Homodimerization of adenosine A1 receptors in brain cortex explains the biphasic effects of caffeine

Neuropharmacology

Volumn 71, Issue , 2013, Pages 56-69

  Gracia, Eduard ^a   Moreno, Estefania ^a   Cortés, Antoni ^a   Lluís, Carme ^a   Mallol, Josefa ^a   McCormick, Peter J ^a   Canela, Enric I ^a   Casadó, Vicent ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Allosteric interaction; Binding parameters cooperativity; G protein coupled receptor; Proximity ligation assay; Two state dimer receptor model

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE DEAMINASE; CAFFEINE;

AGONIST; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIOASSAY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BIPHASIC EFFECT; BRAIN CORTEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; COW; DIMERIZATION; DRUG EFFECT; EMBRYO; HOMODIMERIZATION; HUMAN; HUMAN CELL; LOCOMOTION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTOMER PROTOMER INTERACTION; PROXIMITY LIGATION ASSAY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ADENOSINE A1 RECEPTOR AGONISTS; ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE DEAMINASE; ALLOSTERIC SITE; ANIMALS; BACTERIAL PROTEINS; CAFFEINE; CATTLE; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBRAL CORTEX; DIMERIZATION; HEK293 CELLS; HUMANS; KINETICS; LUMINESCENT PROTEINS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEURONS; RECEPTOR, ADENOSINE A1; RECOMBINANT FUSION PROTEINS;

EID: 84878122075     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.03.005     Document Type: Article

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