Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 9, 1996, Pages 4350-4354

  Khleif, Samir N ^a,b   Degregori, James ^c   Yee, Carole L ^a   Otterson, Gregory A ^a   Kaye, Frederic J ^a   Nevins, Joseph R ^c   Howley, Peter M ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cervical cancer; E7 oncoprotein; Human papillomaviruses; Retinoblastoma protein

Indexed keywords

CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; MESSENGER RNA; ONCOPROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; UTERINE CERVIX CANCER; WART VIRUS;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ENZYME INHIBITORS; FEMALE; GENES, RETINOBLASTOMA; HELA CELLS; HUMANS; KERATINOCYTES; MALE; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; SKIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; UTERINE CERVICAL NEOPLASMS;

CANCER VIRUS; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPES; PAPILLOMAVIRUS; TUMOR VIRUS;

EID: 0029975913     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.9.4350     Document Type: Article

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