Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer

Oncology Research

Volumn 18, Issue 2-3, 2009, Pages 107-116

  Lee, Kyung Hee ^a   Kim, Jae Ryong ^a  

^a Yeungnam University College of Medicine   (South Korea)

Author keywords

Hepatocyte growth factor (HGF); Kiss 1; Matrix metalloproteinase 9 (MMP 9); Metastasis

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; METASTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; SCATTER FACTOR; SHORT HAIRPIN RNA; FLAVONOID; IMIDAZOLE DERIVATIVE; KISS1 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UPREGULATION; CANCER INVASION; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; PHYSIOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ENZYME ACTIVATION; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTE GROWTH FACTOR; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 75649113791     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504009789954591     Document Type: Article

References (25)

1. Lee, J. H.; Miele, M. E.; Hicks, D. J.; Phillips, K. K.; Trent, J. M.; Weissman, B. E.; Welch, D. R. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl. Cancer Inst. 88:1731-1737; 1996.
2. Lee, J. H.; Welch, D. R. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 57:2384-2387; 1997.
3. Kotani, M.; Detheux, M.; Vandenbogaerde, A.; Communi, D.; Vanderwinden, J. M.; Le Poul, E.; Brezillon, S.; Tyldesley, R.; Suarez-Huerta, N.; Vandeput, F.; Blanpain, C.; Schiffmann, S. N.; Vassart, G.; Pamentier, M. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR 54. J. Biol. Chem. 276:34631-34616; 2001.
4. Muir, A. I.; Chamberlain, L.; Elshourbagy, N. A.; Michalovich, D.; Moore, D. J.; Calamari, A.; Szekeres, P. G.; Sarau, H. M.; Chambers, J. K.; Murdock, P.; Steplewski, K.; Shabon, U.; Miller, J. E.; Middleton, S. E.; Darker, J. G.; Larminie, C. G.; Wilson, S.; Bergsma, D. J.; Emson, P.; Faull, R.; Philpott, K. L.; Harrison, D. C. AXOR12, novel human G protein-coupled receptor, activated by the peptide Kiss-1. J. Biol. Chem. 276:28969-28975; 2001.
5. Lee, J. H.; Welch, D. R. Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display. Int. J. Cancer 71:1035-1044; 1997.
6. Miyajima, Y.; Nakano, R.; Morimatsu, M. Analysis of expression of matrix metalloproteinases-2 and -9 in hypopharyngeal squamous cell carcinoma by in situ hybridization. Ann. Otol. Rhinol. Laryngol. 104:678-684; 1995.
7. Bernhard, E. J.; Gruber, S. B.; Muschel, R. J. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci. USA 91:4293-4297; 1994.
8. Hua, J.; Muschel, R. J. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res. 56:5279-5284; 1996.
9. Dong, J. T.; Lamb, P. W.; Rinker-Schaeffer, C. W.; Vukanovic, J.; Ichikawa, T.; Isaacs, J. T.; Barrett, J. C. KAI 1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268:884-886; 1995.
10. Christensen, C. R.; Klingelhofer, J.; Tarabykina, S.; Hulgaard, E. F.; Kramerov, D.; Lukanidin, E. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 58:1238-1244; 1998.
11. Takino, N.; Koshikawa, H.; Miyamori, M.; Tanaka, T.; Sasaki, Y.; Okada, M.; Seiki, M.; Sato, H. Cleavage of metastasis suppressor gene product Kiss-1 protein/metastin by matrix metalloproteinases. Oncogene 22:4617-4626; 2003.
12. Yang, S. H.; Kim, J. S.; Oh, T. J.; Kim, M. S.; Lee, S. W.; Woo, S. K.; Cho, H. S.; Choi, Y. H.; Kim, Y. H.; Rha, S. Y.; Chung, H. C.; An, S. W. Genome-scale analysis of resveratrol-induced gene expression profile in human ovarian cancer cells using a cDNA microarray. Int. J. Oncol. 22:741-750; 2003.
13. Ries, L. A. G.; Eisner, M. P.; Kosary, C. L.; Hankey, B. F.; Miller, B. A.; Clegg, L.; Mariotto, A.; Feuer, E. J.; Edwards, B. K. SEER cancer statistics review. Bethesda, MD: National Cancer Institute; 2004.
14. Sanchez-Carbayo, M.; Capodieci, P.; Cordon-Cardo, C. Tumor suppressor role of KiSS-1 in bladder cancer. Loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am. J. Pathol. 162: 609-617; 2003.
15. Shirasaki, F.; Takata, M.; Hatta, N.; Takehara, K. Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res. 61:7422-7425; 2001.
16. Ringel, M. D.; Hardy, E.; Bernet, V. J.; Burch, H. B.; Schuppert, F.; Burman, K. D.; Saji, M. Metastin receptor is overexpressed in papillary thyroid cencer and activates MAP kinase in thyroid cancer cells. J. Clin. Endocrinol. Metab. 87:2399-2402; 2002.
17. Vu, T. H.; Shipley, J. M.; Bergers, G.; Berger, J. E.; Helms, J. A.; Hanahan, D.; Shapiro, S. D.; Senior, R. M.; Werb, Z. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93:411-422; 1998.
18. Yu, Q.; Stamenkovic, I. Genomic organization and promoter analysis of the murine Id3 gene. Gene 14:163-176; 2000.
19. Tan, C.; Wang, H.; Boyd, D. D. KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NFkB binding to the promoter as a consequence of IkBα-induced block of p65/p50 nuclear translocation. J. Biol. Chem. 276:1164-1172; 2001.
20. Sato, H.; Kita, M.; Seiki, M. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. J. Biol. Chem. 268:23460-23468; 1993.
21. Gum, R.; Lengyel, E.; Juarez, J.; Chen, J. H.; Sato, H.; Seiki, M.; Boyd, D. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J. Biol. Chem. 271:10672-10682; 1996.
22. Masui, T.; Doi, R.; Mori, T.; Toyoda, E.; Koizumi, M.; Kami, K.; Ito, D.; Peiper, S. C.; Broach, J. R.; Oishi, S.; Niida, A.; Fujii, N.; Imamura, M. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem. Biophys. Res. Commun. 315:85-92; 2004.
23. Ringel, M. D.; Hardy, E.; Bernet, V. J.; Burch, H. B.; Schuppert, F.; Burman, K. D.; Saji, M. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP Kinase in thyroid cancer cells. J. Clin. Endocrinol. Metab. 87:2399; 2002.
24. Kotani, M.; Detheux, M.; Vandenbogaerde, A.; Communi, D.; Vanderwinden, J. M.; Le Poul, E.; Brezillon, S.; Tyldesley, R.; Suarez-Huerta, N.; Vandeput, F.; Blanpain, C.; Schiffmann, S. N.; Vassart, G.; Parmentier, M. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276:34631-34636; 2001.
25. Stafford, L. J.; Xia, C.; Ma, W.; Cai, Y.; Liu, M. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 62:5399-5404; 2002.