Distinct inhibitory efficiency of siRNAs and DNAzymes to β1 integrin subunit in blocking tumor growth

Acta Biochimica Polonica

Volumn 60, Issue 1, 2013, Pages 77-82

  Wiktorska, Magdalena ^a   Sacewicz Hofman, Izabela ^a   Stasikowska Kanicka, Olga ^a   Danilewicz, Marian ^a   Niewiarowska, Jolanta ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Adhesion; Invasiveness; Tumor angiogenesis; Tumor growth; 1 integrins

Indexed keywords

EID: 84877811662     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2013_1954     Document Type: Article

References (34)

1. Albelda SM (1993) Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 68: 4-17.
2. Barnes PJ (2008) Role of GATA-3 in allergic diseases. Curr Mol Med 8: 330-334.
3. Bertrand JR, Pottier M, Vekris A, Opolon P, Maksimenko A, Malvy C (2002) Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. Biochem Biophys Res Commun 296: 1000-1004.
4. Cieslak M, Niewiarowska J, Nawrot M, Koziolkiewicz M, Stec WJ, Cierniewski CS (2002) DNAzymes to β1 and β3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel. J Biol Chem 277: 6779-6787.
5. Cieslak M, Szymanski J, Adamiak RW, Cierniewski, CS (2003) Structural rearrangements of the 10-23 DNAzyme to β3 integrin subunit mRNA induced by cations and their relations to the catalytic activity. J Biol Chem 278: 47987-47996.
6. Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR (2005) β1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res 65: 6692-6700.
7. Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR (2004) Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β1 integrins. J Cell Biol 166: 407-418.
8. Hannon GJ (2002) RNA interference. Nature 418: 244-251.
9. Holly SP, Larson MK Parise LV (2000) Multiple roles of integrins in cell motility. Exp Cell Res 261: 69-74.
10. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25.
11. Isaka Y (2007) DNAzymes as potential therapeutic molecules. Curr Opin Mol Ther 9: 132-136.
12. Jackson AL, Bartz SR, Schelter, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21: 635-637.
13. Kohlgraf KG, Gawron AJ, Higashi M, Meza JL, Burdick MD, Kitajima S, Kelly DL, Caffrey TC, Hollingsworth MA (2003) Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Cancer Res 63: 5011-5020.
14. Ma WW, Adjei AA (2009) Novel agents on the horizon for cancer therapy. CA Cancer J Clin 59: 111-137.
15. Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR (2003) Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol 161: 817-826.
16. Mukherjee P. Tinder TL, Basu GD, Gendler SJ (2005) MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells. J Leukoc Biol 77: 90-99.
17. Niewiarowska J, Sacewicz I, Wiktorska M, Wysocki T, Stasikowska O, Wagrowska-Danilewicz M, Cierniewski CS (2009) DNAzymes to mouse beta1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth. Cancer Gene Ther 16: 713-22.
18. Petrocca F, Lieberman J (2011) Promise and challenge of RNA interference- based therapy for cancer. J Clin Oncol 29: 747-754.
19. Pignatelli M, Hanby AM, Stamp GW (1991) Low expression of β1, a2 and a3 subunits of VLA integrins in malignant mammary tumours. J Pathol 165: 25-32.
20. Rathinam R, Alahari SK (2010) Important role of integrins in the cancer biology. Cancer Metastasis Rev 29: 223-237.
21. Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L, Raina D, Chen W, Kharbanda S, Kufe D (2004) Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell 5: 163-175.
22. Santoro SW, Joyce GF (1998) Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry 37: 13330-13342.
23. Schiffelers RM, Woodle MC, Scaria P (2004) Pharmaceutical prospects for RNA interference. Pharm Res 21: 1-7.
24. Schubert S, Gul DC, Grunert HP, Zeichhardt H, Erdmann VA, Kurreck J (2003) RNA cleaving '10-23' DNAzymes with enhanced stability and activity. Nucleic Acids Res 31: 5982-5992.
25. Schubert S, Kurreck J (2004) Ribozyme and deoxyribozyme strategies for medical applications. Curr Drug Targets 5: 667-681.
26. Sel M, Wegmann T, Dicke S, Sel W, Henke AO, Yildirim H, Renz H, Garn H (2008) Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme. J Allergy Clin Immunol 121: 910-916.
27. Silverman SK (2005) In vitro selection, characterization, and application of deoxyribozymes that cleave RNA. Nucleic Acids Res 33: 6151-6163.
28. Sioud M (2006) Innate sensing of self and non-self RNAs by toll-like receptors. Trends Mol Med 12: 167-176.
29. Tritz R, Habita C, Robbins JM, Gomez GG, Kruse CA (2005) Catalytic nucleic acid enzymes for the study and development of therapies in the central nervous system: review article. Gene Ther Mol Biol 9A: 89-106.
30. Uhm JH, Gladson CL, Rao JS (1999) The role of integrins in the malignant phenotype of gliomas. Front Biosci 4D: 188-199.
31. Wiktorska M, Papiewska-Pajak I, Okruszek A, Sacewicz-Hofman I, Niewiarowska J (2010) DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells. Acta Biochim Polon 57: 269-275.
32. Yazji S, Bokowski R, Kondagunta V, Figlin R (2007) Final results from phase II study of volociximab, an a5β1 anti-integrin antibody, in refractory or relapsed metastatic clear cell renal cell carcinoma (mCCRCC). J Clin Oncol 18S (Suppl): 5094 (abstract).
33. Zhu J, Yamane H, Cote-Sierra J, Guo L, Paul WE (2006) GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res 16: 3-10.
34. Zutter MM, Mazoujian G, Santoro SA (1990) Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am J Pathol 137: 863-870.