메뉴 건너뛰기




Volumn 15, Issue 2, 2012, Pages 127-133

Lipidomics

Author keywords

imaging; lipid molecular species; mass spectrometry; stable isotopes

Indexed keywords

BIOLOGICAL MARKER;

EID: 84857048221     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32834fb003     Document Type: Review
Times cited : (37)

References (46)
  • 2
    • 78149356687 scopus 로고    scopus 로고
    • Lipidomics reveals a remarkable diversity of lipids in human plasma
    • This article highlights the complexity of the lipidome by quantifying over 500 individual lipid molecular species in human plasma. The use of multiple analytical platforms to analyse one pooled reference plasma sample demonstrates the technical challenge of achieving a comprehensive quantitative analysis across different lipid classes in population-based studies
    • Quehenberger O, Armando AM, Brown AH, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 2010; 51:3299-3305. This article highlights the complexity of the lipidome by quantifying over 500 individual lipid molecular species in human plasma. The use of multiple analytical platforms to analyse one pooled reference plasma sample demonstrates the technical challenge of achieving a comprehensive quantitative analysis across different lipid classes in population-based studies.
    • (2010) J Lipid Res , vol.51 , pp. 3299-3305
    • Quehenberger, O.1    Armando, A.M.2    Brown, A.H.3
  • 3
    • 0141653274 scopus 로고    scopus 로고
    • Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics
    • DOI 10.1194/jlr.R300004-JLR200
    • Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics. J Lipid Res 2003; 44:1071-1079. (Pubitemid 37279625)
    • (2003) Journal of Lipid Research , vol.44 , Issue.6 , pp. 1071-1079
    • Han, X.1    Gross, R.W.2
  • 4
    • 0141974064 scopus 로고    scopus 로고
    • Electrospray mass spectrometry of phospholipids
    • Pulfer M, Murphy RC. Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev 2003; 22:332-364.
    • (2003) Mass Spectrom Rev , vol.22 , pp. 332-364
    • Pulfer, M.1    Murphy, R.C.2
  • 5
    • 78049355456 scopus 로고    scopus 로고
    • Advances in mass spectrometry for lipidomics
    • A comprehensive review of lipid analysis by mass spectrometry up to 2010
    • Blanksby SJ, Mitchell TW. Advances in mass spectrometry for lipidomics. Annu Rev Anal Chem 2010; 3:433-465.A comprehensive review of lipid analysis by mass spectrometry up to 2010.
    • (2010) Annu Rev Anal Chem , vol.3 , pp. 433-465
    • Blanksby, S.J.1    Mitchell, T.W.2
  • 6
    • 78149454125 scopus 로고    scopus 로고
    • Lipidomics era: Accomplishments and challenges
    • Bou KM, Hou W, Zhou H, et al. Lipidomics era: Accomplishments and challenges. Mass Spectrom Rev 2010; 29:877-929.
    • (2010) Mass Spectrom Rev , vol.29 , pp. 877-929
    • Bou, K.M.1    Hou, W.2    Zhou, H.3
  • 7
    • 44449119583 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-Associated phospholipase A2 in oxidized human low density lipoprotein
    • Davis B, Koster G, Douet LJ, et al. Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-Associated phospholipase A2 in oxidized human low density lipoprotein. J Biol Chem 2008; 283:6428-6437.
    • (2008) J Biol Chem , vol.283 , pp. 6428-6437
    • Davis, B.1    Koster, G.2    Douet, L.J.3
  • 8
    • 80052305736 scopus 로고    scopus 로고
    • Serum lipidomics profiling using LC-MS and high-energy collisional dissociation fragmentation: Focus on triglyceride detection and characterization
    • High mass accuracy mass spectrometry identified 86 triacylglycerol species in rat serum that varied over three and a half orders of magnitude in concentration and documented their changes in response to dietary manipulation
    • Bird SS, Marur VR, Sniatynski MJ, et al. Serum lipidomics profiling using LC-MS and high-energy collisional dissociation fragmentation: Focus on triglyceride detection and characterization. Anal Chem 2011; 83:6648-6657. High mass accuracy mass spectrometry identified 86 triacylglycerol species in rat serum that varied over three and a half orders of magnitude in concentration and documented their changes in response to dietary manipulation.
    • (2011) Anal Chem , vol.83 , pp. 6648-6657
    • Bird, S.S.1    Marur, V.R.2    Sniatynski, M.J.3
  • 9
    • 77954486157 scopus 로고    scopus 로고
    • Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry
    • The study provided effective resolution of isobaric diacyl and alkyl acyl phospholipids
    • Zheng L, T'Kind R, Decuypere S, et al. Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. Rapid Commun Mass Spectrom 2010; 24:2074-2082. The study provided effective resolution of isobaric diacyl and alkyl acyl phospholipids.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , pp. 2074-2082
    • Zheng, L.1    T'Kind, R.2    Decuypere, S.3
  • 10
    • 77957308622 scopus 로고    scopus 로고
    • Comprehensive lipidomics analysis of bioactive lipids in complex regulatory networks
    • This study is a good example of using LC-MS. MS to profile over 100 distinct bioactive lipid mediators
    • Masoodi M, Eiden M, Koulman A, et al. Comprehensive lipidomics analysis of bioactive lipids in complex regulatory networks. Anal Chem 2010; 82:8176-8185. This study is a good example of using LC-MS. MS to profile over 100 distinct bioactive lipid mediators.
    • (2010) Anal Chem , vol.82 , pp. 8176-8185
    • Masoodi, M.1    Eiden, M.2    Koulman, A.3
  • 11
    • 80255140521 scopus 로고    scopus 로고
    • Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry
    • This article demonstrates resolution of isomeric lipids differing in combinations of fatty acyl moieties using ion mobility mass spectrometry
    • Kliman M, May JC, McLean JA. Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry. Biochim Biophys Acta 2011; 1811:935-945. This article demonstrates resolution of isomeric lipids differing in combinations of fatty acyl moieties using ion mobility mass spectrometry
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 935-945
    • Kliman, M.1    May, J.C.2    McLean, J.A.3
  • 12
    • 80255124821 scopus 로고    scopus 로고
    • Chiral lipidomics of E-series resolvins: Aspirin and the biosynthesis of novel mediators
    • This study uses chiral high performance liquid chromatography to separate enantomeric pairs of lipid mediators before MS detection
    • Oh SF, Vickery TW, Serhan CN. Chiral lipidomics of E-series resolvins: Aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta 2011; 1811:737-747. This study uses chiral high performance liquid chromatography to separate enantomeric pairs of lipid mediators before MS detection.
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 737-747
    • Oh, S.F.1    Vickery, T.W.2    Serhan, C.N.3
  • 13
    • 77956813485 scopus 로고    scopus 로고
    • Subcellular organelle lipidomics in TLR-4-Activated macrophages
    • This article from the LIPID MAPS consortium shows the redistribution of subcellular lipids in a RAW 264.7 macrophage model in response to lipopolysaccharide activation
    • Andreyev AY, Fahy E, Guan Z, et al. Subcellular organelle lipidomics in TLR-4-Activated macrophages. J Lipid Res 2010; 51:2785-2797. This article from the LIPID MAPS consortium shows the redistribution of subcellular lipids in a RAW 264.7 macrophage model in response to lipopolysaccharide activation.
    • (2010) J Lipid Res , vol.51 , pp. 2785-2797
    • Andreyev, A.Y.1    Fahy, E.2    Guan, Z.3
  • 14
    • 79954988982 scopus 로고    scopus 로고
    • Procedure for the isolation of mitochondria, cytosolic and nuclear material from a single piece of neurological tissue for high-throughput mass spectral analysis
    • This study presents a methodology for organelle subfractionation of neurological tissues with subsequent mass spectrometric lipidomic analysis
    • Timmons MD, Bradley MA, Lovell MA, Lynn BC. Procedure for the isolation of mitochondria, cytosolic and nuclear material from a single piece of neurological tissue for high-throughput mass spectral analysis. J Neurosci Methods 2011; 197:279-282. This study presents a methodology for organelle subfractionation of neurological tissues with subsequent mass spectrometric lipidomic analysis.
    • (2011) J Neurosci Methods , vol.197 , pp. 279-282
    • Timmons, M.D.1    Bradley, M.A.2    Lovell, M.A.3    Lynn, B.C.4
  • 15
    • 80052342186 scopus 로고    scopus 로고
    • Highly efficient microscale purification of glycerophospholipids by microfluidic cell lysis and lipid extraction for lipidomics profiling
    • The study demonstrates the feasibility of lipid extraction from less than 1 000 bacterial cells by using an online microfluidic system to reduce multiple sample handling process and use of relatively large volumes of organic solvents
    • Sun T, Pawlowski S, Johnson ME. Highly efficient microscale purification of glycerophospholipids by microfluidic cell lysis and lipid extraction for lipidomics profiling. Anal Chem 2011; 83:8828-8834. The study demonstrates the feasibility of lipid extraction from less than 1 000 bacterial cells by using an online microfluidic system to reduce multiple sample handling process and use of relatively large volumes of organic solvents.
    • (2011) Anal Chem , vol.83 , pp. 8828-8834
    • Sun, T.1    Pawlowski, S.2    Johnson, M.E.3
  • 17
    • 80051474460 scopus 로고    scopus 로고
    • Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes
    • This study used the incorporation of methyl-D9-choline in vivo into phosphatidylcholine to calculate absolute rates of mouse lung surfactant lipid synthesis and turnover in mice
    • Postle AD, Henderson NG, Koster G, et al. Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes. Chem Phys Lipids 2011; 164:549-555. This study used the incorporation of methyl-D9-choline in vivo into phosphatidylcholine to calculate absolute rates of mouse lung surfactant lipid synthesis and turnover in mice.
    • (2011) Chem Phys Lipids , vol.164 , pp. 549-555
    • Postle, A.D.1    Henderson, N.G.2    Koster, G.3
  • 18
    • 78751502294 scopus 로고    scopus 로고
    • Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo
    • The first demonstration of the molecular specificity of plasma phosphatidylcholine synthesis in human volunteers by both the CDP-choline and phosphatidylethanolamine methyltransferase
    • Pynn CJ, Henderson NG, Clark H, et al. Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo. J Lipid Res 2011; 52:399-407. The first demonstration of the molecular specificity of plasma phosphatidylcholine synthesis in human volunteers by both the CDP-choline and phosphatidylethanolamine methyltransferase.
    • (2011) J Lipid Res , vol.52 , pp. 399-407
    • Pynn, C.J.1    Henderson, N.G.2    Clark, H.3
  • 19
    • 79956054545 scopus 로고    scopus 로고
    • The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: Assessing pharmacological effects in preclinical species
    • This study used MIDA to calculate synthetic rates of lipids containing [U13C]-oleate
    • McLaren DG, He T, Wang SP, et al. The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: Assessing pharmacological effects in preclinical species. J Lipid Res 2011; 52:1150-1161.This study used MIDA to calculate synthetic rates of lipids containing [U13C]-oleate.
    • (2011) J Lipid Res , vol.52 , pp. 1150-1161
    • McLaren, D.G.1    He, T.2    Wang, S.P.3
  • 20
    • 79960675389 scopus 로고    scopus 로고
    • Factors to consider in using [U-13C] palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry
    • First study to use incorporations of [U13C] palmitate into the both the sphingoid backbone and the N-Acyl fatty acid to calculate absolute synthetic rates of ceramides, monohexosylceramide and sphingomyelin in cultured cells
    • Haynes CA, Allegood JC, Wang EW, et al. Factors to consider in using [U-13C] palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry. J Lipid Res 2011; 52:1583-1594. First study to use incorporations of [U13C] palmitate into the both the sphingoid backbone and the N-Acyl fatty acid to calculate absolute synthetic rates of ceramides, monohexosylceramide and sphingomyelin in cultured cells.
    • (2011) J Lipid Res , vol.52 , pp. 1583-1594
    • Haynes, C.A.1    Allegood, J.C.2    Wang, E.W.3
  • 21
    • 80255129303 scopus 로고    scopus 로고
    • Imaging mass spectrometry for lipidomics
    • A good up-to-date review of MALDI-ToF MS imaging of tissue sections
    • Goto-Inoue N, Hayasaka T, Zaima N, Setou M. Imaging mass spectrometry for lipidomics. Biochim Biophys Acta 2011; 1181:961-969. A good up-to-date review of MALDI-ToF MS imaging of tissue sections.
    • (2011) Biochim Biophys Acta , vol.1181 , pp. 961-969
    • Goto-Inoue, N.1    Hayasaka, T.2    Zaima, N.3    Setou, M.4
  • 22
    • 80255137520 scopus 로고    scopus 로고
    • MALDI imaging of lipids after matrix sublimation/deposition
    • This study demonstrates improved imaging of lipids by MALDI-ToF MS imaging by vapour deposition of matrix
    • Murphy RC, Hankin JA, Barkley RM, Zemski Berry KA.MALDI imaging of lipids after matrix sublimation/deposition. Biochim Biophys Acta 2011; 1811:970-975. This study demonstrates improved imaging of lipids by MALDI-ToF MS imaging by vapour deposition of matrix
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 970-975
    • Murphy, R.C.1    Hankin, J.A.2    Barkley, R.M.3    Zemski Berry, K.A.4
  • 23
    • 79960691660 scopus 로고    scopus 로고
    • MALDI imaging MS of phospholipids in the mouse lung
    • First direct imaging of lipid distributions in lung, showing preferential locations of disaturated phosphatidylcholine and of phosphatidylglycerol in the parenchyma, of unsaturated phosphatidylcholines and phosphatidylinositols in airways and sphingomyelins in lung blood vessels
    • Zemski Berry KA, Li B, Reynolds SD, et al. MALDI imaging MS of phospholipids in the mouse lung. J Lipid Res 2011; 52:1551-1552. First direct imaging of lipid distributions in lung, showing preferential locations of disaturated phosphatidylcholine and of phosphatidylglycerol in the parenchyma, of unsaturated phosphatidylcholines and phosphatidylinositols in airways and sphingomyelins in lung blood vessels.
    • (2011) J Lipid Res , vol.52 , pp. 1551-1552
    • Zemski Berry, K.A.1    Li, B.2    Reynolds, S.D.3
  • 24
    • 77956838048 scopus 로고    scopus 로고
    • Visulaizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass sprctrometry
    • Linking MALDI ionization to the high mass resolution of FT-ICR MS improved the imaging signal by reliably differentiating between authentic lipid signals and those from interfering molecules with the same nominal masses
    • Vidova V, Pol J, Volny M, et al. Visulaizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass sprctrometry. J Lipid Res 2010; 51:2295-2302. Linking MALDI ionization to the high mass resolution of FT-ICR MS improved the imaging signal by reliably differentiating between authentic lipid signals and those from interfering molecules with the same nominal masses.
    • (2010) J Lipid Res , vol.51 , pp. 2295-2302
    • Vidova, V.1    Pol, J.2    Volny, M.3
  • 25
    • 80255123672 scopus 로고    scopus 로고
    • Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging
    • A good up-to-date review of MS imaging of lipids by DES.I.
    • Eberlin LS, Ferreira CR, Dill AL, et al. Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging. Biochim Biophys Acta 2011; 1811:946-960. A good up-to-date review of MS imaging of lipids by DESI.
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 946-960
    • Eberlin, L.S.1    Ferreira, C.R.2    Dill, A.L.3
  • 26
    • 81255144136 scopus 로고    scopus 로고
    • Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections
    • This study demonstrates that adding doping agents to the solvent in the desorption ionization spray can provide added selectivity for the detection and imaging of selected lipids
    • Eberlin LS, Liu X, Ferreira CR, et al. Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections. Anal Chem 2011; 83:8366-8371. This study demonstrates that adding doping agents to the solvent in the desorption ionization spray can provide added selectivity for the detection and imaging of selected lipids.
    • (2011) Anal Chem , vol.83 , pp. 8366-8371
    • Eberlin, L.S.1    Liu, X.2    Ferreira, C.R.3
  • 27
    • 80255133233 scopus 로고    scopus 로고
    • Lipid classification, structure and tools
    • A good summary on the bioinformatic approach to managing lipidomic data within the LIPID MAPS consortium
    • Fahy E, Cotter D, Sud M, Subramaniam S. Lipid classification, structure and tools. Biochim Biophys Acta 2011; 1181:637-647. A good summary on the bioinformatic approach to managing lipidomic data within the LIPID MAPS consortium.
    • (2011) Biochim Biophys Acta , vol.1181 , pp. 637-647
    • Fahy, E.1    Cotter, D.2    Sud, M.3    Subramaniam, S.4
  • 28
    • 79951541434 scopus 로고    scopus 로고
    • Lipid Data Analyzer: Unattended identification and quantitation of lipids in LC-MS data
    • The study presents a freely available novel approach to the automated identification and quantification of lipids analysed by LC-MS
    • Hartler J, Trotzmuller M, Chitraju C, et al. Lipid Data Analyzer: Unattended identification and quantitation of lipids in LC-MS data. Bioinformatics 2011; 27:572-577. The study presents a freely available novel approach to the automated identification and quantification of lipids analysed by LC-MS.
    • (2011) Bioinformatics , vol.27 , pp. 572-577
    • Hartler, J.1    Trotzmuller, M.2    Chitraju, C.3
  • 29
    • 77953361129 scopus 로고    scopus 로고
    • Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search
    • Application of an automated programme (Lipid Search) to identify and quantify glycerophospholipids analyzed by high mass accuracy UPLC-LTQ Orbitrap MS
    • Taguchi R, Ishikawa M. Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search. J Chromatogr A 2010; 1217:4229-4239. Application of an automated programme (Lipid Search) to identify and quantify glycerophospholipids analyzed by high mass accuracy UPLC-LTQ Orbitrap MS.
    • (2010) J Chromatogr A. , vol.1217 , pp. 4229-4239
    • Taguchi, R.1    Ishikawa, M.2
  • 30
    • 80255141886 scopus 로고    scopus 로고
    • High throughput quantitative molecular lipidomics
    • Review of strategies to achieve high-throughput lipidomic analyses by integrating robotic automated sample extraction, a range of mass spectrometry platforms and bioinformatics
    • Jung HR, Sylvanne T, Koistinen KM, et al. High throughput quantitative molecular lipidomics. Biochim Biophys Acta 2011; 1811:925-934. Review of strategies to achieve high-throughput lipidomic analyses by integrating robotic automated sample extraction, a range of mass spectrometry platforms and bioinformatics.
    • (2011) Biochim Biophys Acta , vol.1811 , pp. 925-934
    • Jung, H.R.1    Sylvanne, T.2    Koistinen, K.M.3
  • 31
    • 77954203144 scopus 로고    scopus 로고
    • Multivariate multiway analysis of multisource data
    • Statistical algorithms to integrate complex data from multiple sources including lipidomics, proteomics and genomics
    • Huopaniemi I, Suvitaival T, Nikkila J, et al. Multivariate multiway analysis of multisource data. Bioinformatics 2010; 26:i391-i398. Statistical algorithms to integrate complex data from multiple sources including lipidomics, proteomics and genomics.
    • (2010) Bioinformatics , vol.26
    • Huopaniemi, I.1    Suvitaival, T.2    Nikkila, J.3
  • 32
    • 85028099689 scopus 로고    scopus 로고
    • Determining and interpreting correlations in lipidomic networks found in glioblastoma cells
    • Novel graph clustering approach applied to visualize changes to lipid biomarkers in glioblastoma cells with therapy-induced apoptosis
    • Gorke R, Meyer-Base A, Wagner D, et al. Determining and interpreting correlations in lipidomic networks found in glioblastoma cells. BMC Syst Biol 2010; 4:126. Novel graph clustering approach applied to visualize changes to lipid biomarkers in glioblastoma cells with therapy-induced apoptosis.
    • (2010) BMC Syst Biol , vol.4 , pp. 126
    • Gorke, R.1    Meyer-Base, A.2    Wagner, D.3
  • 33
    • 79551688548 scopus 로고    scopus 로고
    • Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism
    • An approach to model sphingolipid metabolism in macrophages activated with lipopolysaccharide based on time-dependent lipidomic and transcriptomic analyses
    • Gupta S, Maurya MR, Merrill AH Jr., et al. Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. BMC Syst Biol 2011; 5:26. An approach to model sphingolipid metabolism in macrophages activated with lipopolysaccharide based on time-dependent lipidomic and transcriptomic analyses.
    • (2011) BMC Syst Biol , vol.5 , pp. 26
    • Gupta, S.1    Maurya, M.R.2    Merrill Jr., A.H.3
  • 34
    • 79956031443 scopus 로고    scopus 로고
    • A method for visualization of 'omic' datasets for sphingolipid metabolism to predict potentially interesting differences
    • Similar analysis demonstrating lipidomic signatures in different breast cancer cell lines that could be predicted from transcriptomic expression dat
    • Momin AA, Park H, Portz BJ, et al. A method for visualization of 'omic' datasets for sphingolipid metabolism to predict potentially interesting differences. J Lipid Res 2011; 52:1073-1083. Similar analysis demonstrating lipidomic signatures in different breast cancer cell lines that could be predicted from transcriptomic expression data.
    • (2011) J Lipid Res , vol.52 , pp. 1073-1083
    • Momin, A.A.1    Park, H.2    Portz, B.J.3
  • 35
    • 79953232027 scopus 로고    scopus 로고
    • Circulating sphingolipid biomarkers in models of type 1 diabetes
    • First demonstration of elevated sphingosine-1-phosphate in animal models of diabetes and correction by insulin
    • Fox TE, Bewley MC, Unrath KA, et al. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res 2011; 52:509-517. First demonstration of elevated sphingosine-1-phosphate in animal models of diabetes and correction by insulin.
    • (2011) J Lipid Res , vol.52 , pp. 509-517
    • Fox, T.E.1    Bewley, M.C.2    Unrath, K.A.3
  • 36
    • 77956842668 scopus 로고    scopus 로고
    • Sphingolipid distribution changes with age in the human lens
    • MALDI MS imaging shows altered spatial composition of individual sphingomyelin molecular species with age that may contribute to cataract formation in older people
    • Deeley JM, Hankin JA, Friedrich MG, et al. Sphingolipid distribution changes with age in the human lens. J Lipid Res 2010; 51:2753-2760. MALDI MS imaging shows altered spatial composition of individual sphingomyelin molecular species with age that may contribute to cataract formation in older people.
    • (2010) J Lipid Res , vol.51 , pp. 2753-2760
    • Deeley, J.M.1    Hankin, J.A.2    Friedrich, M.G.3
  • 37
    • 79251627763 scopus 로고    scopus 로고
    • Shotgun lipidomics for candidate biomarkers of urinary phospholipids in prostate cancer
    • Preliminary study showing altered urine concentrations of selected phosphatidylserine and phosphatidylinositol molecular species in patients with prostate cancer
    • Min HK, Lim S, Chung BC, Moon MH. Shotgun lipidomics for candidate biomarkers of urinary phospholipids in prostate cancer. Anal Bioanal Chem 2011; 399:823-830. Preliminary study showing altered urine concentrations of selected phosphatidylserine and phosphatidylinositol molecular species in patients with prostate cancer.
    • (2011) Anal Bioanal Chem , vol.399 , pp. 823-830
    • Min, H.K.1    Lim, S.2    Chung, B.C.3    Moon, M.H.4
  • 38
    • 79955007473 scopus 로고    scopus 로고
    • Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients
    • First longitudinal study in children and young adults with cystic fibrosis showing changes to fatty acids, oleoylethanolamide and selected phosphatidylcholine species that correlate with te,poral changes in lung function and may identify specific lipid biomarkers for disease progression in cystic fibrosis
    • Ollero M, Astarita G, Guerrera IC, et al. Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients. J Lipid Res 2011; 52:1011-1022. First longitudinal study in children and young adults with cystic fibrosis showing changes to fatty acids, oleoylethanolamide and selected phosphatidylcholine species that correlate with te,poral changes in lung function and may identify specific lipid biomarkers for disease progression in cystic fibrosis.
    • (2011) J Lipid Res , vol.52 , pp. 1011-1022
    • Ollero, M.1    Astarita, G.2    Guerrera, I.C.3
  • 39
    • 77951255098 scopus 로고    scopus 로고
    • Identification of 48 homologues of phosphatidylethanol in blood by LC-ESI-MS/M.S.
    • Evaluation of an liquid chromatography-multiple reaction monitoring methodology (LC-MRM) for detection and analysis of 48 phosphatidylethanol molecular species in blood as a potential biomarker to determine longer term alcohol intake
    • Gnann H, Engelmann C, Skopp G, et al. Identification of 48 homologues of phosphatidylethanol in blood by LC-ESI-MS/MS. Anal Bioanal Chem 2010; 396:2415-2423. Evaluation of an liquid chromatography-multiple reaction monitoring methodology (LC-MRM) for detection and analysis of 48 phosphatidylethanol molecular species in blood as a potential biomarker to determine longer term alcohol intake.
    • (2010) Anal Bioanal Chem , vol.396 , pp. 2415-2423
    • Gnann, H.1    Engelmann, C.2    Skopp, G.3
  • 40
    • 79956320158 scopus 로고    scopus 로고
    • Method development for routine liquid chromatography-mass spectrometry measurement of the alcohol biomarker phosphatidylethanol (PEth) in blood
    • Establishment of reference ranges of the predominant phosphatidylethanol species in routine blood samples. LC-MRM quantification of these biomarkers has yet to be evaluated prospectively in clinical practice
    • Zheng Y, Beck O, Helander A. Method development for routine liquid chromatography-mass spectrometry measurement of the alcohol biomarker phosphatidylethanol (PEth) in blood. Clin Chim Acta 2011; 412:1428-1435. Establishment of reference ranges of the predominant phosphatidylethanol species in routine blood samples. LC-MRM quantification of these biomarkers has yet to be evaluated prospectively in clinical practice.
    • (2011) Clin Chim Acta , vol.412 , pp. 1428-1435
    • Zheng, Y.1    Beck, O.2    Helander, A.3
  • 41
    • 77953254984 scopus 로고    scopus 로고
    • Multidimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease
    • Review with new results supporting the role for decreased brain apolipoproteinassociated sulphatide and other lipids in the early stage of Alzheimer's disease
    • Han X. Multidimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease. Biochim Biophys Acta 2010; 1801:774-783. Review with new results supporting the role for decreased brain apolipoproteinassociated sulphatide and other lipids in the early stage of Alzheimer's disease.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 774-783
    • Han, X.1
  • 42
    • 81055156279 scopus 로고    scopus 로고
    • Lipidomic investigations for the characterization of circulating serum lipids in multiple sclerosis
    • First demonstration of decreased plasma lysophosphatidylcholine: phosphatidylcholine in multiple sclerosis patients
    • Del BP, Pieragostino D, Di IM, et al. Lipidomic investigations for the characterization of circulating serum lipids in multiple sclerosis. J Proteomics 2011; 74:2826-2836. First demonstration of decreased plasma lysophosphatidylcholine:phosphatidylcholine in multiple sclerosis patients.
    • (2011) J Proteomics , vol.74 , pp. 2826-2836
    • Del, B.P.1    Pieragostino, D.2    Di, I.M.3
  • 43
    • 77953515192 scopus 로고    scopus 로고
    • Oxidative lipidomics of hyperoxic acute lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    • First in a series of articles to demonstrate that oxidative damage to mouse lungs is associated with selective peroxidation of unsaturated cardiolipin and phosphatidylserine molecular species that might be due to mitochondrial free radical generation
    • Tyurina YY, Tyurin VA, Kaynar AM, et al. Oxidative lipidomics of hyperoxic acute lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Am J Physiol Lung Cell Mol Physiol 2010; 299:L73-L85. First in a series of articles to demonstrate that oxidative damage to mouse lungs is associated with selective peroxidation of unsaturated cardiolipin and phosphatidylserine molecular species that might be due to mitochondrial free radical generation.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Tyurina, Y.Y.1    Tyurin, V.A.2    Kaynar, A.M.3
  • 44
    • 80053321306 scopus 로고    scopus 로고
    • Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes
    • Tyurina YY, Kisin ER, Murray A, et al. Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. ACS Nano 2011; 5:7342-7353.
    • (2011) ACS Nano , vol.5 , pp. 7342-7353
    • Tyurina, Y.Y.1    Kisin, E.R.2    Murray, A.3
  • 45
    • 79955395086 scopus 로고    scopus 로고
    • Oxidative lipidomics of gammaradiation-induced lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    • Tyurina YY, Tyurin VA, Kapralova VI, et al. Oxidative lipidomics of gammaradiation-induced lung injury: Mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res 2011; 175:610-621.
    • (2011) Radiat Res , vol.175 , pp. 610-621
    • Tyurina, Y.Y.1    Tyurin, V.A.2    Kapralova, V.I.3
  • 46
    • 75149118930 scopus 로고    scopus 로고
    • Surfactant phospholipids, surfactant proteins, and inflammatory markers during acute lung injury in children
    • Decreased bronchoalveolar lavage surfactant dipalmitoylphosphatidylcholine in children ventilated for acute lung injury is not fully restored before extubation and recovery
    • Todd DA, Marsh MJ, George A, et al. Surfactant phospholipids, surfactant proteins, and inflammatory markers during acute lung injury in children. Pediatr Crit Care Med 2010; 11:82-91. Decreased bronchoalveolar lavage surfactant dipalmitoylphosphatidylcholine in children ventilated for acute lung injury is not fully restored before extubation and recovery.
    • (2010) Pediatr Crit Care Med , vol.11 , pp. 82-91
    • Todd, D.A.1    Marsh, M.J.2    George, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.