Virosomal C. albicans vaccine for vaginal application: Formulation development and toxicity/immunogenicity studies

Journal of Drug Delivery Science and Technology

Volumn 22, Issue 5, 2012, Pages 447-452

  Vacher, G ^a   Gremion, C ^b   Moser, C ^b   Stoffel, S A ^b   Amacker, M ^b   Zurbriggen, R ^b   Gurny, R ^a   Borchard, G ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Pevion Biotech AG   (Switzerland)

Author keywords

Candidiasis; Mucosal vaccination; rtSap2; Vaccine; Vaginal administration; Virosomes

Indexed keywords

CANDIDA ALBICANS VACCINE; VIROSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; IMMUNOGENICITY; IN VIVO STUDY; NONHUMAN; RABBIT; RECURRENT VULVOVAGINAL CANDIDIASIS; SWINE; VAGINA CANDIDIASIS;

EID: 84868682608     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(12)50071-7     Document Type: Article

References (27)

1. Foxman B., Barlow R., D'Arcy H., Gillespie B., Sobel J.D. - Urinary tract infection: self-reported incidence and associated costs - Ann. Epidemiol., 10 (8), 509-515, 2000.
2. Nyirjesy P., Peyton C., Weitz M.V., Mathew L., Culhane J.F. - Causes of chronic vaginitis: analysis of a prospective database of affected women - Obstet. Gynecol., 108 (5), 1185-1191, 2006. (Pubitemid 44665414)
3. Sobel J.D. - Vulvovaginal candidosis - Lancet, 369 (9577), 1961-1971, 2007.
4. Mardh P.A., Rodrigues A.G., Genc M., Novikova N., Martinez-de-Oliveira J., Guaschino S. - Facts and myths on recurrent vulvovaginal candidosis - a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy - Int. J. STD. AIDS., 13 (8), 522-539, 2002. (Pubitemid 34816236)
5. Nyirjesy P. - Chronic vulvovaginal candidiasis - Am. Fam. Physician, 63 (4), 697-702, 2001.
6. Fidel P.L. Jr. - The protective immune response against vaginal candidiasis: lessons learned from clinical studies and animal models - Int. Rev. Immunol., 21 (6), 515-548, 2002.
7. Lev-Sagie A., Prus D., Linhares I.M., Lavy Y., Ledger W.J., Witkin S.S. - Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome - Am. J. Obstet. Gynecol., 200 (3), 303 e1-6, 2009.
8. Babula O., Lazdane G., Kroica J., Ledger W.J., Witkin S.S. - Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women - Clin. Infect. Dis., 37 (5), 733-737, 2003. (Pubitemid 37100818)
9. Babula O., Lazdane G., Kroica J., Linhares I.M., Ledger WJ., Witkin S.S. - Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis - Clin. Infect. Dis., 40 (9), 1258-1262, 2005. (Pubitemid 40570234)
10. Ashman R.B., Kay P.H., Lynch D.M., Ott K. - Association of a complement allotype (C3F) with acute inflammatory responses to Candida albicans infection - Med. J. Aust., 160 (11), 732-733, 1994. (Pubitemid 24166796)
11. Sobel J.D. - Recurrent vulvovaginal candidiasis. A prospective study of the efficacy of maintenance ketoconazole therapy - N. Engl. J. Med., 315 (23), 1455-1458, 1986. (Pubitemid 17051706)
12. Stein G. E., Mummaw N.L., Schooley S.L. - Prevention of recurrent vaginal candidiasis with weekly terconazole cream - Ann. Pharmacother., 30 (10), 1080-1083, 1996. (Pubitemid 26332862)
13. Naglik J.R., Challacombe S.J., Hube B. - Candida albicans secreted aspartyl proteinases in virulence and pathogenesis Microbiol. Mol. Biol. Rev., 67 (3), 400-428, 2003. (Pubitemid 37122527)
14. De Bernardis F., Liu H., O'Mahony R., La Valle R., Bartollino S., Sandini S., Grant S., Brewis N., Tomlinson I., Basset R.C., Holton J., Roitt I.M., Cassone A. - Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis - J. Infect. Dis., 195 (1), 149-157, 2007. (Pubitemid 44958237)
15. Sandini S., La Valle R., Deaglio S., Malavasi F., Cassone A., De Bernardis F. - A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rtSap2) of Candida albicans as a mucosal anticandidal vaccine. FEMS Immunol. Med. Microbiol., 62 (2), 215-224, 2011.
16. Lilic D., Haynes K. - Candida. - In: Immunology of Fungal Infections, Brown G.D., Netea M.G. Eds., Springer, Dordrecht, 2007, p. 361-382.
17. De Bernardis F., Boccanera M., Adriani D., Girolamo A., Cassone A. - Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis - Infect. Immun., 70 (5), 2725-2729, 2002. (Pubitemid 34408424)
18. Moser C., Amacker M., Zurbriggen R. - Influenza virosomes as a vaccine adjuvant and carrier system - Expert Rev. Vaccines, 10 (4), 437-446, 2011.
19. Valenta C. - The use of mucoadhesive polymers in vaginal delivery - Adv. Drug Deliv. Rev., 57 (11), 1692-1712, 2005. (Pubitemid 41444256)
20. Vermani K., Garg S. - The scope and potential of vaginal drug delivery - Pharm. Sci. Technol. Today, 3 (10), 359-364, 2000.
21. Zurbriggen R., De Bernardis F., Cassone A., Rasi S. - Truncated secretory aspartyl proteinase 2. - Internationale Patent WO/2009/036997, 26 March 2009.
22. Kammer A.R., Amacker M., Rasi S., Westerfeld N., Gremion C., Neuhaus D., et al. - A new and versatile virosomal antigen delivery system to induce cellular and humoral immune responses - Vaccine, 25 (41), 7065-7074, 2007.
23. Nagata S. - Cellulose capsules-an alternative to gelatine? Structural, functional and community aspects - In: Biomedical Polymers and Polymer Therapeutics, Chiellini et al. Eds., Springer, New York, 1999, p. 53-62.
24. Outi H. - Biopharmaceutical evaluation of orally and rectally administered hard hydroxypropyl methylcellulose capsules [dissertation] - University of Helsinki, 2004.
25. Nagata S. - Advantages to HPMC capsules: a new generation's - Drug Deliv. Techn., 2 (2), 34-39, 2002.
26. Guyot M., Fawaz F. - Present and future choices of vaginal drug dosage forms. I. Classical forms - J. Pharm. Belg., 48 (5), 393-406, 1993. (Pubitemid 23353289)
27. Bomsel M., Tudor D., Drillet A.S., Alfsen A., Ganor Y., Roger M.G., et al. - Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges - Immunity, 34 (2), 269-280, 2011.