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Volumn 15, Issue 7, 2013, Pages

Pharmacogenomics and cardiovascular disease

Author keywords

Beta blocker, Anti arrhythmic agents; Cardiovascular disease; Clopidogrel; Drug responsiveness; Genetics; Pharmacogenomics; Polymorphism; Statin; Toxicity; Warfarin

Indexed keywords

ANTIARRHYTHMIC AGENT; APOLIPOPROTEIN E; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUCINDOLOL; CARVEDILOL; CLOPIDOGREL; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METOPROLOL; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER 2; PERINDOPRIL; SIMVASTATIN; WARFARIN; CARDIOVASCULAR AGENT; DRUG DERIVATIVE; TICLOPIDINE;

EID: 84877879035     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-013-0376-0     Document Type: Article
Times cited : (14)

References (100)
  • 1
    • 77249113768 scopus 로고    scopus 로고
    • Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation
    • 20179285 1:CAS:528:DC%2BC3cXisFyisbw%3D 10.1001/jama.2010.181
    • Breet NJ, van Werkum JW, Bouman HJ, et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA. 2010;303(8):754-62.
    • (2010) JAMA , vol.303 , Issue.8 , pp. 754-762
    • Breet, N.J.1    Van Werkum, J.W.2    Bouman, H.J.3
  • 2
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • 19812348 1:CAS:528:DC%2BD1MXhs1aqsr7L 10.1124/dmd.109.029132
    • Kazui M, Nishiya Y, Ishizuka T, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010;38(1):92-9.
    • (2010) Drug Metab Dispos , vol.38 , Issue.1 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 3
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • DOI 10.1182/blood-2006-04-013052
    • Hulot JS, Bura A, Villard E, et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood. 2006;108(7):2244-7. (Pubitemid 44497506)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6    Aiach, M.7    Lechat, P.8    Gaussem, P.9
  • 5
    • 73949119561 scopus 로고    scopus 로고
    • Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation
    • 19934793 1:CAS:528:DC%2BD1MXhsFKgurfL 10.1097/FPC.0b013e328333dafe
    • Harmsze A, van Werkum JW, Bouman HJ, et al. Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. Pharmacogenet Genomics. 2010;20(1):18-25.
    • (2010) Pharmacogenet Genomics , vol.20 , Issue.1 , pp. 18-25
    • Harmsze, A.1    Van Werkum, J.W.2    Bouman, H.J.3
  • 7
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • 19706858 1:CAS:528:DC%2BD1MXhtVCnt7zL 10.1001/jama.2009.1232
    • Shuldiner AR, O'Connell JR, Bliden KP, et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA. 2009;302(8):849-57.
    • (2009) JAMA , vol.302 , Issue.8 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 8
    • 79960603688 scopus 로고    scopus 로고
    • Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects
    • 21716274 1:CAS:528:DC%2BC3MXptVOnurY%3D 10.1038/clpt.2011.127
    • Simon T, Bhatt DL, Bergougnan L, et al. Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects. Clin Pharmacol Ther. 2011;90(2):287-95.
    • (2011) Clin Pharmacol Ther , vol.90 , Issue.2 , pp. 287-295
    • Simon, T.1    Bhatt, D.L.2    Bergougnan, L.3
  • 9
    • 79960613122 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy
    • 21716271 1:CAS:528:DC%2BC3MXptVOnurg%3D 10.1038/clpt.2011.132 Guidelines incorporating genetic variation in CYP2C19 on clopidogrel directed therapy
    • •• Scott SA, Sangkuhl K, Gardner EE, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Clin Pharmacol Ther. 2011;90(2):328-32. Guidelines incorporating genetic variation in CYP2C19 on clopidogrel directed therapy.
    • (2011) Clin Pharmacol Ther , vol.90 , Issue.2 , pp. 328-332
    • Scott, S.A.1    Sangkuhl, K.2    Gardner, E.E.3
  • 10
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • 19106084 1:CAS:528:DC%2BD1MXhtVSlsbs%3D 10.1056/NEJMoa0809171
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360(4):354-62.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 11
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • 19108880 1:CAS:528:DC%2BD1MXhtVaqtrY%3D 10.1016/S0140-6736(08)61845-0
    • Collet JP, Hulot JS, Pena A, et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet. 2009;373(9660):309-17.
    • (2009) Lancet , vol.373 , Issue.9660 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3
  • 12
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: A systematic meta-analysis
    • 20620727 1:CAS:528:DC%2BC3cXhtVertL7P 10.1016/j.jacc.2009.12.071
    • Hulot JS, Collet JP, Silvain J, et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis. J Am Coll Cardiol. 2010;56(2):134-43.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.2 , pp. 134-143
    • Hulot, J.S.1    Collet, J.P.2    Silvain, J.3
  • 13
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • 20978260 1:CAS:528:DC%2BC3cXhtlGqurbO 10.1001/jama.2010.1543 Carriers of the CYP2C19*2 risk allele who received clopidogrel post-PCI had a significantly increased risk of a major cardiovascular event, most notably stent thrombosis
    • •• Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA. 2010;304(16):1821-30. Carriers of the CYP2C19*2 risk allele who received clopidogrel post-PCI had a significantly increased risk of a major cardiovascular event, most notably stent thrombosis.
    • (2010) JAMA , vol.304 , Issue.16 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 14
    • 84855958154 scopus 로고    scopus 로고
    • Predicting clopidogrel response using DNA samples linked to an electronic health record
    • 22190063 1:CAS:528:DC%2BC38Xht1Wkurw%3D 10.1038/clpt.2011.221 Confirmed findings on clopidogrel resistance in ABCB1 and CYP2C19 using a real-world population identified from electronic health records coupled with genetic information. No evidence of clopidogrel resistance was found for PON1
    • • Delaney JT, Ramirez AH, Bowton E, et al. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther. 2012;91(2):257-63. Confirmed findings on clopidogrel resistance in ABCB1 and CYP2C19 using a real-world population identified from electronic health records coupled with genetic information. No evidence of clopidogrel resistance was found for PON1.
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.2 , pp. 257-263
    • Delaney, J.T.1    Ramirez, A.H.2    Bowton, E.3
  • 15
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • 20801498 1:CAS:528:DC%2BC3cXht12ks7nM 10.1016/S0140-6736(10)61274-3
    • Wallentin L, James S, Storey RF, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet. 2010;376(9749):1320-8.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 16
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    • 20979470 1:CAS:528:DC%2BC3cXhtlKitL%2FP 10.1056/NEJMoa1008410
    • Pare G, Mehta SR, Yusuf S, et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N Engl J Med. 2010;363(18):1704-14.
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1704-1714
    • Pare, G.1    Mehta, S.R.2    Yusuf, S.3
  • 17
    • 70749149366 scopus 로고    scopus 로고
    • Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations
    • 19891556 1:CAS:528:DC%2BD1MXhtlOiu77J 10.2217/pgs.09.143
    • Ellis KJ, Stouffer GA, McLeod HL, Lee CR. Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations. Pharmacogenomics. 2009;10(11):1799-817.
    • (2009) Pharmacogenomics , vol.10 , Issue.11 , pp. 1799-1817
    • Ellis, K.J.1    Stouffer, G.A.2    McLeod, H.L.3    Lee, C.R.4
  • 18
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • 20083681 1:CAS:528:DC%2BC3cXpsVensg%3D%3D 10.1161/CIRCULATIONAHA.109. 885194
    • Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation. 2010;121(4):512-8.
    • (2010) Circulation , vol.121 , Issue.4 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 20
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • 19106083 1:CAS:528:DC%2BD1MXhtVSlsbY%3D 10.1056/NEJMoa0808227
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360(4):363-75.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 21
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • 20801494 1:CAS:528:DC%2BC3cXht12ks7jF 10.1016/S0140-6736(10)61273-1 ABCB1 associated with adverse cardiovascular events independent of genetic variation in CYP2C19 among clopidogrel treated ACS patients
    • •• Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet. 2010;376(9749):1312-9. ABCB1 associated with adverse cardiovascular events independent of genetic variation in CYP2C19 among clopidogrel treated ACS patients.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 22
    • 77956353400 scopus 로고    scopus 로고
    • Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events
    • 20826260 1:CAS:528:DC%2BC3cXhtFWqsb7J 10.1016/j.ahj.2010.06.039
    • Tiroch KA, Sibbing D, Koch W, et al. Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events. Am Heart J. 2010;160(3):506-12.
    • (2010) Am Heart J , vol.160 , Issue.3 , pp. 506-512
    • Tiroch, K.A.1    Sibbing, D.2    Koch, W.3
  • 23
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • 19414633 1:CAS:528:DC%2BD1MXmtVKntrs%3D 10.1161/CIRCULATIONAHA.109.851949
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation. 2009;119(19):2553-60.
    • (2009) Circulation , vol.119 , Issue.19 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 24
    • 77949907998 scopus 로고    scopus 로고
    • Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions
    • 20031628 1:CAS:528:DC%2BD1MXhsVCksbzK 10.1161/CIRCGENETICS.109.861799
    • Rudez G, Bouman HJ, van Werkum JW, et al. Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions. Circ Cardiovasc Genet. 2009;2(5):515-21.
    • (2009) Circ Cardiovasc Genet , vol.2 , Issue.5 , pp. 515-521
    • Rudez, G.1    Bouman, H.J.2    Van Werkum, J.W.3
  • 25
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efficacy
    • 21170047 1:CAS:528:DC%2BC3cXhsFyisb%2FN 10.1038/nm.2281
    • Bouman HJ, Schomig E, van Werkum JW, et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat Med. 2011;17(1):110-6.
    • (2011) Nat Med , vol.17 , Issue.1 , pp. 110-116
    • Bouman, H.J.1    Schomig, E.2    Van Werkum, J.W.3
  • 26
    • 79960012663 scopus 로고    scopus 로고
    • No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting
    • 21527445 1:CAS:528:DC%2BC3MXos1Smtr8%3D 10.1093/eurheartj/ehr155
    • Sibbing D, Koch W, Massberg S, et al. No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting. Eur Heart J. 2011;32(13):1605-13.
    • (2011) Eur Heart J , vol.32 , Issue.13 , pp. 1605-1613
    • Sibbing, D.1    Koch, W.2    Massberg, S.3
  • 27
    • 77955425743 scopus 로고    scopus 로고
    • ACCF/AHA clopidogrel clinical alert: Approaches to the FDA «boxed warning»: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association
    • 20585015 10.1161/CIR.0b013e3181ee08ed
    • Holmes Jr DR, Dehmer GJ, Kaul S, Leifer D, O'Gara PT, Stein CM. ACCF/AHA clopidogrel clinical alert: approaches to the FDA «boxed warning»: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association. Circulation. 2010;122(5):537-57.
    • (2010) Circulation , vol.122 , Issue.5 , pp. 537-557
    • Holmes, Jr.D.R.1    Dehmer, G.J.2    Kaul, S.3    Leifer, D.4    O'Gara, P.T.5    Stein, C.M.6
  • 28
    • 84862620703 scopus 로고    scopus 로고
    • Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project
    • 22588608 1:CAS:528:DC%2BC38XptVGmu7o%3D 10.1038/clpt.2011.371 Description of the Vanderbilt PREDICT project aimed at implementing and evaluating strategies for personalized medicine
    • • Pulley JM, Denny JC, Peterson JF, et al. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther. 2012;92(1):87-95. Description of the Vanderbilt PREDICT project aimed at implementing and evaluating strategies for personalized medicine.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.1 , pp. 87-95
    • Pulley, J.M.1    Denny, J.C.2    Peterson, J.F.3
  • 30
    • 77949462773 scopus 로고    scopus 로고
    • Pharmacogenetics of oral anticoagulant therapy
    • 20205664 1:CAS:528:DC%2BC3cXisVChtrk%3D 10.2174/138161210790112737
    • Schalekamp T, de Boer A. Pharmacogenetics of oral anticoagulant therapy. Curr Pharm Des. 2010;16(2):187-203.
    • (2010) Curr Pharm des , vol.16 , Issue.2 , pp. 187-203
    • Schalekamp, T.1    De Boer, A.2
  • 33
    • 78649693344 scopus 로고    scopus 로고
    • National estimates of emergency department visits for hemorrhage-related adverse events from clopidogrel plus aspirin and from warfarin
    • 21098354 10.1001/archinternmed.2010.407
    • Shehab N, Sperling LS, Kegler SR, Budnitz DS. National estimates of emergency department visits for hemorrhage-related adverse events from clopidogrel plus aspirin and from warfarin. Arch Intern Med. 2010;170(21):1926-33.
    • (2010) Arch Intern Med , vol.170 , Issue.21 , pp. 1926-1933
    • Shehab, N.1    Sperling, L.S.2    Kegler, S.R.3    Budnitz, D.S.4
  • 34
    • 0036263813 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 polymorphisms: A comprehensive review of the in-vitro and human data
    • DOI 10.1097/00008571-200204000-00010
    • Lee CR, Goldstein JA, Pieper JA. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. 2002;12(3):251-63. (Pubitemid 34596790)
    • (2002) Pharmacogenetics , vol.12 , Issue.3 , pp. 251-263
    • Lee, C.R.1    Goldstein, J.A.2    Pieper, J.A.3
  • 35
    • 62549143945 scopus 로고    scopus 로고
    • Influence of CYP2C9 genotype on warfarin dose requirements-a systematic review and meta-analysis
    • 19031075 1:CAS:528:DC%2BD1MXjt1ShsrY%3D 10.1007/s00228-008-0584-5
    • Lindh JD, Holm L, Andersson ML, Rane A. Influence of CYP2C9 genotype on warfarin dose requirements-a systematic review and meta-analysis. Eur J Clin Pharmacol. 2009;65(4):365-75.
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.4 , pp. 365-375
    • Lindh, J.D.1    Holm, L.2    Andersson, M.L.3    Rane, A.4
  • 37
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • DOI 10.1016/S0140-6736(98)04474-2
    • Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999;353(9154):717-9. (Pubitemid 29103806)
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.L.3    Daly, A.K.4
  • 38
    • 77949567067 scopus 로고    scopus 로고
    • Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement-a systematic review and meta analysis
    • 19942260 1:CAS:528:DC%2BC3cXjs1Omurs%3D 10.1016/j.thromres.2009.10.017
    • Yang L, Ge W, Yu F, Zhu H. Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement-a systematic review and meta analysis. Thromb Res. 2010;125(4):e159-66.
    • (2010) Thromb Res , vol.125 , Issue.4
    • Yang, L.1    Ge, W.2    Yu, F.3    Zhu, H.4
  • 39
    • 51649084617 scopus 로고    scopus 로고
    • Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
    • 18523153 1:CAS:528:DC%2BD1cXpvVOksLo%3D 10.1182/blood-2008-03-144899
    • Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadee W. Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood. 2008;112(4):1013-21.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1013-1021
    • Wang, D.1    Chen, H.2    Momary, K.M.3    Cavallari, L.H.4    Johnson, J.A.5    Sadee, W.6
  • 40
    • 40749123052 scopus 로고    scopus 로고
    • Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations
    • 18252229 1:CAS:528:DC%2BD1cXit1Sisrk%3D 10.1016/j.ajhg.2007.10.002
    • Scott SA, Edelmann L, Kornreich R, Desnick RJ. Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations. Am J Hum Genet. 2008;82(2):495-500.
    • (2008) Am J Hum Genet , vol.82 , Issue.2 , pp. 495-500
    • Scott, S.A.1    Edelmann, L.2    Kornreich, R.3    Desnick, R.J.4
  • 41
    • 66849132349 scopus 로고    scopus 로고
    • CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
    • 19297519 1:CAS:528:DC%2BD1MXmvVWqsb8%3D 10.1124/mol.109.054833
    • McDonald MG, Rieder MJ, Nakano M, Hsia CK, Rettie AE. CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant. Mol Pharmacol. 2009;75(6):1337-46.
    • (2009) Mol Pharmacol , vol.75 , Issue.6 , pp. 1337-1346
    • McDonald, M.G.1    Rieder, M.J.2    Nakano, M.3    Hsia, C.K.4    Rettie, A.E.5
  • 42
    • 79251588402 scopus 로고    scopus 로고
    • Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction
    • 21127708 10.1155/2011/739751
    • Kringen MK, Haug KB, Grimholt RM, et al. Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction. J Biomed Biotechnol. 2011;2011:739751.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 739751
    • Kringen, M.K.1    Haug, K.B.2    Grimholt, R.M.3
  • 43
    • 47949086046 scopus 로고    scopus 로고
    • Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin
    • 18305455 1:CAS:528:DC%2BD1cXhtVShtr7F 10.1038/clpt.2008.10
    • Gage BF, Eby C, Johnson JA, et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther. 2008;84(3):326-31.
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.3 , pp. 326-331
    • Gage, B.F.1    Eby, C.2    Johnson, J.A.3
  • 44
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • 18574025 1:CAS:528:DC%2BD1MXhtlGhsbc%3D 10.1182/blood-2008-04-149070
    • Wadelius M, Chen LY, Lindh JD, et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood. 2009;113(4):784-92.
    • (2009) Blood , vol.113 , Issue.4 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3
  • 45
    • 80052962391 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing
    • 21900891 1:CAS:528:DC%2BC3MXht1WqtbjK 10.1038/clpt.2011.185 Guidelines incorporating genetic variation in CYP2C9 and VKORC1 in warfarin directed therapy
    • •• Johnson JA, Gong L, Whirl-Carrillo M, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther. 2011;90(4):625-9. Guidelines incorporating genetic variation in CYP2C9 and VKORC1 in warfarin directed therapy.
    • (2011) Clin Pharmacol Ther , vol.90 , Issue.4 , pp. 625-629
    • Johnson, J.A.1    Gong, L.2    Whirl-Carrillo, M.3
  • 46
    • 84879897672 scopus 로고    scopus 로고
    • Warfarin label information [Updated January 22]
    • Warfarin label information [Updated January 22, 2010].
    • (2010)
  • 47
    • 70649084116 scopus 로고    scopus 로고
    • Genotype-guided dosing of coumarin derivatives: The European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design
    • 19842940 10.2217/pgs.09.125
    • van Schie RM, Wadelius MI, Kamali F, et al. Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. Pharmacogenomics. 2009;10(10):1687-95.
    • (2009) Pharmacogenomics , vol.10 , Issue.10 , pp. 1687-1695
    • Van Schie, R.M.1    Wadelius, M.I.2    Kamali, F.3
  • 48
    • 78349294600 scopus 로고    scopus 로고
    • Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    • • French B, Joo J, Geller NL, et al. Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial. Trials. 2010;11:108. Study utilizing genetic information in each individual to guide warfarin therapy.
    • (2010) Trials , vol.11 , pp. 108
    • French, B.1    Joo, J.2    Geller, N.L.3
  • 49
    • 33644609683 scopus 로고    scopus 로고
    • Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: The Cholesterol and Pharmacogenetics (CAP) Study
    • 16516587 1:CAS:528:DC%2BD28XitVehtr4%3D 10.1016/j.amjcard.2005.09.134
    • Simon JA, Lin F, Hulley SB, et al. Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study. Am J Cardiol. 2006;97(6):843-50.
    • (2006) Am J Cardiol , vol.97 , Issue.6 , pp. 843-850
    • Simon, J.A.1    Lin, F.2    Hulley, S.B.3
  • 50
    • 33746799030 scopus 로고    scopus 로고
    • Clinical implications of pharmacogenomics of statin treatment
    • DOI 10.1038/sj.tpj.6500384, PII 6500384
    • Mangravite LM, Thorn CF, Krauss RM. Clinical implications of pharmacogenomics of statin treatment. Pharmacogenomics J. 2006;6(6):360-74. (Pubitemid 44811531)
    • (2006) Pharmacogenomics Journal , vol.6 , Issue.6 , pp. 360-374
    • Mangravite, L.M.1    Thorn, C.F.2    Krauss, R.M.3
  • 53
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • 18559695 1:CAS:528:DC%2BD1cXosFSnurc%3D 10.1161/CIRCULATIONAHA.108.773267
    • Medina MW, Gao F, Ruan W, Rotter JI, Krauss RM. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008;118(4):355-62.
    • (2008) Circulation , vol.118 , Issue.4 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3    Rotter, J.I.4    Krauss, R.M.5
  • 54
    • 69549111453 scopus 로고    scopus 로고
    • Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort
    • 20031582 1:CAS:528:DC%2BD1MXmvVyhtrY%3D 10.1161/CIRCGENETICS.108.818062
    • Thompson JF, Hyde CL, Wood LS, et al. Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort. Circ Cardiovasc Genet. 2009;2(2):173-81.
    • (2009) Circ Cardiovasc Genet , vol.2 , Issue.2 , pp. 173-181
    • Thompson, J.F.1    Hyde, C.L.2    Wood, L.S.3
  • 55
    • 0023117993 scopus 로고
    • Apolipoprotein E polymorphism in health and disease
    • DOI 10.1016/0002-8703(87)90610-7
    • Utermann G. Apolipoprotein E polymorphism in health and disease. Am Heart J. 1987;113(2 Pt 2):433-40. (Pubitemid 17026619)
    • (1987) American Heart Journal , vol.113 , Issue.2 , pp. 433-440
    • Utermann, G.1
  • 56
    • 67651196989 scopus 로고    scopus 로고
    • Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response
    • 20031551 1:CAS:528:DC%2BD1MXhtV2is7bL 10.1161/CIRCGENETICS.108.795013
    • Voora D, Shah SH, Reed CR, et al. Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. Circ Cardiovasc Genet. 2008;1(2):100-6.
    • (2008) Circ Cardiovasc Genet , vol.1 , Issue.2 , pp. 100-106
    • Voora, D.1    Shah, S.H.2    Reed, C.R.3
  • 57
    • 67849094103 scopus 로고    scopus 로고
    • APOE gene polymorphisms and response to statin therapy
    • 1:CAS:528:DC%2BD1MXntlGnsLg%3D
    • Zintzaras E, Kitsios GD, Triposkiadis F, Lau J, Raman G. APOE gene polymorphisms and response to statin therapy. Pharm J. 2009;9(4):248-57.
    • (2009) Pharm J , vol.9 , Issue.4 , pp. 248-257
    • Zintzaras, E.1    Kitsios, G.D.2    Triposkiadis, F.3    Lau, J.4    Raman, G.5
  • 58
    • 77955467684 scopus 로고    scopus 로고
    • KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: Results from the PROSPER study
    • 20215968 10.1097/HJR.0b013e328336a0dd
    • Iakoubova OA, Robertson M, Tong CH, et al. KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. Eur J Cardiovasc Prev Rehabil. 2010;17(4):455-61.
    • (2010) Eur J Cardiovasc Prev Rehabil , vol.17 , Issue.4 , pp. 455-461
    • Iakoubova, O.A.1    Robertson, M.2    Tong, C.H.3
  • 59
    • 38349171836 scopus 로고    scopus 로고
    • Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: Results from the PROVE IT-TIMI 22 study
    • 18222355 1:CAS:528:DC%2BD1cXhtV2ntL8%3D 10.1016/j.jacc.2007.10.017
    • Iakoubova OA, Sabatine MS, Rowland CM, et al. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol. 2008;51(4):449-55.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.4 , pp. 449-455
    • Iakoubova, O.A.1    Sabatine, M.S.2    Rowland, C.M.3
  • 60
    • 38349118892 scopus 로고    scopus 로고
    • Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: The CARE and WOSCOPS trials
    • 18222353 1:CAS:528:DC%2BD1cXhtV2nt7c%3D 10.1016/j.jacc.2007.05.057
    • Iakoubova OA, Tong CH, Rowland CM, et al. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008;51(4):435-43.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.4 , pp. 435-443
    • Iakoubova, O.A.1    Tong, C.H.2    Rowland, C.M.3
  • 61
    • 78049327781 scopus 로고    scopus 로고
    • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    • 20933357 1:CAS:528:DC%2BC3cXhsF2htL3N 10.1016/j.jacc.2010.06.022
    • Assimes TL, Holm H, Kathiresan S, et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010;56(19):1552-63.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.19 , pp. 1552-1563
    • Assimes, T.L.1    Holm, H.2    Kathiresan, S.3
  • 62
    • 80052762422 scopus 로고    scopus 로고
    • Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention
    • 21493817 1:CAS:528:DC%2BC3MXps1Onsrk%3D 10.1161/CIRCGENETICS.110.959353
    • Ridker PM, MacFadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention. Circ Cardiovasc Genet. 2011;4(3):312-7.
    • (2011) Circ Cardiovasc Genet , vol.4 , Issue.3 , pp. 312-317
    • Ridker, P.M.1    Macfadyen, J.G.2    Glynn, R.J.3    Chasman, D.I.4
  • 63
    • 69849094785 scopus 로고    scopus 로고
    • Identification of genetic variants associated with response to statin therapy
    • 19667110 1:CAS:528:DC%2BD1MXpsFyktrY%3D 10.1161/ATVBAHA.109.188474
    • Mega JL, Morrow DA, Brown A, Cannon CP, Sabatine MS. Identification of genetic variants associated with response to statin therapy. Arterioscler Thromb Vasc Biol. 2009;29(9):1310-5.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.9 , pp. 1310-1315
    • Mega, J.L.1    Morrow, D.A.2    Brown, A.3    Cannon, C.P.4    Sabatine, M.S.5
  • 64
    • 1842637753 scopus 로고    scopus 로고
    • Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner
    • DOI 10.1016/j.amjcard.2004.01.014, PII S0002914904000347
    • Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner. Am J Cardiol. 2004;93(8):1046-50. (Pubitemid 38479466)
    • (2004) American Journal of Cardiology , vol.93 , Issue.8 , pp. 1046-1050
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 66
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • 16581329 1:CAS:528:DC%2BD28XkvF2gsr4%3D 10.1016/j.amjcard.2005.12.010
    • Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol. 2006;97(8A):52C-60C.
    • (2006) Am J Cardiol , vol.97 , Issue.8 A
    • Law, M.1    Rudnicka, A.R.2
  • 67
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
    • 11477075 1:CAS:528:DC%2BD3MXntFahsb4%3D 10.1074/jbc.M103792200
    • Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem. 2001;276(38):35669-75.
    • (2001) J Biol Chem , vol.276 , Issue.38 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 68
    • 33751096467 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
    • DOI 10.1097/01.fpc.0000230416.82349.90, PII 0121301120061200000004
    • Pasanen MK, Neuvonen M, Neuvonen PJ, Niemi M. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics. 2006;16(12):873-9. (Pubitemid 44772805)
    • (2006) Pharmacogenetics and Genomics , vol.16 , Issue.12 , pp. 873-879
    • Pasanen, M.K.1    Neuvonen, M.2    Neuvonen, P.J.3    Niemi, M.4
  • 69
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • 18650507 1:CAS:528:DC%2BD1cXhtVShtbnF 10.1056/NEJMoa0801936
    • Link E, Parish S, Armitage J, et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med. 2008;359(8):789-99.
    • (2008) N Engl J Med , vol.359 , Issue.8 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 70
    • 70349739250 scopus 로고    scopus 로고
    • The SLCO1B1*5 genetic variant is associated with statin-induced side effects
    • 19833260 1:CAS:528:DC%2BD1MXhsVGnu77E 10.1016/j.jacc.2009.04.053
    • Voora D, Shah SH, Spasojevic I, et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol. 2009;54(17):1609-16.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.17 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3
  • 71
    • 52049123312 scopus 로고    scopus 로고
    • Characterization of low-density lipoprotein cholesterol-lowering efficacy for atorvastatin in a population-based DNA biorepository
    • 18834356 1:CAS:528:DC%2BD1cXht1GmtrnI 10.1111/j.1742-7843.2008.00291.x
    • Wilke RA, Berg RL, Linneman JG, Zhao C, McCarty CA, Krauss RM. Characterization of low-density lipoprotein cholesterol-lowering efficacy for atorvastatin in a population-based DNA biorepository. Basic Clin Pharmacol Toxicol. 2008;103(4):354-9.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , Issue.4 , pp. 354-359
    • Wilke, R.A.1    Berg, R.L.2    Linneman, J.G.3    Zhao, C.4    McCarty, C.A.5    Krauss, R.M.6
  • 72
    • 84862600938 scopus 로고    scopus 로고
    • The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
    • 22617227 1:CAS:528:DC%2BC38XptVGmtbg%3D 10.1038/clpt.2012.57 Guidelines incorporating genetic variation in SLCO1B1 to reduce statin related myopathy
    • •• Wilke RA, Ramsey LB, Johnson SG, et al. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin Pharmacol Ther. 2012;92(1):112-7. Guidelines incorporating genetic variation in SLCO1B1 to reduce statin related myopathy.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.1 , pp. 112-117
    • Wilke, R.A.1    Ramsey, L.B.2    Johnson, S.G.3
  • 73
    • 0036146859 scopus 로고    scopus 로고
    • 1-adrenergic receptor affect agonist-promoted trafficking
    • DOI 10.1097/00005344-200202000-00001
    • Rathz DA, Brown KM, Kramer LA, Liggett SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. J Cardiovasc Pharmacol. 2002;39(2):155-60. (Pubitemid 34093534)
    • (2002) Journal of Cardiovascular Pharmacology , vol.39 , Issue.2 , pp. 155-160
    • Rathz, D.A.1    Brown, K.M.2    Kramer, L.A.3    Liggett, S.B.4
  • 74
    • 0033617342 scopus 로고    scopus 로고
    • A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor
    • DOI 10.1074/jbc.274.18.12670
    • Mason DA, Moore JD, Green SA, Liggett SB. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem. 1999;274(18):12670-4. (Pubitemid 29215505)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.18 , pp. 12670-12674
    • Mason, D.A.1    Moore, J.D.2    Green, S.A.3    Liggett, S.B.4
  • 75
    • 40949113720 scopus 로고    scopus 로고
    • 2-Adrenoceptor polymorphisms and cardiovascular diseases
    • DOI 10.1111/j.1472-8206.2007.00557.x
    • Brodde OE. Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases. Fundam Clin Pharmacol. 2008;22(2):107-25. (Pubitemid 351409349)
    • (2008) Fundamental and Clinical Pharmacology , vol.22 , Issue.2 , pp. 107-125
    • Brodde, O.-E.1
  • 78
    • 76549133595 scopus 로고    scopus 로고
    • An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure
    • 19880803 1:CAS:528:DC%2BC3cXktVSqtA%3D%3D 10.1161/CIRCHEARTFAILURE.109. 885962
    • Bristow MR, Murphy GA, Krause-Steinrauf H, et al. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circ Heart Fail. 2010;3(1):21-8.
    • (2010) Circ Heart Fail , vol.3 , Issue.1 , pp. 21-28
    • Bristow, M.R.1    Murphy, G.A.2    Krause-Steinrauf, H.3
  • 80
    • 33745353777 scopus 로고    scopus 로고
    • 1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension
    • DOI 10.1016/j.clpt.2006.03.004, PII S0009923606000907
    • Liu J, Liu ZQ, Yu BN, et al. beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther. 2006;80(1):23-32. (Pubitemid 43946840)
    • (2006) Clinical Pharmacology and Therapeutics , vol.80 , Issue.1 , pp. 23-32
    • Liu, J.1    Liu, Z.-Q.2    Yu, B.-N.3    Xu, F.-H.4    Mo, W.5    Zhou, G.6    Liu, Y.-Z.7    Li, Q.8    Zhou, H.-H.9
  • 82
    • 0028068550 scopus 로고
    • 2-adrenergic receptor impart distinct agonist-promoted regulatory properties
    • Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 1994;33(32):9414-9. (Pubitemid 24272896)
    • (1994) Biochemistry , vol.33 , Issue.32 , pp. 9414-9419
    • Green, S.A.1    Turki, J.2    Innis, M.3    Liggett, S.B.4
  • 84
    • 64549105750 scopus 로고    scopus 로고
    • Gln(27)->Glubeta(2)-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol
    • 19422106 1:CAS:528:DC%2BD1MXnt1Clt7g%3D 10.1111/j.1742-7843.2008.00370.x
    • Troncoso R, Moraga F, Chiong M, et al. Gln(27)->Glubeta(2)-adrenergic receptor polymorphism in heart failure patients: differential clinical and oxidative response to carvedilol. Basic Clin Pharmacol Toxicol. 2009;104(5):374-8.
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , Issue.5 , pp. 374-378
    • Troncoso, R.1    Moraga, F.2    Chiong, M.3
  • 85
    • 60349128639 scopus 로고    scopus 로고
    • Impact of the CYP2D6 genotype on the clinical effects of metoprolol: A prospective longitudinal study
    • 19037197 1:CAS:528:DC%2BD1MXit1Oguro%3D 10.1038/clpt.2008.218
    • Rau T, Wuttke H, Michels LM, et al. Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study. Clin Pharmacol Ther. 2009;85(3):269-72.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.3 , pp. 269-272
    • Rau, T.1    Wuttke, H.2    Michels, L.M.3
  • 86
    • 57749198655 scopus 로고    scopus 로고
    • Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users
    • 18784654 1:CAS:528:DC%2BD1cXhsFSmtrfF 10.1038/clpt.2008.172
    • Bijl MJ, Visser LE, van Schaik RH, et al. Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Clin Pharmacol Ther. 2009;85(1):45-50.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.1 , pp. 45-50
    • Bijl, M.J.1    Visser, L.E.2    Van Schaik, R.H.3
  • 90
    • 0034725616 scopus 로고    scopus 로고
    • A four amino acid deletion polymorphism in the third intracellular loop of the human α(2C)-adrenergic receptor confers impaired coupling to multiple effectors
    • DOI 10.1074/jbc.M000796200
    • Small KM, Forbes SL, Rahman FF, Bridges KM, Liggett SB. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. J Biol Chem. 2000;275(30):23059-64. (Pubitemid 30646196)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.30 , pp. 23059-23064
    • Small, K.M.1    Forbes, S.L.2    Rahman, F.F.3    Bridges, K.M.4    Liggett, S.B.5
  • 92
    • 79952582396 scopus 로고    scopus 로고
    • Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients
    • 21395649 1:CAS:528:DC%2BC3MXltVKrtb0%3D 10.1111/j.1365-2125.2010.03868.x
    • Petersen M, Andersen JT, Hjelvang BR, et al. Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients. Br J Clin Pharmacol. 2011;71(4):556-65.
    • (2011) Br J Clin Pharmacol , vol.71 , Issue.4 , pp. 556-565
    • Petersen, M.1    Andersen, J.T.2    Hjelvang, B.R.3
  • 93
    • 0026651907 scopus 로고
    • Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels
    • 1319114 1:CAS:528:DyaK38Xlt1yksbw%3D
    • Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992;51(1):197-205.
    • (1992) Am J Hum Genet , vol.51 , Issue.1 , pp. 197-205
    • Tiret, L.1    Rigat, B.2    Visvikis, S.3
  • 94
    • 77955457212 scopus 로고    scopus 로고
    • Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease
    • 20538738 1:CAS:528:DC%2BC3cXpsFOit7g%3D 10.1093/eurheartj/ehq169 First study to identify genetic determinants influencing ACE-I therapy
    • •• Brugts JJ, Isaacs A, Boersma E, et al. Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. Eur Heart J. 2010;31(15):1854-64. First study to identify genetic determinants influencing ACE-I therapy.
    • (2010) Eur Heart J , vol.31 , Issue.15 , pp. 1854-1864
    • Brugts, J.J.1    Isaacs, A.2    Boersma, E.3
  • 96
    • 0036847982 scopus 로고    scopus 로고
    • A meta-analysis of the angiotensin-converting enzyme gene polymorphism and restenosis after percutaneous transluminal coronary revascularization: Evidence for publication bias
    • DOI 10.1067/mhj.2002.125509
    • Agema WR, Jukema JW, Zwinderman AH, van der Wall EE. A meta-analysis of the angiotensin-converting enzyme gene polymorphism and restenosis after percutaneous transluminal coronary revascularization: evidence for publication bias. Am Heart J. 2002;144(5):760-8. (Pubitemid 35335166)
    • (2002) American Heart Journal , vol.144 , Issue.5 , pp. 760-768
    • Agema, W.R.P.1    Jukema, J.W.2    Zwinderman, A.H.3    Van Der Wall, E.E.4
  • 97
    • 1442306232 scopus 로고    scopus 로고
    • Drug-Induced Prolongation of the QT Interval
    • DOI 10.1056/NEJMra032426
    • Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350(10):1013-22. (Pubitemid 38269278)
    • (2004) New England Journal of Medicine , vol.350 , Issue.10 , pp. 1013-1022
    • Roden, D.M.1
  • 98
    • 84881170186 scopus 로고    scopus 로고
    • Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes
    • 10.1038/tpj.2012.14 Directed genotyping demonstrate how patients developing TdP frequently have rare mutations in genes known to associate cardiac arrhythmia
    • • Ramirez AH, Shaffer CM, Delaney JT, et al. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. Pharmacogenomics J. 2012. doi: 10.1038/tpj.2012.14. Directed genotyping demonstrate how patients developing TdP frequently have rare mutations in genes known to associate cardiac arrhythmia.
    • (2012) Pharmacogenomics J
    • Ramirez, A.H.1    Shaffer, C.M.2    Delaney, J.T.3
  • 99
    • 84859315750 scopus 로고    scopus 로고
    • A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes
    • 22100668 10.1161/CIRCGENETICS.111.960930 Polymorphism (D85N) in important potassium channel (KCNE1) associated with TdP
    • •• Kaab S, Crawford DC, Sinner MF, et al. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet. 2012;5(1):91-9. Polymorphism (D85N) in important potassium channel (KCNE1) associated with TdP.
    • (2012) Circ Cardiovasc Genet , vol.5 , Issue.1 , pp. 91-99
    • Kaab, S.1    Crawford, D.C.2    Sinner, M.F.3
  • 100
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical pharmacogenetics implementation consortium of the pharmacogenomics research network
    • 21270786 1:STN:280:DC%2BC3M7ps1WhtA%3D%3D 10.1038/clpt.2010.279
    • Relling MV, Klein TE. CPIC: clinical pharmacogenetics implementation consortium of the pharmacogenomics research network. Clin Pharmacol Ther. 2011;89(3):464-7.
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.3 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2


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