Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs

Journal of Pharmacological and Toxicological Methods

Volumn 63, Issue 2, 2011, Pages 205-208

  Drexler, Dieter M ^a   Tannehill Gregg, Sarah H ^a   Wang, Lifei ^a   Brock, Barry J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Imaging mass spectrometry (IMS); Ion trap mass spectrometer (MS); Matrix assisted laser desorption ionization (MALDI); Ocular drug distribution; Whole body autoradiography (QWBA)

Indexed keywords

DRUG; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORNEA; DRUG DISTRIBUTION; EYE; FEMALE; IMAGE ANALYSIS; IMAGING MASS SPECTROMETRY; ISOTOPE LABELING; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION; NONHUMAN; PHOTOTOXICITY; QUANTITATIVE ANALYSIS; RAT; SINGLE DRUG DOSE; TOXICITY TESTING; UVEA; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; BALB 3T3 CELLS; DERMATITIS, PHOTOTOXIC; EYE; FEMALE; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; PHARMACOKINETICS; RADIOPHARMACEUTICALS; RATS; RATS, LONG-EVANS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE DISTRIBUTION;

RATTUS;

EID: 79951811600     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2010.10.003     Document Type: Article

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