Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7808-7813

  Gerlic, Motti ^a   Faustin, Benjamin ^a   Postigo, Antonio ^b   Yu, Eric Chi Wang ^a   Proell, Martina ^a,c   Gombosuren, Naran ^a   Krajewska, Maryla ^a   Flynn, Rachel ^d   Croft, Michael ^d   Way, Michael ^b   Satterthwait, Arnold ^a   Liddington, Robert C ^a   Salek Ardakani, Shahram ^d,e   Matsuzawa, Shu Ichi ^a   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF SALZBURG   (Austria)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Innate immunity; Poxviruses; Virology; Virus infection

Indexed keywords

F1L PROTEIN; HEXAPEPTIDE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; FEVER; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; VACCINIA VIRUS; VIRUS INFECTION; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

INNATE IMMUNITY; POXVIRUSES; VIROLOGY; VIRUS INFECTION;

AMINO ACID MOTIFS; ANIMALS; CASPASES; CERCOPITHECUS AETHIOPS; CYTOKINES; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; MUTATION; PHENOTYPE; RECOMBINANT PROTEINS; VACCINIA VIRUS; VERO CELLS; VIRAL PROTEINS; VIRULENCE;

EID: 84877339331     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215995110     Document Type: Article

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