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Volumn 20, Issue 6, 2013, Pages 823-833

IL-24 sensitizes tumor cells to TLR3-mediated apoptosis

Author keywords

cancer; IL 24; oncolytic influenza virus; TLR3

Indexed keywords

CASPASE 8; ENZYME INHIBITOR; INTERLEUKIN 24; TOLL LIKE RECEPTOR 3; VIRUS VECTOR;

EID: 84877580504     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.15     Document Type: Article
Times cited : (29)

References (51)
  • 1
    • 0029558740 scopus 로고
    • Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
    • Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 1995; 11: 2477-2486.
    • (1995) Oncogene , vol.11 , pp. 2477-2486
    • Jiang, H.1    Lin, J.J.2    Su, Z.Z.3    Goldstein, N.I.4    Fisher, P.B.5
  • 3
    • 54349120011 scopus 로고    scopus 로고
    • Ad-MDA-7; INGN 241: A review of preclinical and clinical experience
    • Eager R, Harle L, Nemunaitis J. Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. Expert Opin Biol Ther 2008; 8: 1633-1643.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1633-1643
    • Eager, R.1    Harle, L.2    Nemunaitis, J.3
  • 4
    • 19944379432 scopus 로고    scopus 로고
    • Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: A phase i study
    • Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y et al. Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study. Mol Ther 2005; 11: 149-159.
    • (2005) Mol Ther , vol.11 , pp. 149-159
    • Cunningham, C.C.1    Chada, S.2    Merritt, J.A.3    Tong, A.4    Senzer, N.5    Zhang, Y.6
  • 5
    • 84859778026 scopus 로고    scopus 로고
    • Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy
    • Jiang G, Zhang L, Xin Y, Pei DS, Wei ZP, Liu YQ et al. Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy. Acta Oncol 2012; 51: 285-292.
    • (2012) Acta Oncol , vol.51 , pp. 285-292
    • Jiang, G.1    Zhang, L.2    Xin, Y.3    Pei, D.S.4    Wei, Z.P.5    Liu, Y.Q.6
  • 6
    • 0037089491 scopus 로고    scopus 로고
    • Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR)
    • Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H et al. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 2002; 62: 2239-2243.
    • (2002) Cancer Res , vol.62 , pp. 2239-2243
    • Pataer, A.1    Vorburger, S.A.2    Barber, G.N.3    Chada, S.4    Mhashilkar, A.M.5    Zou-Yang, H.6
  • 7
    • 0037162507 scopus 로고    scopus 로고
    • Mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK
    • Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K et al. mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA. 2002; 99: 10054-10059.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 10054-10059
    • Sarkar, D.1    Su, Z.Z.2    Lebedeva, I.V.3    Sauane, M.4    Gopalkrishnan, R.V.5    Valerie, K.6
  • 8
    • 1642383850 scopus 로고    scopus 로고
    • Mda-7 (IL-24) inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling
    • Yacoub A, Mitchell C, Lebedeva IV, Sarkar D, Su ZZ, McKinstry R et al. mda-7 (IL-24) inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling. Cancer Biol Ther 2003; 2: 347-353.
    • (2003) Cancer Biol Ther , vol.2 , pp. 347-353
    • Yacoub, A.1    Mitchell, C.2    Lebedeva, I.V.3    Sarkar, D.4    Su, Z.Z.5    McKinstry, R.6
  • 9
    • 77953805572 scopus 로고    scopus 로고
    • Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine
    • Dash R, Richards JE, Su ZZ, Bhutia SK, Azab B, Rahmani M et al. Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine. Cancer Res 2010; 70: 5034-5045.
    • (2010) Cancer Res , vol.70 , pp. 5034-5045
    • Dash, R.1    Richards, J.E.2    Su, Z.Z.3    Bhutia, S.K.4    Azab, B.5    Rahmani, M.6
  • 10
    • 0345732497 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24
    • Lebedeva IV, Sarkar D, Su ZZ, Kitada S, Dent P, Stein CA et al. Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24. Oncogene 2003; 22: 8758-8773.
    • (2003) Oncogene , vol.22 , pp. 8758-8773
    • Lebedeva, I.V.1    Sarkar, D.2    Su, Z.Z.3    Kitada, S.4    Dent, P.5    Stein, C.A.6
  • 11
    • 34248146982 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma
    • Fisher PB, Sarkar D, Lebedeva IV, Emdad L, Gupta P, Sauane M et al. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma. Toxicol Appl Pharmacol 2007; 224: 300-307.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 300-307
    • Fisher, P.B.1    Sarkar, D.2    Lebedeva, I.V.3    Emdad, L.4    Gupta, P.5    Sauane, M.6
  • 13
    • 84855571972 scopus 로고    scopus 로고
    • AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice
    • Tamai H, Miyake K, Yamaguchi H, Takatori M, Dan K, Inokuchi K et al. AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice. Blood 2012; 119: 64-71.
    • (2012) Blood , vol.119 , pp. 64-71
    • Tamai, H.1    Miyake, K.2    Yamaguchi, H.3    Takatori, M.4    Dan, K.5    Inokuchi, K.6
  • 14
    • 17644388430 scopus 로고    scopus 로고
    • Mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: Identification of IL-20 receptor-mediated bystander activity against pancreatic cancer
    • Chada S, Bocangel D, Ramesh R, Grimm EA, Mumm JB, Mhashilkar AM et al. mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. Mol Ther 2005; 11: 724-733.
    • (2005) Mol Ther , vol.11 , pp. 724-733
    • Chada, S.1    Bocangel, D.2    Ramesh, R.3    Grimm, E.A.4    Mumm, J.B.5    Mhashilkar, A.M.6
  • 15
    • 10344230407 scopus 로고    scopus 로고
    • Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptordependent but STAT3-independent mechanism
    • Chada S, Mhashilkar AM, Ramesh R, Mumm JB, Sutton RB, Bocangel D et al. Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptordependent but STAT3-independent mechanism. Mol Ther 2004; 10: 1085-1095.
    • (2004) Mol Ther , vol.10 , pp. 1085-1095
    • Chada, S.1    Mhashilkar, A.M.2    Ramesh, R.3    Mumm, J.B.4    Sutton, R.B.5    Bocangel, D.6
  • 16
    • 33751505683 scopus 로고    scopus 로고
    • Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10
    • Zheng M, Bocangel D, Doneske B, Mhashilkar A, Ramesh R, Hunt KK et al. Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10. Cancer Immunol Immunother 2007; 56: 205-215.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 205-215
    • Zheng, M.1    Bocangel, D.2    Doneske, B.3    Mhashilkar, A.4    Ramesh, R.5    Hunt, K.K.6
  • 17
    • 7044268950 scopus 로고    scopus 로고
    • Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein
    • Sauane M, Gopalkrishnan RV, Choo HT, Gupta P, Lebedeva IV, Yacoub A et al. Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein. Oncogene 2004; 23: 7679-7690.
    • (2004) Oncogene , vol.23 , pp. 7679-7690
    • Sauane, M.1    Gopalkrishnan, R.V.2    Choo, H.T.3    Gupta, P.4    Lebedeva, I.V.5    Yacoub, A.6
  • 18
    • 2342557922 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways
    • Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K et al. Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Res 2004; 64: 2988-2993.
    • (2004) Cancer Res , vol.64 , pp. 2988-2993
    • Sauane, M.1    Lebedeva, I.V.2    Su, Z.Z.3    Choo, H.T.4    Randolph, A.5    Valerie, K.6
  • 19
    • 0037097637 scopus 로고    scopus 로고
    • The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24
    • Caudell EG, Mumm JB, Poindexter N, Ekmekcioglu S, Mhashilkar AM, Yang XH et al. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. J Immunol 2002; 168: 6041-6046.
    • (2002) J Immunol , vol.168 , pp. 6041-6046
    • Caudell, E.G.1    Mumm, J.B.2    Poindexter, N.3    Ekmekcioglu, S.4    Mhashilkar, A.M.5    Yang, X.H.6
  • 21
    • 4644286871 scopus 로고    scopus 로고
    • FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharide
    • Bannerman DD, Eiting KT, Winn RK, Harlan JM. FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharide. Am J Pathol 2004; 165: 1423-1431.
    • (2004) Am J Pathol , vol.165 , pp. 1423-1431
    • Bannerman, D.D.1    Eiting, K.T.2    Winn, R.K.3    Harlan, J.M.4
  • 22
    • 37549058765 scopus 로고    scopus 로고
    • Toll-like receptors' two-edged sword: When immunity meets apoptosis
    • Salaun B, Romero P, Lebecque S. Toll-like receptors' two-edged sword: when immunity meets apoptosis. Eur J Immunol 2007; 37: 3311-3318.
    • (2007) Eur J Immunol , vol.37 , pp. 3311-3318
    • Salaun, B.1    Romero, P.2    Lebecque, S.3
  • 23
    • 77952241062 scopus 로고    scopus 로고
    • Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
    • Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Hacker G. Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death Differ 2010; 17: 942-951.
    • (2010) Cell Death Differ , vol.17 , pp. 942-951
    • Weber, A.1    Kirejczyk, Z.2    Besch, R.3    Potthoff, S.4    Leverkus, M.5    Hacker, G.6
  • 25
    • 79960922705 scopus 로고    scopus 로고
    • CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    • Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011; 43: 449-463.
    • (2011) Mol Cell , vol.43 , pp. 449-463
    • Feoktistova, M.1    Geserick, P.2    Kellert, B.3    Dimitrova, D.P.4    Langlais, C.5    Hupe, M.6
  • 27
    • 0031925893 scopus 로고    scopus 로고
    • Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells
    • Egorov A, Brandt S, Sereinig S, Romanova J, Ferko B, Katinger D et al. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J Virol 1998; 72: 6437-6441.
    • (1998) J Virol , vol.72 , pp. 6437-6441
    • Egorov, A.1    Brandt, S.2    Sereinig, S.3    Romanova, J.4    Ferko, B.5    Katinger, D.6
  • 28
    • 0345004816 scopus 로고    scopus 로고
    • Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
    • Garcia-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE et al. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 1998; 252: 324-330.
    • (1998) Virology , vol.252 , pp. 324-330
    • Garcia-Sastre, A.1    Egorov, A.2    Matassov, D.3    Brandt, S.4    Levy, D.E.5    Durbin, J.E.6
  • 29
    • 79551708183 scopus 로고    scopus 로고
    • Establishment of a chimeric, replication-deficient influenza A virus vector by modulation of splicing efficiency
    • Wolschek M, Samm E, Seper H, Sturlan S, Kuznetsova I, Schwager C et al. Establishment of a chimeric, replication-deficient influenza A virus vector by modulation of splicing efficiency. J Virol 2011; 85: 2469-2473.
    • (2011) J Virol , vol.85 , pp. 2469-2473
    • Wolschek, M.1    Samm, E.2    Seper, H.3    Sturlan, S.4    Kuznetsova, I.5    Schwager, C.6
  • 30
    • 0036148072 scopus 로고    scopus 로고
    • NS1 protein of influenza A virus downregulates apoptosis
    • Zhirnov OP, Konakova TE, Wolff T, Klenk HD. NS1 protein of influenza A virus downregulates apoptosis. J Virol 2002; 76: 1617-1625.
    • (2002) J Virol , vol.76 , pp. 1617-1625
    • Zhirnov, O.P.1    Konakova, T.E.2    Wolff, T.3    Klenk, H.D.4
  • 31
    • 33947206046 scopus 로고    scopus 로고
    • Cutting edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells
    • Le Goffic R, Pothlichet J, Vitour D, Fujita T, Meurs E, Chignard M et al. Cutting edge: influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol 2007; 178: 3368-3372.
    • (2007) J Immunol , vol.178 , pp. 3368-3372
    • Le Goffic, R.1    Pothlichet, J.2    Vitour, D.3    Fujita, T.4    Meurs, E.5    Chignard, M.6
  • 32
    • 14044267522 scopus 로고    scopus 로고
    • Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    • Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M et al. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 2005; 280: 5571-5580.
    • (2005) J Biol Chem , vol.280 , pp. 5571-5580
    • Guillot, L.1    Le Goffic, R.2    Bloch, S.3    Escriou, N.4    Akira, S.5    Chignard, M.6
  • 33
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis Sousa, E.C.5
  • 34
    • 84871910350 scopus 로고    scopus 로고
    • Cell receptors for influenza a viruses and the innate immune response
    • Ramos I, Fernandez-Sesma A. Cell receptors for influenza a viruses and the innate immune response. Front Microbiol 2012; 3: 117.
    • (2012) Front Microbiol , vol.3 , pp. 117
    • Ramos, I.1    Fernandez-Sesma, A.2
  • 35
    • 33947714475 scopus 로고    scopus 로고
    • Caspase inhibitors promote alternative cell death pathways
    • Vandenabeele P, Vanden Berghe T, Festjens N. Caspase inhibitors promote alternative cell death pathways. Sci STKE 2006; 2006: pe44.
    • (2006) Sci STKE , vol.2006
    • Vandenabeele, P.1    Vanden Berghe, T.2    Festjens, N.3
  • 36
    • 77951251430 scopus 로고    scopus 로고
    • Necroptosis as an alternative form of programmed cell death
    • Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010; 22: 263-268.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 263-268
    • Christofferson, D.E.1    Yuan, J.2
  • 37
    • 23844478190 scopus 로고    scopus 로고
    • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
    • Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol 2005; 175: 3339-3346.
    • (2005) J Immunol , vol.175 , pp. 3339-3346
    • Youn, H.S.1    Lee, J.Y.2    Fitzgerald, K.A.3    Young, H.A.4    Akira, S.5    Hwang, D.H.6
  • 38
    • 85047695547 scopus 로고    scopus 로고
    • The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells
    • Lebedeva IV, Su ZZ, Chang Y, Kitada S, Reed JC, Fisher PB. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 2002; 21: 708-718.
    • (2002) Oncogene , vol.21 , pp. 708-718
    • Lebedeva, I.V.1    Su, Z.Z.2    Chang, Y.3    Kitada, S.4    Reed, J.C.5    Fisher, P.B.6
  • 39
  • 40
    • 33646127801 scopus 로고    scopus 로고
    • Ionizing radiation enhances therapeutic activity of mda-7/IL-24: Overcoming radiation-and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2
    • Su ZZ, Lebedeva IV, Sarkar D, Emdad L, Gupta P, Kitada S et al. Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation-and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2. Oncogene 2006; 25: 2339-2348.
    • (2006) Oncogene , vol.25 , pp. 2339-2348
    • Su, Z.Z.1    Lebedeva, I.V.2    Sarkar, D.3    Emdad, L.4    Gupta, P.5    Kitada, S.6
  • 42
    • 73649117798 scopus 로고    scopus 로고
    • Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis
    • Sauane M, Su ZZ, Dash R, Liu X, Norris JS, Sarkar D et al. Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. J Cell Physiol 2010; 222: 546-555.
    • (2010) J Cell Physiol , vol.222 , pp. 546-555
    • Sauane, M.1    Su, Z.Z.2    Dash, R.3    Liu, X.4    Norris, J.S.5    Sarkar, D.6
  • 43
    • 12144287477 scopus 로고    scopus 로고
    • The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells
    • Sieger KA, Mhashilkar AM, Stewart A, Sutton RB, Strube RW, Chen SY et al. The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells. Mol Ther 2004; 9: 355-367.
    • (2004) Mol Ther , vol.9 , pp. 355-367
    • Sieger, K.A.1    Mhashilkar, A.M.2    Stewart, A.3    Sutton, R.B.4    Strube, R.W.5    Chen, S.Y.6
  • 44
    • 49649109923 scopus 로고    scopus 로고
    • Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo
    • Appledorn DM, Patial S, McBride A, Godbehere S, Van Rooijen N, Parameswaran N et al. Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. J Immunol 2008; 181: 2134-2144.
    • (2008) J Immunol , vol.181 , pp. 2134-2144
    • Appledorn, D.M.1    Patial, S.2    McBride, A.3    Godbehere, S.4    Van Rooijen, N.5    Parameswaran, N.6
  • 45
    • 84855837365 scopus 로고    scopus 로고
    • Adeno-associated virus activates an innate immune response in normal human cells but not in osteosarcoma cells
    • Laredj LN, Beard P. Adeno-associated virus activates an innate immune response in normal human cells but not in osteosarcoma cells. J Virol 2011; 85: 13133-13143.
    • (2011) J Virol , vol.85 , pp. 13133-13143
    • Laredj, L.N.1    Beard, P.2
  • 46
    • 84155178352 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors
    • Hosel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P et al. Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors. Hepatology 2012; 55: 287-297.
    • (2012) Hepatology , vol.55 , pp. 287-297
    • Hosel, M.1    Broxtermann, M.2    Janicki, H.3    Esser, K.4    Arzberger, S.5    Hartmann, P.6
  • 47
    • 84861123852 scopus 로고    scopus 로고
    • Autocrine TNF is critical for the survival of human dendritic cells by regulating BAK, BCL-2, and FLIPL
    • Lehner M, Kellert B, Proff J, Schmid MA, Diessenbacher P, Ensser A et al. Autocrine TNF is critical for the survival of human dendritic cells by regulating BAK, BCL-2, and FLIPL. J Immunol 2012; 188: 4810-4818.
    • (2012) J Immunol , vol.188 , pp. 4810-4818
    • Lehner, M.1    Kellert, B.2    Proff, J.3    Schmid, M.A.4    Diessenbacher, P.5    Ensser, A.6
  • 49
    • 80054852212 scopus 로고    scopus 로고
    • TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer
    • Walczak H. TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer. Immunol Rev 2011; 244: 9-28.
    • (2011) Immunol Rev , vol.244 , pp. 9-28
    • Walczak, H.1
  • 50
    • 75649127312 scopus 로고    scopus 로고
    • A novel type of influenza vaccine: Safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1
    • Wacheck V, Egorov A, Groiss F, Pfeiffer A, Fuereder T, Hoeflmayer D et al. A novel type of influenza vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1. J Infect Dis 2010; 201: 354-362.
    • (2010) J Infect Dis , vol.201 , pp. 354-362
    • Wacheck, V.1    Egorov, A.2    Groiss, F.3    Pfeiffer, A.4    Fuereder, T.5    Hoeflmayer, D.6
  • 51
    • 84858077204 scopus 로고    scopus 로고
    • Cancerinitiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance
    • Lopez J, Poitevin A, Mendoza-Martinez V, Perez-Plasencia C, Garcia-Carranca A. Cancerinitiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance. BMC Cancer 2012; 12: 48.
    • (2012) BMC Cancer , vol.12 , pp. 48
    • Lopez, J.1    Poitevin, A.2    Mendoza-Martinez, V.3    Perez-Plasencia, C.4    Garcia-Carranca, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.