메뉴 건너뛰기




Volumn 355, Issue 9206, 2000, Pages 827-835

Influenza virus neuraminidase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; OSELTAMIVIR; PERAMIVIR; RIMANTADINE; RWJ 270701; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; ZANAMIVIR;

EID: 0034603350     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)11433-8     Document Type: Review
Times cited : (657)

References (69)
  • 1
    • 0027287506 scopus 로고
    • Rational design of potent sialidase-based inhibitors of influenza virus replication
    • von Itzstein M, Wu WY, Kok GB, et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 1993; 363: 418-23.
    • (1993) Nature , vol.363 , pp. 418-423
    • Von Itzstein, M.1    Wu, W.Y.2    Kok, G.B.3
  • 2
    • 0031048319 scopus 로고    scopus 로고
    • Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
    • Kim CU, Lew W, Williams MA, et al. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc 1997; 119: 681-90.
    • (1997) J Am Chem Soc , vol.119 , pp. 681-690
    • Kim, C.U.1    Lew, W.2    Williams, M.A.3
  • 3
    • 0031767836 scopus 로고    scopus 로고
    • New approaches to influenza chemotherapy: Neuraminidase inhibitors
    • Calfee DP, Hayden FG. New approaches to influenza chemotherapy: neuraminidase inhibitors. Drugs 1998; 56: 537-53.
    • (1998) Drugs , vol.56 , pp. 537-553
    • Calfee, D.P.1    Hayden, F.G.2
  • 4
    • 0032796258 scopus 로고    scopus 로고
    • Neuraminidase inhibitors as anti-influenza virus agents
    • Kim CU, Chen X, Mendel DB. Neuraminidase inhibitors as anti-influenza virus agents. Antiviral Chem Chemother 1999; 10: 141-54.
    • (1999) Antiviral Chem Chemother , vol.10 , pp. 141-154
    • Kim, C.U.1    Chen, X.2    Mendel, D.B.3
  • 6
    • 0025895628 scopus 로고
    • Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 Å resolution
    • Varghese JN, Colman PM. Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 Å resolution. J Mol Biol 1991; 221: 473-86.
    • (1991) J Mol Biol , vol.221 , pp. 473-486
    • Varghese, J.N.1    Colman, P.M.2
  • 7
    • 0027243201 scopus 로고
    • Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase
    • Colman PM, Hoyne PA, Lawrence MC. Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase. J Virol 1993; 67: 2972-80.
    • (1993) J Virol , vol.67 , pp. 2972-2980
    • Colman, P.M.1    Hoyne, P.A.2    Lawrence, M.C.3
  • 8
    • 0032544055 scopus 로고    scopus 로고
    • A novel mechanism for the acquisition of virulence by a human influenza A virus
    • Goto H, Kawaoka Y. A novel mechanism for the acquisition of virulence by a human influenza A virus. Proc Natl Acad Sci USA 1998; 95: 10224-28.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10224-10228
    • Goto, H.1    Kawaoka, Y.2
  • 9
    • 0031916471 scopus 로고    scopus 로고
    • Identification of GS4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS4071
    • Li W, Escarpe PA, Eisenberg EJ, et al. Identification of GS4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS4071. Antimicrob Ag Chemother 1998; 42: 647-53.
    • (1998) Antimicrob Ag Chemother , vol.42 , pp. 647-653
    • Li, W.1    Escarpe, P.A.2    Eisenberg, E.J.3
  • 10
    • 0031766022 scopus 로고    scopus 로고
    • Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice
    • Gubareva LV, McCullers JA, Bethall RC, Webster RG. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J Infect Dis 1998; 178: 1592-96.
    • (1998) J Infect Dis , vol.178 , pp. 1592-1596
    • Gubareva, L.V.1    McCullers, J.A.2    Bethall, R.C.3    Webster, R.G.4
  • 12
    • 0002988267 scopus 로고
    • The action of adamantanamines against influenza A viruses: Inhibition of the M2 ion channel protein
    • Hay AJ. The action of adamantanamines against influenza A viruses: inhibition of the M2 ion channel protein. Semin Virol 1992; 3: 21-30.
    • (1992) Semin Virol , vol.3 , pp. 21-30
    • Hay, A.J.1
  • 13
    • 0001971311 scopus 로고    scopus 로고
    • Amantadine and rimantadine - Clinical aspects
    • Richman DD, ed. Chichester: Wiley
    • Hayden FG. Amantadine and rimantadine - clinical aspects. In: Richman DD, ed. Antiviral drug resistance. Chichester: Wiley, 1996: 59-77.
    • (1996) Antiviral Drug Resistance , pp. 59-77
    • Hayden, F.G.1
  • 14
    • 0029560199 scopus 로고
    • Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en
    • Staschke KA, Colacino JM, Baxter AJ, et al. Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en. Virology 1995; 214: 642-46.
    • (1995) Virology , vol.214 , pp. 642-646
    • Staschke, K.A.1    Colacino, J.M.2    Baxter, A.J.3
  • 15
    • 0030028671 scopus 로고    scopus 로고
    • Generation and characterisation of mutants of influenza a virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en
    • Gubareva LV, Bethell R, Hazt GJ, et al. Generation and characterisation of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en. J Virol 1996; 70: 1818-27.
    • (1996) J Virol , vol.70 , pp. 1818-1827
    • Gubareva, L.V.1    Bethell, R.2    Hazt, G.J.3
  • 16
    • 0031787185 scopus 로고    scopus 로고
    • Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071
    • Tai CY, Escarpe PA, Sidwell RW, et al. Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071. Antimicrob Ag Chemother 1998; 42: 3234-41.
    • (1998) Antimicrob Ag Chemother , vol.42 , pp. 3234-3241
    • Tai, C.Y.1    Escarpe, P.A.2    Sidwell, R.W.3
  • 17
    • 0029585928 scopus 로고
    • Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en
    • Blick TJ, Tiong T, Sahasrabudhe A, et al. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology 1995; 214: 475-84.
    • (1995) Virology , vol.214 , pp. 475-484
    • Blick, T.J.1    Tiong, T.2    Sahasrabudhe, A.3
  • 18
    • 0001603941 scopus 로고    scopus 로고
    • Influenza virus resistance to neuraminidase inhibitors
    • Mendel DB, Sidwell RW. Influenza virus resistance to neuraminidase inhibitors. Drug Resistance Updates 1998; 1: 184-89.
    • (1998) Drug Resistance Updates , vol.1 , pp. 184-189
    • Mendel, D.B.1    Sidwell, R.W.2
  • 19
    • 0031911783 scopus 로고    scopus 로고
    • Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    • McKimm-Breschkin JL, Sahasrabudhe A, Blick TJ, et al. Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors. J Virol 1998; 72: 2456-62.
    • (1998) J Virol , vol.72 , pp. 2456-2462
    • McKimm-Breschkin, J.L.1    Sahasrabudhe, A.2    Blick, T.J.3
  • 20
    • 0030296267 scopus 로고    scopus 로고
    • Mutation in the influenza virus neuraminidase gene resulting in decreased senitivity to the neuraminidase inhibitor-4-guanidino-Neu5Ac2en leads to instability of the enzyme
    • McKimm-Breschkin JL, McDonald M, Blick TJ, Colman PM. Mutation in the influenza virus neuraminidase gene resulting in decreased senitivity to the neuraminidase inhibitor-4-guanidino-Neu5Ac2en leads to instability of the enzyme. Virology 1996; 225: 240-42.
    • (1996) Virology , vol.225 , pp. 240-242
    • McKimm-Breschkin, J.L.1    McDonald, M.2    Blick, T.J.3    Colman, P.M.4
  • 21
    • 0031000886 scopus 로고    scopus 로고
    • Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en
    • Gubareva LV, Robinson MJ, Bethell RC, Webster RG. Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en. J Virol 1997; 71: 3385-90.
    • (1997) J Virol , vol.71 , pp. 3385-3390
    • Gubareva, L.V.1    Robinson, M.J.2    Bethell, R.C.3    Webster, R.G.4
  • 22
    • 0031572287 scopus 로고    scopus 로고
    • A single sequence change destabilizes the influenza virus neuraminidase tetramer
    • Colacino JM, Garman E, Chirgadze NY, et al. A single sequence change destabilizes the influenza virus neuraminidase tetramer. Virology 1997; 236: 66-75.
    • (1997) Virology , vol.236 , pp. 66-75
    • Colacino, J.M.1    Garman, E.2    Chirgadze, N.Y.3
  • 23
    • 0006639172 scopus 로고    scopus 로고
    • An oseltamivir-treatment selected influenza A/N2 virus with an R292K mutation in the neuraminidase gene has reduced infectivity in vivo
    • Dec 10-12, Grand Cayman; abstr.
    • Ives J, Caar J, Roberts N, et al. An oseltamivir-treatment selected influenza A/N2 virus with an R292K mutation in the neuraminidase gene has reduced infectivity in vivo. II International Symposium on Influenza and Other Respiratory Viruses (Dec 10-12, 1999, Grand Cayman); abstr.
    • (1999) II International Symposium on Influenza and Other Respiratory Viruses
    • Ives, J.1    Caar, J.2    Roberts, N.3
  • 24
    • 0032551234 scopus 로고    scopus 로고
    • The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en
    • Blick TJ, Sahasrabudhe A, McDonald M, et al. The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en. Virology 1998; 246: 95-103.
    • (1998) Virology , vol.246 , pp. 95-103
    • Blick, T.J.1    Sahasrabudhe, A.2    McDonald, M.3
  • 25
    • 0002957412 scopus 로고    scopus 로고
    • Antiviral efficacy and sequence analysis of HA and NA genes of influenza isolates from zanamivir phase II/III clinical efficacy trials
    • San Francisco, September, abstr 284
    • Gor D, Cadman A, Dempsey M, et al. Antiviral efficacy and sequence analysis of HA and NA genes of influenza isolates from zanamivir phase II/III clinical efficacy trials. 39th ICAAC (San Francisco, September, 1999); abstr 284.
    • (1999) 39th ICAAC
    • Gor, D.1    Cadman, A.2    Dempsey, M.3
  • 26
    • 0003258851 scopus 로고    scopus 로고
    • Clinical and virological efficacy of zanamivir in the treatment of influenza a virus infections during the 1997-98 flu season
    • San Francisco, September, abstr 289a
    • Boivin G, Goyette N, Aoki FY, Wagner A, Trottier S. Clinical and virological efficacy of zanamivir in the treatment of influenza A virus infections during the 1997-98 flu season. 39th ICAAC (San Francisco, September, 1999); abstr 289a.
    • (1999) 39th ICAAC
    • Boivin, G.1    Goyette, N.2    Aoki, F.Y.3    Wagner, A.4    Trottier, S.5
  • 27
    • 0031724750 scopus 로고    scopus 로고
    • Evidence for zanamivir resistance in an immun o compromised child infected with influenza B virus
    • Gubareva LV, Matrosovich MN, Brenner MK, Bethell R, Webster RG. Evidence for zanamivir resistance in an immun o compromised child infected with influenza B virus. J Infect Dis 1998; 178: 1257-62.
    • (1998) J Infect Dis , vol.178 , pp. 1257-1262
    • Gubareva, L.V.1    Matrosovich, M.N.2    Brenner, M.K.3    Bethell, R.4    Webster, R.G.5
  • 29
    • 0032878151 scopus 로고    scopus 로고
    • Safety and efficacy of once daily intransal zanamivir in preventing experimental human influenza A infection
    • Calfee DP, Peng AW, Hussey EK, Lobo M, Hayden FG. Safety and efficacy of once daily intransal zanamivir in preventing experimental human influenza A infection. Antiviral Ther 1999; 4: 143-49.
    • (1999) Antiviral Ther , vol.4 , pp. 143-149
    • Calfee, D.P.1    Peng, A.W.2    Hussey, E.K.3    Lobo, M.4    Hayden, F.G.5
  • 30
    • 0032999877 scopus 로고    scopus 로고
    • Pharmacoscintigraphic evaluation of lung deposition of inhaled zanamivir in healthy volunteers
    • Cass L, Brown J, Pickford M, et al. Pharmacoscintigraphic evaluation of lung deposition of inhaled zanamivir in healthy volunteers. Clin Pharmacokinet 1999; 36: 21-31.
    • (1999) Clin Pharmacokinet , vol.36 , pp. 21-31
    • Cass, L.1    Brown, J.2    Pickford, M.3
  • 31
    • 0003356436 scopus 로고    scopus 로고
    • Sustained concentration in respiratory tract after 10 mg zanamivir (ZMV) inhalation
    • San Francisco, Sept, abstr 46
    • Peng AW. Sustained concentration in respiratory tract after 10 mg zanamivir (ZMV) inhalation. 39th ICAAC (San Francisco, Sept, 1999); abstr 46.
    • (1999) 39th ICAAC
    • Peng, A.W.1
  • 32
    • 0032996541 scopus 로고    scopus 로고
    • Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers
    • Cass L, Efthymiopoulos C, Bye A. Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Clin Pharmacokinet 1999; 36: 1-11.
    • (1999) Clin Pharmacokinet , vol.36 , pp. 1-11
    • Cass, L.1    Efthymiopoulos, C.2    Bye, A.3
  • 33
    • 0003304192 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of the influenza neuraminidase inhibitor Ro-64-0802 (GS4071) following oral administration of the prodrug Ro-64-0796 (GS4104) to health male volunteers
    • Toronto, abstr A-123
    • Wood ND, Aitken M, Sharp S, Evison H. Tolerability and pharmacokinetics of the influenza neuraminidase inhibitor Ro-64-0802 (GS4071) following oral administration of the prodrug Ro-64-0796 (GS4104) to health male volunteers. 37th ICAAC (Toronto, 1997); abstr A-123.
    • (1997) 37th ICAAC
    • Wood, N.D.1    Aitken, M.2    Sharp, S.3    Evison, H.4
  • 34
    • 0004174538 scopus 로고    scopus 로고
    • Oct 27
    • Roche Pharmaceutic als Laboratories. Tamiflu package insert (Oct 27, 1999).
    • (1999) Tamiflu Package Insert
  • 35
    • 0030822685 scopus 로고    scopus 로고
    • Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104
    • Eisenberg G, Bidgood A, Lynch G, Lee WA, Cundy K. Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104. Antimicrob Ag Chemother 1997; 41: 1949-52.
    • (1997) Antimicrob Ag Chemother , vol.41 , pp. 1949-1952
    • Eisenberg, G.1    Bidgood, A.2    Lynch, G.3    Lee, W.A.4    Cundy, K.5
  • 38
    • 0033054511 scopus 로고    scopus 로고
    • Coadministration of orally inhaled zanamivir with inactivated trivalent influenza vaccine does not adversely affect the production of antihaemagglutinin antibodies in the serum of healthy volunteers
    • Webster A, Boyce M, Edmunson S, Miller I. Coadministration of orally inhaled zanamivir with inactivated trivalent influenza vaccine does not adversely affect the production of antihaemagglutinin antibodies in the serum of healthy volunteers. Clin Pharmacokinet 1999; 36: 51-58.
    • (1999) Clin Pharmacokinet , vol.36 , pp. 51-58
    • Webster, A.1    Boyce, M.2    Edmunson, S.3    Miller, I.4
  • 39
    • 85031641099 scopus 로고    scopus 로고
    • Pulmonary function and airway responsiveness in mild to moderate asthmatics given repeated inhaled doses of zanamivir
    • in press
    • Cass L, Gunawardena K, MacMahon M, Bye A. Pulmonary function and airway responsiveness in mild to moderate asthmatics given repeated inhaled doses of zanamivir. Resp Med (in press).
    • Resp Med
    • Cass, L.1    Gunawardena, K.2    MacMahon, M.3    Bye, A.4
  • 41
    • 0032696188 scopus 로고    scopus 로고
    • Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza
    • Hayden FG, Atmar RL, Schilling M, et al. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza. N Engl J Med 1999; 341: 1336-43.
    • (1999) N Engl J Med , vol.341 , pp. 1336-1343
    • Hayden, F.G.1    Atmar, R.L.2    Schilling, M.3
  • 42
    • 0033530264 scopus 로고    scopus 로고
    • Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza
    • Hayden FG, Treanor JJ, Fritz RS, et al. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza. JAMA 1999; 282: 1240-46.
    • (1999) JAMA , vol.282 , pp. 1240-1246
    • Hayden, F.G.1    Treanor, J.J.2    Fritz, R.S.3
  • 43
    • 0030032258 scopus 로고    scopus 로고
    • Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza
    • Hayden FG, Treanor JJ, Betts RF, Lobo M, Esinhart JD, Hussey EK. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza. JAMA 1996; 275: 295-99.
    • (1996) JAMA , vol.275 , pp. 295-299
    • Hayden, F.G.1    Treanor, J.J.2    Betts, R.F.3    Lobo, M.4    Esinhart, J.D.5    Hussey, E.K.6
  • 44
    • 0000305132 scopus 로고    scopus 로고
    • Efficacy of intranasal GG167 in experimental human influenza A and B virus infection
    • Brown LE, Hampson AW, Webster RG, eds. Amsterdam: Elsevier
    • Hayden FG, Lobo M, Hussey EK, Eason CU. Efficacy of intranasal GG167 in experimental human influenza A and B virus infection. In: Brown LE, Hampson AW, Webster RG, eds. Options for the control of influenza. Amsterdam: Elsevier, 1996: vol III, 718-25.
    • (1996) Options for the Control of Influenza , vol.3 , pp. 718-725
    • Hayden, F.G.1    Lobo, M.2    Hussey, E.K.3    Eason, C.U.4
  • 45
    • 85031638018 scopus 로고    scopus 로고
    • Efficacy of oral oseltamivir in experimental human influenza B virus infection
    • Philadelphia, Nov 18-21, abstr.
    • Hayden FG, Robinson R, Jennings L, et al. Efficacy of oral oseltamivir in experimental human influenza B virus infection. IDSA '98 (Philadelphia, Nov 18-21, 1999); 157 abstr.
    • (1999) IDSA '98 , pp. 157
    • Hayden, F.G.1    Robinson, R.2    Jennings, L.3
  • 46
    • 0032779292 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection
    • abstr.
    • Calfee DP, Peng AW, Cass L, Lobo M, Hayden FG. Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection. Antimicrob Ag Chemother 1999; 43: 1616-20 (abstr).
    • (1999) Antimicrob Ag Chemother , vol.43 , pp. 1616-1620
    • Calfee, D.P.1    Peng, A.W.2    Cass, L.3    Lobo, M.4    Hayden, F.G.5
  • 47
    • 0032873656 scopus 로고    scopus 로고
    • Nasal cytokine and chemokine responses in experimental influenza A virus infection: Results of a placebo-controlled trial of intravenous zanamivir treatment
    • Fritz RS, Hayden FG, Calfee DP, et al. Nasal cytokine and chemokine responses in experimental influenza A virus infection: results of a placebo-controlled trial of intravenous zanamivir treatment. J Infect Dis 1999; 180: 586-93.
    • (1999) J Infect Dis , vol.180 , pp. 586-593
    • Fritz, R.S.1    Hayden, F.G.2    Calfee, D.P.3
  • 48
    • 0030724941 scopus 로고    scopus 로고
    • Effects of the neuraminidase inhibitor zanamivir on otologic manifestations of experimental human influenza
    • Walker JB, Hussey EK, Treanor JJ, Montalvo A, Hayden FG. Effects of the neuraminidase inhibitor zanamivir on otologic manifestations of experimental human influenza. J Infect Dis 1997; 176: 1417-22.
    • (1997) J Infect Dis , vol.176 , pp. 1417-1422
    • Walker, J.B.1    Hussey, E.K.2    Treanor, J.J.3    Montalvo, A.4    Hayden, F.G.5
  • 49
    • 9844220300 scopus 로고    scopus 로고
    • Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections
    • Hayden FG, Osterhaus ADME, Treanor JJ, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. N Engl J Med 1997; 337: 874-79.
    • (1997) N Engl J Med , vol.337 , pp. 874-879
    • Hayden, F.G.1    Adme, O.2    Treanor, J.J.3
  • 50
    • 0033495482 scopus 로고    scopus 로고
    • Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections
    • Monto AS, Fleming DM, Henry D, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections. J Infect Dis 1999; 180: 254-61.
    • (1999) J Infect Dis , vol.180 , pp. 254-261
    • Monto, A.S.1    Fleming, D.M.2    Henry, D.3
  • 51
    • 0032512327 scopus 로고    scopus 로고
    • Randomized trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections
    • MIST Study Group. Randomized trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. Lancet 1998; 352: 1877-81.
    • (1998) Lancet , vol.352 , pp. 1877-1881
  • 52
    • 85031646994 scopus 로고    scopus 로고
    • "High risk" and otherwise healthy patients demonstrate alleviation of influenza symptoms 2.5 days earlier following inhaled zanamivir treatment: European study, winter 1997/98
    • Denver, Nov 12-15, abstr 789
    • Fleming D, Makela M, Pauksens K, Man C, Webster A, Keene O. "High risk" and otherwise healthy patients demonstrate alleviation of influenza symptoms 2.5 days earlier following inhaled zanamivir treatment: European study, winter 1997/98. IDSA '98 (Denver, Nov 12-15, 1998); abstr 789.
    • (1998) IDSA '98
    • Fleming, D.1    Makela, M.2    Pauksens, K.3    Man, C.4    Webster, A.5    Keene, O.6
  • 53
    • 0002199644 scopus 로고    scopus 로고
    • The efficacy and safety of inhaled zanamivir in the treatment of influenza in otherwise healthy and 'high risk' individuals in North America
    • abstr.
    • Lalezari J, Klein T, Stapleton JT, Elliott M, Flack N, Keene O. The efficacy and safety of inhaled zanamivir in the treatment of influenza in otherwise healthy and 'high risk' individuals in North America. J Antimicrob Chemother 1999; 44: 42 (abstr).
    • (1999) J Antimicrob Chemother , vol.44 , pp. 42
    • Lalezari, J.1    Klein, T.2    Stapleton, J.T.3    Elliott, M.4    Flack, N.5    Keene, O.6
  • 54
    • 0008462806 scopus 로고    scopus 로고
    • The efficacy of inhaled zanamivir in the treatment of influenza B
    • San Francisco, September, abstr 281
    • Osterhaus AD, Makela M, Webster A, Keene O. The efficacy of inhaled zanamivir in the treatment of influenza B. 39th ICAAC (San Francisco, September, 1999); abstr 281.
    • (1999) 39th ICAAC
    • Osterhaus, A.D.1    Makela, M.2    Webster, A.3    Keene, O.4
  • 55
    • 0003290791 scopus 로고    scopus 로고
    • Efficacy of inhaled zanamivir in reducing complications and antibiotic use in influenza: Results of phase II and III clinical studies
    • San Francisco, September, abstr 1903
    • Kaiser L, Hayden FG, Hammond J, Keene O. Efficacy of inhaled zanamivir in reducing complications and antibiotic use in influenza: results of phase II and III clinical studies. 39th ICAAC (San Francisco, September, 1999); abstr 1903.
    • (1999) 39th ICAAC
    • Kaiser, L.1    Hayden, F.G.2    Hammond, J.3    Keene, O.4
  • 56
    • 17744412173 scopus 로고    scopus 로고
    • Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza
    • Treanor JJ, Hayden FG, Vrooman PS, et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza. JAMA 2000; 283: 1016-24.
    • (2000) JAMA , vol.283 , pp. 1016-1024
    • Treanor, J.J.1    Hayden, F.G.2    Vrooman, P.S.3
  • 57
    • 0003206417 scopus 로고    scopus 로고
    • Oral GS4104 successfully reduces duration and severity of naturally acquired influenza
    • San Diego, abstr LB-5
    • Aoki FY, Osterhaus AD, Rimmelzwaan GF, Kinnersley N, Ward P. Oral GS4104 successfully reduces duration and severity of naturally acquired influenza. 38th ICAAC (San Diego, 1998); abstr LB-5.
    • (1998) 38th ICAAC
    • Aoki, F.Y.1    Osterhaus, A.D.2    Rimmelzwaan, G.F.3    Kinnersley, N.4    Ward, P.5
  • 58
    • 0001201987 scopus 로고    scopus 로고
    • Influenza treatment with oral oseltamivir reduces viral load and antibiotic use related to respiratory complications
    • P1722 (abstr).
    • Oxford JS, Ward P, Kinnersley N. Influenza treatment with oral oseltamivir reduces viral load and antibiotic use related to respiratory complications. Eur Resp J 1999; 14: 254s (P1722) (abstr).
    • (1999) Eur Resp J , vol.14
    • Oxford, J.S.1    Ward, P.2    Kinnersley, N.3
  • 59
    • 0002157364 scopus 로고    scopus 로고
    • Oral GS4104 in the treatment of influenza in adults is effective and reduces influenza-related complications and need for antibiotic treatment
    • abstr.
    • Nicholson KG, Ward P, Kinnersley N. Oral GS4104 in the treatment of influenza in adults is effective and reduces influenza-related complications and need for antibiotic treatment. J Antimicrob Chemother 1999; 44: 41-42 (abstr).
    • (1999) J Antimicrob Chemother , vol.44 , pp. 41-42
    • Nicholson, K.G.1    Ward, P.2    Kinnersley, N.3
  • 61
    • 0005020067 scopus 로고    scopus 로고
    • Inhaled zanamivir for preventing transmission of influenza in families
    • September, San Francisco; abstr LB29
    • Hayden FG, Gubareva LV, Klein T, et al. Inhaled zanamivir for preventing transmission of influenza in families. 39th ICAAC (September, 1999, San Francisco); abstr LB29.
    • (1999) 39th ICAAC
    • Hayden, F.G.1    Gubareva, L.V.2    Klein, T.3
  • 62
    • 85031644734 scopus 로고    scopus 로고
    • Short-term zanamivir to prevent influenza: Results of a placebo controlled study
    • in press
    • Kaiser L, Henry D, Flack N, Keene O, Hayden FG. Short-term zanamivir to prevent influenza: results of a placebo controlled study. Clin Infect Dis (in press).
    • Clin Infect Dis
    • Kaiser, L.1    Henry, D.2    Flack, N.3    Keene, O.4    Hayden, F.G.5
  • 64
    • 0005242966 scopus 로고    scopus 로고
    • Short-term prophylaxis with oral oseltamivir effectively prevents spread of influenza A and B
    • Dec 10-12, Grand Cayman; abstr.
    • Oxford J, Jackson H. Short-term prophylaxis with oral oseltamivir effectively prevents spread of influenza A and B. II International Symposium on Influenza and other Respiratory Viruses (Dec 10-12, 1999, Grand Cayman); abstr.
    • (1999) II International Symposium on Influenza and Other Respiratory Viruses
    • Oxford, J.1    Jackson, H.2
  • 65
    • 0003162508 scopus 로고    scopus 로고
    • Use of zanamivir (AZ) to control an outbreak of influenza A (Flu A)
    • San Francisco, September, abstr 283
    • Lee C, Loeb M, Phillips A, et al. Use of zanamivir (AZ) to control an outbreak of influenza A (Flu A). 39th ICAAC (San Francisco, September, 1999); abstr 283.
    • (1999) 39th ICAAC
    • Lee, C.1    Loeb, M.2    Phillips, A.3
  • 66
    • 85031643608 scopus 로고    scopus 로고
    • Greater effectiveness from zanamivir treatment of influenza with antecedent influenza vaccination in older patients
    • San Francisco, September, abstr 1902
    • Gravenstein S, Freund B, McElhaney JE, Schilling M, Keene O. Greater effectiveness from zanamivir treatment of influenza with antecedent influenza vaccination in older patients. 39th ICAC (San Francisco, September, 1999); abstr 1902.
    • (1999) 39th ICAC
    • Gravenstein, S.1    Freund, B.2    McElhaney, J.E.3    Schilling, M.4    Keene, O.5
  • 67
    • 0032708921 scopus 로고    scopus 로고
    • Randomised, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: Pooled efficacy analysis
    • Monto AS, Webster A, Keene O. Randomised, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis. J Antimicrob Chemother 1999; 44: 23-29.
    • (1999) J Antimicrob Chemother , vol.44 , pp. 23-29
    • Monto, A.S.1    Webster, A.2    Keene, O.3
  • 68
    • 0008868651 scopus 로고    scopus 로고
    • Activity of the neuraminidase inhibitor RWJ-270201 (BCX-1812) against influenza A and B viruses in the neuraminidase inhibition assays
    • Dec 10-12, Grand Cayman; abstr.
    • Gubareva LV, Schallon D, Hayden FG. Activity of the neuraminidase inhibitor RWJ-270201 (BCX-1812) against influenza A and B viruses in the neuraminidase inhibition assays. II International Symposium on Influenza and other Respiratory Viruses (Dec 10-12, 1999, Grand Cayman); abstr.
    • (1999) II International Symposium on Influenza and Other Respiratory Viruses
    • Gubareva, L.V.1    Schallon, D.2    Hayden, F.G.3
  • 69
    • 0343525969 scopus 로고    scopus 로고
    • In vitro activity of the neuraminidase inhibitor RWJ-270201 (BCX-1812) against influenza virus
    • San Francisco, September, abstr 947
    • Bantia S, Ananth SL, Andries K, Horn K, Parker C, Chand P. In vitro activity of the neuraminidase inhibitor RWJ-270201 (BCX-1812) against influenza virus. 39th ICAAC (San Francisco, September, 1999); abstr 947.
    • (1999) 39th ICAAC
    • Bantia, S.1    Ananth, S.L.2    Andries, K.3    Horn, K.4    Parker, C.5    Chand, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.