메뉴 건너뛰기




Volumn 10, Issue 5, 2013, Pages 1596-1609

Recent advances in mucosal immunization using virus-like particles

Author keywords

mucosal immunization; vaccine; virosomes; virus like particles

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; IMMUNOLOGICAL ADJUVANT; INFLUENZA VIROSOME; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS VACCINE; VIROSOME; VIRUS LIKE PARTICLE VACCINE;

EID: 84877256491     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300597g     Document Type: Review
Times cited : (25)

References (155)
  • 1
    • 84877259510 scopus 로고    scopus 로고
    • Overview of vaccine strategies
    • Rappuoli, R. Bagnoli, F. Caister Academic Press: Norwolk, UK
    • Arnon, R. Overview of vaccine strategies. In Vaccine design Innovative approaches and novel strategies; Rappuoli, R., Bagnoli, F., Eds.; Caister Academic Press: Norwolk, UK, 2011; pp 1-19.
    • (2011) Vaccine Design Innovative Approaches and Novel Strategies , pp. 1-19
    • Arnon, R.1
  • 2
    • 33750862932 scopus 로고    scopus 로고
    • Vaccine manufacturing: Challenges and solutions
    • Ulmer, J. B.; Valley, U.; Rappuoli, R. Vaccine manufacturing: challenges and solutions Nat. Biotechnol. 2006, 24 (11) 1377-83
    • (2006) Nat. Biotechnol. , vol.24 , Issue.11 , pp. 1377-1383
    • Ulmer, J.B.1    Valley, U.2    Rappuoli, R.3
  • 3
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • Neutra, M. R.; Kozlowski, P. A. Mucosal vaccines: the promise and the challenge Nat. Rev. Immunol. 2006, 6 (2) 148-58
    • (2006) Nat. Rev. Immunol. , vol.6 , Issue.2 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 5
    • 0034072432 scopus 로고    scopus 로고
    • Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant
    • Gluck, R.; Mischler, R.; Durrer, P.; Furer, E.; Lang, A. B.; Herzog, C.; Cryz, S. J., Jr. Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant J. Infect. Dis. 2000, 181 (3) 1129-32
    • (2000) J. Infect. Dis. , vol.181 , Issue.3 , pp. 1129-1132
    • Gluck, R.1    Mischler, R.2    Durrer, P.3    Furer, E.4    Lang, A.B.5    Herzog, C.6    Cryz, Jr.S.J.7
  • 6
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • Holmgren, J.; Czerkinsky, C. Mucosal immunity and vaccines Nat. Med. 2005, 11 (4 Suppl) S45-S53
    • (2005) Nat. Med. , vol.11 , Issue.4 SUPPL.
    • Holmgren, J.1    Czerkinsky, C.2
  • 7
    • 84877254966 scopus 로고    scopus 로고
    • Mucosal vaccines
    • Rappuoli, R. Bagnoli, F. Caister Academic Press: Norfolk, UK
    • Ravindran, R.; B., P. Mucosal vaccines. In Vaccine Design Innovative Approaches and novel strategies, Rappuoli, R.; Bagnoli, F., Eds.; Caister Academic Press: Norfolk, UK, 2011; pp 171-209.
    • (2011) Vaccine Design Innovative Approaches and Novel Strategies , pp. 171-209
    • Ravindran, R.B.P.1
  • 9
    • 77249150015 scopus 로고    scopus 로고
    • The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
    • Lavelle, E. C.; Murphy, C.; O'Neill, L. A.; Creagh, E. M. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis Mucosal Immunol. 2010, 3 (1) 17-28
    • (2010) Mucosal Immunol. , vol.3 , Issue.1 , pp. 17-28
    • Lavelle, E.C.1    Murphy, C.2    O'Neill, L.A.3    Creagh, E.M.4
  • 11
    • 13444301079 scopus 로고    scopus 로고
    • Mucosal delivery of CpG oligodeoxynucleotides expands functional dendritic cells and macrophages in the vagina
    • Sajic, D.; Patrick, A. J.; Rosenthal, K. L. Mucosal delivery of CpG oligodeoxynucleotides expands functional dendritic cells and macrophages in the vagina Immunology 2005, 114 (2) 213-24
    • (2005) Immunology , vol.114 , Issue.2 , pp. 213-224
    • Sajic, D.1    Patrick, A.J.2    Rosenthal, K.L.3
  • 12
    • 0033568594 scopus 로고    scopus 로고
    • Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization
    • Coffin, S. E.; Clark, S. L.; Bos, N. A.; Brubaker, J. O.; Offit, P. A. Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization J. Immunol. 1999, 163 (6) 3064-70
    • (1999) J. Immunol. , vol.163 , Issue.6 , pp. 3064-3070
    • Coffin, S.E.1    Clark, S.L.2    Bos, N.A.3    Brubaker, J.O.4    Offit, P.A.5
  • 14
    • 77649245307 scopus 로고    scopus 로고
    • Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids
    • Pakkanen, S. H.; Kantele, J. M.; Moldoveanu, Z.; Hedges, S.; Hakkinen, M.; Mestecky, J.; Kantele, A. Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids Clin. Vaccine Immunol. 2010, 17 (3) 393-401
    • (2010) Clin. Vaccine Immunol. , vol.17 , Issue.3 , pp. 393-401
    • Pakkanen, S.H.1    Kantele, J.M.2    Moldoveanu, Z.3    Hedges, S.4    Hakkinen, M.5    Mestecky, J.6    Kantele, A.7
  • 18
    • 0030861590 scopus 로고    scopus 로고
    • Interaction of antigens and antibodies at mucosal surfaces
    • Lamm, M. E. Interaction of antigens and antibodies at mucosal surfaces Annu. Rev. Microbiol. 1997, 51, 311-40
    • (1997) Annu. Rev. Microbiol. , vol.51 , pp. 311-340
    • Lamm, M.E.1
  • 20
    • 0038325751 scopus 로고    scopus 로고
    • Mucosal immunisation and adjuvants: A brief overview of recent advances and challenges
    • Holmgren, J.; Czerkinsky, C.; Eriksson, K.; Mharandi, A. Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges Vaccine 2003, 21 (Suppl 2) S89-95
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2 , pp. 89-95
    • Holmgren, J.1    Czerkinsky, C.2    Eriksson, K.3    Mharandi, A.4
  • 21
    • 0031906229 scopus 로고    scopus 로고
    • Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice
    • Ball, J. M.; Hardy, M. E.; Atmar, R. L.; Conner, M. E.; Estes, M. K. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice J. Virol. 1998, 72 (2) 1345-53
    • (1998) J. Virol. , vol.72 , Issue.2 , pp. 1345-1353
    • Ball, J.M.1    Hardy, M.E.2    Atmar, R.L.3    Conner, M.E.4    Estes, M.K.5
  • 22
    • 40849140609 scopus 로고    scopus 로고
    • An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles
    • Santi, L.; Batchelor, L.; Huang, Z.; Hjelm, B.; Kilbourne, J.; Arntzen, C. J.; Chen, Q.; Mason, H. S. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles Vaccine 2008, 26 (15) 1846-54
    • (2008) Vaccine , vol.26 , Issue.15 , pp. 1846-1854
    • Santi, L.1    Batchelor, L.2    Huang, Z.3    Hjelm, B.4    Kilbourne, J.5    Arntzen, C.J.6    Chen, Q.7    Mason, H.S.8
  • 23
    • 0031668082 scopus 로고    scopus 로고
    • Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions
    • Balmelli, C.; Roden, R.; Potts, A.; Schiller, J.; De Grandi, P.; Nardelli-Haefliger, D. Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions J. Virol. 1998, 72 (10) 8220-9
    • (1998) J. Virol. , vol.72 , Issue.10 , pp. 8220-8229
    • Balmelli, C.1    Roden, R.2    Potts, A.3    Schiller, J.4    De Grandi, P.5    Nardelli-Haefliger, D.6
  • 24
    • 62249122455 scopus 로고    scopus 로고
    • Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles
    • Fraillery, D.; Zosso, N.; Nardelli-Haefliger, D. Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles Vaccine 2009, 27 (17) 2326-34
    • (2009) Vaccine , vol.27 , Issue.17 , pp. 2326-2334
    • Fraillery, D.1    Zosso, N.2    Nardelli-Haefliger, D.3
  • 25
    • 13144279369 scopus 로고    scopus 로고
    • Oral and intraperitoneal immunization with rotavirus 2/6 virus-like particles stimulates a systemic and mucosal immune response in mice
    • Shuttleworth, G.; Eckery, D. C.; Awram, P. Oral and intraperitoneal immunization with rotavirus 2/6 virus-like particles stimulates a systemic and mucosal immune response in mice Arch. Virol. 2005, 150 (2) 341-9
    • (2005) Arch. Virol. , vol.150 , Issue.2 , pp. 341-349
    • Shuttleworth, G.1    Eckery, D.C.2    Awram, P.3
  • 26
    • 0141459014 scopus 로고    scopus 로고
    • Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B
    • Kang, S. M.; Yao, Q.; Guo, L.; Compans, R. W. Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B J. Virol. 2003, 77 (18) 9823-30
    • (2003) J. Virol. , vol.77 , Issue.18 , pp. 9823-9830
    • Kang, S.M.1    Yao, Q.2    Guo, L.3    Compans, R.W.4
  • 27
    • 70649097215 scopus 로고    scopus 로고
    • Induction of mucosal and systemic antibody responses against the HIV coreceptor CCR5 upon intramuscular immunization and aerosol delivery of a virus-like particle based vaccine
    • Hunter, Z.; Smyth, H. D.; Durfee, P.; Chackerian, B. Induction of mucosal and systemic antibody responses against the HIV coreceptor CCR5 upon intramuscular immunization and aerosol delivery of a virus-like particle based vaccine Vaccine 2009, 28 (2) 403-14
    • (2009) Vaccine , vol.28 , Issue.2 , pp. 403-414
    • Hunter, Z.1    Smyth, H.D.2    Durfee, P.3    Chackerian, B.4
  • 28
    • 33645780447 scopus 로고    scopus 로고
    • Intrarectal immunization with rotavirus 2/6 virus-like particles induces an antirotavirus immune response localized in the intestinal mucosa and protects against rotavirus infection in mice
    • Agnello, D.; Herve, C. A.; Lavaux, A.; Darniot, M.; Guillon, P.; Charpilienne, A.; Pothier, P. Intrarectal immunization with rotavirus 2/6 virus-like particles induces an antirotavirus immune response localized in the intestinal mucosa and protects against rotavirus infection in mice J. Virol. 2006, 80 (8) 3823-32
    • (2006) J. Virol. , vol.80 , Issue.8 , pp. 3823-3832
    • Agnello, D.1    Herve, C.A.2    Lavaux, A.3    Darniot, M.4    Guillon, P.5    Charpilienne, A.6    Pothier, P.7
  • 29
    • 0034767238 scopus 로고    scopus 로고
    • Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response
    • Fromantin, C.; Jamot, B.; Cohen, J.; Piroth, L.; Pothier, P.; Kohli, E. Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response J. Virol. 2001, 75 (22) 11010-6
    • (2001) J. Virol. , vol.75 , Issue.22 , pp. 11010-11016
    • Fromantin, C.1    Jamot, B.2    Cohen, J.3    Piroth, L.4    Pothier, P.5    Kohli, E.6
  • 30
    • 0031900149 scopus 로고    scopus 로고
    • Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge
    • O'Neal, C. M.; Clements, J. D.; Estes, M. K.; Conner, M. E. Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge J. Virol. 1998, 72 (4) 3390-3
    • (1998) J. Virol. , vol.72 , Issue.4 , pp. 3390-3393
    • O'Neal, C.M.1    Clements, J.D.2    Estes, M.K.3    Conner, M.E.4
  • 31
    • 0037706953 scopus 로고    scopus 로고
    • Enhanced mucosal and systemic immune responses following intravaginal immunization with human papillomavirus 16 L1 virus-like particle vaccine in thermosensitive mucoadhesive delivery systems
    • Park, J. S.; Oh, Y. K.; Kang, M. J.; Kim, C. K. Enhanced mucosal and systemic immune responses following intravaginal immunization with human papillomavirus 16 L1 virus-like particle vaccine in thermosensitive mucoadhesive delivery systems J. Med. Virol. 2003, 70 (4) 633-41
    • (2003) J. Med. Virol. , vol.70 , Issue.4 , pp. 633-641
    • Park, J.S.1    Oh, Y.K.2    Kang, M.J.3    Kim, C.K.4
  • 33
    • 0030587188 scopus 로고    scopus 로고
    • Mucosal or targeted lymph node immunization of macaques with a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal mucosa and draining lymph nodes
    • Klavinskis, L. S.; Bergmeier, L. A.; Gao, L.; Mitchell, E.; Ward, R. G.; Layton, G.; Brookes, R.; Meyers, N. J.; Lehner, T. Mucosal or targeted lymph node immunization of macaques with a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal mucosa and draining lymph nodes J. Immunol. 1996, 157 (6) 2521-7
    • (1996) J. Immunol. , vol.157 , Issue.6 , pp. 2521-2527
    • Klavinskis, L.S.1    Bergmeier, L.A.2    Gao, L.3    Mitchell, E.4    Ward, R.G.5    Layton, G.6    Brookes, R.7    Meyers, N.J.8    Lehner, T.9
  • 34
    • 0033799021 scopus 로고    scopus 로고
    • Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs
    • Yuan, L.; Geyer, A.; Hodgins, D. C.; Fan, Z.; Qian, Y.; Chang, K. O.; Crawford, S. E.; Parreno, V.; Ward, L. A.; Estes, M. K.; Conner, M. E.; Saif, L. J. Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs J. Virol. 2000, 74 (19) 8843-53
    • (2000) J. Virol. , vol.74 , Issue.19 , pp. 8843-8853
    • Yuan, L.1    Geyer, A.2    Hodgins, D.C.3    Fan, Z.4    Qian, Y.5    Chang, K.O.6    Crawford, S.E.7    Parreno, V.8    Ward, L.A.9    Estes, M.K.10    Conner, M.E.11    Saif, L.J.12
  • 35
    • 0034853336 scopus 로고    scopus 로고
    • Protective immunity and antibody-secreting cell responses elicited by combined oral attenuated Wa human rotavirus and intranasal Wa 2/6-VLPs with mutant Escherichia coli heat-labile toxin in gnotobiotic pigs
    • Yuan, L.; Iosef, C.; Azevedo, M. S.; Kim, Y.; Qian, Y.; Geyer, A.; Nguyen, T. V.; Chang, K. O.; Saif, L. J. Protective immunity and antibody-secreting cell responses elicited by combined oral attenuated Wa human rotavirus and intranasal Wa 2/6-VLPs with mutant Escherichia coli heat-labile toxin in gnotobiotic pigs J. Virol. 2001, 75 (19) 9229-38
    • (2001) J. Virol. , vol.75 , Issue.19 , pp. 9229-9238
    • Yuan, L.1    Iosef, C.2    Azevedo, M.S.3    Kim, Y.4    Qian, Y.5    Geyer, A.6    Nguyen, T.V.7    Chang, K.O.8    Saif, L.J.9
  • 36
    • 0037333412 scopus 로고    scopus 로고
    • Enhancement of mucosal immunization with virus-like particles of simian immunodeficiency virus
    • Kang, S. M.; Compans, R. W. Enhancement of mucosal immunization with virus-like particles of simian immunodeficiency virus J. Virol. 2003, 77 (6) 3615-23
    • (2003) J. Virol. , vol.77 , Issue.6 , pp. 3615-3623
    • Kang, S.M.1    Compans, R.W.2
  • 37
    • 0037086488 scopus 로고    scopus 로고
    • Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes
    • Iosef, C.; Van Nguyen, T.; Jeong, K.; Bengtsson, K.; Morein, B.; Kim, Y.; Chang, K. O.; Azevedo, M. S.; Yuan, L.; Nielsen, P.; Saif, L. J. Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like- particles associated with immunostimulating complexes Vaccine 2002, 20 (13-14) 1741-53
    • (2002) Vaccine , vol.20 , Issue.1314 , pp. 1741-1753
    • Iosef, C.1    Van Nguyen, T.2    Jeong, K.3    Bengtsson, K.4    Morein, B.5    Kim, Y.6    Chang, K.O.7    Azevedo, M.S.8    Yuan, L.9    Nielsen, P.10    Saif, L.J.11
  • 38
    • 10744228649 scopus 로고    scopus 로고
    • Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM
    • Gonzalez, A. M.; Nguyen, T. V.; Azevedo, M. S.; Jeong, K.; Agarib, F.; Iosef, C.; Chang, K.; Lovgren-Bengtsson, K.; Morein, B.; Saif, L. J. Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM Clin. Exp. Immunol. 2004, 135 (3) 361-72
    • (2004) Clin. Exp. Immunol. , vol.135 , Issue.3 , pp. 361-372
    • Gonzalez, A.M.1    Nguyen, T.V.2    Azevedo, M.S.3    Jeong, K.4    Agarib, F.5    Iosef, C.6    Chang, K.7    Lovgren-Bengtsson, K.8    Morein, B.9    Saif, L.J.10
  • 39
    • 0037407849 scopus 로고    scopus 로고
    • Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A
    • Martin, M.; Michalek, S. M.; Katz, J. Role of innate immune factors in the adjuvant activity of monophosphoryl lipid A Infect. Immun. 2003, 71 (5) 2498-507
    • (2003) Infect. Immun. , vol.71 , Issue.5 , pp. 2498-2507
    • Martin, M.1    Michalek, S.M.2    Katz, J.3
  • 41
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz, A. T.; Navas, T. A.; Lyons, S.; Godowski, P. J.; Madara, J. L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression J. Immunol. 2001, 167 (4) 1882-5
    • (2001) J. Immunol. , vol.167 , Issue.4 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 42
    • 78649759121 scopus 로고    scopus 로고
    • Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection
    • Wang, B. Z.; Xu, R.; Quan, F. S.; Kang, S. M.; Wang, L.; Compans, R. W. Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection PLoS One 2010, 5 (11) e13972
    • (2010) PLoS One , vol.5 , Issue.11 , pp. 13972
    • Wang, B.Z.1    Xu, R.2    Quan, F.S.3    Kang, S.M.4    Wang, L.5    Compans, R.W.6
  • 44
    • 79955098392 scopus 로고    scopus 로고
    • Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant
    • Vassilieva, E. V.; Wang, B. Z.; Vzorov, A. N.; Wang, L.; Wang, Y. C.; Bozja, J.; Xu, R.; Compans, R. W. Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant MBio 2011, 2 (1) e00328-10
    • (2011) MBio , vol.2 , Issue.1 , pp. 00328-00410
    • Vassilieva, E.V.1    Wang, B.Z.2    Vzorov, A.N.3    Wang, L.4    Wang, Y.C.5    Bozja, J.6    Xu, R.7    Compans, R.W.8
  • 45
    • 33745851536 scopus 로고    scopus 로고
    • Adjuvant activity of CpG oligodeoxynucleotides
    • Klinman, D. M. Adjuvant activity of CpG oligodeoxynucleotides Int. Rev. Immunol. 2006, 25 (3-4) 135-54
    • (2006) Int. Rev. Immunol. , vol.25 , Issue.34 , pp. 135-154
    • Klinman, D.M.1
  • 46
    • 77952049136 scopus 로고    scopus 로고
    • Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice
    • Lu, B.; Huang, Y.; Huang, L.; Li, B.; Zheng, Z.; Chen, Z.; Chen, J.; Hu, Q.; Wang, H. Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice Immunology 2010, 130 (2) 254-61
    • (2010) Immunology , vol.130 , Issue.2 , pp. 254-261
    • Lu, B.1    Huang, Y.2    Huang, L.3    Li, B.4    Zheng, Z.5    Chen, Z.6    Chen, J.7    Hu, Q.8    Wang, H.9
  • 47
    • 38349049469 scopus 로고    scopus 로고
    • Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: Implications for vaccine design
    • Bessa, J.; Schmitz, N.; Hinton, H. J.; Schwarz, K.; Jegerlehner, A.; Bachmann, M. F. Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design Eur. J. Immunol. 2008, 38 (1) 114-26
    • (2008) Eur. J. Immunol. , vol.38 , Issue.1 , pp. 114-126
    • Bessa, J.1    Schmitz, N.2    Hinton, H.J.3    Schwarz, K.4    Jegerlehner, A.5    Bachmann, M.F.6
  • 49
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: A matter of size, geometry, kinetics and molecular patterns
    • Bachmann, M. F.; Jennings, G. T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns Nat. Rev. Immunol. 2010, 10 (11) 787-96
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.11 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2
  • 51
    • 77958498224 scopus 로고    scopus 로고
    • Vaccine adjuvants: Putting innate immunity to work
    • Coffman, R. L.; Sher, A.; Seder, R. A. Vaccine adjuvants: putting innate immunity to work Immunity 2010, 33 (4) 492-503
    • (2010) Immunity , vol.33 , Issue.4 , pp. 492-503
    • Coffman, R.L.1    Sher, A.2    Seder, R.A.3
  • 52
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    • Mutsch, M.; Zhou, W.; Rhodes, P.; Bopp, M.; Chen, R. T.; Linder, T.; Spyr, C.; Steffen, R. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland N. Engl. J. Med. 2004, 350 (9) 896-903
    • (2004) N. Engl. J. Med. , vol.350 , Issue.9 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3    Bopp, M.4    Chen, R.T.5    Linder, T.6    Spyr, C.7    Steffen, R.8
  • 54
    • 0018149164 scopus 로고
    • Chromatographic separation of the polyoma virus proteins and renaturation of the isolated VP1 major capsid protein
    • Brady, J. N.; Consigli, R. A. Chromatographic separation of the polyoma virus proteins and renaturation of the isolated VP1 major capsid protein J. Virol. 1978, 27 (2) 436-42
    • (1978) J. Virol. , vol.27 , Issue.2 , pp. 436-442
    • Brady, J.N.1    Consigli, R.A.2
  • 55
    • 0023681347 scopus 로고
    • Polyvalent recombinant antigens: A new vaccine strategy
    • Kingsman, S. M.; Kingsman, A. J. Polyvalent recombinant antigens: a new vaccine strategy Vaccine 1988, 6 (4) 304-6
    • (1988) Vaccine , vol.6 , Issue.4 , pp. 304-306
    • Kingsman, S.M.1    Kingsman, A.J.2
  • 56
    • 33748794562 scopus 로고    scopus 로고
    • Virus-like particles: Passport to immune recognition
    • Grgacic, E. V.; Anderson, D. A. Virus-like particles: passport to immune recognition Methods 2006, 40 (1) 60-5
    • (2006) Methods , vol.40 , Issue.1 , pp. 60-65
    • Grgacic, E.V.1    Anderson, D.A.2
  • 57
    • 67349199167 scopus 로고    scopus 로고
    • Comparison of the efficacy of rotavirus VLP vaccines to a live homologous rotavirus vaccine in a pig model of rotavirus disease
    • El-Attar, L.; Oliver, S. L.; Mackie, A.; Charpilienne, A.; Poncet, D.; Cohen, J.; Bridger, J. C. Comparison of the efficacy of rotavirus VLP vaccines to a live homologous rotavirus vaccine in a pig model of rotavirus disease Vaccine 2009, 27 (24) 3201-8
    • (2009) Vaccine , vol.27 , Issue.24 , pp. 3201-3208
    • El-Attar, L.1    Oliver, S.L.2    MacKie, A.3    Charpilienne, A.4    Poncet, D.5    Cohen, J.6    Bridger, J.C.7
  • 58
    • 34247149352 scopus 로고    scopus 로고
    • Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins
    • Quan, F. S.; Sailaja, G.; Skountzou, I.; Huang, C.; Vzorov, A.; Compans, R. W.; Kang, S. M. Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins Vaccine 2007, 25 (19) 3841-50
    • (2007) Vaccine , vol.25 , Issue.19 , pp. 3841-3850
    • Quan, F.S.1    Sailaja, G.2    Skountzou, I.3    Huang, C.4    Vzorov, A.5    Compans, R.W.6    Kang, S.M.7
  • 59
    • 34247602007 scopus 로고    scopus 로고
    • Human immunodeficiency virus-like particles activate multiple types of immune cells
    • Sailaja, G.; Skountzou, I.; Quan, F. S.; Compans, R. W.; Kang, S. M. Human immunodeficiency virus-like particles activate multiple types of immune cells Virology 2007, 362 (2) 331-41
    • (2007) Virology , vol.362 , Issue.2 , pp. 331-341
    • Sailaja, G.1    Skountzou, I.2    Quan, F.S.3    Compans, R.W.4    Kang, S.M.5
  • 60
    • 70349900710 scopus 로고    scopus 로고
    • Virus-like particle vaccines and adjuvants: The HPV paradigm
    • Buonaguro, F. M.; Tornesello, M. L.; Buonaguro, L. Virus-like particle vaccines and adjuvants: the HPV paradigm Expert Rev. Vaccines 2009, 8 (10) 1379-98
    • (2009) Expert Rev. Vaccines , vol.8 , Issue.10 , pp. 1379-1398
    • Buonaguro, F.M.1    Tornesello, M.L.2    Buonaguro, L.3
  • 61
  • 62
    • 79955088826 scopus 로고    scopus 로고
    • Influenza virosomes as a vaccine adjuvant and carrier system
    • Moser, C.; Amacker, M.; Zurbriggen, R. Influenza virosomes as a vaccine adjuvant and carrier system Expert Rev. Vaccines 2011, 10 (4) 437-46
    • (2011) Expert Rev. Vaccines , vol.10 , Issue.4 , pp. 437-446
    • Moser, C.1    Amacker, M.2    Zurbriggen, R.3
  • 63
    • 57349101748 scopus 로고    scopus 로고
    • Self-assembly of the recombinant capsid protein of a swine norovirus into virus-like particles and evaluation of monoclonal antibodies cross-reactive with a human strain from genogroup II
    • Almanza, H.; Cubillos, C.; Angulo, I.; Mateos, F.; Caston, J. R.; van der Poel, W. H.; Vinje, J.; Barcena, J.; Mena, I. Self-assembly of the recombinant capsid protein of a swine norovirus into virus-like particles and evaluation of monoclonal antibodies cross-reactive with a human strain from genogroup II J. Clin. Microbiol. 2008, 46 (12) 3971-9
    • (2008) J. Clin. Microbiol. , vol.46 , Issue.12 , pp. 3971-3979
    • Almanza, H.1    Cubillos, C.2    Angulo, I.3    Mateos, F.4    Caston, J.R.5    Van Der Poel, W.H.6    Vinje, J.7    Barcena, J.8    Mena, I.9
  • 64
    • 0142028883 scopus 로고    scopus 로고
    • Formation of polyomavirus-like particles with different VP1 molecules that bind the urokinase plasminogen activator receptor
    • Shin, Y. C.; Folk, W. R. Formation of polyomavirus-like particles with different VP1 molecules that bind the urokinase plasminogen activator receptor J. Virol. 2003, 77 (21) 11491-8
    • (2003) J. Virol. , vol.77 , Issue.21 , pp. 11491-11498
    • Shin, Y.C.1    Folk, W.R.2
  • 65
    • 0025001943 scopus 로고
    • Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector
    • Hoss, A.; Moarefi, I.; Scheidtmann, K. H.; Cisek, L. J.; Corden, J. L.; Dornreiter, I.; Arthur, A. K.; Fanning, E. Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector J. Virol. 1990, 64 (10) 4799-807
    • (1990) J. Virol. , vol.64 , Issue.10 , pp. 4799-4807
    • Hoss, A.1    Moarefi, I.2    Scheidtmann, K.H.3    Cisek, L.J.4    Corden, J.L.5    Dornreiter, I.6    Arthur, A.K.7    Fanning, E.8
  • 68
    • 0042825878 scopus 로고    scopus 로고
    • Virus-like particles as immunogens
    • Noad, R.; Roy, P. Virus-like particles as immunogens Trends Microbiol. 2003, 11 (9) 438-44
    • (2003) Trends Microbiol. , vol.11 , Issue.9 , pp. 438-444
    • Noad, R.1    Roy, P.2
  • 69
    • 0030560642 scopus 로고    scopus 로고
    • The new generation of recombinant viral subunit vaccines
    • Ellis, R. W. The new generation of recombinant viral subunit vaccines Curr. Opin. Biotechnol. 1996, 7 (6) 646-52
    • (1996) Curr. Opin. Biotechnol. , vol.7 , Issue.6 , pp. 646-652
    • Ellis, R.W.1
  • 70
    • 0028860679 scopus 로고
    • Prospects for a vaccine against human papillomavirus
    • Hines, J. F.; Ghim, S.; Schlegel, R.; Jenson, A. B. Prospects for a vaccine against human papillomavirus Obstet. Gynecol. 1995, 86 (5) 860-6
    • (1995) Obstet. Gynecol. , vol.86 , Issue.5 , pp. 860-866
    • Hines, J.F.1    Ghim, S.2    Schlegel, R.3    Jenson, A.B.4
  • 71
    • 14844300825 scopus 로고    scopus 로고
    • Virus-like particles as HIV-1 vaccines
    • Doan, L. X.; Li, M.; Chen, C.; Yao, Q. Virus-like particles as HIV-1 vaccines Rev. Med. Virol. 2005, 15 (2) 75-88
    • (2005) Rev. Med. Virol. , vol.15 , Issue.2 , pp. 75-88
    • Doan, L.X.1    Li, M.2    Chen, C.3    Yao, Q.4
  • 72
    • 0036199391 scopus 로고    scopus 로고
    • Structural requirements for the assembly of Norwalk virus-like particles
    • Bertolotti-Ciarlet, A.; White, L. J.; Chen, R.; Prasad, B. V.; Estes, M. K. Structural requirements for the assembly of Norwalk virus-like particles J. Virol. 2002, 76 (8) 4044-55
    • (2002) J. Virol. , vol.76 , Issue.8 , pp. 4044-4055
    • Bertolotti-Ciarlet, A.1    White, L.J.2    Chen, R.3    Prasad, B.V.4    Estes, M.K.5
  • 74
    • 0027080416 scopus 로고
    • Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
    • Gluck, R.; Mischler, R.; Brantschen, S.; Just, M.; Althaus, B.; Cryz, S. J., Jr. Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A J. Clin. Invest. 1992, 90 (6) 2491-5
    • (1992) J. Clin. Invest. , vol.90 , Issue.6 , pp. 2491-2495
    • Gluck, R.1    Mischler, R.2    Brantschen, S.3    Just, M.4    Althaus, B.5    Cryz, Jr.S.J.6
  • 75
    • 9244234954 scopus 로고    scopus 로고
    • Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
    • Felnerova, D.; Viret, J. F.; Gļck, R.; Moser, C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs Curr. Opin. Biotechnol. 2004, 15 (6) 518-29
    • (2004) Curr. Opin. Biotechnol. , vol.15 , Issue.6 , pp. 518-529
    • Felnerova, D.1    Viret, J.F.2    Glìck, R.3    Moser, C.4
  • 76
    • 0028822890 scopus 로고
    • Virosomes as carriers for combined vaccines
    • Mengiardi, B.; Berger, R.; Just, M.; Gluck, R. Virosomes as carriers for combined vaccines Vaccine 1995, 13 (14) 1306-15
    • (1995) Vaccine , vol.13 , Issue.14 , pp. 1306-1315
    • Mengiardi, B.1    Berger, R.2    Just, M.3    Gluck, R.4
  • 77
    • 0036555140 scopus 로고    scopus 로고
    • Delivery of protein antigens to the immune system by fusion-active virosomes: A comparison with liposomes and ISCOMs
    • Bungener, L.; Huckriede, A.; Wilschut, J.; Daemen, T. Delivery of protein antigens to the immune system by fusion-active virosomes: a comparison with liposomes and ISCOMs Biosci. Rep. 2002, 22 (2) 323-38
    • (2002) Biosci. Rep. , vol.22 , Issue.2 , pp. 323-338
    • Bungener, L.1    Huckriede, A.2    Wilschut, J.3    Daemen, T.4
  • 78
    • 84877256253 scopus 로고    scopus 로고
    • Virosomes
    • Rappuoli, R. de Gregorio, E. Future medicine: Novato, CA
    • Moser, C. Virosomes. In Novel immunologic adjuvants; Rappuoli, R.; de Gregorio, E., Eds.; Future medicine: Novato, CA, 2009; pp 43-53.
    • (2009) Novel Immunologic Adjuvants , pp. 43-53
    • Moser, C.1
  • 79
    • 53849128926 scopus 로고    scopus 로고
    • Epaxal: A virosomal vaccine to prevent hepatitis A infection
    • Bovier, P. A. Epaxal: a virosomal vaccine to prevent hepatitis A infection Expert Rev. Vaccines 2008, 7 (8) 1141-50
    • (2008) Expert Rev. Vaccines , vol.7 , Issue.8 , pp. 1141-1150
    • Bovier, P.A.1
  • 84
    • 0000657854 scopus 로고
    • Oral immunization against poliomyelitis
    • Payne, A. M. Oral immunization against poliomyelitis Bull. W. H. O. 1960, 23 (6) 695-703
    • (1960) Bull. W. H. O. , vol.23 , Issue.6 , pp. 695-703
    • Payne, A.M.1
  • 86
    • 0015406280 scopus 로고
    • Comparative immunogenicity of heat-killed and living oral Salmonella vaccines
    • Collins, F. M.; Carter, P. B. Comparative immunogenicity of heat-killed and living oral Salmonella vaccines Infect. Immun. 1972, 6 (4) 451-8
    • (1972) Infect. Immun. , vol.6 , Issue.4 , pp. 451-458
    • Collins, F.M.1    Carter, P.B.2
  • 87
    • 0034042562 scopus 로고    scopus 로고
    • Mucosal immunity and gastrointestinal antigen processing
    • Mayer, L. Mucosal immunity and gastrointestinal antigen processing J. Pediatr. Gastroenterol. Nutr. 2000, 30 (Suppl) S4-12
    • (2000) J. Pediatr. Gastroenterol. Nutr. , vol.30 , Issue.SUPPL. , pp. 4-12
    • Mayer, L.1
  • 88
  • 90
    • 0023837323 scopus 로고
    • A tissue-specific endothelial cell molecule involved in lymphocyte homing
    • Streeter, P. R.; Berg, E. L.; Rouse, B. T.; Bargatze, R. F.; Butcher, E. C. A tissue-specific endothelial cell molecule involved in lymphocyte homing Nature 1988, 331 (6151) 41-6
    • (1988) Nature , vol.331 , Issue.6151 , pp. 41-46
    • Streeter, P.R.1    Berg, E.L.2    Rouse, B.T.3    Bargatze, R.F.4    Butcher, E.C.5
  • 91
    • 0029891823 scopus 로고    scopus 로고
    • Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
    • Mason, H. S.; Ball, J. M.; Shi, J. J.; Jiang, X.; Estes, M. K.; Arntzen, C. J. Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice Proc. Natl. Acad. Sci. U.S.A. 1996, 93 (11) 5335-40
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.11 , pp. 5335-5340
    • Mason, H.S.1    Ball, J.M.2    Shi, J.J.3    Jiang, X.4    Estes, M.K.5    Arntzen, C.J.6
  • 92
    • 0035858098 scopus 로고    scopus 로고
    • Oral administration of hepatitis e virus-like particles induces a systemic and mucosal immune response in mice
    • Li, T.; Takeda, N.; Miyamura, T. Oral administration of hepatitis E virus-like particles induces a systemic and mucosal immune response in mice Vaccine 2001, 19 (25-26) 3476-84
    • (2001) Vaccine , vol.19 , Issue.2526 , pp. 3476-3484
    • Li, T.1    Takeda, N.2    Miyamura, T.3
  • 93
  • 95
    • 76149109751 scopus 로고    scopus 로고
    • Molecular characterization of the VP1, VP2, VP4, VP6, NSP1 and NSP2 genes of bovine group B rotaviruses: Identification of a novel VP4 genotype
    • Ghosh, S.; Kobayashi, N.; Nagashima, S.; Chawla-Sarkar, M.; Krishnan, T.; Ganesh, B.; Naik, T. N. Molecular characterization of the VP1, VP2, VP4, VP6, NSP1 and NSP2 genes of bovine group B rotaviruses: identification of a novel VP4 genotype Arch. Virol. 2010, 155 (2) 159-67
    • (2010) Arch. Virol. , vol.155 , Issue.2 , pp. 159-167
    • Ghosh, S.1    Kobayashi, N.2    Nagashima, S.3    Chawla-Sarkar, M.4    Krishnan, T.5    Ganesh, B.6    Naik, T.N.7
  • 96
    • 84862673527 scopus 로고    scopus 로고
    • ISCOMATRIX: A novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases
    • Morelli, A. B.; Becher, D.; Koernig, S.; Silva, A.; Drane, D.; Maraskovsky, E. ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases J. Med. Microbiol. 2012, 61 (Pt 7) 935-43
    • (2012) J. Med. Microbiol. , vol.61 , Issue.PART 7 , pp. 935-943
    • Morelli, A.B.1    Becher, D.2    Koernig, S.3    Silva, A.4    Drane, D.5    Maraskovsky, E.6
  • 97
  • 98
    • 18744368156 scopus 로고    scopus 로고
    • Induction of systemic and mucosal cross-clade neutralizing antibodies in BALB/c mice immunized with human immunodeficiency virus type 1 clade A virus-like particles administered by different routes of inoculation
    • Buonaguro, L.; Visciano, M. L.; Tornesello, M. L.; Tagliamonte, M.; Biryahwaho, B.; Buonaguro, F. M. Induction of systemic and mucosal cross-clade neutralizing antibodies in BALB/c mice immunized with human immunodeficiency virus type 1 clade A virus-like particles administered by different routes of inoculation J. Virol. 2005, 79 (11) 7059-67
    • (2005) J. Virol. , vol.79 , Issue.11 , pp. 7059-7067
    • Buonaguro, L.1    Visciano, M.L.2    Tornesello, M.L.3    Tagliamonte, M.4    Biryahwaho, B.5    Buonaguro, F.M.6
  • 99
    • 0030821175 scopus 로고    scopus 로고
    • Rotavirus virus-like particles administered mucosally induce protective immunity
    • O'Neal, C. M.; Crawford, S. E.; Estes, M. K.; Conner, M. E. Rotavirus virus-like particles administered mucosally induce protective immunity J. Virol. 1997, 71 (11) 8707-17
    • (1997) J. Virol. , vol.71 , Issue.11 , pp. 8707-8717
    • O'Neal, C.M.1    Crawford, S.E.2    Estes, M.K.3    Conner, M.E.4
  • 100
    • 0242349122 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice
    • Bertolotti-Ciarlet, A.; Ciarlet, M.; Crawford, S. E.; Conner, M. E.; Estes, M. K. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice Vaccine 2003, 21 (25-26) 3885-900
    • (2003) Vaccine , vol.21 , Issue.2526 , pp. 3885-3900
    • Bertolotti-Ciarlet, A.1    Ciarlet, M.2    Crawford, S.E.3    Conner, M.E.4    Estes, M.K.5
  • 101
    • 77649252796 scopus 로고    scopus 로고
    • An oral versus intranasal prime/boost regimen using attenuated human rotavirus or VP2 and VP6 virus-like particles with immunostimulating complexes influences protection and antibody-secreting cell responses to rotavirus in a neonatal gnotobiotic pig model
    • Azevedo, M. S.; Gonzalez, A. M.; Yuan, L.; Jeong, K. I.; Iosef, C.; Van Nguyen, T.; Lovgren-Bengtsson, K.; Morein, B.; Saif, L. J. An oral versus intranasal prime/boost regimen using attenuated human rotavirus or VP2 and VP6 virus-like particles with immunostimulating complexes influences protection and antibody-secreting cell responses to rotavirus in a neonatal gnotobiotic pig model Clin. Vaccine Immunol. 2010, 17 (3) 420-8
    • (2010) Clin. Vaccine Immunol. , vol.17 , Issue.3 , pp. 420-428
    • Azevedo, M.S.1    Gonzalez, A.M.2    Yuan, L.3    Jeong, K.I.4    Iosef, C.5    Van Nguyen, T.6    Lovgren-Bengtsson, K.7    Morein, B.8    Saif, L.J.9
  • 102
    • 44749093425 scopus 로고    scopus 로고
    • Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs
    • Yuan, L.; Wen, K.; Azevedo, M. S.; Gonzalez, A. M.; Zhang, W.; Saif, L. J. Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs Vaccine 2008, 26 (26) 3322-31
    • (2008) Vaccine , vol.26 , Issue.26 , pp. 3322-3331
    • Yuan, L.1    Wen, K.2    Azevedo, M.S.3    Gonzalez, A.M.4    Zhang, W.5    Saif, L.J.6
  • 103
    • 0030808208 scopus 로고    scopus 로고
    • Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice
    • Nardelli-Haefliger, D.; Roden, R. B.; Benyacoub, J.; Sahli, R.; Kraehenbuhl, J. P.; Schiller, J. T.; Lachat, P.; Potts, A.; De Grandi, P. Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice Infect. Immun. 1997, 65 (8) 3328-36
    • (1997) Infect. Immun. , vol.65 , Issue.8 , pp. 3328-3336
    • Nardelli-Haefliger, D.1    Roden, R.B.2    Benyacoub, J.3    Sahli, R.4    Kraehenbuhl, J.P.5    Schiller, J.T.6    Lachat, P.7    Potts, A.8    De Grandi, P.9
  • 104
    • 0035027908 scopus 로고    scopus 로고
    • Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA
    • Gerber, S.; Lane, C.; Brown, D. M.; Lord, E.; DiLorenzo, M.; Clements, J. D.; Rybicki, E.; Williamson, A. L.; Rose, R. C. Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA J. Virol. 2001, 75 (10) 4752-60
    • (2001) J. Virol. , vol.75 , Issue.10 , pp. 4752-4760
    • Gerber, S.1    Lane, C.2    Brown, D.M.3    Lord, E.4    Dilorenzo, M.5    Clements, J.D.6    Rybicki, E.7    Williamson, A.L.8    Rose, R.C.9
  • 105
    • 34247877512 scopus 로고    scopus 로고
    • Mucosal dendritic cells
    • Iwasaki, A. Mucosal dendritic cells Annu. Rev. Immunol. 2007, 25, 381-418
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 381-418
    • Iwasaki, A.1
  • 106
    • 4544258068 scopus 로고    scopus 로고
    • NALT- versus Peyer's-patch-mediated mucosal immunity
    • Kiyono, H.; Fukuyama, S. NALT- versus Peyer's-patch-mediated mucosal immunity Nat. Rev. Immunol. 2004, 4 (9) 699-710
    • (2004) Nat. Rev. Immunol. , vol.4 , Issue.9 , pp. 699-710
    • Kiyono, H.1    Fukuyama, S.2
  • 107
    • 0035800739 scopus 로고    scopus 로고
    • Individual rotavirus-like particles containing 120 molecules of fluorescent protein are visible in living cells
    • Charpilienne, A.; Nejmeddine, M.; Berois, M.; Parez, N.; Neumann, E.; Hewat, E.; Trugnan, G.; Cohen, J. Individual rotavirus-like particles containing 120 molecules of fluorescent protein are visible in living cells J. Biol. Chem. 2001, 276 (31) 29361-7
    • (2001) J. Biol. Chem. , vol.276 , Issue.31 , pp. 29361-29367
    • Charpilienne, A.1    Nejmeddine, M.2    Berois, M.3    Parez, N.4    Neumann, E.5    Hewat, E.6    Trugnan, G.7    Cohen, J.8
  • 111
    • 18844377157 scopus 로고    scopus 로고
    • Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine
    • Nardelli-Haefliger, D.; Lurati, F.; Wirthner, D.; Spertini, F.; Schiller, J. T.; Lowy, D. R.; Ponci, F.; De Grandi, P. Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine Vaccine 2005, 23 (28) 3634-41
    • (2005) Vaccine , vol.23 , Issue.28 , pp. 3634-3641
    • Nardelli-Haefliger, D.1    Lurati, F.2    Wirthner, D.3    Spertini, F.4    Schiller, J.T.5    Lowy, D.R.6    Ponci, F.7    De Grandi, P.8
  • 112
    • 0036893497 scopus 로고    scopus 로고
    • Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles
    • Balmelli, C.; Demotz, S.; Acha-Orbea, H.; De Grandi, P.; Nardelli-Haefliger, D. Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles J. Virol. 2002, 76 (24) 12596-602
    • (2002) J. Virol. , vol.76 , Issue.24 , pp. 12596-12602
    • Balmelli, C.1    Demotz, S.2    Acha-Orbea, H.3    De Grandi, P.4    Nardelli-Haefliger, D.5
  • 113
    • 0032488255 scopus 로고    scopus 로고
    • Mucosal immunisation with papillomavirus virus-like particles elicits systemic and mucosal immunity in mice
    • Liu, X. S.; Abdul-Jabbar, I.; Qi, Y. M.; Frazer, I. H.; Zhou, J. Mucosal immunisation with papillomavirus virus-like particles elicits systemic and mucosal immunity in mice Virology 1998, 252 (1) 39-45
    • (1998) Virology , vol.252 , Issue.1 , pp. 39-45
    • Liu, X.S.1    Abdul-Jabbar, I.2    Qi, Y.M.3    Frazer, I.H.4    Zhou, J.5
  • 114
    • 0033008860 scopus 로고    scopus 로고
    • The nature of the attenuation of Salmonella typhimurium strains expressing human papillomavirus type 16 virus-like particles determines the systemic and mucosal antibody responses in nasally immunized mice
    • Benyacoub, J.; Hopkins, S.; Potts, A.; Kelly, S.; Kraehenbuhl, J. P.; Curtiss, R., 3rd; De Grandi, P.; Nardelli-Haefliger, D. The nature of the attenuation of Salmonella typhimurium strains expressing human papillomavirus type 16 virus-like particles determines the systemic and mucosal antibody responses in nasally immunized mice Infect. Immun. 1999, 67 (7) 3674-9
    • (1999) Infect. Immun. , vol.67 , Issue.7 , pp. 3674-3679
    • Benyacoub, J.1    Hopkins, S.2    Potts, A.3    Kelly, S.4    Kraehenbuhl, J.P.5    Curtiss III, R.6    De Grandi, P.7    Nardelli-Haefliger, D.8
  • 115
    • 0032826809 scopus 로고    scopus 로고
    • Mucosal but not parenteral immunization with purified human papillomavirus type 16 virus-like particles induces neutralizing titers of antibodies throughout the estrous cycle of mice
    • Nardelli-Haefliger, D.; Roden, R.; Balmelli, C.; Potts, A.; Schiller, J.; De Grandi, P. Mucosal but not parenteral immunization with purified human papillomavirus type 16 virus-like particles induces neutralizing titers of antibodies throughout the estrous cycle of mice J. Virol. 1999, 73 (11) 9609-13
    • (1999) J. Virol. , vol.73 , Issue.11 , pp. 9609-9613
    • Nardelli-Haefliger, D.1    Roden, R.2    Balmelli, C.3    Potts, A.4    Schiller, J.5    De Grandi, P.6
  • 116
    • 0037035866 scopus 로고    scopus 로고
    • Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity
    • Yao, Q.; Vuong, V.; Li, M.; Compans, R. W. Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity Vaccine 2002, 20 (19-20) 2537-45
    • (2002) Vaccine , vol.20 , Issue.1920 , pp. 2537-2545
    • Yao, Q.1    Vuong, V.2    Li, M.3    Compans, R.W.4
  • 117
    • 0033799028 scopus 로고    scopus 로고
    • Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea
    • Coste, A.; Sirard, J. C.; Johansen, K.; Cohen, J.; Kraehenbuhl, J. P. Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea J. Virol. 2000, 74 (19) 8966-71
    • (2000) J. Virol. , vol.74 , Issue.19 , pp. 8966-8971
    • Coste, A.1    Sirard, J.C.2    Johansen, K.3    Cohen, J.4    Kraehenbuhl, J.P.5
  • 118
    • 32044443378 scopus 로고    scopus 로고
    • Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs)
    • Blutt, S. E.; Warfield, K. L.; O'Neal, C. M.; Estes, M. K.; Conner, M. E. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs) Vaccine 2006, 24 (8) 1170-9
    • (2006) Vaccine , vol.24 , Issue.8 , pp. 1170-1179
    • Blutt, S.E.1    Warfield, K.L.2    O'Neal, C.M.3    Estes, M.K.4    Conner, M.E.5
  • 119
    • 34447509610 scopus 로고    scopus 로고
    • DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity
    • Buonaguro, L.; Devito, C.; Tornesello, M. L.; Schroder, U.; Wahren, B.; Hinkula, J.; Buonaguro, F. M. DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity Vaccine 2007, 25 (32) 5968-77
    • (2007) Vaccine , vol.25 , Issue.32 , pp. 5968-5977
    • Buonaguro, L.1    Devito, C.2    Tornesello, M.L.3    Schroder, U.4    Wahren, B.5    Hinkula, J.6    Buonaguro, F.M.7
  • 121
    • 84855823916 scopus 로고    scopus 로고
    • A murine genital-challenge model is a sensitive measure of protective antibodies against human papillomavirus infection
    • Longet, S.; Schiller, J. T.; Bobst, M.; Jichlinski, P.; Nardelli-Haefliger, D. A murine genital-challenge model is a sensitive measure of protective antibodies against human papillomavirus infection J. Virol. 2011, 85 (24) 13253-9
    • (2011) J. Virol. , vol.85 , Issue.24 , pp. 13253-13259
    • Longet, S.1    Schiller, J.T.2    Bobst, M.3    Jichlinski, P.4    Nardelli-Haefliger, D.5
  • 122
    • 34547467742 scopus 로고    scopus 로고
    • Humoral and cellular immune responses to airway immunization of mice with human papillomavirus type 16 virus-like particles and mucosal adjuvants
    • Revaz, V.; Zurbriggen, R.; Moser, C.; Schiller, J. T.; Ponci, F.; Bobst, M.; Nardelli-Haefliger, D. Humoral and cellular immune responses to airway immunization of mice with human papillomavirus type 16 virus-like particles and mucosal adjuvants Antiviral Res. 2007, 76 (1) 75-85
    • (2007) Antiviral Res. , vol.76 , Issue.1 , pp. 75-85
    • Revaz, V.1    Zurbriggen, R.2    Moser, C.3    Schiller, J.T.4    Ponci, F.5    Bobst, M.6    Nardelli-Haefliger, D.7
  • 123
    • 66149101000 scopus 로고    scopus 로고
    • Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge
    • Perrone, L. A.; Ahmad, A.; Veguilla, V.; Lu, X.; Smith, G.; Katz, J. M.; Pushko, P.; Tumpey, T. M. Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge J. Virol. 2009, 83 (11) 5726-34
    • (2009) J. Virol. , vol.83 , Issue.11 , pp. 5726-5734
    • Perrone, L.A.1    Ahmad, A.2    Veguilla, V.3    Lu, X.4    Smith, G.5    Katz, J.M.6    Pushko, P.7    Tumpey, T.M.8
  • 124
    • 0035178074 scopus 로고    scopus 로고
    • Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans
    • Johansson, E. L.; Wassen, L.; Holmgren, J.; Jertborn, M.; Rudin, A. Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans Infect. Immun. 2001, 69 (12) 7481-6
    • (2001) Infect. Immun. , vol.69 , Issue.12 , pp. 7481-7486
    • Johansson, E.L.1    Wassen, L.2    Holmgren, J.3    Jertborn, M.4    Rudin, A.5
  • 125
    • 0036239831 scopus 로고    scopus 로고
    • Route of administration of chimeric BPV1 VLP determines the character of the induced immune responses
    • Liu, X. S.; Liu, W. J.; Zhao, K. N.; Liu, Y. H.; Leggatt, G.; Frazer, I. H. Route of administration of chimeric BPV1 VLP determines the character of the induced immune responses Immunol. Cell Biol. 2002, 80 (1) 21-9
    • (2002) Immunol. Cell Biol. , vol.80 , Issue.1 , pp. 21-29
    • Liu, X.S.1    Liu, W.J.2    Zhao, K.N.3    Liu, Y.H.4    Leggatt, G.5    Frazer, I.H.6
  • 127
    • 0035888254 scopus 로고    scopus 로고
    • What are the limits of adjuvanticity?
    • Del Giudice, G.; Podda, A.; Rappuoli, R. What are the limits of adjuvanticity? Vaccine 2001, 20 (Suppl 1) S38-41
    • (2001) Vaccine , vol.20 , Issue.SUPPL. 1 , pp. 38-41
    • Del Giudice, G.1    Podda, A.2    Rappuoli, R.3
  • 128
    • 0142188592 scopus 로고    scopus 로고
    • Disruption of the upper female reproductive tract epithelium by nonoxynol-9
    • Dayal, M. B.; Wheeler, J.; Williams, C. J.; Barnhart, K. T. Disruption of the upper female reproductive tract epithelium by nonoxynol-9 Contraception 2003, 68 (4) 273-9
    • (2003) Contraception , vol.68 , Issue.4 , pp. 273-279
    • Dayal, M.B.1    Wheeler, J.2    Williams, C.J.3    Barnhart, K.T.4
  • 130
    • 79958137861 scopus 로고    scopus 로고
    • Aerosol delivery of virus-like particles to the genital tract induces local and systemic antibody responses
    • Hunter, Z.; Tumban, E.; Dziduszko, A.; Chackerian, B. Aerosol delivery of virus-like particles to the genital tract induces local and systemic antibody responses Vaccine 2011, 29 (28) 4584-92
    • (2011) Vaccine , vol.29 , Issue.28 , pp. 4584-4592
    • Hunter, Z.1    Tumban, E.2    Dziduszko, A.3    Chackerian, B.4
  • 131
    • 28144449069 scopus 로고    scopus 로고
    • Immunological microenvironments in the human vagina and cervix: Mediators of cellular immunity are concentrated in the cervical transformation zone
    • Pudney, J.; Quayle, A. J.; Anderson, D. J. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone Biol. Reprod. 2005, 73 (6) 1253-63
    • (2005) Biol. Reprod. , vol.73 , Issue.6 , pp. 1253-1263
    • Pudney, J.1    Quayle, A.J.2    Anderson, D.J.3
  • 132
    • 0036046562 scopus 로고    scopus 로고
    • Human papilloma virus (HPV) infection and its relationship with central intra-epithelial neoplasia (CIN)
    • Ivanov, S.; Khadzhiolov, N. Human papilloma virus (HPV) infection and its relationship with central intra-epithelial neoplasia (CIN) Akush Ginekol. 2002, 41 (2) 34-5
    • (2002) Akush Ginekol. , vol.41 , Issue.2 , pp. 34-35
    • Ivanov, S.1    Khadzhiolov, N.2
  • 134
    • 0036644724 scopus 로고    scopus 로고
    • Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: Influence of the menstrual cycle
    • Kozlowski, P. A.; Williams, S. B.; Lynch, R. M.; Flanigan, T. P.; Patterson, R. R.; Cu-Uvin, S.; Neutra, M. R. Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle J. Immunol. 2002, 169 (1) 566-74
    • (2002) J. Immunol. , vol.169 , Issue.1 , pp. 566-574
    • Kozlowski, P.A.1    Williams, S.B.2    Lynch, R.M.3    Flanigan, T.P.4    Patterson, R.R.5    Cu-Uvin, S.6    Neutra, M.R.7
  • 136
    • 1642408438 scopus 로고    scopus 로고
    • Alternative routes of mucosal immunization in large animals
    • Sedgmen, B. J.; Meeusen, E. N.; Lofthouse, S. A. Alternative routes of mucosal immunization in large animals Immunol. Cell Biol. 2004, 82 (1) 10-6
    • (2004) Immunol. Cell Biol. , vol.82 , Issue.1 , pp. 10-16
    • Sedgmen, B.J.1    Meeusen, E.N.2    Lofthouse, S.A.3
  • 137
    • 0026089144 scopus 로고
    • Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice
    • Owen, R. L.; Piazza, A. J.; Ermak, T. H. Ultrastructural and cytoarchitectural features of lymphoreticular organs in the colon and rectum of adult BALB/c mice Am. J. Anat. 1991, 190 (1) 10-8
    • (1991) Am. J. Anat. , vol.190 , Issue.1 , pp. 10-18
    • Owen, R.L.1    Piazza, A.J.2    Ermak, T.H.3
  • 139
    • 32444440288 scopus 로고    scopus 로고
    • Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection
    • Parez, N.; Fourgeux, C.; Mohamed, A.; Dubuquoy, C.; Pillot, M.; Dehee, A.; Charpilienne, A.; Poncet, D.; Schwartz-Cornil, I.; Garbarg-Chenon, A. Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection J. Virol. 2006, 80 (4) 1752-61
    • (2006) J. Virol. , vol.80 , Issue.4 , pp. 1752-1761
    • Parez, N.1    Fourgeux, C.2    Mohamed, A.3    Dubuquoy, C.4    Pillot, M.5    Dehee, A.6    Charpilienne, A.7    Poncet, D.8    Schwartz-Cornil, I.9    Garbarg-Chenon, A.10
  • 140
    • 84858256662 scopus 로고    scopus 로고
    • Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP
    • Pedersen, G. K.; Ebensen, T.; Gjeraker, I. H.; Svindland, S.; Bredholt, G.; Guzman, C. A.; Cox, R. J. Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP PLoS One 2011, 6 (11) e26973
    • (2011) PLoS One , vol.6 , Issue.11 , pp. 26973
    • Pedersen, G.K.1    Ebensen, T.2    Gjeraker, I.H.3    Svindland, S.4    Bredholt, G.5    Guzman, C.A.6    Cox, R.J.7
  • 141
    • 0034660349 scopus 로고    scopus 로고
    • Immunopotentiating of mucosal and systemic antibody responses in mice by intranasal immunization with HLT-combined influenza virosomal vaccine
    • Cusi, M. G.; Lomagistro, M. M.; Valassina, M.; Valensin, P. E.; Gluck, R. Immunopotentiating of mucosal and systemic antibody responses in mice by intranasal immunization with HLT-combined influenza virosomal vaccine Vaccine 2000, 18 (25) 2838-42
    • (2000) Vaccine , vol.18 , Issue.25 , pp. 2838-2842
    • Cusi, M.G.1    Lomagistro, M.M.2    Valassina, M.3    Valensin, P.E.4    Gluck, R.5
  • 142
    • 0348078299 scopus 로고    scopus 로고
    • Mucosal antibody response induced with a nasal virosome-based influenza vaccine
    • Durrer, P.; Gluck, U.; Spyr, C.; Lang, A. B.; Zurbriggen, R.; Herzog, C.; Gluck, R. Mucosal antibody response induced with a nasal virosome-based influenza vaccine Vaccine 2003, 21 (27-30) 4328-34
    • (2003) Vaccine , vol.21 , Issue.2730 , pp. 4328-4334
    • Durrer, P.1    Gluck, U.2    Spyr, C.3    Lang, A.B.4    Zurbriggen, R.5    Herzog, C.6    Gluck, R.7
  • 143
    • 0036327056 scopus 로고    scopus 로고
    • Intranasal immunization against influenza
    • Gluck, R. Intranasal immunization against influenza J. Aerosol. Med. 2002, 15 (2) 221-8
    • (2002) J. Aerosol. Med. , vol.15 , Issue.2 , pp. 221-228
    • Gluck, R.1
  • 144
    • 0037019885 scopus 로고    scopus 로고
    • Influenza virosomes are an efficient delivery system for respiratory syncytial virus-F antigen inducing humoral and cell-mediated immunity
    • Cusi, M. G.; Zurbriggen, R.; Correale, P.; Valassina, M.; Terrosi, C.; Pergola, L.; Valensin, P. E.; Gluck, R. Influenza virosomes are an efficient delivery system for respiratory syncytial virus-F antigen inducing humoral and cell-mediated immunity Vaccine 2002, 20 (29-30) 3436-42
    • (2002) Vaccine , vol.20 , Issue.2930 , pp. 3436-3442
    • Cusi, M.G.1    Zurbriggen, R.2    Correale, P.3    Valassina, M.4    Terrosi, C.5    Pergola, L.6    Valensin, P.E.7    Gluck, R.8
  • 146
    • 77951648840 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of virosome based vaccines against Newcastle disease
    • Singh, R.; Verma, P. C.; Singh, S. Immunogenicity and protective efficacy of virosome based vaccines against Newcastle disease Trop. Anim. Health Prod. 2010, 42 (3) 465-71
    • (2010) Trop. Anim. Health Prod. , vol.42 , Issue.3 , pp. 465-471
    • Singh, R.1    Verma, P.C.2    Singh, S.3
  • 148
    • 84862020845 scopus 로고    scopus 로고
    • A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models
    • De Bernardis, F.; Amacker, M.; Arancia, S.; Sandini, S.; Gremion, C.; Zurbriggen, R.; Moser, C.; Cassone, A. A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models Vaccine 2012, 30 (30) 4490-8
    • (2012) Vaccine , vol.30 , Issue.30 , pp. 4490-4498
    • De Bernardis, F.1    Amacker, M.2    Arancia, S.3    Sandini, S.4    Gremion, C.5    Zurbriggen, R.6    Moser, C.7    Cassone, A.8
  • 151
    • 77955053788 scopus 로고    scopus 로고
    • Lipopeptide-adjuvanted respiratory syncytial virus virosomes: A safe and immunogenic non-replicating vaccine formulation
    • Stegmann, T.; Kamphuis, T.; Meijerhof, T.; Goud, E.; de Haan, A.; Wilschut, J. Lipopeptide-adjuvanted respiratory syncytial virus virosomes: A safe and immunogenic non-replicating vaccine formulation Vaccine 2010, 28 (34) 5543-50
    • (2010) Vaccine , vol.28 , Issue.34 , pp. 5543-5550
    • Stegmann, T.1    Kamphuis, T.2    Meijerhof, T.3    Goud, E.4    De Haan, A.5    Wilschut, J.6
  • 152
    • 17644424942 scopus 로고    scopus 로고
    • The process development challenge for a new vaccine
    • Buckland, B. C. The process development challenge for a new vaccine Nat. Med. 2005, 11 (4 Suppl) S16-9
    • (2005) Nat. Med. , vol.11 , Issue.4 SUPPL. , pp. 16-19
    • Buckland, B.C.1
  • 154
    • 0141676777 scopus 로고    scopus 로고
    • Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers
    • Tacket, C. O.; Sztein, M. B.; Losonsky, G. A.; Wasserman, S. S.; Estes, M. K. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers Clin. Immunol. 2003, 108 (3) 241-7
    • (2003) Clin. Immunol. , vol.108 , Issue.3 , pp. 241-247
    • Tacket, C.O.1    Sztein, M.B.2    Losonsky, G.A.3    Wasserman, S.S.4    Estes, M.K.5
  • 155
    • 0013651896 scopus 로고    scopus 로고
    • Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes
    • Tacket, C. O.; Mason, H. S.; Losonsky, G.; Estes, M. K.; Levine, M. M.; Arntzen, C. J. Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes J. Infect. Dis. 2000, 182 (1) 302-5
    • (2000) J. Infect. Dis. , vol.182 , Issue.1 , pp. 302-305
    • Tacket, C.O.1    Mason, H.S.2    Losonsky, G.3    Estes, M.K.4    Levine, M.M.5    Arntzen, C.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.