Effects of free fatty acids on human salivary gland epithelial cells

Journal of Dental Research

Volumn 92, Issue 6, 2013, Pages 540-546

  Shikama, Y ^a   Ishimaru, N ^b   Kudo, Y ^b   Bando, Y ^a   Aki, N ^a,c   Hayashi, Y ^b   Funaki, M ^a  

^a TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

alpha fodrin; apoptosis; interleukin 6; lipids; palmitate; Sj gren's syndrome

Indexed keywords

ACTIN BINDING PROTEIN; AUTACOID; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASPASE 3; ENZYME INHIBITOR; FATTY ACID; FODRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPID; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PALMITIC ACID; PALMITIC ACID DERIVATIVE; STEARIC ACID DERIVATIVE; UNSATURATED FATTY ACID;

ALPHA-FODRIN; APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; HUMAN; KERATINOCYTE; MOUTH TUMOR; PAROTID GLAND; PATHOLOGY; PHOSPHORYLATION; SJÖGREN'S SYNDROME; SJOEGREN SYNDROME; SQUAMOUS CELL CARCINOMA; SUBMANDIBULAR GLAND; TUMOR CELL LINE;

ALPHA-FODRIN; APOPTOSIS; INTERLEUKIN-6; LIPIDS; PALMITATE; SJÖGREN'S SYNDROME;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CASPASE 3; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; EPITHELIAL CELLS; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, UNSATURATED; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; KERATINOCYTES; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MOUTH NEOPLASMS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITATES; PAROTID GLAND; PHOSPHORYLATION; SJOGREN'S SYNDROME; STEARATES; SUBMANDIBULAR GLAND;

EID: 84877849358     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034513487378     Document Type: Article

References (29)

1. Ajibade AA, Wang Q, Cui J, Zou J, Xia X, Wang M, et al. TAK1 negatively regulates NF-kappaB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. Immunity. 2012 ; 36: 43-54
2. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006 ; 124: 783-801 (Pubitemid 43261452)
3. Boden G. Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care. 2002 ; 5: 545-549 (Pubitemid 40684651)
4. Carafoli E, Molinari M. Calpain: a protease in search of a function?. Biochem Biophys Res Commun. 1998 ; 247: 193-203 (Pubitemid 28420799)
5. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell. 1996 ; 84: 853-862 (Pubitemid 26106855)
6. Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem Soc Trans. 2008 ; 36 (Pt 3). 348-352 (Pubitemid 351839329)
7. Cousin SP, Hugl SR, Wrede CE, Kajio H, Myers MG, Rhodes CJ. Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Endocrinology. 2001 ; 142: 229-240 (Pubitemid 32183685)
8. Dasu MR, Jialal I. Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab. 2011 ; 300: E145 - E154
9. Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, et al. Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation. Cell Metab. 2012 ; 15: 518-533
10. Goldman JA, Julian EH. Pseudo-Sjogren syndrome with hyperlipoproteinemia. J Am Med Assoc. 1977 ; 237: 1582-1584
11. Hall BE, Zheng C, Swaim WD, Cho A, Nagineni CN, Eckhaus MA, et al. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest. 2010 ; 90: 543-555
12. Haneji N, Nakamura T, Takio K, Yanagi K, Higashiyama H, Saito I, et al. Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren's syndrome. Science. 1997 ; 276: 604-607 (Pubitemid 27193686)
13. Hardy S, Langelier Y, Prentki M. Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res. 2000 ; 60: 6353-6358
14. Hill JO. Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev. 2006 ; 27: 750-761 (Pubitemid 44936058)
15. Isley WL, Harris WS, Miles JM. The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus. Metabolism. 2006 ; 55: 758-762
16. Kang JH, Lin HC. Comorbidities in patients with primary Sjogren's syndrome: a registry-based case-control study. J Rheumatol. 2010 ; 37: 1188-1194
17. Kurimoto C, Kawano S, Tsuji G, Hatachi S, Jikimoto T, Sugiyama D, et al. Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjogren's syndrome. J Rheumatol. 2007 ; 34: 2035-2043 (Pubitemid 47548207)
18. Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE. Diabetes and apoptosis: lipotoxicity. Apoptosis. 2009 ; 14: 1484-1495
19. Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem. 2001 ; 276: 14890-14895
20. Manoussakis MN, Kapsogeorgou EK. The role of epithelial cells in the pathogenesis of Sjogren's syndrome. Clin Rev Allergy Immunol. 2007 ; 32: 225-230 (Pubitemid 350242568)
21. Manoussakis MN, Kapsogeorgou EK. The role of intrinsic epithelial activation in the pathogenesis of Sjogren's syndrome. J Autoimmun. 2010 ; 35: 219-224
22. Ramos-Casals M, Brito-Zerón P, Sisó A, Vargas A, Ros E, Bove A, et al. High prevalence of serum metabolic alterations in primary Sjogren's syndrome: influence on clinical and immunological expression. J Rheumatol. 2007 ; 34: 754-761 (Pubitemid 46641382)
23. Sekiguchi M, Iwasaki T, Kitano M, Kuno H, Hashimoto N, Kawahito Y, et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjogren's syndrome. J Immunol. 2008 ; 180: 1921-1928
24. Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada H, et al. Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1beta and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). Innate Immun. 2011 ; 17: 3-15
25. Shirasuna K, Sato M, Miyazaki T. A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer. 1981 ; 48: 745-752 (Pubitemid 11075229)
26. Spachidou MP, Bourazopoulou E, Maratheftis CI, Kapsogeorgou EK, Moutsopoulos HM, Tzioufas AG, et al. Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren's syndrome. Clin Exp Immunol. 2007 ; 147: 497-503 (Pubitemid 46208051)
27. Wang X, McLennan SV, Allen TJ, Tsoutsman T, Semsarian C, Twigg SM. Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. Am J Physiol Cell Physiol. 2009 ; 297: C1490 - C1500
28. Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011 ; 12: 408-415
29. Yanagawa T, Hayashi Y, Nagamine S, Yoshida H, Yura Y, Sato M. Generation of cells with phenotypes of both intercalated duct-type and myoepithelial cells in human parotid gland adenocarcinoma clonal cells grown in athymic nude mice. Virchows Arch B Cell Pathol Incl Mol Pathol. 1986 ; 51: 187-195 (Pubitemid 16084105)