the crypt and stem cell niche. Transl Res 156: 180-7.
    • (2010) Transl Res , vol.156 , pp. 180-187
    • Shaker, A.1    Rubin, D.C.2
  • 63
    • 80455174708 scopus 로고    scopus 로고
    • Stem cell self-renewal in intestinal crypt
    • Simons BD, Clevers H (2011) Stem cell self-renewal in intestinal crypt. Exp Cell Res 317: 2719-24.
    • (2011) Exp Cell Res , vol.317 , pp. 2719-2724
    • Simons, B.D.1    Clevers, H.2
  • 64
    • 84856005960 scopus 로고    scopus 로고
    • Physiological and pathological role of local and immigrating colonic stem cells
    • Sipos F, Valcz G, Molnar B (2012) Physiological and pathological role of local and immigrating colonic stem cells. World J Gastroenterol 18: 295-301.
    • (2012) World J Gastroenterol , vol.18 , pp. 295-301
    • Sipos, F.1    Valcz, G.2    Molnar, B.3
  • 69
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • TakedaN, Jain R, LeBoeuf MR,Wang Q, Lu MM, Epstein JA (2011) Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420-4.
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1    Jain, R.2    LeBoeuf, M.R.3    Wang, Q.4    Lu, M.M.5    Epstein, J.A.6
  • 70
    • 84857789336 scopus 로고    scopus 로고
    • Understanding cancer stem cell heterogeneity and plasticity
    • Tang DG (2012) Understanding cancer stem cell heterogeneity and plasticity. Cell Res 22: 457-72.
    • (2012) Cell Res , vol.22 , pp. 457-472
    • Tang, D.G.1
  • 72
  • 74
    • 77958187285 scopus 로고    scopus 로고
    • Intestinal stem cells
    • Umar S (2010) Intestinal stem cells. Curr Gastroenterol Rep 12: 340-8.
    • (2010) Curr Gastroenterol Rep , vol.12 , pp. 340-348
    • Umar, S.1
  • 75
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71: 241-60.
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • van der Flier, L.G.1    Clevers, H.2
  • 76
  • 78
    • 79959187704 scopus 로고    scopus 로고
    • Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
    • van Es JH, de Geest N, van de Born M, Clevers H, Hassan BA (2010) Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat Commun 1: 18.
    • (2010) Nat Commun , vol.1 , pp. 18
    • van Es, J.H.1    de Geest, N.2    van de Born, M.3    Clevers, H.4    Hassan, B.A.5
  • 79
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader JE (2011) Cells of origin in cancer. Nature 469: 314-22.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 81
    • 79960885004 scopus 로고    scopus 로고
    • LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
    • Walker F, Zhang HH, Odorizzi A, Burgess AW (2011) LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS ONE 6: e22733.
    • (2011) PLoS ONE , vol.6
    • Walker, F.1    Zhang, H.H.2    Odorizzi, A.3    Burgess, A.W.4
  • 82
    • 77955403113 scopus 로고    scopus 로고
    • Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133{thorn} primary colon cancer cells
    • Wang YK, Zhu YL, Qiu FM, Zhang T, Chen ZG, Zheng S, Huang J (2010) Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133{thorn} primary colon cancer cells. Carcinogenesis 31: 1376-80.
    • (2010) Carcinogenesis , vol.31 , pp. 1376-1380
    • Wang, Y.K.1    Zhu, Y.L.2    Qiu, F.M.3    Zhang, T.4    Chen, Z.G.5    Zheng, S.6    Huang, J.7
  • 83
    • 4243156105 scopus 로고    scopus 로고
    • Regulation of intestinal stem cells
    • Wong MH (2004) Regulation of intestinal stem cells. J Investig Dermatol Symp Proc 9: 224-8.
    • (2004) J Investig Dermatol Symp Proc , vol.9 , pp. 224-228
    • Wong, M.H.1
  • 85
    • 64249126794 scopus 로고    scopus 로고
    • Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor
    • Yamaguchi S, Asanoma K, Takao T, Kato K, Wake N (2009) Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. Int J Cancer 124: 2577-88.
    • (2009) Int J Cancer , vol.124 , pp. 2577-2588
    • Yamaguchi, S.1    Asanoma, K.2    Takao, T.3    Kato, K.4    Wake, N.5
  • 87
    • 85027935285 scopus 로고    scopus 로고
    • Regulation of self-renewal and differentiation by the intestinal stem cell niche
    • Yeung TM, Chia LA, Kosinski CM, Kuo CJ (2011) Regulation of self-renewal and differentiation by the intestinal stem cell niche. Cell Mol Life Sci 68: 2513-23.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2513-2523
    • Yeung, T.M.1    Chia, L.A.2    Kosinski, C.M.3    Kuo, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.