Development of cell-active non-peptidyl inhibitors of cysteine cathepsins

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 2975-2987

  Dana, Dibyendu ^a   Davalos, Anibal R ^a   De, Shatarupa ^a   Rathod, Pratikkumar ^a,b   Gamage, Ranjith K ^a   Huestis, Juliana ^a   Afzal, Nisar ^a   Zavlanov, Yuriy ^a   Paroly, Suneeta S ^a   Rotenberg, Susan A ^a   Subramaniam, Gopal ^a   Mark, Kevin J ^b   Chang, Emmanuel J ^b   Kumar, Sanjai ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cancer metastasis; Cathepsin inhibitor; Cell migration; Cysteine protease inhibitor; Sulfonyloxiranes

Indexed keywords

2 (2 ETHYLPHENYLSULFONYL)OXIRANE; 2 (2,5 DIMETHOXYPHENYLSULFONYL)OXIRANE; 2 (2,5 DIMETHYLPHENYLSULFONYL)OXIRANE; 2 (3 METHOXYPHENYLSULFONYL)OXIRANE; 2 (3 TOLYLSULFONYL)OXIRANE; 2 (3,5 DICHLOROPHENYLSULFONYL)OXIRANE; 2 (4 FLUOROPHENYL) 3 (PHENYLSULFONYL)OXIRANE; 2 (NAPHTHALEN 3 YLSULFONYL)OXIRANE; 2 (PHENYLSULFONYL) 3 PROPYLOXIRANE; 2 [(4 CHLOROPHENYL)SULFONYL]OXIRANE; 2 [(PHENYLSULFONYL)METHYL]OXIRANE; 2 [(PHENYLSULFONYL)METHYL]THIIRANE; 2 [4 (TRIFLUOROMETHOXY)PHENYLSULFONYL]OXIRANE; CATHEPSIN; CYSTEINE PROTEINASE INHIBITOR; SULFONYLOXIRANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST METASTASIS; CANCER CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MIGRATION INHIBITION;

CATHEPSINS; CELL LINE, TUMOR; CELL MOVEMENT; CYSTEINE; CYSTEINE PROTEINASE INHIBITORS; EPOXY COMPOUNDS; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THERMODYNAMICS;

EID: 84877834358     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.062     Document Type: Article

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