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Volumn 5, Issue 5, 2013, Pages 1231-1249

Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins

Author keywords

Biomarker; Cervical cancer; Histone methylation; Tumor suppressor

Indexed keywords

BMI1 PROTEIN; HISTONE H3; HOMEODOMAIN PROTEIN; KDM6A PROTEIN; KDM6B PROTEIN; LYSINE; POLYCOMB GROUP PROTEIN; PROTEIN E7; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR HOXA10; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84877913853     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v5051231     Document Type: Review
Times cited : (27)

References (93)
  • 1
    • 77950938389 scopus 로고    scopus 로고
    • Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    • Bernard, H.U.; Burk, R.D.; Chen, Z.; van Doorslaer, K.; Hausen, H.; de Villiers, E.M. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 2010, 401, 70-79.
    • (2010) Virology , vol.401 , pp. 70-79
    • Bernard, H.U.1    Burk, R.D.2    Chen, Z.3    van Doorslaer, K.4    Hausen, H.5    de Villiers, E.M.6
  • 2
    • 77954955259 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins: Pathways to transformation
    • Moody, C.A.; Laimins, L.A. Human papillomavirus oncoproteins: Pathways to transformation. Nat. Rev. Cancer 2010, 10, 550-560.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 550-560
    • Moody, C.A.1    Laimins, L.A.2
  • 4
    • 84873606312 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2009, Featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels
    • Jemal, A.; Simard, E.P.; Dorell, C.; Noone, A.M.; Markowitz, L.E.; Kohler, B.; Eheman, C.; Saraiya, M.; Bandi, P.; Saslow, D. et al. Annual report to the nation on the status of cancer, 1975-2009, Featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J. Nat. Cancer Inst. 2013, 105, 175-201.
    • (2013) J. Nat. Cancer Inst , vol.105 , pp. 175-201
    • Jemal, A.1    Simard, E.P.2    Dorell, C.3    Noone, A.M.4    Markowitz, L.E.5    Kohler, B.6    Eheman, C.7    Saraiya, M.8    Bandi, P.9    Saslow, D.10
  • 5
    • 84877074785 scopus 로고    scopus 로고
    • Implementation of human papillomavirus immunization in the developing world
    • Kane, M.A.; Serrano, B.; de Sanjose, S.; Wittet, S. Implementation of human papillomavirus immunization in the developing world. Vaccine 2012, 30 (Suppl. 5), F192-F200.
    • (2012) Vaccine , vol.30 , Issue.SUPPL. 5
    • Kane, M.A.1    Serrano, B.2    de Sanjose, S.3    Wittet, S.4
  • 6
    • 0345827680 scopus 로고    scopus 로고
    • Prevention of cervical cancer through papillomavirus vaccination
    • Frazer, I.H. Prevention of cervical cancer through papillomavirus vaccination. Nat. Rev. Immunol. 2004, 4, 46-54.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 46-54
    • Frazer, I.H.1
  • 7
    • 33645211201 scopus 로고    scopus 로고
    • Human papillomaviruses: Basic mechanisms of pathogenesis and oncogenicity
    • Hebner, C.M.; Laimins, L.A. Human papillomaviruses: Basic mechanisms of pathogenesis and oncogenicity. Rev. Med. Virol. 2006, 16, 83-97.
    • (2006) Rev. Med. Virol , vol.16 , pp. 83-97
    • Hebner, C.M.1    Laimins, L.A.2
  • 8
    • 78650748371 scopus 로고    scopus 로고
    • Persistence of human papillomavirus infection: Keys to malignant progression
    • Bodily, J.; Laimins, L.A. Persistence of human papillomavirus infection: Keys to malignant progression. Trends Microbiol. 2011, 19, 33-39.
    • (2011) Trends Microbiol , vol.19 , pp. 33-39
    • Bodily, J.1    Laimins, L.A.2
  • 9
    • 0023144684 scopus 로고
    • Structural and translational analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker, C.C.; Phelps, W.C.; Lindgren, V.; Braun, M.J.; Gonda, M.A.; Howley, P.M. Structural and translational analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol. 1987, 61, 962-971.
    • (1987) J. Virol , vol.61 , pp. 962-971
    • Baker, C.C.1    Phelps, W.C.2    Lindgren, V.3    Braun, M.J.4    Gonda, M.A.5    Howley, P.M.6
  • 10
    • 0021986880 scopus 로고
    • Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
    • Schwarz, E.; Freese, U.K.; Gissmann, L.; Mayer, W.; Roggenbuck, B.; Stremlau, A.; Zur Hausen, H. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985, 314, 111-114.
    • (1985) Nature , vol.314 , pp. 111-114
    • Schwarz, E.1    Freese, U.K.2    Gissmann, L.3    Mayer, W.4    Roggenbuck, B.5    Stremlau, A.6    Zur, H.H.7
  • 11
    • 68949194550 scopus 로고    scopus 로고
    • Oncogenic activities of human papillomaviruses
    • McLaughlin-Drubin, M.E.; Munger, K. Oncogenic activities of human papillomaviruses. Virus Res. 2009, 143, 195-208.
    • (2009) Virus Res , vol.143 , pp. 195-208
    • McLaughlin-Drubin, M.E.1    Munger, K.2
  • 12
    • 0042440926 scopus 로고    scopus 로고
    • Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis
    • Riley, R.R.; Duensing, S.; Brake, T.; Munger, K.; Lambert, P.F.; Arbeit, J.M. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res. 2003, 63, 4862-4871.
    • (2003) Cancer Res , vol.63 , pp. 4862-4871
    • Riley, R.R.1    Duensing, S.2    Brake, T.3    Munger, K.4    Lambert, P.F.5    Arbeit, J.M.6
  • 13
    • 0342948594 scopus 로고    scopus 로고
    • Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells
    • Francis, D.A.; Schmid, S.I.; Howley, P.M. Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J. Virol. 2000, 74, 2679-2686.
    • (2000) J. Virol , vol.74 , pp. 2679-2686
    • Francis, D.A.1    Schmid, S.I.2    Howley, P.M.3
  • 14
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin, E.C.; DiMaio, D. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. USA 2000, 97, 12513-81251.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12513-81251
    • Goodwin, E.C.1    Dimaio, D.2
  • 15
    • 0023441712 scopus 로고
    • The BPV-1 E2 trans-acting protein can be either an activator or repressor of the HPV-18 regulatory region
    • Thierry, F.; Yaniv, M. The BPV-1 E2 trans-acting protein can be either an activator or repressor of the HPV-18 regulatory region. EMBO 1987, 6, 3391-3397.
    • (1987) EMBO , vol.6 , pp. 3391-3397
    • Thierry, F.1    Yaniv, M.2
  • 16
    • 70350500219 scopus 로고    scopus 로고
    • Polycomb group proteins: Navigators of lineage pathways led astray in cancer
    • Bracken, A.P.; Helin, K. Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nat. Rev. Cancer 2009, 9, 773-784.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 773-784
    • Bracken, A.P.1    Helin, K.2
  • 17
    • 79955972412 scopus 로고    scopus 로고
    • L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure
    • Trojer, P.; Cao, A.R.; Gao, Z.; Li, Y.; Zhang, J.; Xu, X.; Li, G.; Losson, R.; Erdjument-Bromage, H.; Tempst, P. et al. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol. Cell 2011, 42, 438-450.
    • (2011) Mol. Cell , vol.42 , pp. 438-450
    • Trojer, P.1    Cao, A.R.2    Gao, Z.3    Li, Y.4    Zhang, J.5    Xu, X.6    Li, G.7    Losson, R.8    Erdjument-Bromage, H.9    Tempst, P.10
  • 19
    • 84862894023 scopus 로고    scopus 로고
    • Epigenetic regulation of skin: Focus on the Polycomb complex
    • Zhang, J.; Bardot, E.; Ezhkova, E. Epigenetic regulation of skin: Focus on the Polycomb complex. Cell Mol. Life Sci. 2012, 69, 2161-2172.
    • (2012) Cell Mol. Life Sci , vol.69 , pp. 2161-2172
    • Zhang, J.1    Bardot, E.2    Ezhkova, E.3
  • 21
    • 68249128477 scopus 로고    scopus 로고
    • Epigenetic reprogramming during wound healing: Loss of polycomb-mediated silencing may enable upregulation of repair genes
    • Shaw, T.; Martin, P. Epigenetic reprogramming during wound healing: Loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep. 2009, 10, 881-886.
    • (2009) EMBO Rep , vol.10 , pp. 881-886
    • Shaw, T.1    Martin, P.2
  • 22
    • 83255191898 scopus 로고    scopus 로고
    • The role of Hox proteins in leukemogenesis: Insights into key regulatory events in hematopoiesis
    • Eklund, E. The role of Hox proteins in leukemogenesis: Insights into key regulatory events in hematopoiesis. Crit. Rev. Oncog. 2011, 16, 65-76.
    • (2011) Crit. Rev. Oncog , vol.16 , pp. 65-76
    • Eklund, E.1
  • 27
    • 0033590974 scopus 로고    scopus 로고
    • HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes
    • Alami, Y.; Castronovo, V.; Belotti, D.; Flagiello, D.; Clausse, N. HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Biochem. Biophys. Res. Commun. 1999, 257, 738-745.
    • (1999) Biochem. Biophys. Res. Commun , vol.257 , pp. 738-745
    • Alami, Y.1    Castronovo, V.2    Belotti, D.3    Flagiello, D.4    Clausse, N.5
  • 29
    • 35948969388 scopus 로고    scopus 로고
    • Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion
    • Zhai, Y.; Kuick, R.; Nan, B.; Ota, I.; Weiss, S.J.; Trimble, C.L.; Fearon, E.R.; Cho, K.R. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res. 2007, 67, 10163-10172.
    • (2007) Cancer Res , vol.67 , pp. 10163-10172
    • Zhai, Y.1    Kuick, R.2    Nan, B.3    Ota, I.4    Weiss, S.J.5    Trimble, C.L.6    Fearon, E.R.7    Cho, K.R.8
  • 30
    • 84870725909 scopus 로고    scopus 로고
    • Proteomic approaches to the study of papillomavirus-host interactions
    • White, E.A.; Howley, P.M. Proteomic approaches to the study of papillomavirus-host interactions. Virology 2013, 435, 57-69.
    • (2013) Virology , vol.435 , pp. 57-69
    • White, E.A.1    Howley, P.M.2
  • 31
    • 23844456912 scopus 로고    scopus 로고
    • Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
    • Huh, K.W.; DeMasi, J.; Ogawa, H.; Nakatani, Y.; Howley, P.M.; Munger, K. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc. Natl. Acad. Sci. USA 2005, 102, 11492-11497.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11492-11497
    • Huh, K.W.1    Demasi, J.2    Ogawa, H.3    Nakatani, Y.4    Howley, P.M.5    Munger, K.6
  • 32
    • 50149100141 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 oncoprotein associates with E2F6
    • McLaughlin-Drubin, M.E.; Huh, K.W.; Munger, K. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J. Virol. 2008, 82, 8695-8705.
    • (2008) J. Virol , vol.82 , pp. 8695-8705
    • McLaughlin-Drubin, M.E.1    Huh, K.W.2    Munger, K.3
  • 33
    • 0032490832 scopus 로고    scopus 로고
    • E2F-6: A novel member of the E2F family is an inhibitor of E2F-dependent transcription
    • Cartwright, P.; Muller, H.; Wagener, C.; Holm, K.; Helin, K. E2F-6: A novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 1998, 17, 611-623.
    • (1998) Oncogene , vol.17 , pp. 611-623
    • Cartwright, P.1    Muller, H.2    Wagener, C.3    Holm, K.4    Helin, K.5
  • 34
    • 0032482981 scopus 로고    scopus 로고
    • Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
    • Gaubatz, S.; Wood, J.G.; Livingston, D.M. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. USA 1998, 95, 9190-9195.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9190-9195
    • Gaubatz, S.1    Wood, J.G.2    Livingston, D.M.3
  • 35
    • 0035852632 scopus 로고    scopus 로고
    • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
    • Trimarchi, J.M.; Fairchild, B.; Wen, J.; Lees, J.A. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. USA 2001, 98, 1519-1524.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1519-1524
    • Trimarchi, J.M.1    Fairchild, B.2    Wen, J.3    Lees, J.A.4
  • 36
    • 0037052539 scopus 로고    scopus 로고
    • A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells
    • Ogawa, H.; Ishiguro, K.; Gaubatz, S.; Livingston, D.M.; Nakatani, Y. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 2002, 296, 1132-1136.
    • (2002) Science , vol.296 , pp. 1132-1136
    • Ogawa, H.1    Ishiguro, K.2    Gaubatz, S.3    Livingston, D.M.4    Nakatani, Y.5
  • 39
    • 79952140358 scopus 로고    scopus 로고
    • Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming
    • McLaughlin-Drubin, M.E.; Crum, C.P.; Munger, K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc. Natl. Acad. Sci. USA 2011, 108, 2130-2135.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2130-2135
    • McLaughlin-Drubin, M.E.1    Crum, C.P.2    Munger, K.3
  • 40
    • 80055108218 scopus 로고    scopus 로고
    • Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes
    • Hyland, P.L.; McDade, S.S.; McCloskey, R.; Dickson, G.J.; Arthur, K.; McCance, D.J.; Patel, D. Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. J. Virol. 2011, 85, 10999-11006.
    • (2011) J. Virol , vol.85 , pp. 10999-11006
    • Hyland, P.L.1    McDade, S.S.2    McCloskey, R.3    Dickson, G.J.4    Arthur, K.5    McCance, D.J.6    Patel, D.7
  • 41
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, Essential for proliferation and amplified in cancer
    • Bracken, A.P.; Pasini, D.; Capra, M.; Prosperini, E.; Colli, E.; Helin, K. EZH2 is downstream of the pRB-E2F pathway, Essential for proliferation and amplified in cancer. EMBO J. 2003, 22, 5323-5335.
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 43
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase, A.; Cross, N.C. Aberrations of EZH2 in cancer. Clin. Cancer Res. 2011, 17, 2613-2618.
    • (2011) Clin. Cancer Res , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 45
    • 26844520965 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    • Cha, T.L.; Zhou, B.P.; Xia, W.; Wu, Y.; Yang, C.C.; Chen, C.T.; Ping, B.; Otte, A.P.; Hung, M.C. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 2005, 310, 306-310.
    • (2005) Science , vol.310 , pp. 306-310
    • Cha, T.L.1    Zhou, B.P.2    Xia, W.3    Wu, Y.4    Yang, C.C.5    Chen, C.T.6    Ping, B.7    Otte, A.P.8    Hung, M.C.9
  • 46
    • 33745241083 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein
    • Menges, C.W.; Baglia, L.A.; Lapoint, R.; McCance, D.J. Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein. Cancer Res. 2006, 66, 5555-5559.
    • (2006) Cancer Res , vol.66 , pp. 5555-5559
    • Menges, C.W.1    Baglia, L.A.2    Lapoint, R.3    McCance, D.J.4
  • 47
    • 77956024826 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis
    • Spangle, J.M.; Munger, K. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J. Virol. 2010, 84, 9398-9407.
    • (2010) J. Virol , vol.84 , pp. 9398-9407
    • Spangle, J.M.1    Munger, K.2
  • 48
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu, K.; Wu, Z.J.; Groner, A.C.; He, H.H.; Cai, C.; Lis, R.T.; Wu, X.; Stack, E.C.; Loda, M.; Liu, T. et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012, 338, 1465-1469.
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4    Cai, C.5    Lis, R.T.6    Wu, X.7    Stack, E.C.8    Loda, M.9    Liu, T.10
  • 51
    • 79959829390 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of Bmi-1 expression in human cervical cancer
    • Min, L.; Dong-Xiang, S.; Xiao-Tong, G.; Ting, G.; Xiao-Dong, C. Clinicopathological and prognostic significance of Bmi-1 expression in human cervical cancer. Acta Obstet. Gynecol. Scand. 2011, 90, 737-745.
    • (2011) Acta Obstet. Gynecol. Scand , vol.90 , pp. 737-745
    • Min, L.1    Dong-Xiang, S.2    Xiao-Tong, G.3    Ting, G.4    Xiao-Dong, C.5
  • 53
    • 84860222900 scopus 로고    scopus 로고
    • Detection of circulating Bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer
    • Zhang, X.; Wang, C.; Wang, L.; Du, L.; Wang, S.; Zheng, G.; Li, W.; Zhuang, X.; Dong, Z. Detection of circulating Bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer. Int. J. Cancer 2012, 131, 165-172.
    • (2012) Int. J. Cancer , vol.131 , pp. 165-172
    • Zhang, X.1    Wang, C.2    Wang, L.3    Du, L.4    Wang, S.5    Zheng, G.6    Li, W.7    Zhuang, X.8    Dong, Z.9
  • 54
    • 81455140663 scopus 로고    scopus 로고
    • BMI-1 autoantibody as a new potential biomarker for cervical carcinoma
    • Tong, Y.Q.; Liu, B.; Zheng, H.Y.; He, Y.J.; Gu, J.; Li, F.; Li, Y. BMI-1 autoantibody as a new potential biomarker for cervical carcinoma. PLoS One 2011, 6, e27804.
    • (2011) PLoS One , vol.6
    • Tong, Y.Q.1    Liu, B.2    Zheng, H.Y.3    He, Y.J.4    Gu, J.5    Li, F.6    Li, Y.7
  • 55
    • 84876817779 scopus 로고    scopus 로고
    • HPV16 E7 Protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes
    • Miller, J.; Dakic, A.; Chen, R.; Palechor-Ceron, N.; Dai, Y.; Kallakury, B.; Schlegel, R.; Liu, X. HPV16 E7 Protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog. 2013, 9, e1003284.
    • (2013) PLoS Pathog , vol.9
    • Miller, J.1    Dakic, A.2    Chen, R.3    Palechor-Ceron, N.4    Dai, Y.5    Kallakury, B.6    Schlegel, R.7    Liu, X.8
  • 56
    • 84655170252 scopus 로고    scopus 로고
    • Knockdown of BMI-1 causes cell-cycle arrest and derepresses p16INK4a, HOXA9 and HOXC13 mRNA expression in HeLa cells
    • Chen, F.; Li, Y.; Wang, L.; Hu, L. Knockdown of BMI-1 causes cell-cycle arrest and derepresses p16INK4a, HOXA9 and HOXC13 mRNA expression in HeLa cells. Med. Oncol. 2011, 28, 1201-1209.
    • (2011) Med. Oncol , vol.28 , pp. 1201-1209
    • Chen, F.1    Li, Y.2    Wang, L.3    Hu, L.4
  • 58
    • 84866912634 scopus 로고    scopus 로고
    • UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
    • Shpargel, K.B.; Sengoku, T.; Yokoyama, S.; Magnuson, T. UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet. 2012, 8, e1002964.
    • (2012) PLoS Genet , vol.8
    • Shpargel, K.B.1    Sengoku, T.2    Yokoyama, S.3    Magnuson, T.4
  • 59
    • 84855957128 scopus 로고    scopus 로고
    • UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    • Lee, S.; Lee, J.W.; Lee, S.K. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev. Cell 2012, 22, 25-37.
    • (2012) Dev. Cell , vol.22 , pp. 25-37
    • Lee, S.1    Lee, J.W.2    Lee, S.K.3
  • 61
    • 84866530722 scopus 로고    scopus 로고
    • Regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
    • Wang, C.; Lee, J.E.; Cho, Y.W.; Xiao, Y.; Jin, Q.; Liu, C.; Ge, K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc. Natl. Acad. Sci. USA 2012, 109, 15324-15329.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 15324-15329
    • Wang, C.1    Lee, J.E.2    Cho, Y.W.3    Xiao, Y.4    Jin, Q.5    Liu, C.6    Ge, K.U.T.X.7
  • 63
    • 34548644772 scopus 로고    scopus 로고
    • The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    • De Santa, F.; Totaro, M.G.; Prosperini, E.; Notarbartolo, S.; Testa, G.; Natoli, G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007, 130, 1083-1094.
    • (2007) Cell , vol.130 , pp. 1083-1094
    • de Santa, F.1    Totaro, M.G.2    Prosperini, E.3    Notarbartolo, S.4    Testa, G.5    Natoli, G.6
  • 69
    • 47549105128 scopus 로고    scopus 로고
    • Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
    • Sen, G.L.; Webster, D.E.; Barragan, D.I.; Chang, H.Y.; Khavari, P.A. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Gene. Develop. 2008, 22, 1865-1870.
    • (2008) Gene. Develop , vol.22 , pp. 1865-1870
    • Sen, G.L.1    Webster, D.E.2    Barragan, D.I.3    Chang, H.Y.4    Khavari, P.A.5
  • 70
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M.; Lin, A.W.; McCurrach, M.E.; Beach, D.; Lowe, S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88, 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 72
    • 66149138053 scopus 로고    scopus 로고
    • The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    • Agger, K.; Cloos, P.A.; Rudkjaer, L.; Williams, K.; Andersen, G.; Christensen, J.; Helin, K. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Gene. Develop. 2009, 23, 1171-1176.
    • (2009) Gene. Develop , vol.23 , pp. 1171-1176
    • Agger, K.1    Cloos, P.A.2    Rudkjaer, L.3    Williams, K.4    Andersen, G.5    Christensen, J.6    Helin, K.7
  • 73
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • Sano, T.; Oyama, T.; Kashiwabara, K.; Fukuda, T.; Nakajima, T. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Amer. J. Pathol. 1998, 153, 1741-1748.
    • (1998) Amer. J. Pathol , vol.153 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3    Fukuda, T.4    Nakajima, T.5
  • 75
    • 0029975913 scopus 로고    scopus 로고
    • Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity
    • Khleif, S.N.; DeGregori, J.; Yee, C.L.; Otterson, G.A.; Kaye, F.J.; Nevins, J.R.; Howley, P.M. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc. Natl. Acad. Sci. USA 1996, 93, 4350-4354.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4350-4354
    • Khleif, S.N.1    Degregori, J.2    Yee, C.L.3    Otterson, G.A.4    Kaye, F.J.5    Nevins, J.R.6    Howley, P.M.7
  • 76
    • 0034899522 scopus 로고    scopus 로고
    • Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7
    • Gonzalez, S.L.; Stremlau, M.; He, X.; Basile, J.R.; Münger, K. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J. Virol. 2001, 75, 7583-7591.
    • (2001) J. Virol , vol.75 , pp. 7583-7591
    • Gonzalez, S.L.1    Stremlau, M.2    He, X.3    Basile, J.R.4    Münger, K.5
  • 77
    • 84874772161 scopus 로고    scopus 로고
    • Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr Virus (EBV) transforms primary B cells into lymphoblastoid cell lines
    • Skalska, L.; White, R.E.; Parker, G.A.; Sinclair, A.J.; Paschos, K.; Allday, M.J. Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr Virus (EBV) transforms primary B cells into lymphoblastoid cell lines. PLoS Pathog. 2013, 9, e1003187.
    • (2013) PLoS Pathog , vol.9
    • Skalska, L.1    White, R.E.2    Parker, G.A.3    Sinclair, A.J.4    Paschos, K.5    Allday, M.J.6
  • 78
    • 77954664053 scopus 로고    scopus 로고
    • Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP
    • Skalska, L.; White, R.E.; Franz, M.; Ruhmann, M.; Allday, M.J. Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP. PLoS Pathog. 2010, 6, e1000951.
    • (2010) PLoS Pathog , vol.6
    • Skalska, L.1    White, R.E.2    Franz, M.3    Ruhmann, M.4    Allday, M.J.5
  • 79
    • 78649746843 scopus 로고    scopus 로고
    • Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification
    • White, R.E.; Groves, I.J.; Turro, E.; Yee, J.; Kremmer, E.; Allday, M.J. Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modification. PLoS One 2010, 5, e13979.
    • (2010) PLoS One , vol.5
    • White, R.E.1    Groves, I.J.2    Turro, E.3    Yee, J.4    Kremmer, E.5    Allday, M.J.6
  • 80
    • 84867288340 scopus 로고    scopus 로고
    • BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV
    • Paschos, K.; Parker, G.A.; Watanatanasup, E.; White, R.E.; Allday, M.J. BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV. Nucleic Acids Res. 2012, 40, 7233-7246.
    • (2012) Nucleic Acids Res , vol.40 , pp. 7233-7246
    • Paschos, K.1    Parker, G.A.2    Watanatanasup, E.3    White, R.E.4    Allday, M.J.5
  • 81
    • 84875347265 scopus 로고    scopus 로고
    • Deregulation of epigenetic mechanisms by the hepatitis B virus x protein in hepatocarcinogenesis
    • Andrisani, O.M. Deregulation of epigenetic mechanisms by the hepatitis B virus x protein in hepatocarcinogenesis. Viruses 2013, 5, 858-872.
    • (2013) Viruses , vol.5 , pp. 858-872
    • Andrisani, O.M.1
  • 82
    • 59449086167 scopus 로고    scopus 로고
    • The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
    • Herschkowitz, J.I.; He, X.; Fan, C.; Perou, C.M. The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. Breast Cancer Res. 2008, 10, R75.
    • (2008) Breast Cancer Res , vol.10
    • Herschkowitz, J.I.1    He, X.2    Fan, C.3    Perou, C.M.4
  • 83
    • 0037191509 scopus 로고    scopus 로고
    • Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer
    • Jarrard, D.F.; Modder, J.; Fadden, P.; Fu, V.; Sebree, L.; Heisey, D.; Schwarze, S.R.; Friedl, A. Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer. Cancer Lett. 2002, 185, 191-199.
    • (2002) Cancer Lett , vol.185 , pp. 191-199
    • Jarrard, D.F.1    Modder, J.2    Fadden, P.3    Fu, V.4    Sebree, L.5    Heisey, D.6    Schwarze, S.R.7    Friedl, A.8
  • 84
    • 33846527856 scopus 로고    scopus 로고
    • Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: A translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group
    • Kommoss, S.; du Bois, A.; Ridder, R.; Trunk, M.J.; Schmidt, D.; Pfisterer, J.; Kommoss, F. Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Br. J. Cancer 2007, 96, 306-313.
    • (2007) Br. J. Cancer , vol.96 , pp. 306-313
    • Kommoss, S.1    du Bois, A.2    Ridder, R.3    Trunk, M.J.4    Schmidt, D.5    Pfisterer, J.6    Kommoss, F.7
  • 86
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres, M.; Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 2001, 1, 222-231.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 87
    • 1842484279 scopus 로고    scopus 로고
    • Repression of the human papillomavirus E6 gene initiates p53-dependent, Telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells
    • Horner, S.M.; DeFilippis, R.A.; Manuelidis, L.; DiMaio, D. Repression of the human papillomavirus E6 gene initiates p53-dependent, Telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. J. Virol. 2004, 78, 4063-4073.
    • (2004) J. Virol , vol.78 , pp. 4063-4073
    • Horner, S.M.1    Defilippis, R.A.2    Manuelidis, L.3    Dimaio, D.4
  • 88
    • 2342478606 scopus 로고    scopus 로고
    • Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells
    • Psyrri, A.; DeFilippis, R.A.; Edwards, A.P.; Yates, K.E.; Manuelidis, L.; DiMaio, D. Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res. 2004, 64, 3079-3086.
    • (2004) Cancer Res , vol.64 , pp. 3079-3086
    • Psyrri, A.1    Defilippis, R.A.2    Edwards, A.P.3    Yates, K.E.4    Manuelidis, L.5    Dimaio, D.6
  • 89
    • 0037229178 scopus 로고    scopus 로고
    • Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells
    • DeFilippis, R.A.; Goodwin, E.C.; Wu, L.; DiMaio, D. Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J. Virol. 2003, 77, 1551-1563.
    • (2003) J. Virol , vol.77 , pp. 1551-1563
    • Defilippis, R.A.1    Goodwin, E.C.2    Wu, L.3    Dimaio, D.4
  • 91
    • 0034127794 scopus 로고    scopus 로고
    • A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: A potential role in derepression of neuroendocrine genes and a useful clinical marker
    • Coulson, J.M.; Edgson, J.L.; Woll, P.J.; Quinn, J.P. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: A potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res. 2000, 60, 1840-1844.
    • (2000) Cancer Res , vol.60 , pp. 1840-1844
    • Coulson, J.M.1    Edgson, J.L.2    Woll, P.J.3    Quinn, J.P.4


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