-
1
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
DOI 10.1158/1078-0432.CCR-05-1554
-
M. Scaltriti, J. Baselga The epidermal growth factor receptor pathway: a model for targeted therapy Clin Cancer Res 12 2006 5268 5272 (Pubitemid 44497237)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.18
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
2
-
-
0033992633
-
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
-
L.N. Klapper, M.H. Kirschbaum, M. Sela Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors Adv Cancer Res 77 2000 25 79 (Pubitemid 29439302)
-
(2000)
Advances in Cancer Research
, vol.77
, pp. 25-79
-
-
Klapper, L.N.1
Kirschbaum, M.H.2
Sela, M.3
Yarden, Y.4
-
3
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
DOI 10.1093/emboj/16.7.1647
-
D. Graus-Porta, R.R. Beerli, J.M. Daly ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling EMBO J 16 1997 1647 1655 (Pubitemid 27151960)
-
(1997)
EMBO Journal
, vol.16
, Issue.7
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
4
-
-
0037099732
-
Evaluation of HER-2/neu gene amplification and overexpression: Comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens
-
DOI 10.120/JCO.2002.09.094
-
M.F. Press, D.J. Slamon, K.J. Flom Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens J Clin Oncol 20 2002 3095 3105 (Pubitemid 34791099)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.14
, pp. 3095-3105
-
-
Press, M.F.1
Slamon, D.J.2
Flom, K.J.3
Park, J.4
Zhou, J.-Y.5
Bernstein, L.6
-
5
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
D.J. Slamon, G.M. Clark, S.G. Wong Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 1987 177 182 (Pubitemid 17231334)
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
6
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
D.J. Slamon, W. Godolphin, L.A. Jones Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer Science 244 1989 707 712 (Pubitemid 19147683)
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
Press, M.F.11
-
7
-
-
34547854801
-
The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
-
DOI 10.1038/sj.onc.1210477, PII 1210477
-
M.M. Moasser The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis Oncogene 26 2007 6469 6487 (Pubitemid 47530601)
-
(2007)
Oncogene
, vol.26
, Issue.45
, pp. 6469-6487
-
-
Moasser, M.M.1
-
8
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2
-
DOI 10.1056/NEJM200103153441101
-
D.J. Slamon, B. Leyland-Jones, S. Shak Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 N Engl J Med 344 2001 783 792 (Pubitemid 32222155)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
9
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
DOI 10.1158/0008-5472.CAN-04-3841
-
R. Nahta, L.X. Yuan, B. Zhang Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells Cancer Res 65 2005 11118 11128 (Pubitemid 41713383)
-
(2005)
Cancer Research
, vol.65
, Issue.23
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.H.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
10
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to transtuzumab (Herceptin)
-
Y. Lu, X. Zi, Y. Zhao Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin) J Natl Cancer Inst 93 2001 1852 1857 (Pubitemid 34048651)
-
(2001)
Journal of the National Cancer Institute
, vol.93
, Issue.24
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
Mascarenhas, D.4
Pollak, M.5
-
11
-
-
73349085919
-
Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
-
N.L. Spector, K.L. Blackwell Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer J Clin Oncol 27 2009 5838 5847
-
(2009)
J Clin Oncol
, vol.27
, pp. 5838-5847
-
-
Spector, N.L.1
Blackwell, K.L.2
-
12
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
DOI 10.1200/JCO.2003.01.504
-
J. Mendelsohn, J. Baselga Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer J Clin Oncol 21 2003 2787 2799 (Pubitemid 46606324)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.14
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
13
-
-
17844372539
-
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
-
DOI 10.1200/JCO.2005.11.890
-
J. Baselga, C.L. Arteaga Critical update and emerging trends in epidermal growth factor receptor targeting in cancer J Clin Oncol 23 2005 2445 2459 (Pubitemid 47050835)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2445-2459
-
-
Baselga, J.1
Arteaga, C.L.2
-
14
-
-
25144517586
-
Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab
-
R.D. Mass, M.F. Press, S. Anderson Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab Clin Breast Cancer 6 2005 240 246 (Pubitemid 47050800)
-
(2005)
Clinical Breast Cancer
, vol.6
, Issue.3
, pp. 240-246
-
-
Mass, R.D.1
Press, M.F.2
Anderson, S.3
Cobleigh, M.A.4
Vogel, C.L.5
Dybdal, N.6
Leiberman, G.7
Slamon, D.J.8
Paton, V.E.9
-
15
-
-
43249115659
-
Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: Final results of Cancer and Leukemia Group B protocol 9840
-
A.D. Seidman, D. Berry, C. Cirrincione Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840 J Clin Oncol 26 2008 1642 1649
-
(2008)
J Clin Oncol
, vol.26
, pp. 1642-1649
-
-
Seidman, A.D.1
Berry, D.2
Cirrincione, C.3
-
16
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
DOI 10.1200/JCO.2005.01.014
-
J. Baselga, X. Carbonell, N.J. Castaneda-Soto Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule J Clin Oncol 23 2005 2162 2171 (Pubitemid 46218708)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.10
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.-J.3
Clemens, M.4
Green, M.5
Harvey, V.6
Morales, S.7
Barton, C.8
Ghahramani, P.9
-
17
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
DOI 10.1200/JCO.20.3.719
-
C.L. Vogel, M.A. Cobleigh, D. Tripathy Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer J Clin Oncol 20 2002 719 726 (Pubitemid 34111379)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.3
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
Press, M.13
-
18
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
M.A. Cobleigh, C.L. Vogel, D. Tripathy Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease J Clin Oncol 17 1999 2639 2648 (Pubitemid 29415219)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.9
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
Robert, N.J.4
Scholl, S.5
Fehrenbacher, L.6
Wolter, J.M.7
Paton, V.8
Shak, S.9
Lieberman, G.10
Slamon, D.J.11
-
19
-
-
2942659576
-
Rational combinations of Trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
M.D. Pegram, G.E. Konecny, C. O'Callaghan Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer J Natl Cancer Inst 96 2004 739 749 (Pubitemid 38771819)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.10
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'Callaghan, C.3
Beryt, M.4
Pietras, R.5
Slamon, D.J.6
-
20
-
-
34548178720
-
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
-
DOI 10.1002/cncr.22885
-
H.J. Burstein, A. Keshaviah, A.D. Baron Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study Cancer 110 2007 965 972 (Pubitemid 47312860)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 965-972
-
-
Burstein, H.J.1
Keshaviah, A.2
Baron, A.D.3
Hart, R.D.4
Lambert-Falls, R.5
Marcom, P.K.6
Gelman, R.7
Winer, E.P.8
-
21
-
-
0036409086
-
+ metastatic breast cancer
-
DOI 10.1634/theoncologist.7-5-410
-
M. Jahanzeb, J.E. Mortimer, F. Yunus Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2(+) metastatic breast cancer Oncologist 7 2002 410 417 (Pubitemid 35266133)
-
(2002)
Oncologist
, vol.7
, Issue.5
, pp. 410-417
-
-
Jahanzeb, M.1
Mortimer, J.E.2
Yunus, F.3
Irwin, D.H.4
Speyer, J.5
Koletsky, A.J.6
Klein, P.7
Sabir, T.8
Kronish, L.9
-
22
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
DOI 10.1200/JCO.2005.04.173
-
M. Marty, F. Cognetti, D. Maraninchi Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group J Clin Oncol 23 2005 4265 4274 (Pubitemid 46207001)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.19
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
Snyder, R.4
Mauriac, L.5
Tubiana-Hulin, M.6
Chan, S.7
Grimes, D.8
Anton, I.9
Lluch, A.10
Kennedy, J.11
O'Byrne, K.12
Conte, P.13
Green, M.14
Ward, C.15
Mayne, K.16
Extra, J.-M.17
-
23
-
-
37249055069
-
A phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial
-
DOI 10.1007/s00280-007-0497-5
-
D. Yamamoto, S. Iwase, K. Kitamura A phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial Cancer Chemother Pharmacol 61 2008 509 514 (Pubitemid 350275987)
-
(2008)
Cancer Chemotherapy and Pharmacology
, vol.61
, Issue.3
, pp. 509-514
-
-
Yamamoto, D.1
Iwase, S.2
Kitamura, K.3
Odagiri, H.4
Yamamoto, C.5
Nagumo, Y.6
-
24
-
-
84856042576
-
Phase II study of the combination of oral vinorelbine (NVBo), capecitabine (X), and trastuzumab (H) in HER2-positive, metastatic breast cancer (MBC): Recent analysis of the results with a median follow-up of 44 months
-
[abstract 1077]
-
L.B. Petruzelka, V. Ganju, D. Becquart Phase II study of the combination of oral vinorelbine (NVBo), capecitabine (X), and trastuzumab (H) in HER2-positive, metastatic breast cancer (MBC): recent analysis of the results with a median follow-up of 44 months J Clin Oncol 28 2010 [abstract 1077]
-
(2010)
J Clin Oncol
, vol.28
-
-
Petruzelka, L.B.1
Ganju, V.2
Becquart, D.3
-
25
-
-
58149250717
-
A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer
-
D.A. Yardley, H.A. Burris III, L. Simons A phase II trial of gemcitabine/carboplatin with or without trastuzumab in the first-line treatment of patients with metastatic breast cancer Clin Breast Cancer 8 2008 425 431
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 425-431
-
-
Yardley, D.A.1
Burris Iii, H.A.2
Simons, L.3
-
26
-
-
79951974161
-
Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA study
-
M. Andersson, E. Lidbrink, K. Bjerre Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study J Clin Oncol 29 2011 264 271
-
(2011)
J Clin Oncol
, vol.29
, pp. 264-271
-
-
Andersson, M.1
Lidbrink, E.2
Bjerre, K.3
-
27
-
-
65349110371
-
Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A german breast group 26/breast international group 03-05 study
-
G. Von Minckwitz, B.A. du, M. Schmidt Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study J Clin Oncol 27 2009 1999 2006
-
(2009)
J Clin Oncol
, vol.27
, pp. 1999-2006
-
-
Von Minckwitz, G.1
Du, B.A.2
Schmidt, M.3
-
28
-
-
49749094419
-
Trastuzumab and gemcitabine as salvage therapy in heavily pre-treated patients with metastatic breast cancer
-
R. Bartsch, C. Wenzel, S.P. Gampenrieder Trastuzumab and gemcitabine as salvage therapy in heavily pre-treated patients with metastatic breast cancer Cancer Chemother Pharmacol 62 2008 903 910
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 903-910
-
-
Bartsch, R.1
Wenzel, C.2
Gampenrieder, S.P.3
-
29
-
-
0036498781
-
Cardiac dysfunction in the trastuzumab clinical trials experience
-
DOI 10.1200/JCO.20.5.1215
-
A. Seidman, C. Hudis, M.K. Pierri Cardiac dysfunction in the trastuzumab clinical trials experience J Clin Oncol 20 2002 1215 1221 (Pubitemid 34177427)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.5
, pp. 1215-1221
-
-
Seidman, A.1
Hudis, C.2
Kathryn Pierri, M.3
Shak, S.4
Paton, V.5
Ashby, M.6
Murphy, M.7
Stewart, S.J.8
Keefe, D.9
-
30
-
-
34548444589
-
Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: A meta-analysis of published randomized trials
-
G.A. Viani, S.L. Afonso, E.J. Stefano Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials BMC Cancer 7 2007 153
-
(2007)
BMC Cancer
, vol.7
, pp. 153
-
-
Viani, G.A.1
Afonso, S.L.2
Stefano, E.J.3
-
31
-
-
55249119148
-
HER-2-positive metastatic breast cancer: Trastuzumab and beyond
-
G. Metro, M. Mottolese, A. Fabi HER-2-positive metastatic breast cancer: trastuzumab and beyond Expert Opin Pharmacother 9 2008 2583 2601
-
(2008)
Expert Opin Pharmacother
, vol.9
, pp. 2583-2601
-
-
Metro, G.1
Mottolese, M.2
Fabi, A.3
-
32
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to Anti-HER2 therapies in breast cancer
-
DOI 10.1093/jnci/djk134
-
M. Scaltriti, F. Rojo, A. Ocana Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer J Natl Cancer Inst 99 2007 628 638 (Pubitemid 47073544)
-
(2007)
Journal of the National Cancer Institute
, vol.99
, Issue.8
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocana, A.3
Anido, J.4
Guzman, M.5
Cortes, J.6
Di Cosimo, S.7
Matias-Guiu, X.8
Ramon Y Cajal, S.9
Arribas, J.10
Baselga, J.11
-
33
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
G.D. Lewis Phillips, G. Li, D.L. Dugger Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate Cancer Res 68 2008 9280 9290
-
(2008)
Cancer Res
, vol.68
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
34
-
-
77954031486
-
Phase i study of trastuzumab-DM1, a HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
-
I.E. Krop, M. Beeram, S. Modi Phase I study of trastuzumab-DM1, a HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer J Clin Oncol 28 2010 398 405
-
(2010)
J Clin Oncol
, vol.28
, pp. 398-405
-
-
Krop, I.E.1
Beeram, M.2
Modi, S.3
-
35
-
-
78651447411
-
A phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2 metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab
-
December 9-13, 2009; San Antonio, TX; [abstract 5090]
-
Krop I, LoRusso P, Miller KD, et al. A phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2 metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab. Presented at: the 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX; [abstract 5090].
-
Presented At: The 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium
-
-
Krop, I.1
Lorusso, P.2
Miller, K.D.3
-
36
-
-
79551585669
-
Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC) who had progressed on prior HER2-directed therapy
-
[abstract 1016]
-
P. LoRusso, I.E. Krop, H.A. Burris III Quantitative assessment of diagnostic markers and correlations with efficacy in two phase II studies of trastuzumab-DM1 (T-DM1) for patients (pts) with metastatic breast cancer (MBC) who had progressed on prior HER2-directed therapy J Clin Oncol 28 15S 2010 [abstract 1016]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Lorusso, P.1
Krop, I.E.2
Burris Iii, H.A.3
-
37
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
DOI 10.1016/S1535-6108(02)00097-1
-
D.B. Agus, R.W. Akita, W.D. Fox Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth Cancer Cell 2 2002 127 137 (Pubitemid 41039113)
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
Lewis, G.D.4
Higgins, B.5
Pisacane, P.I.6
Lofgren, J.A.7
Tindell, C.8
Evans, D.P.9
Maiese, K.10
Scher, H.I.11
Sliwkowski, M.X.12
-
38
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
DOI 10.1016/S1535-6108(04)00083-2, PII S1535610804000832
-
M.C. Franklin, K.D. Carey, F.F. Vajdos Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex Cancer Cell 5 2004 317 328 (Pubitemid 38482068)
-
(2004)
Cancer Cell
, vol.5
, Issue.4
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
De Vos, A.M.5
Sliwkowski, M.X.6
-
39
-
-
20244378677
-
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
DOI 10.1200/JCO.2005.03.184
-
D.B. Agus, M.S. Gordon, C. Taylor Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer J Clin Oncol 23 2005 2534 2543 (Pubitemid 47050843)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
Natale, R.B.4
Karlan, B.5
Mendelson, D.S.6
Press, M.F.7
Allison, D.E.8
Sliwkowski, M.X.9
Lieberman, G.10
Kelsey, S.M.11
Fyfe, G.12
-
40
-
-
63849224412
-
Phase i and pharmacokinetic study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese patients with solid tumors
-
N. Yamamoto, Y. Yamada, Y. Fujiwara Phase I and pharmacokinetic study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese patients with solid tumors Jpn J Clin Oncol 39 2009 260 266
-
(2009)
Jpn J Clin Oncol
, vol.39
, pp. 260-266
-
-
Yamamoto, N.1
Yamada, Y.2
Fujiwara, Y.3
-
41
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
W. Scheuer, T. Friess, H. Burtscher Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models Cancer Res 69 2009 9330 9336
-
(2009)
Cancer Res
, vol.69
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
-
42
-
-
1942474587
-
The HER-2-Targeting Antibodies Trastuzumab and Pertuzumab Synergistically Inhibit the Survival of Breast Cancer Cells
-
DOI 10.1158/0008-5472.CAN-03-3856
-
R. Nahta, M.C. Hung, F.J. Esteva The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells Cancer Res 64 2004 2343 2346 (Pubitemid 38523885)
-
(2004)
Cancer Research
, vol.64
, Issue.7
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.-C.2
Esteva, F.J.3
-
43
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
J. Baselga, K.A. Gelmon, S. Verma Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy J Clin Oncol 28 2010 1138 1144
-
(2010)
J Clin Oncol
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
44
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
DOI 10.1016/j.ccr.2004.06.022, PII S1535610804002107
-
Y. Nagata, K.H. Lan, X. Zhou PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients Cancer Cell 6 2004 117 127 (Pubitemid 39485684)
-
(2004)
Cancer Cell
, vol.6
, Issue.2
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.-H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.-C.12
Yu, D.13
-
45
-
-
0038607569
-
1 cell cycle arrest and tumor growth inhibition
-
DOI 10.1074/jbc.M300848200
-
X.F. Le, F.X. Claret, A. Lammayot The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition J Biol Chem 278 2003 23441 23450 (Pubitemid 36830161)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.26
, pp. 23441-23450
-
-
Le, X.-F.1
Claret, F.-X.2
Lammayot, A.3
Tian, L.4
Deshpande, D.5
LaPushin, R.6
Tari, A.M.7
Bast Jr., R.C.8
-
46
-
-
34548071359
-
Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network
-
DOI 10.1158/1078-0432.CCR-07-0701
-
C.A. Ritter, M. Perez-Torres, C. Rinehart Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network Clin Cancer Res 13 2007 4909 4919 (Pubitemid 47294799)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4909-4919
-
-
Ritter, C.A.1
Perez-Torres, M.2
Rinehart, C.3
Guix, M.4
Dugger, T.5
Engelman, J.A.6
Arteaga, C.L.7
-
48
-
-
2942592008
-
Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ErbB-2 inhibitor lapatinib
-
H.A. Burris III Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib Oncologist 9 suppl 3 2004 10 15
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL 3
, pp. 10-15
-
-
Burris Iii, H.A.1
-
49
-
-
44149098849
-
Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
-
A. Sassen, J. Rochon, P. Wild Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients Breast Cancer Res 10 2008 R2
-
(2008)
Breast Cancer Res
, vol.10
, pp. 2
-
-
Sassen, A.1
Rochon, J.2
Wild, P.3
-
50
-
-
74549210351
-
Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer
-
A.J. Tevaarwerk, J.M. Kolesar Lapatinib: a small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer Clin Ther 31 Pt 2 2009 2332 2348
-
(2009)
Clin Ther
, vol.312 PART
, pp. 2332-2348
-
-
Tevaarwerk, A.J.1
Kolesar, J.M.2
-
51
-
-
0037068741
-
Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
-
W. Xia, R.J. Mullin, B.R. Keith Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways Oncogene 21 2002 6255 6263
-
(2002)
Oncogene
, vol.21
, pp. 6255-6263
-
-
Xia, W.1
Mullin, R.J.2
Keith, B.R.3
-
52
-
-
84898696911
-
-
[package insert] GlaxoSmithKline Research Triangle Park, NC
-
® (lapatinib) tablets [package insert] 2010 GlaxoSmithKline Research Triangle Park, NC
-
(2010)
® (Lapatinib) Tablets
-
-
-
53
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
DOI 10.1056/NEJMoa064320
-
C.E. Geyer, J. Forster, D. Lindquist Lapatinib plus capecitabine for HER2-positive advanced breast cancer N Engl J Med 355 2006 2733 2743 (Pubitemid 46021510)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
54
-
-
77957771125
-
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: Final survival analysis of a phase III randomized trial
-
D. Cameron, M. Casey, C. Oliva Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial Oncologist 15 2010 924 934
-
(2010)
Oncologist
, vol.15
, pp. 924-934
-
-
Cameron, D.1
Casey, M.2
Oliva, C.3
-
55
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
H.L. Gomez, D.C. Doval, M.A. Chavez Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer J Clin Oncol 26 2008 2999 3005
-
(2008)
J Clin Oncol
, vol.26
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
Chavez, M.A.3
-
56
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
A. Di Leo, H.L. Gomez, Z. Aziz Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer J Clin Oncol 26 2008 5544 5552
-
(2008)
J Clin Oncol
, vol.26
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
Aziz, Z.3
-
57
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
N.U. Lin, L.A. Carey, M.C. Liu Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer J Clin Oncol 26 2008 1993 1999
-
(2008)
J Clin Oncol
, vol.26
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
Liu, M.C.3
-
58
-
-
63149110733
-
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
-
N.U. Lin, V. Dieras, D. Paul Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer Clin Cancer Res 15 2009 1452 1459
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1452-1459
-
-
Lin, N.U.1
Dieras, V.2
Paul, D.3
-
59
-
-
77954586996
-
Dose-dense doxorubicin and cyclophosphamide followed by weekly paclitaxel with trastuzumab and lapatinib in HER2/neu-overexpressed/amplified breast cancer is not feasible because of excessive diarrhea
-
C. Dang, N. Lin, B. Moy Dose-dense doxorubicin and cyclophosphamide followed by weekly paclitaxel with trastuzumab and lapatinib in HER2/neu-overexpressed/amplified breast cancer is not feasible because of excessive diarrhea J Clin Oncol 28 2010 2982 2988
-
(2010)
J Clin Oncol
, vol.28
, pp. 2982-2988
-
-
Dang, C.1
Lin, N.2
Moy, B.3
-
60
-
-
79952258750
-
First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): A phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer
-
December 8-12 San Antonio, TX; [abstract S3-3]
-
Baselga J, Bradbury I, Eidtmann H, et al. First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): a phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract S3-3].
-
(2010)
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Baselga, J.1
Bradbury, I.2
Eidtmann, H.3
-
61
-
-
70449722853
-
Irreversible pan-ErbB.tyrosine kinase inhibitorsbreast cancer: Current status and future directions
-
A. Ocana, E. Amir Irreversible pan-ErbB.tyrosine kinase inhibitorsbreast cancer: current status and future directions Cancer Treat Rev 35 2009 685 691
-
(2009)
Cancer Treat Rev
, vol.35
, pp. 685-691
-
-
Ocana, A.1
Amir, E.2
-
62
-
-
0035476866
-
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
-
D.W. Rusnak, K. Affleck, S.G. Cockerill The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer Cancer Res 61 2001 7196 7203 (Pubitemid 32946515)
-
(2001)
Cancer Research
, vol.61
, Issue.19
, pp. 7196-7203
-
-
Rusnak, D.W.1
Affleck, K.2
Cockerill, S.G.3
Stubberfield, C.4
Harris, R.5
Page, M.6
Smith, K.J.7
Guntrip, S.B.8
Carter, M.C.9
Shaw, R.J.10
Jowett, A.11
Stables, J.12
Topley, P.13
Wood, E.R.14
Brignola, P.S.15
Kadwell, S.H.16
Reep, B.R.17
Mullin, R.J.18
Alligood, K.J.19
Keith, B.R.20
Crosby, R.M.21
Murray, D.M.22
Knight, W.B.23
Gilmer, T.M.24
Lackey, K.25
more..
-
63
-
-
38049038935
-
A phase i dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
-
F.A. Eskens, C.H. Mom, A.S. Planting A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours Br J Cancer 98 2008 80 85
-
(2008)
Br J Cancer
, vol.98
, pp. 80-85
-
-
Eskens, F.A.1
Mom, C.H.2
Planting, A.S.3
-
64
-
-
57349141390
-
BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors
-
N. Minkovsky, A. Berezov BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors Curr Opin Investig Drugs 9 2008 1336 1346
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1336-1346
-
-
Minkovsky, N.1
Berezov, A.2
-
65
-
-
77957585027
-
Phase i trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
-
T.A. Yap, L. Vidal, J. Adam Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors J Clin Oncol 28 2010 3965 3972
-
(2010)
J Clin Oncol
, vol.28
, pp. 3965-3972
-
-
Yap, T.A.1
Vidal, L.2
Adam, J.3
-
66
-
-
84855397252
-
Use of BIBW 2992, a novel irreversible EGFR/HER1 and HER2 tyrosine kinase inhibitor to treat patients with HER2-positive metastatic breast cancer after failure of treatment with trastuzumab
-
T. Hickish, D. Wheatley, N. Lin Use of BIBW 2992, a novel irreversible EGFR/HER1 and HER2 tyrosine kinase inhibitor to treat patients with HER2-positive metastatic breast cancer after failure of treatment with trastuzumab Cancer Res 69 2009 2191 2194
-
(2009)
Cancer Res
, vol.69
, pp. 2191-2194
-
-
Hickish, T.1
Wheatley, D.2
Lin, N.3
-
67
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
-
DOI 10.1158/0008-5472.CAN-03-2868
-
S.K. Rabindran, C.M. Discafani, E.C. Rosfjord Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase Cancer Res 64 2004 3958 3965 (Pubitemid 38697310)
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 3958-3965
-
-
Rabindran, S.K.1
Discafani, C.M.2
Rosfjord, E.C.3
Baxter, M.4
Floyd, M.B.5
Golas, J.6
Hallett, W.A.7
Johnson, B.D.8
Nilakantan, R.9
Overbeek, E.10
Reich, M.F.11
Shen, R.12
Shi, X.13
Tsou, H.-R.14
Wang, Y.-F.15
Wissner, A.16
-
68
-
-
13944262091
-
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity
-
DOI 10.1021/jm040159c
-
H.R. Tsou, E.G. Overbeek-Klumpers, W.A. Hallett Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity J Med Chem 48 2005 1107 1131 (Pubitemid 40270454)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.4
, pp. 1107-1131
-
-
Tsou, H.-R.1
Overbeek-Klumpers, E.G.2
Hallett, W.A.3
Reich, M.F.4
Floyd, M.B.5
Johnson, B.D.6
Michalak, R.S.7
Nilakantan, R.8
Discafani, C.9
Golas, J.10
Rabindran, S.K.11
Shen, R.12
Shi, X.13
Wang, Y.-F.14
Upeslacis, J.15
Wissner, A.16
-
69
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
E.L. Kwak, R. Sordella, D.W. Bell Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib Proc Natl Acad Sci U S A 102 2005 7665 7770
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 7665-7770
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
-
70
-
-
65249170861
-
A phase i study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors
-
K.K. Wong, P.M. Fracasso, R.M. Bukowski A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors Clin Cancer Res 15 2009 2552 2558
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2552-2558
-
-
Wong, K.K.1
Fracasso, P.M.2
Bukowski, R.M.3
-
71
-
-
77950497981
-
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
-
H.J. Burstein, Y. Sun, L.Y. Dirix Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer J Clin Oncol 28 2010 1301 1307
-
(2010)
J Clin Oncol
, vol.28
, pp. 1301-1307
-
-
Burstein, H.J.1
Sun, Y.2
Dirix, L.Y.3
-
72
-
-
77949693587
-
Efficacy and safety of neratinib (HKI-272) in combination with paclitaxel in Her2+ metastatic breast cancer
-
December 8-12, 2010; San Antonio, TX; [abstract P3-14-04]
-
Chow L, Gupta S, Hershman DL, et al. Efficacy and safety of neratinib (HKI-272) in combination with paclitaxel in Her2+ metastatic breast cancer. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract P3-14-04].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Chow, L.1
Gupta, S.2
Hershman, D.L.3
-
73
-
-
84878621801
-
Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2+ metastatic breast cancer Pretreated with anti-HER2 therapy
-
December 8-12, 2010; San Antonio, TX; [abstract P3-14-05]
-
Staroslawska E, Dirix L, Luu T, et al. Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2+ metastatic breast cancer Pretreated with anti-HER2 therapy. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract P3-14-05].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Staroslawska, E.1
Dirix, L.2
Luu, T.3
-
74
-
-
77949726449
-
Safety of neratinib (HKI-272) in combination with capecitabine in patients with solid tumors: A phase 1/2 study
-
December 9-13, 2009; San Antonio, TX; [abstract 5108]
-
Saura C, Martin M, Moroose R, et al. Safety of neratinib (HKI-272) in combination with capecitabine in patients with solid tumors: a phase 1/2 study. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX; [abstract 5108].
-
Presented At: 32nd Annual San Antonio Breast Cancer Symposium
-
-
Saura, C.1
Martin, M.2
Moroose, R.3
-
75
-
-
69049101061
-
A randomized, phase II, dose-finding study of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in patients with pretreated metastatic breast cancer
-
O. Rixe, S.X. Franco, D.A. Yardley A randomized, phase II, dose-finding study of the pan-ErbB receptor tyrosine-kinase inhibitor CI-1033 in patients with pretreated metastatic breast cancer Cancer Chemother Pharmacol 64 2009 1139 1148
-
(2009)
Cancer Chemother Pharmacol
, vol.64
, pp. 1139-1148
-
-
Rixe, O.1
Franco, S.X.2
Yardley, D.A.3
-
76
-
-
53949101266
-
Pooled analysis of diarrhea events in patients with cancer treated with lapatinib
-
J.P. Crown, H.A. Burris III, F. Boyle Pooled analysis of diarrhea events in patients with cancer treated with lapatinib Breast Cancer Res Treat 112 2008 317 325
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 317-325
-
-
Crown, J.P.1
Burris Iii, H.A.2
Boyle, F.3
-
77
-
-
84898702481
-
Gastrointestinal and cardiovascular safety profiles of neratinib monotherapy in patients with advanced ErbB2-positive breast cancer
-
December 9-13, 2009; San Antonio, TX; [abstract 5096]
-
Burstein HJ, Sun Y, Dirix L, et al. Gastrointestinal and cardiovascular safety profiles of neratinib monotherapy in patients with advanced ErbB2-positive breast cancer. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX; [abstract 5096].
-
Presented At: 32nd Annual San Antonio Breast Cancer Symposium
-
-
Burstein, H.J.1
Sun, Y.2
Dirix, L.3
-
78
-
-
34548222618
-
Lapatinib-associated toxicity and practical management recommendations
-
DOI 10.1634/theoncologist.12-7-756
-
B. Moy, P.E. Goss Lapatinib-associated toxicity and practical management recommendations Oncologist 12 2007 756 765 (Pubitemid 47328219)
-
(2007)
Oncologist
, vol.12
, Issue.7
, pp. 756-765
-
-
Moy, B.1
Goss, P.E.2
-
79
-
-
84856063647
-
BIBW 2992, a novel irreversible EGFR/HER1 and HER2 tyrosine kinase inhibitor, for the treatment of patients with HER2-negative metastatic breast cancer after failure of no more than two prior chemotherapies
-
[abstract 1065]
-
M.H. Schuler, M.M. Uttenreuther-Fischer, M.J. Piccart-Gebhart BIBW 2992, a novel irreversible EGFR/HER1 and HER2 tyrosine kinase inhibitor, for the treatment of patients with HER2-negative metastatic breast cancer after failure of no more than two prior chemotherapies J Clin Oncol 28 15S 2010 [abstract 1065]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Schuler, M.H.1
Uttenreuther-Fischer, M.M.2
Piccart-Gebhart, M.J.3
-
80
-
-
84856063645
-
Addition of BIBW 2992, an irreversible inhibitor of EGFR/HER1 and HER2, to letrozole in estrogen receptor (ER)-positive metastatic breast cancer (mBC) progressing on letrozole monotherapy
-
[abstract 1072]
-
K. Gunzer, H. de Mont-Serrat, M.M. Uttenreuther-Fischer Addition of BIBW 2992, an irreversible inhibitor of EGFR/HER1 and HER2, to letrozole in estrogen receptor (ER)-positive metastatic breast cancer (mBC) progressing on letrozole monotherapy J Clin Oncol 28 15S 2010 [abstract 1072]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Gunzer, K.1
De Mont-Serrat, H.2
Uttenreuther-Fischer, M.M.3
-
81
-
-
70350619736
-
Trastuzumab versus lapatinib: The cardiac side of the story
-
H. Azim, H.A. Azim Jr, B. Escudier Trastuzumab versus lapatinib: the cardiac side of the story Cancer Treat Rev 35 2009 633 638
-
(2009)
Cancer Treat Rev
, vol.35
, pp. 633-638
-
-
Azim, H.1
Azim, Jr.H.A.2
Escudier, B.3
-
82
-
-
44949253343
-
Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials
-
DOI 10.4065/83.6.679
-
E.A. Perez, M. Koehler, J. Byrne Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials Mayo Clin Proc 83 2008 679 686 (Pubitemid 351810568)
-
(2008)
Mayo Clinic Proceedings
, vol.83
, Issue.6
, pp. 679-686
-
-
Perez, E.A.1
Koehler, M.2
Byrne, J.3
Preston, A.J.4
Rappold, E.5
Ewer, M.S.6
-
83
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
P. Perrotte, T. Matsumoto, K. Inoue Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice Clin Cancer Res 5 1999 257 265 (Pubitemid 29085177)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.2
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
Kuniyasu, H.4
Eve, B.Y.5
Hicklin, D.J.6
Radinsky, R.7
Dinney, C.P.N.8
-
84
-
-
0348149066
-
Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer
-
DOI 10.1016/S0960-9776(03)00137-1
-
C.K. Osborne, R. Schiff Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer Breast 12 2003 362 367 (Pubitemid 38008644)
-
(2003)
Breast
, vol.12
, Issue.6
, pp. 362-367
-
-
Osborne, C.K.1
Schiff, R.2
-
85
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
DOI 10.1158/0008-5472.CAN-05-1182
-
G.E. Konecny, M.D. Pegram, N. Venkatesan Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells Cancer Res 66 2006 1630 1639 (Pubitemid 43259947)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
Finn, R.4
Yang, G.5
Rahmeh, M.6
Untch, M.7
Rusnak, D.W.8
Spehar, G.9
Mullin, R.J.10
Keith, B.R.11
Gilmer, T.M.12
Berger, M.13
Podratz, K.C.14
Slamon, D.J.15
-
86
-
-
79951997890
-
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers
-
B. Dave, I. Migliaccio, M.C. Gutierrez Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers J Clin Oncol 29 2011 166 173
-
(2011)
J Clin Oncol
, vol.29
, pp. 166-173
-
-
Dave, B.1
Migliaccio, I.2
Gutierrez, M.C.3
-
87
-
-
77949884661
-
Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
K.L. Blackwell, H.J. Burstein, A.M. Storniolo Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer J Clin Oncol 28 2010 1124 1130
-
(2010)
J Clin Oncol
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
-
88
-
-
77949721591
-
Updated survival analysis of a randomized study of lapatinib alone or in combination with trastuzumab in women with HER2-positive metastatic breast cancer progressing on trastuzumab therapy
-
December 9-13, 2009; San Antonio, TX; [abstract 61]
-
Blackwell KL, Burstein HJ, Sledge GW, et al. Updated survival analysis of a randomized study of lapatinib alone or in combination with trastuzumab in women with HER2-positive metastatic breast cancer progressing on trastuzumab therapy. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX; [abstract 61].
-
Presented At: 32nd Annual San Antonio Breast Cancer Symposium
-
-
Blackwell, K.L.1
Burstein, H.J.2
Sledge, G.W.3
-
89
-
-
84856029331
-
Updated efficacy and safety assessment of first-line therapy with lapatinib, trastuzumab, and paclitaxel in HER2+ metastatic breast cancer
-
[abstract 1046]
-
F.J. Esteva, S. Franco, M.K. Hagan Updated efficacy and safety assessment of first-line therapy with lapatinib, trastuzumab, and paclitaxel in HER2+ metastatic breast cancer J Clin Oncol 28 15S 2010 [abstract 1046]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Esteva, F.J.1
Franco, S.2
Hagan, M.K.3
-
90
-
-
73849142191
-
Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study
-
[abstract 1004]
-
R. Swaby, K. Blackwell, Z. Jiang Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: a phase I/II study J Clin Oncol 27 15S 2009 [abstract 1004]
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Swaby, R.1
Blackwell, K.2
Jiang, Z.3
-
91
-
-
65349157788
-
Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients (pts) with HER2-positive metastatic breast cancer (MBC) who had progressed during trastuzumab therapy
-
[abstract 1026]
-
K.A. Gelmon, P. Fumoleau, S. Verma Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients (pts) with HER2-positive metastatic breast cancer (MBC) who had progressed during trastuzumab therapy J Clin Oncol 25 15S 2008 [abstract 1026]
-
(2008)
J Clin Oncol
, vol.25
, Issue.15 S
-
-
Gelmon, K.A.1
Fumoleau, P.2
Verma, S.3
-
92
-
-
79952274439
-
Neoadjuvant pertuzumab (P) and trastuzumab (H): Antitumor and safety analysis of a randomized phase II study ('NeoSphere')
-
December 8-12, 2010; San Antonio, TX; [abstract S3-2]
-
Gianni L, Pienkowski T, Im YH, et al. Neoadjuvant pertuzumab (P) and trastuzumab (H): antitumor and safety analysis of a randomized phase II study ('NeoSphere'). Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract S3-2].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
-
93
-
-
77955884154
-
A phase Ib/II trial of trastuzumab-DM1 (T-DM1) with pertuzumab (P) for women with HER2-positive, locally advanced or metastatic breast cancer (BC) who were previously treated with trastuzumab (T)
-
[abstract 1012]
-
K. Miller, L. Gianni, F. Andre A phase Ib/II trial of trastuzumab-DM1 (T-DM1) with pertuzumab (P) for women with HER2-positive, locally advanced or metastatic breast cancer (BC) who were previously treated with trastuzumab (T) J Clin Oncol 28 15S 2010 [abstract 1012]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Miller, K.1
Gianni, L.2
Andre, F.3
-
94
-
-
12144291334
-
Association between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients
-
DOI 10.1158/1078-0432.CCR-0951-3
-
G.E. Konecny, Y.G. Meng, M. Untch Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients Clin Cancer Res 10 2004 1706 1716 (Pubitemid 38435562)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.5
, pp. 1706-1716
-
-
Konecny, G.E.1
Meng, Y.G.2
Untch, M.3
Wang, H.-J.4
Bauerfeind, I.5
Epstein, M.6
Stieber, P.7
Vernes, J.-M.8
Gutierrez, J.9
Hong, K.10
Beryt, M.11
Hepp, H.12
Slamon, D.J.13
Pegram, M.D.14
-
95
-
-
32944458087
-
Strategies for delaying or treating In vivo acquired resistance to trastuzumab in human breast cancer xenografts
-
DOI 10.1158/1078-0432.CCR-05-1109
-
J.M. du Manoir, G. Francia, S. Man Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts Clin Cancer Res 12 2006 904 916 (Pubitemid 43259873)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.3
, pp. 904-916
-
-
Du Manoir, J.M.1
Francia, G.2
Man, S.3
Mossoba, M.4
Medin, J.A.5
Viloria-Petit, A.6
Hicklin, D.J.7
Emmenegger, U.8
Kerbel, R.S.9
-
96
-
-
21044443432
-
Phase i combined biological therapy of breast cancer using 2 humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF)
-
[abstract 3039]
-
M.D. Pegram, C. Yeon, N.C. Ku Phase I combined biological therapy of breast cancer using 2 humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF) Breast Cancer Res Treatment 88 Suppl 1 2010 S124 [abstract 3039]
-
(2010)
Breast Cancer Res Treatment
, vol.88
, Issue.SUPPL 1
, pp. 124
-
-
Pegram, M.D.1
Yeon, C.2
Ku, N.C.3
-
97
-
-
77649134730
-
Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer
-
December 9-13, 2009; San Antonio, TX; [abstract 6094]
-
Hurvitz SA, Pegram MD, Lin L-S, et al. Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer. Presented at: 32nd Annual San Antonio Breast Cancer Symposium; December 9-13, 2009; San Antonio, TX; [abstract 6094].
-
Presented At: 32nd Annual San Antonio Breast Cancer Symposium
-
-
Hurvitz, S.A.1
Pegram, M.D.2
Lin, L.-S.3
-
98
-
-
53449094091
-
A phase II evaluation of lapatinib (L) and bevacizumab (B) in HER2+ metastatic breast cancer (MBC)
-
[abstract 1042]
-
H.S. Rugo, S. Franco, P. Munster A phase II evaluation of lapatinib (L) and bevacizumab (B) in HER2+ metastatic breast cancer (MBC) J Clin Oncol 26 15S 2008 [abstract 1042]
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Rugo, H.S.1
Franco, S.2
Munster, P.3
-
99
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
J. Shou, S. Massarweh, C.K. Osborne Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer J Natl Cancer Inst 96 2004 926 935 (Pubitemid 38868139)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.12
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
Wakeling, A.E.4
Ali, S.5
Weiss, H.6
Schiff, R.7
-
100
-
-
51149092061
-
The role of hormonal therapy in the management of hormonal-receptor- positive breast cancer with co-expression of HER2
-
A. Prat, J. Baselga The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2 Nat Clin Pract Oncol 5 2008 531 542
-
(2008)
Nat Clin Pract Oncol
, vol.5
, pp. 531-542
-
-
Prat, A.1
Baselga, J.2
-
101
-
-
73949105921
-
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
-
B. Kaufman, J.R. Mackey, M.R. Clemens Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study J Clin Oncol 27 2009 5529 5537
-
(2009)
J Clin Oncol
, vol.27
, pp. 5529-5537
-
-
Kaufman, B.1
MacKey, J.R.2
Clemens, M.R.3
-
102
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
S. Johnston, J. Pippen Jr, X. Pivot Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer J Clin Oncol 27 2009 5538 5546
-
(2009)
J Clin Oncol
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, Jr.J.2
Pivot, X.3
-
103
-
-
77649100030
-
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
-
L.S. Schwartzberg, S.X. Franco, A. Florance Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer Oncologist 15 2010 122 129
-
(2010)
Oncologist
, vol.15
, pp. 122-129
-
-
Schwartzberg, L.S.1
Franco, S.X.2
Florance, A.3
-
104
-
-
0037087535
-
Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
-
DOI 10.1200/JCO.20.6.1467
-
A. Lipton, S.M. Ali, K. Leitzel Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer J Clin Oncol 20 2002 1467 1472 (Pubitemid 34260524)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.6
, pp. 1467-1472
-
-
Lipton, A.1
Ali, S.M.2
Leitzel, K.3
Demers, L.4
Chinchilli, V.5
Engle, L.6
Harvey, H.A.7
Brady, C.8
Nalin, C.M.9
Dugan, M.10
Carney, W.11
Allard, J.12
-
105
-
-
0028997307
-
HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells
-
R.J. Pietras, J. Arboleda, D.M. Reese HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells Oncogene 10 1995 2435 2446
-
(1995)
Oncogene
, vol.10
, pp. 2435-2446
-
-
Pietras, R.J.1
Arboleda, J.2
Reese, D.M.3
-
106
-
-
58149250652
-
Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors
-
F.L. Chen, W. Xia, N.L. Spector Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors Clin Cancer Res 14 2008 6730 6734
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6730-6734
-
-
Chen, F.L.1
Xia, W.2
Spector, N.L.3
-
107
-
-
84898693092
-
Activation of SRC and MAPK mediates resistance to lapatinib in ER-/ERBB2+ breast cancer
-
December 8-12, 2010; San Antonio, TX; [abstract P3-14-14]
-
Jegg A-M, Ward T, Iorns E, et al. Activation of SRC and MAPK mediates resistance to lapatinib in ER-/ERBB2+ breast cancer. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract P3-14-14].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Jegg, A.-M.1
Ward, T.2
Iorns, E.3
-
108
-
-
77955879325
-
Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: A multicenter phase II clinical trial
-
[abstract 1013]
-
F. Dalenc, M. Campone, P. Hupperets Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: a multicenter phase II clinical trial J Clin Oncol 28 15S 2010 [abstract 1013]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Dalenc, F.1
Campone, M.2
Hupperets, P.3
-
109
-
-
79960599214
-
Phase I/II trial of everolimus (RAD001) and trastuzumab in patients with trastuzumab-resistant, HER2-overexpressing breast cancer
-
[abstract 1014]
-
P.H. Morrow, G.M. Wulf, D.J. Booser Phase I/II trial of everolimus (RAD001) and trastuzumab in patients with trastuzumab-resistant, HER2-overexpressing breast cancer J Clin Oncol 28 15S 2010 [abstract 1014]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Morrow, P.H.1
Wulf, G.M.2
Booser, D.J.3
-
110
-
-
78649719737
-
Maintenance with everolimus (RAD001) and trastuzumab (T) after discontinuation of chemotherapy in patients (pts) with heavily pretreated HER2-positive metastatic breast cancer (MBC): Pooled data of extension cohorts of phase Ib/II studies
-
[abstract 1041]
-
G.H. Jerusalem, A. Fasolo, C. Massacesi Maintenance with everolimus (RAD001) and trastuzumab (T) after discontinuation of chemotherapy in patients (pts) with heavily pretreated HER2-positive metastatic breast cancer (MBC): pooled data of extension cohorts of phase Ib/II studies J Clin Oncol 28 15S 2010 [abstract 1041]
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Jerusalem, G.H.1
Fasolo, A.2
Massacesi, C.3
-
111
-
-
78650967232
-
Phase i trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast cancer
-
G. Jerusalem, A. Fasolo, V. Dieras Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast cancer Breast Cancer Res Treat 125 2011 447 455
-
(2011)
Breast Cancer Res Treat
, vol.125
, pp. 447-455
-
-
Jerusalem, G.1
Fasolo, A.2
Dieras, V.3
-
112
-
-
84655175180
-
Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: A multicenter phase 2 clinical trial
-
[abstract 3091]
-
D.A. Yardley, M. Seiler, I. Ray-Coquard Ridaforolimus (AP23573; MK-8669) in combination with trastuzumab for patients with HER2-positive trastuzumab-refractory metastatic breast cancer: a multicenter phase 2 clinical trial Cancer Res 69 Suppl 24 2009 [abstract 3091]
-
(2009)
Cancer Res
, vol.69
, Issue.SUPPL 24
-
-
Yardley, D.A.1
Seiler, M.2
Ray-Coquard, I.3
-
113
-
-
1942431966
-
The Achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
-
A. Citri, B.S. Kochupurakkal, Y. Yarden The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention Cell Cycle 3 2004 51 60 (Pubitemid 40268587)
-
(2004)
Cell Cycle
, vol.3
, Issue.1
, pp. 51-60
-
-
Citri, A.1
Kochupurakkal, B.S.2
Yarden, Y.3
-
114
-
-
12144266330
-
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
-
DOI 10.1038/sj.embor.7400300
-
A. Citri, J. Gan, Y. Mosesson Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation EMBO Rep 5 2004 1165 1170 (Pubitemid 40103611)
-
(2004)
EMBO Reports
, vol.5
, Issue.12
, pp. 1165-1170
-
-
Citri, A.1
Gan, J.2
Mosesson, Y.3
Vereb, G.4
Szollosi, J.5
Yarden, Y.6
-
115
-
-
79960985354
-
HSP90 inhibition is effective in breast cancer: A phase 2 trial of tanespimycin (17AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
-
S. Modi, A.T. Stopeck, H.M. Linden HSP90 inhibition is effective in breast cancer: a phase 2 trial of tanespimycin (17AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab Clin Cancer Res 17 2011 5132 5139
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5132-5139
-
-
Modi, S.1
Stopeck, A.T.2
Linden, H.M.3
-
116
-
-
84856032294
-
Efficacy and safety of retaspimycin hydrochloride (IPI-504) in combination with trastuzumab in patients (pts) with pretreated, locally advanced or metastatic HER2-positive breast cancer
-
[abstract 590]
-
S. Modi, C. Saura, C.A. Henderson Efficacy and safety of retaspimycin hydrochloride (IPI-504) in combination with trastuzumab in patients (pts) with pretreated, locally advanced or metastatic HER2-positive breast cancer J Clin Oncol 29 Suppl 2011 [abstract 590]
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL
-
-
Modi, S.1
Saura, C.2
Henderson, C.A.3
-
117
-
-
84898697501
-
Phase 1 dose-escalation study of the heat shock protein 90 inhibitor BIIB021 with trastuzumab in HER2+ metastatic breast cancer
-
December 8-12, 2010; San Antonio, TX; [abstract P3-14-02]
-
Modi S, Ismail-Khan R, Munster P, et al. Phase 1 dose-escalation study of the heat shock protein 90 inhibitor BIIB021 with trastuzumab in HER2+ metastatic breast cancer. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract P3-14-02].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Modi, S.1
Ismail-Khan, R.2
Munster, P.3
-
118
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
DOI 10.1016/j.molcel.2005.04.021, PII S1097276505012840
-
J.J. Kovacs, P.J. Murphy, S. Gaillard HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor Mol Cell 18 2005 601 607 (Pubitemid 40726236)
-
(2005)
Molecular Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.M.2
Gaillard, S.3
Zhao, X.4
Wu, J.-T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.-P.10
-
119
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
DOI 10.1038/nrc1716
-
L. Whitesell, S.L. Lindquist HSP90 and the chaperoning of cancer Nat Rev Cancer 5 2005 761 772 (Pubitemid 41400776)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.10
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
120
-
-
78149468330
-
A phase i study of panobinostat (LBH589) with capecitabine with or without lapatinib
-
N.W. Peacock, S.F. Jones, D.A. Yardley A phase I study of panobinostat (LBH589) with capecitabine with or without lapatinib J Clin Oncol 28 2010 1115
-
(2010)
J Clin Oncol
, vol.28
, pp. 1115
-
-
Peacock, N.W.1
Jones, S.F.2
Yardley, D.A.3
-
121
-
-
0036963448
-
Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells
-
A. Camirand, Y. Lu, M. Pollak Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells Med Sci Monit 8 2002 BR521 BR526
-
(2002)
Med Sci Monit
, vol.8
-
-
Camirand, A.1
Lu, Y.2
Pollak, M.3
-
122
-
-
84898690087
-
Pathological complete response after neoadjuvant chemotherapy + trastuzumab treatment predicts survival and detects a patient subgroup at high need for improvement of anti-HER2 therapy. Three year median follow-up data of the TECHNO trial
-
December 8-12, 2010; San Antonio, TX; [abstract P1-11-03]
-
Untch M, Fasching PA, Konecny GE, et al. Pathological complete response after neoadjuvant chemotherapy + trastuzumab treatment predicts survival and detects a patient subgroup at high need for improvement of anti-HER2 therapy. Three year median follow-up data of the TECHNO trial. Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract P1-11-03].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Untch, M.1
Fasching, P.A.2
Konecny, G.E.3
-
123
-
-
79953772036
-
Lapatinib vs trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: Primary efficacy endpoint analysis of the GEPARQUINTO STUDY (GBG 44)
-
December 8-12, 2010; San Antonio, TX; [abstract S3-1]
-
Untch M, Loibl S, Bischoff J, et al. Lapatinib vs trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: primary efficacy endpoint analysis of the GEPARQUINTO STUDY (GBG 44). Presented at: 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX; [abstract S3-1].
-
Presented At: 33rd Annual San Antonio Breast Cancer Symposium
-
-
Untch, M.1
Loibl, S.2
Bischoff, J.3
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