A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

Biochemical Journal

Volumn 435, Issue 3, 2011, Pages 701-709

  Gracia, Eduard ^a   Pérez Capote, Kamil ^a   Moreno, Estefanía ^a   Barkešová, Jana ^a   Mallol, Josefa ^a   Lluís, Carme ^a   Franco, Rafael ^a,b   Cortés, Antoni ^a   Casadó, Vicent ^a   Canela, Enric I ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Adenosine deaminase; Adenosine receptor; Allosteric interaction; G protein coupled receptor; Protein protein interaction; Receptor binding parameter

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL STRAIN HEK293; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; SHEEP; ANIMAL; CHO CELL; CORPUS STRIATUM; CRICETULUS; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ADENOSINE DEAMINASE; ANIMALS; BRAIN; CHO CELLS; CORPUS STRIATUM; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; PROTEIN BINDING; RECEPTOR, ADENOSINE A2A; RECEPTORS, GABA-B; SHEEP; SIGNAL TRANSDUCTION;

EID: 79954472515     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101749     Document Type: Article

References (49)

1. Marianayagam, N. J., Sunde, M. and Matthews, J. M. (2004) The power of two: protein dimerization in biology. Trends Biochem. Sci. 29, 618-625
2. Franco, R., Canals, M., Marcellino, D., Ferré, S., Agnati, L., Mallol, J., Casadó, V., Ciruela, F., Fuxe, K., Lluís, C. and Canela, E. I. (2003) Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. Trends Biochem. Sci. 28, 238-243
3. Ferré, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux, T., Fuxe, K., George, S. R., Javitch, J. A., Lohse, M. J. et al. (2009) Building a new conceptual framework for receptor heteromers. Nat. Chem. Bio. 5, 131-134
4. Trincavelli, M. L., Daniele, S. and Martini, C. (2010) Adenosine receptors: what we know and what we are learning. Curr. Top. Med. Chem. 10, 860-877
5. Ciruela, F., Casadó, V., Mallol, J., Canela, E. I., Lluis, C. and Franco, R. (1995) Immunological identification of A1 adenosine receptors in brain cortex. J. Neurosci. Res. 42, 818-828
6. Canals, M., Burgueño, J., Marcellino, D., Cabello, N., Canela, E. I., Mallol, J., Agnati, L., Ferré, S., Bouvier, M., Fuxe, K. et al. (2004) Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J. Neurochem. 88, 726-734 (Pubitemid 38140216)
7. Gandia, J., Galino, J., Amaral, O. B., Soriano, A., Lluís, C., Franco, R. and Ciruela, F. (2008) Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. FEBS Lett. 582, 2979-2984
8. Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J. et al. (2006) Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J. Neurosci. 26, 2080-2087
9. 2 receptor-receptor heteromerization. Qualitative and quantitative assessment by fluorescence and bioluminescence resonance energy transfer. J. Biol. Chem. 278, 46741-46749
10. Franco, R., Ciruela, F., Casadó, V., Cortes, A., Canela, E. I., Mallol, J., Agnati, L. F., Ferré, S., Fuxe, K. and Lluís, C. (2005) Partners for adenosine A1 receptors. J. Mol. Neurosci. 26, 221-232
11. Carriba, P., Navarro, G., Ciruela, F., Ferré, S., Casadó, V., Agnati, L., Cortés, A., Mallol, J., Fuxe, K., Canela, E. I. et al. (2008) Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nat. Methods 5, 727-733
12. Ferré, S., Ciruela, F., Quiroz, C., Luján, R., Popoli, P., Cunha, R. A., Agnati, L. F., Fuxe, K., Woods, A. S., Lluis, C. and Franco, R. (2007) Adenosine receptor heteromers and their integrative role in striatal function. ScientificWorldJournal 7, 74-85 (Pubitemid 350277595)
13. Casadó, V., Cortés, A., Mallol, J., Pérez-Capote, K., Ferré, S., Lluís, C., Franco, R. and Canela, E. I. (2009) GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? Pharmacol. Ther. 124, 248-257
14. 1 adenosine receptors to form functional modules in the cell membrane. Mol. Cell. Biol. 20, 5164-5174
15. Ciruela, F., Saura, C., Canela, E. I., Mallol, J., Lluís, C. and Franco, R. (1996) Adenosine deaminase affects ligand-induced signaling by interacting with cell surface adenosine receptors. FEBS Lett. 380, 219-223 (Pubitemid 26063938)
16. 1 adenosine receptors in pig brain cortical membranes. J. Neurochem. 66, 1675-1682
17. 2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells. Mol. Pharmacol. 59, 127-134
18. 3H](R)-PIA binding to the caudate nucleus. J. Neurochem. 107, 161-170
19. Franco, R., Valenzuela, A., Lluís, C. and Blanco, J. (1998) Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes. Immunol. Rev. 161, 27-42
20. Hershfield, M. S. (2003) Genotype is an important determinant of phenotype in adenosine deaminase deficiency. Curr. Opin. Immunol. 15, 571-577
21. Hirschhorn, R. (1985) Complete and partial adenosine deaminase deficiency. Ann. NY Acad. Sci. 451, 20-26
22. Ruiz, M. A., Escriche, M., Lluís, C., Franco, R., Martín, M., Andrés, A. and Ros, M. (2000) Adenosine A1 receptor in cultured neurons from rat cerebral cortex: colocalization with adenosine deaminase. J. Neurochem. 75, 656-664 (Pubitemid 30485446)
23. Engel, M., Hoffmann, T., Wagner, L., Wermann, M., Heiser, U., Kiefersauer, R., Huber, R., Bode, W., Demuth, H. U. and Brandstetter, H. (2003) The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc. Natl. Acad. Sci. U.S.A. 100, 5063-5068
24. Pacheco, R., Martínez-Navío, J. M., Lejeune, M., Climent, N., Oliva, H., Gatell, J. M., Gallart, T., Mallol, J., Lluís, C. and Franco, R. (2005) CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc. Natl. Acad. Sci. U.S.A. 102, 9583-9588
25. Martinez-Navio, J. M., Climent, N., Pacheco, R., Garcia, F., Plana, M., Nomdedeu, M., Oliva, H., Rovira, C., Miralles, L., Gatell, J. M. et al. (2009) Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation. Immunology 128, 393-404
26. Climent, N., Martinez-Navio, J. M., Gil, C., Garcia, F., Rovira, C., Hurtado, C., Miralles, L., Gatell, J. M., Gallart, T., Mallol, J. et al. (2009) Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV. Immunol. Cell. Biol. 87, 634-639
27. Saura, C., Mallol, J., Canela, E. I., Lluís, C. and Franco, R. (1998) Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization. J. Biol. Chem. 273, 17610-17617
28. 2A receptors in psychiatric disorders. Curr. Pharm. Des. 14, 1512-1524
29. Hillion, J., Canals, M., Torvinen, M., Casadó, V., Scott, R., Terasmaa, A., Hansson, A., Watson, S., Olah, M. E., Mallol, J. et al. (2002) Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J. Biol. Chem. 277, 18091-18097
30. 1 adenosine receptor and adenosine deaminase in an epithelial cell line. Mol. Pharmacol. 59, 1314-23
31. Casadó, V., Cantí, C., Mallol, J., Canela, E. I., Lluís, C. and Franco, R. (1990) Solubilization of A1 adenosine receptor from pig brain: characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states. J. Neurosci. Res. 26, 461-473
32. Franco, R., Casadó, V., Mallol, J., Ferré, S., Fuxe, K., Cortés, A., Ciruela, F., Lluís, C. and Canela, E. I. (2005) Dimer-based model for heptaspanning membrane receptors. Trends Biochem. Sci. 30, 360-366
33. Franco, R., Casadó, V., Mallol, J., Ferrada, C., Ferré, S., Fuxe, K., Cortés, A., Ciruela, F., Lluís, C. and Canela, E. I. (2006) The two-state dimer receptor model: a general model for receptor dimers. Mol. Pharmacol. 69, 1905-1912
34. Casadó, V., Cortés, A., Ciruela, F., Mallol, J., Ferré, S., Lluís, C., Canela, E. I. and Franco, R. (2007) Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index. Pharmacol. Ther. 116, 343-354
35. Casadó, V., Ferrada, C., Bonaventura, J., Gracia, E., Mallol, J., Canela, E. I., Lluís, C., Cortés, A. and Franco, R. (2009) Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation. Biochem. Pharmacol. 78, 1456-1463
36. Dong, R.-P., Tachibana, K., Hegen, M., Munakata, Y., Cho, D., Schlossman, S. F. and Morimoto, C. (1997) Determination of adenosine deaminase binding domain on CD26 and its immunoregulatory effect on T cell activation. J. Immunol. 159, 6070-6076 (Pubitemid 127471544)
37. Gao, Z. G., Mamedova, L. K., Chen, P. and Jacobson, K. A. (2004) 2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors. Biochem. Pharmacol. 68, 1985-1993
38. Olah, M. E. and Stiles, G. L. (2000) The role of receptor structure in determining adenosine receptor activity. Pharmacol. Ther. 85, 55-75
39. May, L. T., Leach, K., Sexton, P. M. and Christopoulos, A. (2007) Allosteric modulation of G protein-coupled receptors. Annu. Rev. Pharmacol. Toxicol. 47, 1-51
40. Conn, P. J., Christopoulos, A. and Lindsley, C. W. (2009) Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat. Rev. Drug Discovery 8, 41-54
41. Kreth, S., Kaufmann, I., Ledderose, C., Luchting, B. and Thiel, M. (2009) Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis. J. Cell. Mol. Med. 13, 985-994
42. van den Nieuwendijk, A. M., Pietra, D., Heitman, L., Göblyös, A. and Ijzerman, A. P. (2004) Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors. J. Med. Chem. 47, 663-672
43. Gao, Z. G., Kim, S. K., Ijzerman, A. P. and Jacobson, K. A. (2005) Allosteric modulation of the adenosine family of receptors. Mini Rev. Med. Chem. 5, 545-553
44. 278 in ligand binding and sodium modulation. Biochem. Pharmacol. 60, 661-668
45. Göblyös, A. and Ijzerman, A. P. (2010) Allosteric modulation of adenosine receptors. Biochim. Biophys. Acta, doi:10.1016/j. bbamem.2010.06.013
46. Stone, T. W., Ceruti, S. and Abbracchio, M. P. (2009) Adenosine receptors and neurological disease: neuroprotection and neurodegeneration. Handb. Exp. Pharmacol. 193, 535-587
47. Cristalli, G., Lambertucci, C., Marucci, G., Volpini, R. and Dal Ben, D. (2008) A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists. Curr. Pharm. Des. 14, 1525-1552
48. Carlsson, J., Yoo, L., Gao, Z. G., Irwin, J. J., Shoichet, B. K. and Jacobson, K. A. (2010) Structure-based discovery of A2A adenosine receptor ligands. J. Med. Chem. 53, 3748-3755
49. Katritch, V., Jaakola, V. P., Lane, J. R., Lin, J., Ijzerman, A. P., Yeager, M., Kufareva, I., Stevens, R. C. and Abagyan, R. (2010) Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J. Med. Chem. 53, 1799-1809