PET neuroimaging of clomipramine challenge in humans: Focus on the thalamus

Brain Research

Volumn 892, Issue 1, 2001, Pages 193-197

  Frederick Smith, Donald ^a   Geday, Jacob ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Clomipramine; Fenfluramine substitute; Human brain; Limbic system; PET; Serotonin responsivity; Thalamus

Indexed keywords

CLOMIPRAMINE; FENFLURAMINE;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EMOTIONALITY; HUMAN; HYPOTHALAMUS NUCLEUS; LIMBIC SYSTEM; NERVE TRACT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

AGED; CLOMIPRAMINE; HUMANS; MEDIODORSAL THALAMIC NUCLEUS; MIDDLE AGED; OXYGEN RADIOISOTOPES; RADIOPHARMACEUTICALS; REFERENCE VALUES; REGIONAL BLOOD FLOW; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED; WATER;

EID: 0035895843     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03237-6     Document Type: Article

References (48)

1. The primate serotonergic system: A review of human and animal studies and a report of Macaca fascicularis
2. Rating scales for mood disorders: Applicability, consistency and construct validity
3. Mini-compendium of rating scales for states of anxiety, depression, mania, schizophrenia with corresponding DSM-III syndromes
4. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse
5. Serotonin release and metabolism in the frontal cortex: Effect of drugs, tryptophan and stress
6. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
7. 3H]paroxetine
8. Clomipramine dose-effect study in patients with depression: Clinical end points and pharmacokinetics
9. Serotonergic drugs in the treatment of depressive and anxiety disorders
10. Functional neuroimaging studies of depression: The anatomy of melancholia
11. Neuroanatomical circuits in depression: Implications for treatment mechanisms
12. 'Minimental state' - A practical method for grading the cognitive state of patients for the clinician
13. 123I]beta-CIT binding in the striatum with clomipramine: Is there a serotonin-dopamine interaction?
14. Brain activity during transient sadness and happiness in healthy women
15. Neuroendocrine effects of intravenous clomipramine in depressed patients and healthy subjects
16. The effects of intravenous clomipramine on neurohormones in normal subjects
17. Autoradiographic analysis of [3H]imipramine binding in the human brain postmortem: Effects of age and alcohol
18. Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus
19. Citalopram - Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
20. Cortical responses to sustained and divided attention in Alzheimer's disease
21. Modulation of cortical neuronal activation by a serotonergic agent: A PET study in humans
22. Neuroanatomical correlates of happiness, sadness, and disgust
23. Emotional memory systems in the brain
24. Hormone responses to fenfluramine and placebo challenge in endogenous depression
25. The serotonin/noradrenaline-link in brain. I. The role of noradrenaline and serotonin in the regulation of density and function of beta adrenoceptors and its alteration by desipramine
26. Positron emission tomographic imaging of serotonin activation effects on prefrontal cortex in healthy volunteers
27. 2O PET study in humans
28. 2O PET response to intravenous D-fenfluramine
29. A proposed mechanism of emotion
30. Statistical limitation in functional neuroimaging. I. Non-inferential methods and statistical models
31. Statistical limitation in functional neuroimaging. II. Signal detection and statistical inference
32. Networks related to the orbital and medial prefrontal cortex; A substrate for emotional behavior
33. Prolactin secretion in man: A useful tool to evaluate the activity of drugs on central 5-hydroxytryptaminergic neurons. Studies with fenfluramine
34. Serotonin neurons project to small blood vessels in the brain
35. Mapping brain activity associated with emotion
36. Neurobiology of an anorectic drug: Fenfluramine
37. 1D receptor subtype
38. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the thalamus of humans and 'higher' animals
39. Quantitative PET analysis of regional cerebral blood flow and glucose and oxygen metabolism in response to fenfluramine in living porcine brain
40. A fenfluramine-activated FDG-PET study of borderline personality disorder
41. Long-term clomipramine treatment upregulates forebrain acetylcholine muscarinic receptors, and reduces behavioural sensitivity to scopolamine in mice
42. Changes in regional cerebral blood flow following light treatment for seasonal affective disorders: Responders versus nonresponders
43. Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine
44. Brain asymmetry in the control of autonomic-physiologic activity
45. Rapid automated algorithm for aligning and reslicing PET images
46. A three-dimensional statistical analysis for CBF activation studies in human brain
47. A unified statistical approach for determining significant signals in images of cerebral activation