메뉴 건너뛰기




Volumn 125, Issue 4, 2010, Pages

Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement- A systematic review and meta analysis

Author keywords

Gene polymorphism; Meta analysis; Systematic review; VKORC1; Warfarin

Indexed keywords

OXIDOREDUCTASE; UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1; WARFARIN;

EID: 77949567067     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.10.017     Document Type: Article
Times cited : (116)

References (40)
  • 1
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • Aithal G.P., Day C.P., Kesteven P.J., and Daly A.K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 353 (1998) 717-719
    • (1998) Lancet , vol.353 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.3    Daly, A.K.4
  • 2
    • 11244332058 scopus 로고    scopus 로고
    • A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    • D'Andrea G., D'Ambrosio R.L., Di Perna P., Chetta M., Santacroce R., Brancaccio V., et al. A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. Blood 105 (2005) 645-649
    • (2005) Blood , vol.105 , pp. 645-649
    • D'Andrea, G.1    D'Ambrosio, R.L.2    Di Perna, P.3    Chetta, M.4    Santacroce, R.5    Brancaccio, V.6
  • 3
    • 36148985283 scopus 로고    scopus 로고
    • Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients
    • Miao L., Yang J., Huang C., and Shen Z. Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients. Eur J Clin Pharmacol 63 (2007) 1135-1141
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 1135-1141
    • Miao, L.1    Yang, J.2    Huang, C.3    Shen, Z.4
  • 6
    • 0842308834 scopus 로고    scopus 로고
    • Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin
    • Khan T., Wynne H., Wood P., Torrance A., Hankey C., Avery P., et al. Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin. Br J Haematol 124 (2004) 348-354
    • (2004) Br J Haematol , vol.124 , pp. 348-354
    • Khan, T.1    Wynne, H.2    Wood, P.3    Torrance, A.4    Hankey, C.5    Avery, P.6
  • 7
    • 16844373618 scopus 로고    scopus 로고
    • Interaction of warfarin with drugs, natural substances, and foods
    • Greenblatt D.J., and von Moltke L.L. Interaction of warfarin with drugs, natural substances, and foods. J Clin Pharmacol 45 (2005) 127-132
    • (2005) J Clin Pharmacol , vol.45 , pp. 127-132
    • Greenblatt, D.J.1    von Moltke, L.L.2
  • 8
    • 10744228888 scopus 로고    scopus 로고
    • Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
    • Rost S., Fregin A., Ivaskevicius V., Conzelmann E., Hörtnagel K., Pelz H.J., et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427 (2004) 537-541
    • (2004) Nature , vol.427 , pp. 537-541
    • Rost, S.1    Fregin, A.2    Ivaskevicius, V.3    Conzelmann, E.4    Hörtnagel, K.5    Pelz, H.J.6
  • 10
    • 24944503322 scopus 로고    scopus 로고
    • A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity
    • Yuan H.Y., Chen J.J., Lee M.T., Wung J.C., Chen Y.F., Charng M.J., et al. A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum Mol Genet 14 (2005) 1745-1751
    • (2005) Hum Mol Genet , vol.14 , pp. 1745-1751
    • Yuan, H.Y.1    Chen, J.J.2    Lee, M.T.3    Wung, J.C.4    Chen, Y.F.5    Charng, M.J.6
  • 11
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
    • Sconce E.A., Khan T.I., Wynne H.A., Avery P., Monkhouse L., King B.P., et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 106 (2005) 2329-2333
    • (2005) Blood , vol.106 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3    Avery, P.4    Monkhouse, L.5    King, B.P.6
  • 12
    • 33749258021 scopus 로고    scopus 로고
    • Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation
    • Li T., Lange L.A., Li X., Susswein L., Bryant B., Malone R., et al. Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J Med Genet 43 (2006) 740-744
    • (2006) J Med Genet , vol.43 , pp. 740-744
    • Li, T.1    Lange, L.A.2    Li, X.3    Susswein, L.4    Bryant, B.5    Malone, R.6
  • 14
    • 33645849823 scopus 로고    scopus 로고
    • Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
    • Aquilante C.L., Langaee T.Y., Lopez L.M., Yarandi H.N., Tromberg J.S., Mohuczy D., et al. Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements. Clin Pharmacol Ther 79 (2006) 291-302
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 291-302
    • Aquilante, C.L.1    Langaee, T.Y.2    Lopez, L.M.3    Yarandi, H.N.4    Tromberg, J.S.5    Mohuczy, D.6
  • 15
    • 34347403221 scopus 로고    scopus 로고
    • Estimation of Warfarin Maintenance Dose Based on VKORC1 (- 1639 G > A) and CYP2C9 Genotypes
    • Zhu Y., Shennan M., Reynolds K.K., Johnson N.A., Herrnberger M.R., Valdes Jr. R., et al. Estimation of Warfarin Maintenance Dose Based on VKORC1 (- 1639 G > A) and CYP2C9 Genotypes. Clin Chem 53 (2007) 1199-1205
    • (2007) Clin Chem , vol.53 , pp. 1199-1205
    • Zhu, Y.1    Shennan, M.2    Reynolds, K.K.3    Johnson, N.A.4    Herrnberger, M.R.5    Valdes Jr., R.6
  • 16
    • 13844315559 scopus 로고    scopus 로고
    • CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet™ systematic review and meta-analysis
    • Sanderson S., Emery J., and Higgins J. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet™ systematic review and meta-analysis. Genet Med 7 (2005) 97-104
    • (2005) Genet Med , vol.7 , pp. 97-104
    • Sanderson, S.1    Emery, J.2    Higgins, J.3
  • 17
    • 62549143945 scopus 로고    scopus 로고
    • Influence of CYP2C9 genotype on warfarin dose requirements-a systematic review and meta-analysis
    • [Electronic publication 2008 Nov 25]
    • Lindh J.D., Holm L., Andersson M.L., and Rane A. Influence of CYP2C9 genotype on warfarin dose requirements-a systematic review and meta-analysis. Eur J Clin Pharmacol 65 (2009) 365-375 [Electronic publication 2008 Nov 25]
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 365-375
    • Lindh, J.D.1    Holm, L.2    Andersson, M.L.3    Rane, A.4
  • 18
    • 33845260086 scopus 로고    scopus 로고
    • Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study
    • Carlquist J.F., Horne B.D., Muhlestein J.B., Lappé D.L., Whiting B.M., Kolek M.J., et al. Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study. J Thromb Thrombolysis 22 (2006) 191-197
    • (2006) J Thromb Thrombolysis , vol.22 , pp. 191-197
    • Carlquist, J.F.1    Horne, B.D.2    Muhlestein, J.B.3    Lappé, D.L.4    Whiting, B.M.5    Kolek, M.J.6
  • 19
    • 37349045083 scopus 로고    scopus 로고
    • Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians
    • Borgiani P., Ciccacci C., Forte V., Romano S., Federici G., and Novelli G. Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians. Pharmacogenomics 8 (2007) 1545-1550
    • (2007) Pharmacogenomics , vol.8 , pp. 1545-1550
    • Borgiani, P.1    Ciccacci, C.2    Forte, V.3    Romano, S.4    Federici, G.5    Novelli, G.6
  • 20
    • 68549087157 scopus 로고    scopus 로고
    • Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients
    • [Article in Chinese]
    • Jiang N.X., Song J., and Xu B. Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients. Zhonghua Xin Xue Guan Bing Za Zhi 35 (2007) 652-654 [Article in Chinese]
    • (2007) Zhonghua Xin Xue Guan Bing Za Zhi , vol.35 , pp. 652-654
    • Jiang, N.X.1    Song, J.2    Xu, B.3
  • 21
    • 34248580622 scopus 로고    scopus 로고
    • Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients
    • Kimura R., Miyashita K., Kokubo Y., Akaiwa Y., Otsubo R., Nagatsuka K., et al. Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients. Thromb Res 120 (2007) 181-186
    • (2007) Thromb Res , vol.120 , pp. 181-186
    • Kimura, R.1    Miyashita, K.2    Kokubo, Y.3    Akaiwa, Y.4    Otsubo, R.5    Nagatsuka, K.6
  • 22
    • 34548060277 scopus 로고    scopus 로고
    • Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients
    • Nakai K., Tsuboi J., Okabayashi H., Fukuhiro Y., Oka T., Habano W., et al. Ethnic differences in the VKORC1 gene polymorphism and an association with warfarin dosage requirements in cardiovascular surgery patients. Pharmacogenomics 8 (2007) 713-719
    • (2007) Pharmacogenomics , vol.8 , pp. 713-719
    • Nakai, K.1    Tsuboi, J.2    Okabayashi, H.3    Fukuhiro, Y.4    Oka, T.5    Habano, W.6
  • 23
    • 34247215617 scopus 로고    scopus 로고
    • Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians
    • Schelleman H., Chen Z., Kealey C., Whitehead A.S., Christie J., Price M., et al. Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians. Clin Pharmacol Ther 81 (2007) 742-747
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 742-747
    • Schelleman, H.1    Chen, Z.2    Kealey, C.3    Whitehead, A.S.4    Christie, J.5    Price, M.6
  • 24
    • 77949570024 scopus 로고    scopus 로고
    • Influence of VKORC1-1639G > A and CYP2C9 1061A/C polymorphisms on warfarin dose
    • [Article in Chinese]
    • Zhang W.P., Chen H., Luo J.W., and Wu X.Y. Influence of VKORC1-1639G > A and CYP2C9 1061A/C polymorphisms on warfarin dose. J Med Mol Biol 4 (2007) 396-400 [Article in Chinese]
    • (2007) J Med Mol Biol , vol.4 , pp. 396-400
    • Zhang, W.P.1    Chen, H.2    Luo, J.W.3    Wu, X.Y.4
  • 25
    • 46649090575 scopus 로고    scopus 로고
    • Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction
    • Haug K.B., Sharikabad M.N., Kringen M.K., Narum S., Sjaatil S.T., Johansen P.W., et al. Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction. Thromb J 6 (2008) 7
    • (2008) Thromb J , vol.6 , pp. 7
    • Haug, K.B.1    Sharikabad, M.N.2    Kringen, M.K.3    Narum, S.4    Sjaatil, S.T.5    Johansen, P.W.6
  • 26
    • 33746765022 scopus 로고    scopus 로고
    • VKORC1 gene variations are the major contributors of variation in warfarin dose in Japanese patients
    • Obayashi K., Nakamura K., Kawana J., Ogata H., Hanada K., Kurabayashi M., et al. VKORC1 gene variations are the major contributors of variation in warfarin dose in Japanese patients. Clin Pharmacol Ther 80 (2006) 169-178
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 169-178
    • Obayashi, K.1    Nakamura, K.2    Kawana, J.3    Ogata, H.4    Hanada, K.5    Kurabayashi, M.6
  • 27
    • 50849101979 scopus 로고    scopus 로고
    • VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients
    • Oner Ozgon G., Langaee T.Y., Feng H., Buyru N., Ulutin T., Hatemi A.C., et al. VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients. Eur J Clin Pharmacol 64 (2008) 889-894
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 889-894
    • Oner Ozgon, G.1    Langaee, T.Y.2    Feng, H.3    Buyru, N.4    Ulutin, T.5    Hatemi, A.C.6
  • 28
    • 59649117935 scopus 로고    scopus 로고
    • The largest prospective warfarin-treated cohort supports genetic forecasting
    • [Electronic publication 2008 Jun 23]
    • Wadelius M., Chen L.Y., Lindh J.D., Eriksson N., Ghori M.J., Bumpstead S., et al. The largest prospective warfarin-treated cohort supports genetic forecasting. Blood 113 (2009) 784-792 [Electronic publication 2008 Jun 23]
    • (2009) Blood , vol.113 , pp. 784-792
    • Wadelius, M.1    Chen, L.Y.2    Lindh, J.D.3    Eriksson, N.4    Ghori, M.J.5    Bumpstead, S.6
  • 29
    • 67249147218 scopus 로고    scopus 로고
    • Effect of VKORC1 - 1639 G A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients
    • [Electronic publication, 2009 Jan 9]
    • Yoshizawa M., Hayashi H., Tashiro Y., Sakawa S., Moriwaki H., Akimoto T., et al. Effect of VKORC1 - 1639 G A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients. Thromb Res 124 2 (2009) 161-166 [Electronic publication, 2009 Jan 9]
    • (2009) Thromb Res , vol.124 , Issue.2 , pp. 161-166
    • Yoshizawa, M.1    Hayashi, H.2    Tashiro, Y.3    Sakawa, S.4    Moriwaki, H.5    Akimoto, T.6
  • 32
    • 34248589343 scopus 로고    scopus 로고
    • Identifying the genotype behind the phenotype a role model found in VKORC1 and its association with warfarin dosing
    • Crawford D.C., Ritchie M., and Rieder M.J. Identifying the genotype behind the phenotype a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics 8 (2007) 487-496
    • (2007) Pharmacogenomics , vol.8 , pp. 487-496
    • Crawford, D.C.1    Ritchie, M.2    Rieder, M.J.3
  • 33
    • 38049181030 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues
    • Gage B.F., and Lesko L.J. Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues. J Thromb Thrombolysis 25 (2008) 45-51
    • (2008) J Thromb Thrombolysis , vol.25 , pp. 45-51
    • Gage, B.F.1    Lesko, L.J.2
  • 34
    • 27744485315 scopus 로고    scopus 로고
    • A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data
    • Hillman M.A., Wilke R.A., Yale S.H., Vidaillet H.J., Caldwell M.D., Glurich I., et al. A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data. Clin Med Res 3 (2005) 137-145
    • (2005) Clin Med Res , vol.3 , pp. 137-145
    • Hillman, M.A.1    Wilke, R.A.2    Yale, S.H.3    Vidaillet, H.J.4    Caldwell, M.D.5    Glurich, I.6
  • 35
    • 36549030324 scopus 로고    scopus 로고
    • Carlquist JF; Couma-Gen Investigators. Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    • Anderson J.L., Horne B.D., Stevens S.M., Grove A.S., Barton S., Nicholas Z.P., et al. Carlquist JF; Couma-Gen Investigators. Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation. Circulation 116 (2007) 2563-2570
    • (2007) Circulation , vol.116 , pp. 2563-2570
    • Anderson, J.L.1    Horne, B.D.2    Stevens, S.M.3    Grove, A.S.4    Barton, S.5    Nicholas, Z.P.6
  • 38
    • 38349098717 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans
    • Kimmel S.E., Christie J., Kealey C., Chen Z., Price M., Thorn C.F., et al. Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans. Pharmacogenomics J 8 (2008) 53-60
    • (2008) Pharmacogenomics J , vol.8 , pp. 53-60
    • Kimmel, S.E.1    Christie, J.2    Kealey, C.3    Chen, Z.4    Price, M.5    Thorn, C.F.6
  • 39
    • 35448960483 scopus 로고    scopus 로고
    • γ-Glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose
    • Rieder M.J., Reiner A.P., and Rettie A.E. γ-Glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose. J Thromb Haemost 5 (2007) 2227-2234
    • (2007) J Thromb Haemost , vol.5 , pp. 2227-2234
    • Rieder, M.J.1    Reiner, A.P.2    Rettie, A.E.3
  • 40
    • 34848854159 scopus 로고    scopus 로고
    • High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population
    • Cha P.C., Mushiroda T., Takahashi A., Saito S., Shimomura H., Suzuki T., et al. High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population. J Hum Genet 52 (2007) 856-864
    • (2007) J Hum Genet , vol.52 , pp. 856-864
    • Cha, P.C.1    Mushiroda, T.2    Takahashi, A.3    Saito, S.4    Shimomura, H.5    Suzuki, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.