Broadly neutralizing antibodies against influenza viruses

Antiviral Research

Volumn 98, Issue 3, 2013, Pages 476-483

  Laursen, Nick S ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Broadly neutralizing antibodies; Hemagglutinin; Influenza

Indexed keywords

CR 6261 ANTIBODY; CR 8020 ANTIBODY; CR 8033 ANTIBODY; CR 8071 ANTIBODY; CR 9114 ANTIBODY; F 10 ANTIBODY; FI 6V3 ANTIBODY; INFLUENZA VACCINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C05 HA; MONOCLONAL ANTIBODY CH65; MONOCLONAL ANTIBODY S139 1; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

BINDING AFFINITY; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG STRUCTURE; HUMAN; INFLUENZA A (H1N1); INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; DRUG DESIGN; EPITOPES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA VACCINES; INFLUENZA, HUMAN; NEUTRALIZATION TESTS; ORTHOMYXOVIRIDAE; PROTEIN CONFORMATION; VACCINATION;

ORTHOMYXOVIRIDAE;

EID: 84877620734     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.03.021     Document Type: Review

References (52)

1. Ambrose C.S., Levin M.J. The rationale for quadrivalent influenza vaccines. Hum. Vaccin. Immunother. 2012, 8:81-88.
2. Bommakanti G., Citron M.P., Hepler R.W., Callahan C., Heidecker G.J., Najar T.A., Lu X., Joyce J.G., Shiver J.W., Casimiro D.R., ter Meulen J., Liang X., Varadarajan R. Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge. Proc. Natl. Acad. Sci. USA 2010, 107:13701-13706.
3. Bullough P.A., Hughson F.M., Skehel J.J., Wiley D.C. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 1994, 371:37-43.
4. Carrat F., Flahault A. Influenza vaccine: the challenge of antigenic drift. Vaccine 2007, 25:6852-6862.
5. Caton A.J., Brownlee G.G., Yewdell J.W., Gerhard W. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 1982, 31:417-427.
6. Claas E.C., Osterhaus A.D., van Beek R., De Jong J.C., Rimmelzwaan G.F., Senne D.A., Krauss S., Shortridge K.F., Webster R.G. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 1998, 351:472-477.
7. Corti D., Voss J., Gamblin S.J., Codoni G., Macagno A., Jarrossay D., Vachieri S.G., Pinna D., Minola A., Vanzetta F., Silacci C., Fernandez-Rodriguez B.M., Agatic G., Bianchi S., Giacchetto-Sasselli I., Calder L., Sallusto F., Collins P., Haire L.F., Temperton N., Langedijk J.P., Skehel J.J., Lanzavecchia A. A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 2011, 333:850-856.
8. de Jong M.D., Tran T.T., Truong H.K., Vo M.H., Smith G.J., Nguyen V.C., Bach V.C., Phan T.Q., Do Q.H., Guan Y., Peiris J.S., Tran T.H., Farrar J. Oseltamivir resistance during treatment of influenza A (H5N1) infection. N. Engl. J. Med. 2005, 353:2667-2672.
9. Dreyfus C., Laursen N.S., Kwaks T., Zuijdgeest D., Khayat R., Ekiert D.C., Lee J.H., Metlagel Z., Bujny M.V., Jongeneelen M., van der Vlugt R., Lamrani M., Korse H.J., Geelen E., Sahin O., Sieuwerts M., Brakenhoff J.P., Vogels R., Li O.T., Poon L.L., Peiris M., Koudstaal W., Ward A.B., Wilson I.A., Goudsmit J., Friesen R.H. Highly conserved protective epitopes on influenza B viruses. Science 2012, 337:1343-1348.
10. Dreyfus C.,Ekiert D.C., Wilson I.A. Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin. J Virol. 2013. [Epub ahead of print].
11. Ekiert D.C., Bhabha G., Elsliger M.A., Friesen R.H., Jongeneelen M., Throsby M., Goudsmit J., Wilson I.A. Antibody recognition of a highly conserved influenza virus epitope. Science 2009, 324:246-251.
12. Ekiert D.C., Friesen R.H., Bhabha G., Kwaks T., Jongeneelen M., Yu W., Ophorst C., Cox F., Korse H.J., Brandenburg B., Vogels R., Brakenhoff J.P., Kompier R., Koldijk M.H., Cornelissen L.A., Poon L.L., Peiris M., Koudstaal W., Wilson I.A., Goudsmit J. A highly conserved neutralizing epitope on group 2 influenza A viruses. Science 2011, 333:843-850.
13. Ekiert D.C., Kashyap A.K., Steel J., Rubrum A., Bhabha G., Khayat R., Lee J.H., Dillon M.A., O'Neil R.E., Faynboym A.M., Horowitz M., Horowitz L., Ward A.B., Palese P., Webby R., Lerner R.A., Bhatt R.R., Wilson I.A. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature 2012, 489:526-532.
14. Fiore A.E., Uyeki T.M., Broder K., Finelli L., Euler G.L., Singleton J.A., Iskander J.K., Wortley P.M., Shay D.K., Bresee J.S., Cox N.J. Prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices (ACIP), 2010. MMWR Recomm. Rep. 2010, 59:1-62.
15. Fleishman S.J., Whitehead T.A., Ekiert D.C., Dreyfus C., Corn J.E., Strauch E.M., Wilson I.A., Baker D. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science 2011, 332:816-821.
16. Gubareva L.V., Kaiser L., Hayden F.G. Influenza virus neuraminidase inhibitors. Lancet 2000, 355:827-835.
17. Harris A., Cardone G., Winkler D.C., Heymann J.B., Brecher M., White J.M., Steven A.C. Influenza virus pleiomorphy characterized by cryoelectron tomography. Proc. Natl. Acad. Sci. USA 2006, 103:19123-19127.
18. He X.S., Holmes T.H., Zhang C., Mahmood K., Kemble G.W., Lewis D.B., Dekker C.L., Greenberg H.B., Arvin A.M. Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. J. Virol. 2006, 80:11756-11766.
19. Hurt A.C., Holien J.K., Parker M., Kelso A., Barr I.G. Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. J. Virol. 2009, 83:10366-10373.
20. Kashyap A.K., Steel J., Rubrum A., Estelles A., Briante R., Ilyushina N.A., Xu L., Swale R.E., Faynboym A.M., Foreman P.K., Horowitz M., Horowitz L., Webby R., Palese P., Lerner R.A., Bhatt R.R. Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries. PLoS Pathog. 2010, 6:e1000990.
21. Krause J.C., Tsibane T., Tumpey T.M., Huffman C.J., Albrecht R., Blum D.L., Ramos I., Fernandez-Sesma A., Edwards K.M., Garcia-Sastre A., Basler C.F., Crowe J.E. Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. J. Virol. 2012, 86:6334-6340.
22. Lambert L.C., Fauci A.S. Influenza vaccines for the future. N. Engl. J. Med. 2010, 363:2036-2044.
23. Lee P.S., Yoshida R., Ekiert D.C., Sakai N., Suzuki Y., Takada A., Wilson I.A. Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc. Natl. Acad. Sci. USA 2012, 109:17040-17045.
24. Lingwood D., McTamney P.M., Yassine H.M., Whittle J.R., Guo X., Boyington J.C., Wei C.J., Nabel G.J. Structural and genetic basis for development of broadly neutralizing influenza antibodies. Nature 2012, 489:566-570.
25. Monto A.S., McKimm-Breschkin J.L., Macken C., Hampson A.W., Hay A., Klimov A., Tashiro M., Webster R.G., Aymard M., Hayden F.G., Zambon M. Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3years of their use. Antimicrob. Agents Chemother. 2006, 50:2395-2402.
26. Nobusawa E., Sato K. Comparison of the mutation rates of human influenza A and B viruses. J. Virol. 2006, 80:3675-3678.
27. Okuno Y., Isegawa Y., Sasao F., Ueda S. A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. J. Virol. 1993, 67:2552-2558.
28. Osterhaus A.D., Rimmelzwaan G.F., Martina B.E., Bestebroer T.M., Fouchier R.A. Influenza B virus in seals. Science 2000, 288:1051-1053.
29. Roberts P.C., Garten W., Klenk H.D. Role of conserved glycosylation sites in maturation and transport of influenza A virus hemagglutinin. J. Virol. 1993, 67:3048-3060.
30. Rota P.A., Wallis T.R., Harmon M.W., Rota J.S., Kendal A.P., Nerome K. Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. Virology 1990, 175:59-68.
31. Sagawa H., Ohshima A., Kato I., Okuno Y., Isegawa Y. The immunological activity of a deletion mutant of influenza virus haemagglutinin lacking the globular region. J. Gen. Virol. 1996, 77(Pt 7):1483-1487.
32. Sawyer L.A. Antibodies for the prevention and treatment of viral diseases. Antiviral Res. 2000, 47:57-77.
33. Steel J., Lowen A.C., Wang T.T., Yondola M., Gao Q., Haye K., Garcia-Sastre A., Palese P. Influenza virus vaccine based on the conserved hemagglutinin stalk domain. MBio 2010, 1. e000018-10.
34. Sui J., Hwang W.C., Perez S., Wei G., Aird D., Chen L.M., Santelli E., Stec B., Cadwell G., Ali M., Wan H., Murakami A., Yammanuru A., Han T., Cox N.J., Bankston L.A., Donis R.O., Liddington R.C., Marasco W.A. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 2009, 16:265-273.
35. Tan G.S., Krammer F., Eggink D., Kongchanagul A., Moran T.M., Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J. Virol. 2012, 86:6179-6188.
36. Thompson W.W., Shay D.K., Weintraub E., Brammer L., Bridges C.B., Cox N.J., Fukuda K. Influenza-associated hospitalizations in the United States. JAMA 2004, 292:1333-1340.
37. Throsby M., van den Brink E., Jongeneelen M., Poon L.L., Alard P., Cornelissen L., Bakker A., Cox F., van Deventer E., Guan Y., Cinatl J., ter Meulen J., Lasters I., Carsetti R., Peiris M., de Kruif J., Goudsmit J. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One 2008, 3:e3942.
38. Tsibane T., Ekiert D.C., Krause J.C., Martinez O., Crowe J.E., Wilson I.A., Basler C.F. Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses. PLoS Pathog. 2012, 8:e1003067.
39. Wang T.T., Tan G.S., Hai R., Pica N., Ngai L., Ekiert D.C., Wilson I.A., Garcia-Sastre A., Moran T.M., Palese P. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc. Natl. Acad. Sci. USA 2010, 107:18979-18984.
40. Wang T.T., Tan G.S., Hai R., Pica N., Petersen E., Moran T.M., Palese P. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog. 2010, 6:e1000796.
41. Webster R.G., Bean W.J., Gorman O.T., Chambers T.M., Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol. Rev. 1992, 56:152-179.
42. Wei C.J., Boyington J.C., McTamney P.M., Kong W.P., Pearce M.B., Xu L., Andersen H., Rao S., Tumpey T.M., Yang Z.Y., Nabel G.J. Induction of broadly neutralizing H1N1 influenza antibodies by vaccination. Science 2010, 329:1060-1064.
43. Wei C.J., Yassine H.M., McTamney P.M., Gall J.G., Whittle J.R., Boyington J.C., Nabel G.J. Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure. Sci. Transl. Med. 2012, 4:147ra114.
44. Whitehead T.A., Chevalier A., Song Y., Dreyfus C., Fleishman S.J., De Mattos C., Myers C.A., Kamisetty H., Blair P., Wilson I.A., Baker D. Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat. Biotechnol. 2012, 30:543-548.
45. Whittle J.R., Zhang R., Khurana S., King L.R., Manischewitz J., Golding H., Dormitzer P.R., Haynes B.F., Walter E.B., Moody M.A., Kepler T.B., Liao H.X., Harrison S.C. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 2011, 108:14216-14221.
46. Wiley D.C., Wilson I.A., Skehel J.J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 1981, 289:373-378.
47. Wilson I.A., Skehel J.J., Wiley D.C. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3A resolution. Nature 1981, 289:366-373.
48. Xu R., Ekiert D.C., Krause J.C., Hai R., Crowe J.E., Wilson I.A. Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science. 2010, 328:357-360.
49. Xu R., Krause J.C., McBride R., Paulson J.C., Crowe J.E., Wilson I.A. A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. Nat. Struct. Mol. Biol. 2013, 20:363-370.
50. Yamashita M., Krystal M., Fitch W.M., Palese P. Influenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses. Virology 1988, 163:112-122.
51. Yoshida R., Igarashi M., Ozaki H., Kishida N., Tomabechi D., Kida H., Ito K., Takada A. Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS Pathog. 2009, 5:e1000350.
52. Zhu P., Liu J., Bess J., Chertova E., Lifson J.D., Grise H., Ofek G.A., Taylor K.A., Roux K.H. Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 2006, 441:847-852.