Complement expression in retinal pigment epithelial cells is modulated by activated macrophages

Experimental Eye Research

Volumn 112, Issue , 2013, Pages 93-101

  Luo, Chang ^a   Zhao, Jiawu ^a   Madden, Angelina ^a   Chen, Mei ^a   Xu, Heping ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Complement; Macrophages; Retinal pigment epithelial cells

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CD59 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5; COMPLEMENT FACTOR H; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RETINAL PIGMENT EPITHELIAL CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT FACTOR B; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT SYSTEM PROTEINS; CULTURE MEDIA, CONDITIONED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; STAT1 TRANSCRIPTION FACTOR;

EID: 84878050497     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.04.016     Document Type: Article

References (50)

1. Agnello D., Lankford C.S., Bream J., Morinobu A., Gadina M., O'Shea J.J., Frucht D.M. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J.Clin. Immunol. 2003, 23:147-161.
2. An E., Gordish-Dressman H., Hathout Y. Effect of TNF-alpha on human ARPE-19-secreted proteins. Mol. Vis. 2008, 14:2292-2303.
3. Anderson C.F., Mosser D.M. Anovel phenotype for an activated macrophage: the type 2 activated macrophage. J.Leukoc. Biol. 2002, 72:101-106.
4. Anderson D.H., Mullins R.F., Hageman G.S., Johnson L.V. Arole for local inflammation in the formation of drusen in the aging eye. Am. J. Ophthalmol. 2002, 134:411-431.
5. Anderson D.H., Radeke M.J., Gallo N.B., Chapin E.A., Johnson P.T., Curletti C.R., Hancox L.S., Hu J., Ebright J.N., Malek G., Hauser M.A., Rickman C.B., Bok D., Hageman G.S., Johnson L.V. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog. Retin. Eye Res. 2010, 29:95-112.
6. Caspi R.R., Chan C.C., Wiggert B., Chader G.J. The mouse as a model of experimental autoimmune uveoretinitis (EAU). Curr. Eye Res. 1990, 9:169-174.
7. Chen M., Forrester J.V., Xu H. Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp. Eye Res. 2007, 84:635-645.
8. Chen M., Forrester J.V., Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One 2011, 6:e22818.
9. Chen M., Muckersie E., Luo C., Forrester J.V., Xu H. Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. Eur. J. Immunol. 2010, 40:2870-2881.
10. Chen M., Muckersie E., Robertson M., Forrester J.V., Xu H. Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Exp. Eye Res. 2008, 87:543-550.
11. Chinnery H.R., McLenachan S., Humphries T., Kezic J.M., Chen X., Ruitenberg M.J., McMenamin P.G. Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX(3)CR1. Neurobiol. Aging 2011, 33:1769-1776.
12. Combadiere C., Feumi C., Raoul W., Keller N., Rodero M., Pezard A., Lavalette S., Houssier M., Jonet L., Picard E., Debre P., Sirinyan M., Deterre P., Ferroukhi T., Cohen S.Y., Chauvaud D., Jeanny J.C., Chemtob S., Behar-Cohen F., Sennlaub F. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J.Clin. Invest. 2007, 117:2920-2928.
13. Copland D.A., Hussain K., Baalasubramanian S., Hughes T.R., Morgan B.P., Xu H., Dick A.D., Nicholson L.B. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clin. Exp. Immunol. 2010, 159:303-314.
14. Detrick B., Hooks J.J. Immune regulation in the retina. Immunol. Res. 2010, 47:153-161.
15. Dick A.D., Forrester J.V., Liversidge J., Cope A.P. The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU). Prog. Retin. Eye Res. 2004, 23:617-637.
16. Enzmann V., Hollborn M., Poschinger K., Wiedemann P., Kohen L. Immunosuppression by IL-10-transfected human retinal pigment epithelial cells invitro. Curr. Eye Res. 2001, 23:98-105.
17. Forrester J.V., Huitinga I., Lumsden L., Dijkstra C.D. Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats. Curr. Eye Res. 1998, 17:426-437.
18. Forrester J.V., Liversidge J., Dua H.S., Dick A., Harper F., McMenamin P.G. Experimental autoimmune uveoretinitis: a model system for immunointervention: a review. Curr. Eye Res. 1992, 11:33-40.
19. Gerl V.B., Bohl J., Pitz S., Stoffelns B., Pfeiffer N., Bhakdi S. Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2002, 43:1104-1108.
20. Gupta N., Brown K.E., Milam A.H. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp. Eye Res. 2003, 76:463-471.
21. Hageman G.S., Luthert P.J., Victor Chong N.H., Johnson L.V., Anderson D.H., Mullins R.F. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res. 2001, 20:705-732.
22. Hollborn M., Enzmann V., Barth W., Wiedemann P., Kohen L. Changes in the mRNA expression of cytokines and chemokines by stimulated RPE cells invitro. Curr. Eye Res. 2000, 20:488-495.
23. Jiang H.R., Lumsden L., Forrester J.V. Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. Invest. Ophthalmol. Vis. Sci. 1999, 40:3177-3185.
24. Juel H.B., Kaestel C., Folkersen L., Faber C., Heegaard N.H., Borup R., Nissen M.H. Retinal pigment epithelial cells upregulate expression of complement factors after co-culture with activated T cells. Exp. Eye Res. 2011, 92:180-188.
25. Kociok N., Heppekausen H., Schraermeyer U., Esser P., Thumann G., Grisanti S., Heimann K. The mRNA expression of cytokines and their receptors in cultured iris pigment epithelial cells: a comparison with retinal pigment epithelial cells. Exp. Eye Res. 1998, 67:237-250.
26. Lawrence T., Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat. Rev. Immunol. 2011, 11:750-761.
27. Liversidge J., Dick A., Gordon S. Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas/Fas-ligand interactions in experimental autoimmune uveitis. Am. J. Pathol. 2002, 160:905-916.
28. Luo C., Chen M., Madden A., Xu H. Expression of complement components and regulators by different subtypes of bone marrow-derived macrophages. Inflammation 2012, 35:1448-1461.
29. Luo C., Chen M., Xu H. Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol. Vis. 2011, 17:1588-1597.
30. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
31. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002, 23:549-555.
32. Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front. Biosci. 2008, 13:453-461.
33. McLaughlin B.J., Fan W., Zheng J.J., Cai H., Del Priore L.V., Bora N.S., Kaplan H.J. Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion. Invest. Ophthalmol. Vis. Sci. 2003, 44:3669-3674.
34. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
35. Mullins R.F., Russell S.R., Anderson D.H., Hageman G.S. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000, 14:835-846.
36. Penfold P.L., Liew S.C., Madigan M.C., Provis J.M. Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 1997, 38:2125-2133.
37. Qin S., Ni M., Wang X., Maurier-Mahe F., Shurland D.L., Rodrigues G.A. Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor. Exp. Eye Res. 2011, 93:889-897.
38. Read R.W., Szalai A.J., Vogt S.D., McGwin G., Barnum S.R. Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. Exp. Eye Res. 2006, 82:389-394.
39. Robertson M.J., Erwig L.P., Liversidge J., Forrester J.V., Rees A.J., Dick A.D. Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest. Ophthalmol. Vis. Sci. 2002, 43:2250-2257.
40. Vogt S.D., Curcio C.A., Wang L., Li C.M., McGwin G., Medeiros N.E., Philp N.J., Kimble J.A., Read R.W. Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp. Eye Res. 2011, 93:413-423.
41. Weischenfeldt J., Porse B. Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protoc. 2008, 3(12):1-6.
42. Willermain F., Caspers-Velu L., Baudson N., Dubois C., Hamdane M., Willems F., Velu T., Bruyns C. Role and expression of CD40 on human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 2000, 41:3485-3491.
43. Xu H., Chen M., Forrester J.V. Para-inflammation in the aging retina. Prog. Retin. Eye Res. 2009, 28:348-368.
44. Xu H., Chen M., Manivannan A., Lois N., Forrester J.V. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008, 7:58-68.
45. Yang P., Tyrrell J., Han I., Jaffe G.J. Expression and modulation of RPE cell membrane complement regulatory proteins. Invest. Ophthalmol. Vis. Sci. 2009, 50:3473-3481.
46. Zamiri P., Masli S., Kitaichi N., Taylor A.W., Streilein J.W. Thrombospondin plays a vital role in the immune privilege of the eye. Invest. Ophthalmol. Vis. Sci. 2005, 46:908-919.
47. Zamiri P., Sugita S., Streilein J.W. Immunosuppressive properties of the pigmented epithelial cells and the subretinal space. Chem. Immunol. Allergy 2007, 92:86-93.
48. Zhang J., Gerhardinger C., Lorenzi M. Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. Diabetes 2002, 51:3499-3504.
49. Zhang X., Mosser D.M. Macrophage activation by endogenous danger signals. J.Pathol. 2008, 214:161-178.
50. Zhou J., Jang Y.P., Kim S.R., Sparrow J.R. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16182-16187.