Anaesthesia for positron emission tomography scanning of animal brains

Laboratory Animals

Volumn 47, Issue 1, 2013, Pages 12-18

  Alstrup, Aage Kristian Olsen ^a   Smith, Donald F ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Anaesthesia; Brain imaging; Cerebral blood flow (CBF); Neuroscience; Neurotransmission, microPET; Positron emission tomography; Radiotracer

Indexed keywords

CANNABINOID RECEPTOR; CHLORAL HYDRATE; CHLORALOSE; DOPAMINE 1 RECEPTOR; DOPAMINE TRANSPORTER; HALOTHANE; HYPNORM; ISOFLURANE; KETAMINE; MEDETOMIDINE; MIDAZOLAM MALEATE; MUSCARINIC RECEPTOR; NORADRENALIN TRANSPORTER; PENTOBARBITAL; PHOSPHODIESTERASE; PROPOFOL; REBOXETINE; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; TILETAMINE; URETHAN; XYLAZINE; ZOLAZEPAM;

ANESTHESIA; AUTONOMIC NERVOUS SYSTEM; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN METABOLISM; CHOLINERGIC TRANSMISSION; ENZYME INHIBITION; GLUCOSE METABOLISM; HAPLORHINI; MONOAMINERGIC SYSTEM; NEUROIMAGING; NEUROTRANSMISSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRESSORECEPTOR; RAT; REVIEW;

ANESTHESIA; ANESTHETICS; ANIMALS; BLOOD VOLUME; BRAIN; LABORATORY ANIMAL SCIENCE; NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY; REGIONAL BLOOD FLOW; SYNAPTIC TRANSMISSION;

EID: 84878033633     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2012.011173     Document Type: Review

References (87)

1. Celsis P, Goldman T, Henriksen L, Lassen NA. A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comput Assist Tomogr 1981;5:641-5
2. Henriksen L, Paulson OB, Lassen NA. Visual cortex activation recorded by dynamic emission computed tomography of inhaled xenon 133. Eur J Nucl Med 1981;6:487-9
3. Lauritzen M, Henriksen L, Lassen NA. Regional cerebral blood flow during rest and skilled hand movements by xenon-133 inhalation and emission computerized tomography. J Cereb Blood Flow Metab 1981;1:385-7
4. Jones AK, Friston K, Dolan R. Positron emission tomography as a research tool in the investigation of psychiatric and psychological disorders. Baillieres Clin Endocrinol Metab 1991;5:187-203
5. Csonka C, Kupai K, Kocsis GF, et al. Measurement of myocardial infarct size in preclinical studies. J Pharmacol Toxicol Methods 2010;61:163-70
6. Toyohara J, Ishiwata K. Animal tumor models for PET in drug development. Ann Nucl Med 2011;25:717-31
7. Winterdahl M, Keiding S, Sørensen M, Mortensen FV, Alstrup AKO, Munk OL. Tracer input for kinetic modelling of liver physiology determined without sampling portal venous blood in pigs. Eur J Nucl Med Mol Imaging 2011;38:263-70
8. Alstrup AKO, Winterdahl M. Imaging techniques in large animals. Scand J Lab Animal Sci 2009;36:55-66
9. Alstrup AKO, Smith DF. PET neuroimaging in pigs. Scand J Lab Anim Sci 2012 (in press)
10. Perlmutter JS, Lich LL, Margenau W, Buchholz S. PET measured evoked cerebral blood flow responses in an awake monkey. J Cereb Blood Flow Metab 1991;11:229-35
11. Howell LL, Hoffman JM, Votaw JR, Landrum AM, Jordan JF. An apparatus and behavioral training protocol to conduct positron emission tomography (PET) neuroimaging in conscious rhesus monkeys. J Neurosci Methods 2001;106:161-9
12. Noda A, Takamatsu H, Minoshima S, Tsukada H, Nishimura S. Determination of kinetic rate constants for 2-[18F]fluoro-2-deoxy-D-glucose and partition coefficient of water in conscious macaques and alterations in aging or anaesthesia examined on parametric images with an anatomic standardization technique. J Cereb Blood Flow Metab 2003;23:1441-7
13. Stehouwer JS, Jarkas N, Zeng F, et al. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)- 3beta-(30-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem 2008;51:7788-99
14. Schoultz BW, Hjornevik T, Willoch F, et al. Evaluation of the kappa-opioid receptor-selective tracer [(11)C]GR103545 in awake rhesus macaques. Eur J Nucl Med Mol Imaging 2010;37:1174-80
15. Carson RE, Sandiego C, Mulnix T, et al. Awake nonhuman primate brain PET imaging without head restraint. Neuroimage 2010;52(Suppl. 1):S18
16. Zimmer L, Fournet G, Benoit J, Guillaumet G, Le Bars D. Carbon-11 labelling of 8[[3-[4-(2-[(11)C]methoxyphenyl)piperazin-1-yl]- 2-hydroxypropyl]oxy]thiochroman, a presynaptic 5-HT(1A) receptor agonist, and its in vivo evaluation in anaesthetised rat and in awake cat. Nucl Med Biol 2003;30:541-6
17. Hassoun W, Le Cavorsin M, Ginovart N, et al. PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow. Eur J Nucl Med Mol Imaging 2003;30:141-8
18. Momosaki S, Hatano K, Kawasumi Y, et al. Rat-PET study without anaesthesia: anaesthetics modify the dopamine D1 receptor binding in rat brain. Synapse 2004;54:207-13
19. Hosoi R, Matsumura A, Mizokawa S, et al. MicroPET detection of enhanced 18F-FDG utilization by KBA inhibitor in awake rat brain. Brain Res 2005;1039:199-202
20. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H. Establishment of in vivo brain imaging in conscious mice. J Nucl Med 2010;51:1068-75
21. Lasbennes F, Lestage P, Bobillier P, Seylaz J. Stress and local cerebral blood flow: studies on restrained and unrestrained rats. Exp Brain Res 1986;63:163-8
22. Casada JH, Dafny N. Restraint stress modulates sensory evoked potentials. Int J Neurosci 1990;53:265-74
23. McLaughlin KJ, Gomez JL, Baran SE, Conrad CD. The effects of chronic stress on hippocampal morphology and function: an evaluation of chronic restraint paradigms. Brain Res 2007;1161:56-64
24. Hu W, Zhang M, Czéh B, Zhang W, Flügge G. Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats. Brain Res Bull 2011;85:374-9
25. Vaska P, Woody CL, Schlyer DJ, et al. RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging. IEEE Trans Nucl Sci 2004;51:2718-22
26. Patel VD, Lee DE, Alexoff DL, Dewey SL, Schiffer WK. Imaging dopamine release with positron emission tomography (PET) and 11C-raclopride in freely moving animals. Neuroimage 2008;41:1051-66
27. Alstrup AKO, Jakobsen S, Wegener G, et al. Anaesthesia in animal imaging: differing effects of propofol versus isoflurane on dopamine 1 receptor binding in Gottingen minipig brain. Neuroimage 2010;52:S181
28. Alstrup AKO, Simonsen M, Landau AM. Type of anaesthesia influences positron emission tomography measurements of dopamine D2/3 receptor binding in the rat brain. Scand J Lab Anim Sci 2011;38:195-200
29. Elfving B, Bjornholm B, Knudsen GM. Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med Mol Imaging 2003;30:912-15
30. Plumb DC. Plumb's Veterinary Drug Handbook. 6th edn. NJ: Blackwell Publishing, 2008
31. Matsumura A, Mizokawa S, Tanaka M, et al. Assessment of microPET performance in analyzing the rat brain under different types of anaesthesia: comparison between quantitative data obtained with microPET and ex vivo autoradiography. Neuroimage 2003;20:2040-50
32. Tsukada H, Nishiyama S, Kakiuchi T, Ohba H, Sato K, Harada N. Ketamine alters the availability of striatal dopamine transporter as measured by [11C]beta-CFT and [11C]beta-CIT-FE in the monkey brain. Synapse 2001;42:273-80
33. Hildebrandt IJ, Su H, Weber WA. Anaesthesia and other considerations for in vivo imaging of small animals. ILAR J 2008;49:17-26
34. Wang Z, Schuler B, Vogel O, Arras M, Vogel J. What is the optimal anaesthetic protocol measurements of cerebral autoregulation in spontaneously breathing mice? Exp Brain Res 2010;207:249-58
35. Colby LA, Morenko BJ. Clinical considerations in rodent bioimaging. Comp Med 2004; 54: 623-30
36. García-Bonilla L, Rosell A, Torregrosa G, et al. Recommendations guide for experimental animal models in stroke research. Neurologia 2011;26:105-10
37. Logan J, Fowler JS, Ding YS, et al. Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline. J Cereb Blood Metab 2002;22:1367-76
38. Olsen AK, Keiding S, Munk OL. Effect of hypercapnia on cerebral blood flow and blood volume in pigs studied by positron emission tomography. Comp Med 2006;56:416-20
39. Akeson J, Björkman S, Messeter K, Rosén I, Helfer M. Cerebral pharmacodynamics of anaesthetics and subanaesthetic doses of ketamine in the normoventilated pig. Act Anaesthesiol Scand 1993;37:211-18
40. Dawson B, Michenfelder JD, Theye RA. Effects of ketamine on canine cerebral blood flow and metabolism: modificationby prior administration of thiopental. Anaesth Analg 1971;50: 443-7
41. Hudetz JA, Pagel SP. Neuroprotection by ketamine: a review of the experimental and clinical evidence. J Cardiothorac Vasc Anaesth 2010;24:131-42
42. Schwedler M, Miletich DJ, Albrecht RF. Cerebral blood flow and metabolism following ketamine administration. Can Anaesth Soc J 1982;29:222-6
43. Dagal A, Lam AM. Cerebral autoregulation and anaesthesia. Curr Opin Anaesthesiol 2009;22:547-52
44. Swindley MM. Anaesthesia, analgesia, and perioperative care. In: Swindley MM, ed. Swine in the Laboratory. Surgery, Anaesthesia, Imaging, and Experimental Techniques. Boca Raton: CRC Press, 2007: 35-79
45. Toyama H, Ichise M, Liow JS, et al. Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med 2004;45:1398-405
46. Lee MS, Ko J, Lee AR, et al. Effects of anaesthetic protocol on normal canine brain uptake of 18F-FDG assessed by PET/CT. Vet Radiol Ultrasound 2010;51:130-5
47. Jolkkonen J, Puurunen K, Koistinaho J, et al. Neuroprotecting by the alpha-2-adrenoceptor agonist, dexmedetomidine, in regional cerebral ischemia. Eur J Pharmacol 1999;372:31-6
48. Avena NM, Rada PV. Cholinergic modulation of food and drug satiety and withdrawal. Physiol Behav 2012;106:332-6
49. Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol Neurobiol 2005;32:173-202
50. Neukirchen M, Kienbaum P. Sympathetic nervous system: evaluation and importance for clinical general anesthesia. Anesthesiology 2008;109:1113-31
51. Eger EI, Zhang Y, Laster M, Flood P, Kendig JJ, Sonner JM. Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics. Anesth Analg 2002;94:1500-4, table of contents
52. Zhang Y, Laster MJ, Eger EI, Sharma M, Sonner JM. Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats. Anesth Analg 2007;104:850-2
53. Kilbourn MR, Ma B, Butch ER, Quesada C, Sherman PS. Anaesthesia increases in vivo N-([F-18]fluoroethyl)piperidinyl benzilate binding to the muscarinic cholinergic receptor. Nucl Med Biol 2007;34:479-82
54. Hindmarch I. Beyond the monoamine hypothesis: mechanisms, molecules and methods. Eur Psychiatry 2002;17(Suppl. 3):294-9
55. Millan MJ. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics 2009;6:53-77
56. Piccini P, Pavese N, Brooks DJ. Endogenous dopamine release after pharmacological challenges in Parkinson's disease. Ann Neurol 2003;53:647-53
57. Seeman P. All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neurosci Ther 2011;17:118-32
58. Votaw J, Byas-Smith M, Hua J, et al. Interaction of isoflurane with the dopamine transporter. Anaesthesiology 2003;98:404-11
59. Du C, Tully M, Volkow ND, et al. Differential effects of anaesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brain. Eur J Neurosci 2009;30:1565-75
60. Tsukada H, Nishiyama S, Kakiuchi T, et al. Isofluorane anaesthesia enchances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain Res 1999;849:85-96
61. Nader MA, Grant KA, Gage HD, Ehrenkaufer RL, Kaplan JR, Mach RH. PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anaesthesia. Neuropsychopharmacology 1999;21:589-96
62. Kobayashi K, Inoue O, Watanabe Y, Onoe H, La°ngström B. Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anaesthetics in rhesus monkey brain. J Neural Transm Gen Sect 1995;100:147-51
63. Tsukada H, Miyasato K, Kakiuchi T, Nishiyama S, Harada N, Domino EF. Comparative effects of metamphetamine and nicotine on the striatal [(11C)]raclopride binding in unanaesthetized monkeys. Synapse 2002;45:207-12
64. McCormick PN, Ginovart N, Vasdev N, Seeman P, Kapur S, Wilson AA. Isoflurane increases both the specific binding ratio and sensitivity to amphetamine challenge of [11C]-(̈)-PHNO. Neuroimage 2006;31:T33
65. McCormick PN, Kapur S, Reckless G, Wilson AA. Ex vivo [11C]-(̈)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro. Synapse 2009;63:998-1009
66. Zeng F, Mun J, Jarkas N, et al. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter. J Med Chem 2009;52:62-73
67. Kung MP, Choi SR, Hou C, Zhuang ZP, Foulon C, Kung HF. Selective binding of 2-[125I]iodo-nisoxetine to norepinephrine transporters in the brain. Nucl Med Biol 2004;31:533-41
68. Schou M, Halldin C, Sovago J, et al. PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain. Synapse 2004;53:57-67
69. Smith DF, Jakobsen S. Molecular tools for assessing human depression by positron emission tomography. Eur Neuropsychopharmacol 2009;19:611-28
70. King MV, Marsden CA, Fone KC. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends Pharmacol Sci 2008;29:482-92
71. Savitz J, Lucki I, Drevets WC. 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 2009;88:17-31
72. Tokugawa J, Ravasi L, Nakayama T, et al. Distribution of the 5-HT1A receptor antagonist [18F]FPWAY in blood and brain of the rat with and without isoflurane anaesthesia. Eur J Nucl Med Mol Imaging 2007;34:259-66
73. Smith DF, Geday J. PET neuroimaging of clomipramine challenge in humans: focus on the thalamus. Brain Res 2001;892:193-7
74. Geday J, Hermansen F, Rosenberg R, Smith DF. Serotonin modulation of cerebral blood flow measured with positron emission tomography (PET) in humans. Synapse 2005;55:224-9
75. Jagoda EM, Lang L, Tokugawa J, et al. Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT. Synapse 2006;59:330-41
76. Martikainen IK, Hirvonen J, Kajander J, et al. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res 2007;1172:21-31
77. Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7:137-51
78. Kupfer DJ, Frank E, Phillips ML. Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 2002;379:1045-55
79. Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:664-75
80. Kleppisch T. Phosphodiesterases in the central nervous system. Handb Exp Pharmacol 2009;(191):71-92
81. Wachtel H. Potential antidepressant activity of rolipram and other selective cyclic adenosine 30,50-monophosphate phosphodiesterase inhibitors. Neuropharmacology 1983;22:267-72
82. Itoh T, Abe K, Zoghbi SS, et al. PET measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in the brains of conscious and anaesthetized rats. J NuclMed 2009;50:749-56
83. Nakanishi S, Nakajima Y, Masu M, et al. Glutamate receptors: brain function and signal transduction. Brain Res Rev 1998;26:230-5
84. Severance AJ, Parsey RV, Kumar JS, et al. In vitro and in vivo evaluation of [11C]MPEPy as a potential PET ligand for mGlu5 receptors. Nucl Med Biol 2006;33:1021-7
85. Van Laere K. In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans. Eur J Nucl Med Mol Imaging 2007;34:1719-26
86. Casteels C, Bormans G, Laere KV. The effect of anaesthesia on [18F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain. Eur J Nucl Med Mol Imaging 2010;37:1164-73
87. Syvanen S, Lindhe O, Palner M, et al. Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport. Drug Metab Dispos 2009;37:635-43