Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: The receptor-dimer cooperativity index

Pharmacology and Therapeutics

Volumn 116, Issue 3, 2007, Pages 343-354

  Casadó, Vincent ^a,b   Cortés, Antoni ^a,b   Ciruela, Francisco ^a,b   Mallol, Josefa ^a,b   Ferré, Sergi ^c   Lluis, Carmen ^a,b   Canela, Enric I ^a,b   Franco, Rafael ^a,b  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Affinity; Agonist; Antagonist; G protein

Indexed keywords

DIMER; G PROTEIN COUPLED RECEPTOR; MONOMER; PROTEIN TYROSINE KINASE;

AGONIST; BINDING AFFINITY; DEUTERON NUCLEAR MAGNETIC RESONANCE; DIMERIZATION; ISOTHERM; LIGAND BINDING; PRIORITY JOURNAL; REVIEW;

EID: 36249020990     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2007.05.010     Document Type: Review

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