The 2′-trifluoromethyl analogue of indomethacin is a potent and selective COX-2 inhibitor

ACS Medicinal Chemistry Letters

Volumn 4, Issue 5, 2013, Pages 486-490

  Blobaum, Anna L ^a   Uddin, Md Jashim ^a   Felts, Andrew S ^a   Crews, Brenda C ^a   Rouzer, Carol A ^a   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

arachidonic acid; coxib; Cyclooxygenase; inflammation; nonsteroidal anti inflammatory drug; prostaglandin

Indexed keywords

ANTIINFLAMMATORY AGENT; CARRAGEENAN; CF3 INDOMETHACIN; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HYDROPHOBICITY; IC 50; IN VIVO STUDY; KINETICS; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; SUBSTITUTION REACTION;

EID: 84877716794     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400066a     Document Type: Article

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