LRIG1 expression in colorectal cancer

Acta Oncologica

Volumn 46, Issue 8, 2007, Pages 1118-1122

  Ljuslinder, Ingrid ^a,d   Golovleva, Irina ^b   Palmqvist, Richard ^b   Öberg, Åke ^a   Stenling, Roger ^b   Jonsson, Yvonne ^a   Hedman, Håkan ^a   Henriksson, Roger ^a,c   Malmer, Beatrice ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b Department of Medical Biosciences Medical and Clinical Genetics ^*  (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN LRIG1; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 3P; CLINICAL ARTICLE; COLORECTAL CANCER; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE DOSAGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LRIG1 GENE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; FROZEN SECTIONS; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 35848960594     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.1080/02841860701426823     Document Type: Article

References (12)

1. Suzuki Y, Sato N, Tohyama M, Wanaka A, Takagi T. cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. J Biol Chem 1996;271:22522-7.
2. Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, et al. Cloning, characterization, and expression of human LIG1. Biochem Biophys Res Commun 2001;284:1155-61.
3. Nilsson J, Starefeldt A, Henriksson R, Hedman H, et al. LRIG1 protein in human cells and tissues. Cell Tissue Res 2003;312:65-71.
4. Gur G, Rubin C, Katz M, Amit I, Citri A, Nilsson J, et al. LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. Embo J 2004;23:3270-81.
5. Laederich MB, Funes-Duran M, Yen L, Ingalla E, Wu X, Carraway KL 3rd, et al. The leucine-rich repeat protein LRIG1 is a negativeregulator of ErbB family receptor tyrosine kinasesregulator of ErbB family receptor tyrosine kinases. J Biol Chem 2004;279:47050-6.
6. Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: Implications for a standardized scoring system. Cancer 2001;92:1331-46.
7. Mayer A, Takimoto M, Fritz E, Schellander G, Kofler K, Ludwig H, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993;71:2454-60.
8. Koretz K, Schlag P, Moller P. Expression of epidermal growth factor receptor in normal colorectal mucosa, adenoma, and carcinoma. Virchows Arch A Pathol Anat Histopathol 1990;416:343-9.
9. Chung KY, Shia J, Kemeny NE, Shan M, Schwartz GK, Tse A, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005;23:1803-10.
10. Tanemura A, Nagasawa T, Inui S, Itami S. LRIG-1 provides a novel prognostic predictor in squamous cell carcinoma of the skin: Immunohistochemical analysis for 38 cases. Dermatol Surg 2005;31:423-30.
11. Ljuslinder I, Malmer B, Golovleva I, Thomasson M, Grankvist K, Hockenstrom T, et al. Increased copy number at 3p14 in breast cancer. Breast Cancer Res 2005;5:719-27.
12. Tabernero J, Salazar R, Casado E, Martinelli E, Gomez P, Baselga J, et al. Targeted therapy in advanced colon cancer: The role of new therapies. Ann Oncol 2004;15:55-62.