Animal tumor models for PET in drug development

Annals of Nuclear Medicine

Volumn 25, Issue 10, 2011, Pages 717-731

  Toyohara, Jun ^a   Ishiwata, Kiichi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Animal tumor models; Anticancer agent; Drug development; Positron emission tomography

Indexed keywords

3' FLUOROTHYMIDINE F 18; 5 ETHYL 2' FLUOROURACIL ARABINOSIDE; ALPHA INTERMEDIN DERIVATIVE; ANTIESTROGEN; ANTINEOPLASTIC AGENT; AVE 8026; CARBON 11; CE 355621; CISPLATIN; COPPER 64; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL DERIVATIVE; EXEMESTANE; FLUORODEOXYGLUCOSE F 18; FLUOROESTRADIOL F18; GALLIUM 68; IBRITUMOMAB TIUXETAN; LETROZOLE; LIFICIGUAT; METHOTREXATE; PROTEIN TYROSINE KINASE INHIBITOR; RALOXIFENE; TAMOXIFEN; TRACER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; ZEBULARINE;

ABLATION THERAPY; ADRENAL TUMOR; ANGIOGENESIS; BAGG ALBINO MOUSE; BERLIN DRUCKSEY IX RAT; BRAIN TUMOR; BREAST CANCER; BREAST TUMOR; C3H MOUSE; C57BL 6 MOUSE; CANCER CELL CULTURE; CANCER CONTROL; CANCER HORMONE THERAPY; CANCER TRANSPLANTATION; CASTRATION; CELL CYCLE; CELL DEATH; CELL KILLING; CHEMOSENSITIVITY; CHRONIC MYELOID LEUKEMIA; COLON ADENOCARCINOMA; COLON TUMOR; COPENHAGEN RAT; CYTOTOXICITY; DNA DAMAGE; DNA METHYLATION; DRUG MEGADOSE; DRUG METABOLISM; DRUG SCREENING; ESOPHAGUS TUMOR; EXPERIMENTAL RABBIT; FIBROSARCOMA; FISCHER 344 RAT; GENE EXPRESSION; GENE SILENCING; GLIOBLASTOMA; HEAD AND NECK CANCER; HUMAN; KIDNEY TUMOR; LARGE CELL LYMPHOMA; LUNG ALVEOLUS CELL CARCINOMA; LUNG TUMOR; LYMPHOMA; MELANOMA; MUTATION RATE; NONHUMAN; NONOBESE DIABETIC MOUSE; NUDE MOUSE; NUDE RAT; ONCOGENE; OVARY CANCER; OVARY TUMOR; PANCREAS TUMOR; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN EXPRESSION; REVIEW; SARCOMA; SCID MOUSE; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TRANSGENIC MOUSE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR MODEL; TUMOR VOLUME; TUMOR XENOGRAFT; UTERINE CERVIX TUMOR; WISTAR RAT;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; ENDOCRINE SYSTEM; HUMANS; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS;

EID: 83855160889     PISSN: 09147187     EISSN: 18646433     Source Type: Journal    
DOI: 10.1007/s12149-011-0531-x     Document Type: Review

References (107)

1. 3-integrin expression J Nucl Med 45 1776 1783 15471848 1:CAS:528:DC%2BD2cXpslCqsLY%3D (Pubitemid 47618490)
2. 18F-labeled PEGylated RGD peptide Eur J Nucl Med Mol Imaging 31 1081 1089 15118844 1:CAS:528:DC%2BD2cXmtFWks7k%3D (Pubitemid 39050174)
3. 3 integrin expression J Nucl Med 48 1162 1171 17574975 1:CAS:528:DC%2BD2sXhtVertL7F (Pubitemid 47052657)
4. 3 expression Bioconjug Chem 18 1987 1994 18030991 1:CAS:528:DC%2BD2sXhtlKlurjL (Pubitemid 350220000)
5. 3 expression Eur J Nucl Med Mol Imaging 35 1100 1108 18204838 1:CAS:528: DC%2BD1cXlvVClt70%3D
6. 3 integrin expression Eur J Nucl Med Mol Imaging 34 1823 1831 17492285 1:CAS:528:DC%2BD2sXhtFylu7%2FE (Pubitemid 47599045)
7. 18F]Galacto-RGD PLoS Med 2 e70 15783258
8. JL Eiseman C Brown-Proctor PE Kinahan JM Collins LW Anderson E Joseph, et al. 2004 Distribution of 1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase Clin Cancer Res 10 6669 6676 15475457 1:CAS:528:DC%2BD2cXot1Oiu7c%3D (Pubitemid 39346564)
9. S Froidevaux M Calame-Christe J Schuhmacher H Tanner R Saffrich M Henze, et al. 2004 A gallium-labeled DOTA-α-melanocyte- stimulating hormone analog for PET imaging of melanoma metastases J Nucl Med 45 116 123 14734683 1:CAS:528:DC%2BD2cXht1artbg%3D (Pubitemid 47611617)
10. JE Sprague WP Li K Liang S Achilefu CJ Anderson 2006 In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models Nucl Med Biol 33 227 237 16546677 1:CAS:528:DC%2BD28Xis1ehsbo%3D
11. H Wang W Cai K Chen ZB Li A Kashefi L He, et al. 2007 A new PET tracer specific for vascular endothelial growth factor receptor 2 Eur J Nucl Med Mol Imaging 34 2001 2010 17694307 1:CAS:528:DC%2BD2sXhtlyiurrP (Pubitemid 350212131)
12. 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems J Nucl Med 48 1327 1337 17631556 1:CAS:528:DC%2BD2sXhtVSktbzP (Pubitemid 47242799)
13. 124I-labeled small molecular tracer and positron emission tomography Mol Imaging Biol 8 262 277 16897320 1:STN:280:DC%2BD28rmtlSitA%3D%3D (Pubitemid 44446020)
14. 177Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab J Nucl Med 46 1898 1906 16269605 1:CAS:528: DC%2BD28XitVGltLY%3D (Pubitemid 46196653)
15. MK Robinson M Doss C Shaller D Narayanan JD Marks LP Adler, et al. 2005 Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody Cancer Res 65 1471 1478 15735035 1:CAS:528:DC%2BD2MXhsFKqtL0%3D (Pubitemid 40270176)
16. 18F-labeled T84.66 anti-carcinoembryonic antigen diabody J Nucl Med 48 304 310 17268029 1:CAS:528:DC%2BD2sXjsVKmsbk%3D (Pubitemid 47555358)
17. A Aliaga JA Rousseau R Ouellette J Cadorette JE van Lier R Lecomte, et al. 2004 Breast cancer models to study the expression of estrogen receptors with small animal PET imaging Nucl Med Biol 31 761 770 15246367 1:CAS:528: DC%2BD2cXlsFylt74%3D (Pubitemid 38887758)
18. A Aliaga JA Rousseau J Cadorette E Croteau JE van Lier R Lecomte, et al. 2007 A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-[F-18]fluoro-d- glucose in murine models of breast cancer Mol Imaging Biol 09 144 150 (Pubitemid 46705708)
19. JE Mortimer F Dehdashti BA Siegel K Trinkaus JA Katzenellenbogen MJ Welch 2001 Metabolic flare: indicator of hormone responsiveness in advanced breast cancer J Clin Oncol 19 2797 2803 11387350 1:CAS:528:DC%2BD3MXltVGgs7w%3D (Pubitemid 32538187)
20. L Ottobrini P Ciana R Moresco M Lecchi S Belloli C Martelli, et al. 2008 Development of a bicistronic vector for multimodality imaging of estrogen receptor activity in a breast cancer model: preliminary application Eur J Nucl Med Mol Imaging 35 365 378 17926035
21. N Oyama DE Ponde C Dence J Kim YC Tai MJ Welch 2004 Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation J Nucl Med 45 519 525 15001697 1:CAS:528:DC%2BD2cXivVCisr4%3D (Pubitemid 47618630)
22. 18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer J Nucl Med 48 46 55 17204698 1:CAS:528:DC%2BD2sXhvFKmsbw%3D (Pubitemid 47555375)
23. N Graf K Herrmann J den Hollander F Fend T Schuster HJ Wester, et al. 2008 Imaging proliferation to monitor early response of lymphoma to cytotoxic treatment Mol Imaging Biol 10 349 355 18704591
24. 3H-fluorothymidine using preclinical tumor models Clin Cancer Res 12 4590 4597 16899606 1:CAS:528:DC%2BD28XnvVGks74%3D (Pubitemid 44297809)
25. 18F]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo Cancer Res 65 4202 4210 15899811 1:CAS:528:DC%2BD2MXktlSmtrs%3D (Pubitemid 40775658)
26. 18F]FLT Eur J Nucl Med Mol Imaging 34 1775 1782 17541585 1:CAS:528:DC%2BD2sXhtFylu7zM (Pubitemid 47599048)
27. 18F-FDG small-animal PET J Nucl Med 49 129 134 18077531
28. S Assadian A Aliaga RF Del Maestro AC Evans BJ Bedell 2008 FDG-PET imaging for the evaluation of antiglioma agents in a rat model Neuro Oncol 10 292 299 18430796
29. M Herranz J Martin-Caballero MF Fraga J Ruiz-Cabello JM Flores M Desco, et al. 2006 The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma Blood 107 1174 1177 16239434 1:CAS:528:DC%2BD28Xht1OntLk%3D (Pubitemid 43156320)
30. JS Lee H Orita K Gabrielson S Alvey RL Hagemann FP Kuhajda, et al. 2007 FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer Pharm Res 24 1202 1207 17404812 1:CAS:528:DC%2BD2sXlsVGgu7c%3D (Pubitemid 46798899)
31. TJ Kim M Ravoori CN Landen AA Kamat LY Han C Lu, et al. 2007 Antitumor and antivascular effects of AVE8062 in ovarian carcinoma Cancer Res 67 9337 9345 17909042 1:CAS:528:DC%2BD2sXhtFSnur3F (Pubitemid 47535923)
32. C Cullinane DS Dorow M Kansara N Conus D Binns RJ Hicks, et al. 2005 An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development Cancer Res 65 9633 9636 16266981 1:CAS:528:DC%2BD2MXhtFKkt7nM (Pubitemid 41541437)
33. AR Hsu W Cai A Veeravagu KA Mohamedali K Chen S Kim, et al. 2007 Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel J Nucl Med 48 445 454 17332623 1:CAS:528:DC%2BD2sXhtVertLzF (Pubitemid 47604931)
34. 18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition Cancer Res 67 11463 11469 18056475 1:CAS:528: DC%2BD2sXhtlyiu7vK (Pubitemid 350248575)
35. 18F]fluorothymidine positron emission tomography Cancer Res 66 7621 7629 16885362 1:CAS:528: DC%2BD28XnsFyru74%3D (Pubitemid 44289219)
36. DC Drummond CO Noble DB Kirpotin Z Guo GK Scott CC Benz 2005 Clinical development of histone deacetylase inhibitors as anticancer agents Annu Rev Pharmacol Toxicol 45 495 528 15822187 1:CAS:528:DC%2BD2MXisVWjtLs%3D (Pubitemid 40261815)
37. DS Dorow C Cullinane N Conus P Roselt D Binns TJ McCarthy, et al. 2006 Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033 Eur J Nucl Med Mol Imaging 33 441 452 16450138
38. G Niu W Cai K Chen X Chen 2008 Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor Mol Imaging Biol 10 99 106 18157579
39. 18F]FDG in the liver metastasis rat model Ann Nucl Med 20 463 469 17037278 1:CAS:528: DC%2BD28Xht1entbrE (Pubitemid 44543864)
40. 18F] FDG J Hepatobiliary Pancreat Surg 14 276 282 17520203 (Pubitemid 46863917)
41. 18F-FDG imaging of lung metastasis tumors using small animal PET Nucl Med Biol 35 143 150 18158953 1:CAS:528:DC%2BD2sXhsVOlt7zP (Pubitemid 350298253)
42. C Franzius M Hotfilder C Poremba S Hermann K Schäfers HE Gabbert, et al. 2006 Successful high-resolution animal positron emission tomography of human Ewing tumours and their metastases in a murine xenograft model Eur J Nucl Med Mol Imaging 33 1432 1441 16896672 (Pubitemid 44885409)
43. 18F-fluoride PET/CT J Nucl Med 49 414 421 18287261 (Pubitemid 351355207)
44. Q Cao W Cai G Niu L He X Chen 2008 Multimodality imaging of IL-18-binding protein-Fc therapy of experimental lung metastasis Clin Cancer Res 14 6137 6145 18829492 1:CAS:528:DC%2BD1cXhtF2nurvJ
45. MC van Kouwen P Laverman JH van Krieken WJ Oyen JB Jansen JP Drenth 2005 FDG-PET in the detection of early pancreatic cancer in a BOP hamster model Nucl Med Biol 32 445 450 15982574 (Pubitemid 40854095)
46. 18F]FDG-PET in the azoxymethane model Nucl Med Biol 33 245 248 16546679
47. Y Li C Woodall JM Wo H Zheng CK Ng MB Ray, et al. 2008 The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma Cancer Invest 26 278 285 18317969 1:CAS:528:DC%2BD1cXislalsro%3D (Pubitemid 351329005)
48. CN Yeh KJ Lin IT Hsiao TC Yen TW Chen YY Jan, et al. 2008 Animal PET for thioacetamide-induced rat cholangiocarcinoma: a novel and reliable platform Mol Imaging Biol 10 209 216 18491193
49. 18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas J Nucl Med 49 422 429 18287265 (Pubitemid 351355208)
50. SH Choi WK Moon JH Hong KR Son N Cho BJ Kwon, et al. 2007 Lymph node metastasis: ultrasmall superparamagnetic iron oxide-enhanced MR imaging versus PET/CT in a rabbit model Radiology 242 137 143 17090719 (Pubitemid 44956018)
51. HS Park JW Chung HJ Jae YI Kim KR Son MJ Lee, et al. 2007 FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model Korean J Radiol 8 216 224 17554189
52. 18F-FDG uptake within minutes after chemotherapy in a rabbit VX2 tumor model J Nucl Med 49 303 309 18199614 (Pubitemid 351225670)
53. EE Stewart X Chen J Hadway TY Lee 2006 Correlation between hepatic tumor blood flow and glucose utilization in a rabbit liver tumor model Radiology 239 740 750 16621929 (Pubitemid 43830609)
54. 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy J Nucl Med 46 2068 2075 16330572 1:CAS:528:DC%2BD28XivVSrug%3D%3D (Pubitemid 46657455)
55. 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis Nucl Med Biol 31 179 189 15013483 1:CAS:528: DC%2BD2cXhvVyht7g%3D (Pubitemid 38315112)
56. X Chen R Park V Khankaldyyan I Gonzales-Gomez M Tohme RA Moats, et al. 2006 Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide Mol Imaging Biol 8 9 15 16315003 1:CAS:528:DC%2BD2sXntlyisr8%3D (Pubitemid 44193397)
57. 131I]iodo-l-phenylalanine for nuclear medicine applications in malignant gliomas Appl Radiat Isot 66 513 522 18024046 1:CAS:528: DC%2BD1cXisl2ju74%3D (Pubitemid 351288532)
58. 18F-FDS and its potential application in molecular imaging Mol Imaging Biol 10 92 98 18097725
59. M Tian H Zhang T Higuchi N Oriuchi T Inoue K Endo 2004 Effect of mitomycin C and vinblastine on FDG uptake of human nonsmall-cell lung cancer xenografts in nude mice Cancer Biother Radiopharm 19 601 605 15650452 1:CAS:528:DC%2BD2cXpvFWrsrc%3D (Pubitemid 39546299)
60. A Bao WT Phillips B Goins HS McGuff X Zheng FR Woolley, et al. 2006 Setup and characterization of a human head and neck squamous cell carcinoma xenograft model in nude rats Otolaryngol Head Neck Surg 135 853 857 17141073 (Pubitemid 44820627)
61. 18F-fluoro-l-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo J Nucl Med 48 2063 2071 18056335 1:CAS:528: DC%2BD1cXnvFSlsg%3D%3D (Pubitemid 350232318)
62. 18F]fluoro-3′-deoxythymidine (FLT) Mol Imaging Biol 9 340 347 17643202
63. 2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models Int J Radiat Oncol Biol Phys 61 1493 1502 15817355 (Pubitemid 40470433)
64. C Schütze R Bergmann A Yaromina F Hessel J Kotzerke J Steinbach, et al. 2007 Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice Radiother Oncol 83 311 315 17502117 (Pubitemid 46915542)
65. Q Cao ZB Li K Chen Z Wu L He N Neamati, et al. 2008 Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer Eur J Nucl Med Mol Imaging 35 1489 1498 18373091 1:CAS:528:DC%2BD1cXovFyqtbo%3D
66. X Fei QH Zheng JQ Wang KL Stone TD Martinez KD Miller, et al. 2004 Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues Bioorg Med Chem Lett 14 1247 1251 14980675 1:CAS:528:DC%2BD2cXhsFemu78%3D (Pubitemid 38229866)
67. 18F-FDG-microPET or external caliper BMC Med Imaging 8 16 18925932
68. J Lee GI Jallo M Guarnieri BS Carson Sr MB Penno 2005 A novel brainstem tumor model: guide screw technology with functional, radiological, and histopathological characterization Neurosurg Focus 18 E11 16048287
69. C Nanni K Di Leo R Tonelli C Pettinato D Rubello A Spinelli, et al. 2007 FDG small animal PET permits early detection of malignant cells in a xenograft murine model Eur J Nucl Med Mol Imaging 34 755 762 17160412 (Pubitemid 46669360)
70. 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer J Nucl Med 49 1362 1370
71. JE Flores LM McFarland A Vanderbilt AK Ogasawara SP Williams 2008 The effects of anesthetic agent and carrier gas on blood glucose and tissue uptake in mice undergoing dynamic FDG-PET imaging: sevoflurane and isoflurane compared in air and in oxygen Mol Imaging Biol 10 192 200 18516648
72. F He X Deng B Wen Y Liu X Sun L Xing, et al. 2008 Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers Cancer Res 68 8597 8606 18922936 1:CAS:528:DC%2BD1cXht1CmsbjP
73. PJ Kok JE van Eerd OC Boerman FH Corstens WJ Oyen 2005 Biodistribution and imaging of FDG in rats with LS174T carcinoma xenografts and focal Escherichia coli infection Cancer Biother Radiopharm 20 310 315 15989476 1:CAS:528:DC%2BD2MXls1Kgs74%3D (Pubitemid 41003835)
74. J Leyton G Smith M Lees M Perumal QD Nguyen FI Aigbirhio, et al. 2008 Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901 Mol Cancer Ther 7 3112 3121 18790789 1:CAS:528:DC%2BD1cXhtFSmsL%2FE
75. 11C-labeled cyclooxygenase-2 (COX-2) inhibitor Bioorg Med Chem 16 7662 7670 18650097 1:CAS:528:DC%2BD1cXhtVSisr3O
76. 89Zr- labeled cG250 monoclonal antibody in nude rats Cancer Biother Radiopharm 19 155 163 15186595 1:CAS:528:DC%2BD2cXktVyjt7o%3D (Pubitemid 38685113)
77. 18F-labeled protein scaffold molecules J Nucl Med 49 804 813 18413392 1:CAS:528:DC%2BD1cXmvVSju7o%3D (Pubitemid 351717547)
78. 18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice J Nucl Med 45 1754 1758 15471845 1:CAS:528:DC%2BD2cXpslCqsLw%3D (Pubitemid 47618487)
79. 11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice Mol Imaging Biol 10 217 223 18454299
80. 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma Nucl Med Biol 33 371 380 16631086 1:CAS:528:DC%2BD28Xjs1GktrY%3D
81. 18F]FAZA-first small animal PET results J Pharm Pharm Sci 10 203 211 17706178 1:CAS:528:DC%2BD2sXptlKrsb0%3D
82. A Hajitou DC Lev JA Hannay B Korchin FI Staquicini S Soghomonyan, et al. 2008 A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging Proc Natl Acad Sci USA 105 4471 4476 18337507 1:CAS:528:DC%2BD1cXkt1eiu7w%3D (Pubitemid 351754404)
83. 18F]Fluoromisonidazole positron emission tomography Int J Oncol 30 873 881 17332926 1:CAS:528:DC%2BD2sXkt1Wht7c%3D
84. 18F-EF5 and positron emission tomography BJU Int 99 1154 1160 17309552
85. MH Pan SC Huang YP Liao D Schaue CC Wang DB Stout, et al. 2008 FLT-PET imaging of radiation responses in murine tumors Mol Imaging Biol 10 325 334 18670825 1:STN:280:DC%2BD1cnkt1Wruw%3D%3D
86. 18F-fluorothymidine for quantitative cell proliferation imaging in subcutaneous tumor models in mice J Nucl Med 49 2057 2066 18997037
87. K Dobrenkov M Olszewska Y Likar L Shenker G Gunset S Cai, et al. 2008 Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging J Nucl Med 49 1162 1170 18552144 (Pubitemid 351948026)
88. 11), a cyclized peptide analogue of α-MSH J Med Chem 48 2985 2992 15828837 1:CAS:528:DC%2BD2MXitVShs7c%3D (Pubitemid 40548110)
89. C Chaise E Itti Y Petegnief E Wirquin C Copie-Bergman JP Farcet, et al. 2007 [F-18]-Fluoro-2-deoxy-d-glucose positron emission tomography as a tool for early detection of immunotherapy response in a murine B cell lymphoma model Cancer Immunol Immunother 56 1163 1171 17171356 (Pubitemid 46763931)
90. 18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model Eur J Nucl Med Mol Imaging 34 1348 1354 17334763 1:CAS:528:DC%2BD2sXpsVarurs%3D (Pubitemid 47312583)
91. 18F]FBPA-F in rats with F98 glioma Appl Radiat Isot 61 887 891 15308163 1:CAS:528:DC%2BD2cXms1yhtro%3D (Pubitemid 39092635)
92. 18F-fluoro-l-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain barrier disruption J Nucl Med 46 1858 1865 16269600 1:CAS:528:DC%2BD28XitVGltLo%3D
93. 18F-fluoro-l-phenylalanine-fructose as a probe for boron neutron capture therapy in a glioma-bearing rat model J Nucl Med 45 302 308 14960653 1:CAS:528:DC%2BD2cXitVCrtb8%3D
94. 18F]FDG as PET probes in a brain tumor-bearing animal model Nucl Med Biol 32 367 375 15878506 1:CAS:528:DC%2BD2MXjvVKksr4%3D
95. 18F]FHPG membrane transport Br J Cancer 91 2079 2085 15599382 1:CAS:528:DC%2BD2cXhtVOjsLbI (Pubitemid 40128775)
96. 18F-FDG for differentiating tumor from inflammation in a rodent model J Nucl Med 45 695 700 15073267 (Pubitemid 47618601)
97. A van Waarde PL Jager K Ishiwata RA Dierckx PH Elsinga 2006 Comparison of sigma-ligands and metabolic PET tracers for differentiating tumor from inflammation J Nucl Med 47 150 154 16391199 (Pubitemid 46768524)
98. 64Cu-ATSM in a rodent model of cancer Nucl Med Biol 35 713 720 18678357 1:CAS:528:DC%2BD1cXpsVCrtLk%3D
99. H Miletic YH Fischer T Giroglou MA Rueger A Winkeler H Li, et al. 2007 Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma Clin Cancer Res 13 6761 6768 18006778 1:CAS:528: DC%2BD2sXhtlSmu7fO (Pubitemid 350206814)
100. P Kunz J Hoffend A Altmann A Dimitrakopoulou-Strauss D Koczan M Eisenhut, et al. 2006 Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angiogenesis-promoting genes J Nucl Med 47 1515 1524 16954561 1:CAS:528:DC%2BD28XhtVCmtLfO (Pubitemid 47544940)
101. 18F-fluoromethylcholine and 2-deoxy-d-glucose in the distribution of tumor and inflammation Ann Nucl Med 20 527 533 17134019 1:CAS:528:DC%2BD2sXkvFOrug%3D%3D (Pubitemid 44818582)
102. S Zhao Y Kuge M Kohanawa T Takahashi H Kawashima T Temma, et al. 2007 Extensive FDG uptake and its modification with corticosteroid in a granuloma rat model: an experimental study for differentiating granuloma from tumors Eur J Nucl Med Mol Imaging 34 2096 2105 17763849 1:CAS:528:DC%2BD2sXhtlyiur3O (Pubitemid 350212134)
103. 18F]fluoromisonidazole PET and immunohistochemistry Br J Cancer 91 1947 1954 15520822 1:STN:280:DC%2BD2croslyitQ%3D%3D (Pubitemid 40065524)
104. A Dutour J Monteil F Paraf JL Charissoux C Kaletta B Sauer, et al. 2005 Endostatin cDNA/cationic liposome complexes as a promising therapy to prevent lung metastases in osteosarcoma: study in a human-like rat orthotopic tumor Mol Ther 11 311 319 15668143 1:CAS:528:DC%2BD2MXms1Gksg%3D%3D
105. 64Cu- bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging J Nucl Med 49 1862 1868 18927340 1:CAS:528:DC%2BD1cXhsVOhtLbE
106. DM Raffel YW Jung DL Gildersleeve PS Sherman JJ Moskwa LJ Tluczek, et al. 2007 Radiolabeled phenethylguanidines: novel imaging agents for cardiac sympathetic neurons and adrenergic tumors J Med Chem 50 2078 2088 17419605 1:CAS:528:DC%2BD2sXjvFCht74%3D (Pubitemid 46683061)
107. Y Hamazawa K Koyama T Okamura Y Wada T Wakasa T Okuma, et al. 2007 Comparison of dynamic FDG-microPET study in a rabbit turpentine-induced inflammatory model and in a rabbit VX2 tumor model Ann Nucl Med 21 47 55 17373336 (Pubitemid 46280149)