Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Liu, Rui Hua ^a,b   Yang, Mei Hua ^c   Xiang, Hua ^b   Bao, Li Ming ^a,d   Yang, Hua An ^e   Yue, Li Wen ^f   Jiang, Xue ^b   Ang, Na ^b   Wu, Li Ya ^b   Huang, Yi ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e Department of Urologic Surgery   (China)

^f WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis resistance; Cell growth; Gastric cancer; Olfactomedin 4; RNA interference

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; GLYCOPROTEIN; HYDROGEN PEROXIDE; OLFACTOMEDIN 4; RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Z VAD FMK; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; CYSTEINE PROTEINASE INHIBITOR; GRANULOCYTE COLONY STIMULATING FACTOR; OLFM4 PROTEIN, HUMAN; OXIDIZING AGENT; PEPTIDE CHLOROMETHYL KETONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CARCINOGENICITY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SENSITIZATION; STOMACH CANCER; CELL CYCLE CHECKPOINT; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; G1 PHASE; GENE DELETION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; HYDROGEN PEROXIDE; OXIDANTS; RNA INTERFERENCE; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84859170707     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-38     Document Type: Article

References (25)

1. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Zhang J, Liu WL, Tang DC, Chen L, Wang M, Pack SD, Zhuang Z, Rodgers GP, Gene 2002 283 83 93 10.1016/S0378-1119(01)00763-6 11867215 (Pubitemid 34178512)
2. GW112, a novel antiapoptotic protein that promotes tumor growth. Zhang X, Huang Q, Yang Z, Li Y, Li CY, Cancer Res 2004 64 2474 2481 10.1158/0008-5472. CAN-03-3443 15059901 (Pubitemid 38523902)
3. Characterization and differential expression of a human gene family of olfactomedin-related proteins. Kulkarni NH, Karavanich CA, Atchley WR, Anholt RR, Genet Res 2000 76 41 50 10.1017/S0016672300004584 11006633 (Pubitemid 30649601)
4. Upregulation of Reg 1alpha and GW112 in the epithelium of inflamed colonic mucosa. Shinozaki S, Nakamura T, Iimura M, Kato Y, Iizuka B, Kobayashi M, Hayashi N, Gut 2001 48 623 629 10.1136/gut.48.5.623 11302958 (Pubitemid 32378580)
5. Gene expression in gastric biopsies from patients infected with Helicobacter pylori. Mannick EE, Schurr JR, Zapata A, Lentz JJ, Gastanaduy M, Cote RL, Delgado A, Correa P, Correa H, Scand J Gastroenterol 2004 39 1192 1200 10.1080/00365520410003588 15742995 (Pubitemid 39656833)
6. Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Liu W, Yan M, Liu Y, Wang R, Li C, Deng C, Singh A, Coleman WG Jr, Rodgers GP, Proc Natl Acad Sci USA 2010 107 11056 11061 10.1073/pnas.1001269107 20534456
7. Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas. Grutzmann R, Pilarsky C, Staub E, Schmitt AO, Foerder M, Specht T, Hinzmann B, Dahl E, Alldinger I, Rosenthal A, Ockert D, Saeger HD, Pancreatology 2003 3 169 178 10.1159/000070087 12748427 (Pubitemid 36577080)
8. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. Kobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N, Cancer Sci 2007 98 334 340 10.1111/j.1349-7006.2007.00397.x 17270022 (Pubitemid 46195603)
9. Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N, Cancer Sci 2007 98 315 320 10.1111/j.1349-7006.2006.00383.x 17270020 (Pubitemid 46195600)
10. Expression of hGC-1 is correlated with differentiation of gastric carcinoma. Liu W, Zhu J, Cao L, Rodgers GP, Histopathology 2007 51 157 165 10.1111/j.1365-2559.2007.02763.x 17650212 (Pubitemid 47084003)
11. Identification of differentially expressed genes associated with colorectal cancer liver metastasis. Li SR, Dorudi S, Bustin SA, Eur Surg Res 2003 35 327 336 12802093 (Pubitemid 36736900)
12. Identification of differentially expressed genes in colorectal adenoma compared to normal tissue by suppression subtractive hybridization. Wentzensen N, Wilz B, Findeisen P, Wagner R, Dippold W, von Knebel Doeberitz M, Gebert J, Int J Oncol 2004 24 987 994 15010839
13. Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP, Clin Cancer Res 2008 14 1041 1049 10.1158/1078-0432.CCR-07-4125 18281536 (Pubitemid 351302549)
14. Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis. Conrotto P, Roesli C, Rybak J, Kischel P, Waltregny D, Neri D, Castronovo V, Int J Cancer 2008 123 2856 2864 10.1002/ijc.23861 18798264
15. Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1. Chen L, Li H, Liu W, Zhu J, Zhao X, Wright E, Cao L, Ding I, Rodgers GP, Carcinogenesis 2011 32 986 994 10.1093/carcin/bgr065 21470957
16. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. Liu W, Lee HW, Liu Y, Wang R, Rodgers GP, Blood 2010 116 4938 4947 10.1182/blood-2009-10-246439 20724538
17. Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line. Huang Y, Yang M, Yang H, Zeng Z, Exp Cell Res 2010 316 2061 2070 10.1016/j.yexcr.2010.05.010 20478305
18. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
19. Molecular-pathological prognostic factors of gastric cancer: a review. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H, Gastric Cancer 2005 8 86 94 10.1007/s10120-005-0320-0 15864715 (Pubitemid 40655517)
20. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metaloproteinase-10 are novel prognostic factors in patients with gastric cancer. Aung PP, Oue N, Mitani Y, Nakayama H, Yoshida K, Noguchi T, Bosserhoff AK, Yasui W, Oncogene 2006 25 2546 2557 10.1038/sj.onc.1209279 16331256
21. Establishment of conditional vectors for hairpin siRNA knockdowns. Matsukura S, Jones PA, Takai D, Nucleic Acids Res 2003 31 77 10.1093/nar/gng077 12888529
22. Validating survivin as a cancer therapeutic target. Altieri DC, Nat Rev Cancer 2003 3 46 54 10.1038/nrc968 12509766 (Pubitemid 37328886)
23. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Chene P, Nat Rev Cancer 2003 3 102 109 10.1038/nrc991 12563309 (Pubitemid 37328877)
24. Blocking of NF-kappaB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line. Ueda M, Kokura S, Imamoto E, Naito Y, Handa O, Takagi T, Yoshida N, Yoshikawa T, Cancer Lett 2003 193 177 182 10.1016/S0304-3835(03)00002-8 12706875 (Pubitemid 36428900)
25. Up regulation of GW112 gene by NFkB promotes an antiapoptotic property in gastric cancer cells. Kim KK, Park KS, Song SB, Kim KE, Mol Carcinog 2010 49 259 270 19908244