A vision for better health: Mass spectrometry imaging for clinical diagnostics

Clinica Chimica Acta

Volumn 420, Issue , 2013, Pages 11-22

  Ye, Hui ^a   Gemperline, Erin ^a   Li, Lingjun ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Biomarkers; Clinical; DESI; MALDI; Mass spectrometry imaging

Indexed keywords

ARTICLE; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; DATA ANALYSIS; DISEASE MARKER; DISEASE SEVERITY; EQUIPMENT; HISTOLOGY; IONIZATION; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLISM; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; TREATMENT RESPONSE;

BIOLOGICAL MARKERS; DIAGNOSTIC IMAGING; HUMANS; MASS SPECTROMETRY;

EID: 84877596695     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.10.018     Document Type: Article

References (129)

1. Teng P.N., Hood B.L., Sun M., Dhir R., Conrads T.P. Differential proteomic analysis of renal cell carcinoma tissue interstitial fluid. J Proteome Res 2011, 10:1333-1342.
2. Lowenthal M.S., Mehta A.I., Frogale K., et al. Analysis of albumin-associated peptides and proteins from ovarian cancer patients. Clin Chem 2005, 51:1933-1945.
3. Hu S., Arellano M., Boontheung P., et al. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res 2008, 14:6246-6252.
4. Craig-Schapiro R., Perrin R.J., Roe C.M., et al. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry 2010, 68:903-912.
5. Flint M.S., Hood B.L., Sun M., Stewart N.A., Jones-Laughner J., Conrads T.P. Proteomic analysis of the murine liver in response to a combined exposure to psychological stress and 7,12-Dimethylbenz(a)anthracene. J Proteome Res 2010, 9:509-520.
6. Ishimura R., Ohsako S., Kawakami T., Sakaue M., Aoki Y., Tohyama C. Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats. Toxicol Appl Pharmacol 2002, 185:197-206.
7. Ruepp S.U., Tonge R.P., Shaw J., Wallis N., Pognan F. Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol Sci 2002, 65:135-150.
8. Li T.A., Xu S.L., Oses-Prieto J.A., et al. Proteomics analysis reveals post-translational mechanisms for cold-induced metabolic changes in Arabidopsis. Mol Plant 2011, 4:361-374.
9. Cazares L.H., Troyer D., Mendrinos S., et al. Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin Cancer Res 2009, 15:5541-5551.
10. Deininger S.O., Ebert M.P., Futterer A., Gerhard M., Rocken C. MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. J Proteome Res 2008, 7:5230-5236.
11. Murphy R.C., Hankin J.A., Barkley R.M. Imaging of lipid species by MALDI mass spectrometry. J Lipid Res 2009, 50:S317-S322.
12. Chen R., Hui L., Sturm R.M., Li L. Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging. J Am Soc Mass Spectrom 2009, 20:1068-1077.
13. DeKeyser S.S., Kutz-Naber K.K., Schmidt J.J., Barrett-Wilt G.A., Li L. Mass spectral imaging of neuropeptides in crustacean nervous tissue by MALDI TOF/TOF. J Proteome Res 2007, 6:1782-1791.
14. Schwamborn K., Caprioli R.M. Molecular imaging by mass spectrometry-looking beyond classical histology. Nat Rev Cancer 2010, 10:639-646.
15. Suckau D., Resemann A., Schuerenberg M., Hufnagel P., Franzen J., Holle A. A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics. Anal Bioanal Chem 2003, 376:952-965.
16. Fletcher J.S., Lockyer N.P., Vickerman J.C. Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions. Mass Spectrom Rev 2011, 30:142-174.
17. Jones E.A., Lockyer N.P., Vickerman J.C. Mass spectral analysis and imaging of tissue by ToF-SIMS - the role of buckminsterfullerene, C-60(+), primary ions. Int J Mass Spectrom 2007, 260:146-157.
18. Dill A.L., Eberlin L.S., Costa A.B., et al. Multivariate statistical identification of human bladder carcinomas using ambient ionization imaging mass spectrometry. Chem Eur J 2011, 17:2897-2902.
19. Gao Y.H., Yang C.H., Liu X., Ma R.J., Kong D.L., Shi L.Q. A multifunctional nanocarrier based on nanogated mesoporous silica for enhanced tumor-specific uptake and intracellular delivery. Macromol Biosci 2012, 12:251-259.
20. Laskin J., Heath B.S., Roach P.J., Cazares L., Semmes O.J. Tissue imaging using nanospray desorption electrospray ionization mass spectrometry. Anal Chem 2012, 84:141-148.
21. Vismeh R., Waldon D.J., Teffera Y., Zhao Z.Y. Localization and quantification of drugs in animal tissues by use of desorption electrospray ionization mass spectrometry imaging. Anal Chem 2012, 84:5439-5445.
22. Takats Z., Wiseman J.M., Gologan B., Cooks R.G. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306:471-473.
23. Ifa D.R., Wu C.P., Ouyang Z., Cooks R.G. Desorption electrospray ionization and other ambient ionization methods: current progress and preview. Analyst 2010, 135:669-681.
24. Cooks R.G., Manicke N.E., Dill A.L., et al. New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring. Faraday Discuss 2011, 149:247-267.
25. Jehl B., Bauer R., Dorge A., Rick R. The use of propane-isopentane mixtures for rapid freezing of biological specimens. J Microsc (Oxford) 1981, 123:307-309.
26. Schwartz S.A., Reyzer M.L., Caprioli R.M. Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J Mass Spectrom 2003, 38:699-708.
27. Che F.Y., Lim J., Pan H., Biswas R., Fricker L.D. Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary. Mol Cell Proteomics 2005, 4:1391-1405.
28. Svensson M., Boren M., Skold K., et al. Heat stabilization of the tissue proteome: a new technology for improved proteomics. J Proteome Res 2009, 8:974-981.
29. Rountree C.B., Van Kirk C.A., You H.N., et al. Clinical application for the preservation of phosphoproteins through in-situ tissue stabilization. Proteome Sci 2010, 8.
30. Crossman L., McHugh N.A., Hsieh Y.S., Korfmacher W.A., Chen J.W. Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid Commun Mass Spectrom 2006, 20:284-290.
31. (TM) hybrid instrument. Mass Spectrom Imaging: Princ Protoc 2010, 656:433-449.
32. Chaurand P., Fouchecourt S., DaGue B.B., et al. Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry. Proteomics 2003, 3:2221-2239.
33. Chaurand P., Schriver K.E., Caprioli R.M. Instrument design and characterization for high resolution MALDI-MS imaging of tissue sections. J Mass Spectrom 2007, 42:476-489.
34. Kaletas B.K., van der Wiel I.M., Stauber J., et al. Sample preparation issues for tissue imaging by imaging MS. Proteomics 2009, 9:2622-2633.
35. Lemaire R., Wisztorski M., Desmons A., et al. MALDI-MS direct tissue analysis of proteins: improving signal sensitivity using organic treatments. Anal Chem 2006, 78:7145-7153.
36. Seeley E.H., Oppenheimer S.R., Mi D., Chaurand P., Caprioli R.M. Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections. J Am Soc Mass Spectrom 2008, 19:1069-1077.
37. Scicchitano M.S., Dalmas D.A., Boyce R.W., Thomas H.C., Frazier K.S. Protein extraction of formalin-fixed, paraffin-embedded tissue enables robust proteomic profiles by mass spectrometry. J Histochem Cytochem 2009, 57:849-860.
38. Casadonte R., Caprioli R.M. Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometry. Nat Protoc 2011, 6:1695-1709.
39. EmmertBuck M.R., Bonner R.F., Smith P.D., et al. Laser capture microdissection. Science 1996, 274:998-1001.
40. Wang Z., Han J., Schey K.L. Spatial differences in an integral membrane proteome detected in laser capture microdissected samples. J Proteome Res 2008, 7:2696-2702.
41. Xu B.G.J., Caprioli R.M. Direct analysis of laser capture microdissected cells by MALDI mass spectrometry. J Am Soc Mass Spectrom 2002, 13:1292-1297.
42. Xu B.J., Shyr Y., Liang X.B., et al. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol 2005, 16:2967-2975.
43. Groseclose M.R., Andersson M., Hardesty W.M., Caprioli R.M. Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J Mass Spectrom 2007, 42:254-262.
44. Ronci M., Bonanno E., Colantoni A., et al. Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: application to MALDI-TOF imaging MS investigations. Proteomics 2008, 8:3702-3714.
45. Djidja M.C., Francese S., Loadman P.M., et al. Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections. Proteomics 2009, 9:2750-2763.
46. Stauber J., MacAleese L., Franck J., et al. On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry. J Am Soc Mass Spectrom 2010, 21:338-347.
47. Boggio K.J., Obasuyi E., Sugino K., Nelson S.B., Agar N.Y.R., Agar J.N. Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact. Expert Rev Proteomics 2011, 8:591-604.
48. McDonnell L.A., Corthals G.L., Willems S.M., van Remoortere A., van Zeijl R.J.M., Deelder A.M. Peptide and protein imaging mass spectrometry in cancer research. J Proteomics 2010, 73:1921-1944.
49. Tu T., Sauter A.D., Sauter A.D., Gross M.L. Improving the signal intensity and sensitivity of MALDI mass spectrometry by using nanoliter spots deposited by induction-based fluidics. J Am Soc Mass Spectrom 2008, 19:1086-1090.
50. Zimmerman T.A., Monroe E.B., Sweedler J.V. Adapting the stretched sample method from tissue profiling to imaging. Proteomics 2008, 8:3809-3815.
51. Zimmerman T.A., Rubakhin S.S., Sweedler J.V. MALDI mass spectrometry imaging of neuronal cell cultures. J Am Soc Mass Spectrom 2011, 22:828-836.
52. Jurchen J.C., Rubakhin S.S., Sweedler J.V. MALDI-MS imaging of features smaller than the size of the laser beam. J Am Soc Mass Spectrom 2005, 16:1654-1659.
53. Koestler M., Kirsch D., Hester A., Leisner A., Guenther S., Spengler B. A high-resolution scanning microprobe matrix-assisted laser desorption/ionization ion source for imaging analysis on an ion trap/Fourier transform ion cyclotron resonance mass spectrometer. Rapid Commun Mass Spectrom 2008, 22:3275-3285.
54. Römpp A., Guenther S., Schober Y., et al. Histology by Mass Spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging. Angew Chem Int Ed Engl 2010, 49:3834-3838.
55. Guenther S., Römpp A., Kummer W., Spengler B. AP-MALDI imaging of neuropeptides in mouse pituitary gland with 5 mu m spatial resolution and high mass accuracy. Int J Mass Spectrom 2011, 305:228-237.
56. Schober Y., Guenther S., Spengler B., Römpp A. Single cell matrix-assisted laser desorption/ionization mass spectrometry imaging. Anal Chem 2012, 84:6293-6297.
57. Schafer R. ultrafleXtreme: redefining MALDI mass spectrometry performance. LC GC N Am 2009, 14-15.
58. Luxembourg S.L., Mize T.H., McDonnell L.A., Heeren R.M.A. High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface. Anal Chem 2004, 76:5339-5344.
59. Klerk L.A., Altelaar A.F.M., Froesch M., McDonnell L.A., Heeren R.M.A. Fast and automated large-area imaging MALDI mass spectrometry in microprobe and microscope mode. Int J Mass Spectrom 2009, 285:19-25.
60. Altelaar A.F.M., Taban I.M., McDonnell L.A., et al. High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections. Int J Mass Spectrom 2007, 260:203-211.
61. Fitzgerald J.J.D., Kunnath P., Walker A.V. Matrix-enhanced secondary ion mass spectrometry (ME-SIMS) using room temperature ionic liquid matrices. Anal Chem 2010, 82:4413-4419.
62. Lemaire R., Tabet J.C., Ducoroy P., Hendra J.B., Salzet M., Fournier I. Solid ionic matrixes for direct tissue analysis and MALDI Imaging. Anal Chem 2006, 78:809-819.
63. Deutskens F., Yang J.H., Caprioli R.M. High spatial resolution imaging mass spectrometry and classical histology on a single tissue section. J Mass Spectrom 2011, 46:568-571.
64. Ye H., Greer T., Li L. Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. J Proteomics 2012, 75:5014-5026.
65. Thomas A., Charbonneau J.L., Fournaise E., Chaurand P. Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. Anal Chem 2012, 84:2048-2054.
66. Cohen M.Z. A historical overview of the phenomenologic movement. Image J Nurs Sch 1987, 19:31-34.
67. Leinweber B.D., Tsaprailis G., Monks T.J., Lau S.S. Improved MALDI-TOF imaging yields increased protein signals at high molecular mass. J Am Soc Mass Spectrom 2009, 20:89-95.
68. Vestal M.L., Campbell J.M. Tandem time-of-flight mass spectrometry. Methods Enzymol 2005, 402:79-108.
69. Kanu A.B., Dwivedi P., Tam M., Matz L., Hill H.H. Ion mobility-mass spectrometry. J Mass Spectrom 2008, 43:1-22.
70. Marshall A.G., Hendrickson C.L., Jackson G.S. Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom Rev 1998, 17:1-35.
71. Kutz K.K., Schmidt J.J., Li L.J. In situ tissue analysis of neuropeptides by MALDI FTMS in-cell accumulation. Anal Chem 2004, 76:5630-5640.
72. Fuchser J., Cornet S., Becker M. High Resolution Molecular Imaging of Pharmaceuticals at Therapeutic Levels 2008, Bruker Daltonik GmbH.
73. Makarov A. Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis. Anal Chem 2000, 72:1156-1162.
74. Hu Q.Z., Noll R.J., Li H.Y., Makarov A., Hardman M., Cooks R.G. The Orbitrap: a new mass spectrometer. J Mass Spectrom 2005, 40:430-443.
75. Seeley E.H., Caprioli R.M. Imaging mass spectrometry: towards clinical diagnostics. Proteomics Clin Appl 2008, 2:1435-1443.
76. Seeley E.H., Caprioli R.M. MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives. Trends Biotechnol 2011, 29:136-143.
77. Rauser S., Deininger S.O., Suckau D., Hofler H., Walch A. Approaching MALDI molecular imaging for clinical proteomic research: current state and fields of application. Expert Rev Proteomics 2010, 7:927-941.
78. Cazares L.H., Troyer D.A., Wang B.H., Drake R.R., Semmes O.J. MALDI tissue imaging: from biomarker discovery to clinical applications. Anal Bioanal Chem 2011, 401:17-27.
79. Chaurand P., Schwartz S., Billheimer D., Xu B., Crecelius A., Caprioli R.M. Integrating histology and imaging mass spectrometry. Anal Chem 2004, 76:1145-1155.
80. Drexler D.M., Tannehill-Gregg S.H., Wang L.F., Brock B.J. Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs. J Pharmacol Toxicol Methods 2011, 63:205-208.
81. Takai N., Tanaka Y., Inazawa K., Saji H. Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry. Rapid Commun Mass Spectrom 2012, 26:1549-1556.
82. Wiseman J.M., Ifa D.R., Zhu Y.X., et al. Desorption electrospray ionization mass spectrometry: imaging drugs and metabolites in tissues. Proc Natl Acad Sci U S A 2008, 105:18120-18125.
83. Greer T., Sturm R., Li L.J. Mass spectrometry imaging for drugs and metabolites. J Proteomics 2011, 74:2617-2631.
84. Markowitz L., Anis S.I., Linehan S.T. QWBA - current methodologies and future advancements positioning of image. J Labelled Comp Radiopharm 2010, 53:330-331.
85. Cornett D.S., Frappier S.L., Caprioli R.M. MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal Chem 2008, 80:5648-5653.
86. Römpp A., Guenther S., Takats Z., Spengler B. Mass spectrometry imaging with high resolution in mass and space (HR2 MSI) for reliable investigation of drug compound distributions on the cellular level. Anal Bioanal Chem 2011, 401:65-73.
87. Lorey D.R., Morrison G.H., Chandra S. Dynamic secondary ion mass spectrometry analysis of boron from boron neutron capture therapy drugs in co-cultures: single-cell imaging of two different cell types within the same ion microscopy field of imaging. Anal Chem 2001, 73:3947-3953.
88. Prideaux B., Staab D., Stoeckli M. Applications of MALDI-MSI to pharmaceutical research. Methods Mol Biol 2010, 656:405-413.
89. Trim P.J., Francese S., Clench M.R. Imaging mass spectrometry for the assessment of drugs and metabolites in tissue. Bioanalysis 2009, 1:309-319.
90. Wittig A., Arlinghaus H.F., Kriegeskotte C., et al. Laser postionization secondary neutral mass spectrometry in tissue: a powerful tool for elemental and molecular imaging in the development of targeted drugs. Mol Cancer Ther 2008, 7:1763-1771.
91. Lagarrigue M., Lavigne R., Guevel B., Com E., Chaurand P., Pineau C. Matrix-assisted laser desorption/ionization imaging mass spectrometry: a promising technique for reproductive research. Biol Reprod 2012, 86.
92. Nilsson A., Fehniger T.E., Gustavsson L., et al. Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PLoS One 2010, 5.
93. Trim P.J., Henson C.M., Avery J.L., et al. Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Anal Chem 2008, 80:8628-8634.
94. Young S.P., Piraud M., Goldstein J.L., et al. Assessing disease severity in Pompe disease: the roles of a urinary glucose tetrasaccharide biomarker and imaging techniques. Am J Med Genet C Semin Med Genet 2012, 160C:50-58.
95. Meding S., Nitsche U., Balluff B., et al. Tumor classification of six common cancer types based on proteomic profiling by MALDI imaging. J Proteome Res 2012, 11:1996-2003.
96. Postle A.D. Lipidomics. Curr Opin Clin Nutr Metab Care 2012, 15:127-133.
97. Walsh N., Crotty K., Palmer A., McCarthy S. Spitz nevus versus spitzoid malignant melanoma: an evaluation of the current distinguishing histopathologic criteria. Hum Pathol 1998, 29:1105-1112.
98. Lazova R., Seeley E.H., Keenan M., Gueorguieva R., Caprioli R.M. Imaging mass spectrometry-a new and promising method to differentiate Spitz Nevi From Spitzoid malignant melanomas. Am J Dermatopathol 2012, 34:82-90.
99. Kim D.W., Huamani J., Reyzer M.L., Mi D., Caprioli R.M., Hallahan D.E. Imaging mass spectrometry to map distribution of radiation enhancing vasculature targeted drug and protein biomarkers of response to therapy in prostate cancer. Int J Radiat Oncol Biol Phys 2006, 66:S554-S554.
100. Thomas A., Lenglet S., Chaurand P., et al. Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics. Thromb Haemost 2011, 106:20-33.
101. Hanada M., Sugiura Y., Shinjo R., et al. Spatiotemporal alteration of phospholipids and prostaglandins in a rat model of spinal cord injury. Anal Bioanal Chem 2012, 403:1873-1884.
102. Weaver C.M., Liebman M. Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis. Br J Nutr 2002, 88:S225-S232.
103. Gamez-Pozo A., Sanchez-Navarro I., Calvo E., et al. PTRF/Cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics. PLoS One 2012, 7.
104. Tanaka H., Zaima N., Yamamoto N., et al. Imaging mass spectrometry reveals unique lipid distribution in primary varicose veins. Eur J Vasc Endovasc Surg 2010, 40:657-663.
105. Klerk L.A., Dankers P.Y.W., Popa E.R., et al. TOF-secondary ion mass spectrometry imaging of polymeric scaffolds with surrounding tissue after in vivo implantation. Anal Chem 2010, 82:4337-4343.
106. Zoehrer R., Perilli E., Kuliwaba J.S., Shapter J.G., Fazzalari N.L., Voelcker N.H. Human bone material characterization: integrated imaging surface investigation of male fragility fractures. Osteoporos Int 2012, 23:1297-1309.
107. Tanaka H., Zaima N., Yamamoto N., et al. Distribution of phospholipid molecular species in autogenous access grafts for hemodialysis analyzed using imaging mass spectrometry. Anal Bioanal Chem 2011, 400:1873-1880.
108. Luckhaus C., Mahabadi B., Grass-Kapanke B., Janner M., Willenberg H., Jager M., et al. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer's disease. J Neural Transm 2009, 116:905-911.
109. Garnero P. Biomarkers for osteoporosis management - utility in diagnosis, fracture risk prediction and therapy monitoring. Mol Diagn Ther 2008, 12:157-170.
110. Bhattacharyya S., Siegel E., Jennings S., Khosla S., Suva L.J. The discovery of new biomarkers for the diagnosis of osteoporosis: is SELDI the answer?. J Bone Miner Res 2005, 20:S224-S225.
111. Ryder K.M., Tanner S.B., Carbone L., Williams J.E., Taylor H.M., Bush A., et al. Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosis. J Bone Miner Metab 2010, 28:233-239.
112. Eastell R., Hannon R.A. Biomarkers of bone health and osteoporosis risk. P Nutr Soc 2008, 67:157-162.
113. Schaller S., Henriksen K., Hoegh-Andersen P., Sondergaard C., Sumer E.U., Tanko L.B., et al. In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?. Assay Drug Dev Techn 2005, 3:553-580.
114. Moayyeri A., Hammond C.J., Spector T.D. Novel metabolomic biomarkers for osteoporosis and longitudinal bone loss. Bone 2012, 50:S45-S45.
115. Chytil P., Etrych T., Kostka L., Ulbrich K. Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors. Macromol Chem Phys 2012, 213:858-867.
116. Ooya T., Mori H., Terano M., Yui N. Synthesis of a biodegradable polymeric supramolecular assembly for drug-delivery. Macromol Rapid Commun 1995, 16:259-263.
117. Salmaso S., Bersani S., Scomparin A., Mastrotto F., Caliceti P. Supramolecular bioconjugates for protein and small drug delivery. Isr J Chem 2010, 50:160-174.
118. Nakayama M., Okano T. Intelligent thermoresponsive polymeric micelles for targeted drug delivery. J Drug Deliv Sci Technol 2006, 16:35-44.
119. Sant V.P., Smith D., Leroux J.C. Novel pH-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs: preparation and characterization. J Control Release 2004, 97:301-312.
120. Vergaro V., Scarlino F., Bellomo C., et al. Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells. Adv Drug Deliv Rev 2011, 63:847-863.
121. Gillies E.R., Frechet J.M.J. Development of acid-sensitive copolymer micelles for drug delivery. Pure Appl Chem 2004, 76:1295-1307.
122. Lin C.H., Mardini S., Lin Y.T., Yeh J.T., Wei F.C., Chen H.C. Sixty-five clinical cases of free tissue transfer using long arteriovenous fistulas or vein grafts. J Trauma 2004, 56:1107-1117.
123. Zhu Y., Lin J.H.C., Liao H.L., Verna L., Stemerman M.B. Activation of ICAM-1 promoter by lysophosphatidylcholine: possible involvement of protein tyrosine kinases. Bba-Lipid Lipid Met 1997, 1345:93-98.
124. Rong J.X., Berman J.W., Taubman M.B., Fisher E.A. Lysophosphatidylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cells. Arterioscler Thromb Vasc Biol 2002, 22:1617-1623.
125. Ye H., Greer T., Li L.J. From pixel to voxel: a deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis 2011, 3:313-332.
126. Jones E.A., van Zeijl R.J.M., Andren P.E., Deelder A.M., Wolters L., McDonnell L.A. High speed data processing for imaging MS-based molecular histology using graphical processing units. J Am Soc Mass Spectrom 2012, 23:745-752.
127. Ergin B., Meding S., Langer R., et al. Proteomic analysis of PAXgene-fixed tissues. J Proteome Res 2010, 9:5188-5196.
128. Hattori K., Kajimura M., Hishiki T., et al. Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. Antioxid Redox Signal 2010, 13:1157-1167.
129. Wang H.A.O., Grolimund D., Van Loon L.R., et al. Quantitative chemical imaging of element diffusion into heterogeneous media using laser ablation inductively coupled plasma mass spectrometry, synchrotron micro-X-ray fluorescence, and extended X-ray absorption fine structure spectroscopy. Anal Chem 2011, 83:6259-6266.