Mucosal or Targeted Lymph Node Immunization of Macaques with a Particulate SIVp27 Protein Elicits Virus-Specific CTL in the Genito-Rectal Mucosa and Draining Lymph Nodes

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2521-2527

  Klavinskis, Linda S ^a,c   Bergmeier, Lesley A ^a   Gao, Liquan ^a   Mitchell, Elaine ^a   Ward, Robert G ^a   Layton, Guy ^b   Brookes, Roger ^a   Meyers, Nicola J ^b   Lehner, Thomas ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b British Biotechnology Limited   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; GAG PROTEIN P27, SIMIAN IMMUNODEFICIENCY VIRUS; HLA ANTIGEN CLASS 1; VIRUS VACCINE;

ANIMAL; ARTICLE; CD8+ T LYMPHOCYTE; CELL LINE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY TEST; FEMALE; IMMUNOLOGY; IMMUNOPHENOTYPING; INTESTINE MUCOSA; LYMPH NODE; MACACA; MONKEY DISEASE; MUCOSAL IMMUNITY; RECTUM; SIMIAN IMMUNODEFICIENCY VIRUS; UTERINE CERVIX; VAGINA; VIROLOGY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CERVIX UTERI; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; GENE PRODUCTS, GAG; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNITY, MUCOSAL; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; LYMPH NODES; MACACA MULATTA; RECTUM; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES, CYTOTOXIC; VAGINA; VIRAL VACCINES;

EID: 0030587188     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viraemia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650.
2. + CTL activity associated with control of viraemia in primary HIV-1 infection. J. Virol. 68:6103.
3. + cell anti-HIV activity correlates with clinical state of the infected individual. J. Clin. Invest. 87:1462.
4. McDermott, M. R., C. H. Goldsmit, K. L. Rosenthal, and L. J. Brais. 1989. T lymphocytes in genital lymph nodes protect mice from intravaginal infection with herpes simplex virus type 2. J. Infect. Dis. 159:460.
5. Miller C. J., M. McChesney, and P. F. Moore. 1992. Langerhans cells, macrophages and lymphocyte subsets in the cervix and vagina of rhesus macaques. Lab. Invest. 67:628.
6. Edwards, J. N. T., and H. B. Morris. 1985. Langerhans cells and lymphocyte subsets in the female genital tract. Br. J. Obstet. Gynaecol. 92:974.
7. Lohman B. L., C. J. Miller, and M. B. McChesney. 1995. Antiviral cytotoxic T lymphocytes in the vaginal mucosa of simian immunodeficiency virus infected rhesus macaques. J. Immunol. 155:5855.
8. Yasutomi Y., S. Koenig, S. S. Haunn, C. K. Stover, R. H. Jackson, P. Conrad, A. J. Conley, E. A. Eminini, T. R. Fuerst, and N. L. Letvin. 1993. Immunization with a recombinant BCG elicits simian immunodeficiency virus specific cytotoxic T lymphocytes in rhesus monkeys. J. Immunol. 150:3101.
9. + cytotoxic T lymphocytes. Science 252:440.
10. + cytotoxic T lymphocytes. J. Exp. Med. 176:1739.
11. McGhee J. R., J. Mestecky, M. T. Dertzbaugh, J. H. Eldridge, M. Hirasawa, and H. Kiyono. 1992. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10:75.
12. Adams S. E., K. E. Dawson, K. Gull, M. Kingsman, and A. J. Kingsman. 1987. The expression of hybrid HIV: Ty virus-like particles in yeast. Nature 329:68.
13. Lehner T., L. A. Bergmeier, C. Panagiotidi, L. Tao, L. S. Klavinskis, R. Brookes, P. Walker, J. Walker, R. G. Ward, L. Hussain, A. J. H. Gearing, and S. E. Adams. 1992. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein. Science 258:1365.
14. Lehner T., R. Brookes, C. Panagiotidi, L. Tao, L. A. Bergmeier, L. S. Klavinskis, J. Walker, P. Walker, R. Ward, L. Hussain, A. J. H. Gearing, and S. E. Adams. 1993. T and B cell functions and epitope expression in non-human primates immunized with SIV by the rectal as compared with the systemic route. Proc. Natl. Acad. Sci. USA 90:8638.
15. Lehner T., L. A. Bergmeier, L. Tao, C. Panagiotidi, L. S. Klavinskis, L. Hussain, R. G. Ward, N. Meyers, S. E. Adams, A. J. H. Gearing, and R. Brookes. 1994. Targeted lymph node immunization with simian immunodeficiency virus p27 antigen to elicit genital, rectal and urinary immune responses in non human primates. J. Immunol. 153:1858.
16. Czerkinsky C., M. W. Russell, N. Lycke, M. Lindblad, and J. Holmgren. 1989. Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues. Infect. Immun. 57:1072.
17. Brookes R., L. A. Bergmeier, E. Mitchell, J. Walker, L. Tao, L. S. Klavinskis, N. J. Meyers, G. Layton, S. E. Adams, and T. Lehner. 1995. Generation of diversity in the hierarchy of T cell epitope responses following different routes of immunization with simian immunodeficiency virus protein. AIDS 9:1017.
18. Moore M., F. Carbone, and M. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777.
19. Quidling M., I. Nordstrom, A. Kilander, G. Anderson, L. A. Hanson, J. Holmgren, and C. Czerkinsky. 1991. Intestinal immune responses in humans: oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production evokes local immunotogical memory. J. Clin. Invest. 88:143.
20. Rabin H., R. Neubaner, E. Hopkins, E. Dzhikize, Z. Shevtsova, and B. Lapin. 1977. Transforming activity and antigenicity of an Epstein-Barr-like virus from lymphoblastoid cell lines of baboons with lymphoid disease. Intervirol. 8:240.
21. Roger J. H., W. van Vreeswijk, and H. Balner. 1980. The major histocompatibility complex of rhesus monkeys. XIII Current Knowledge of DR and other B-cell specific antigens. J. Immunogenet. 7:333.
22. Vernet, A., I. Baurgault, A. M. Aubertin, M. P. Kieny, and J. P. Levy. 1992. Cytotoxic T lymphocyte response against multiple simian immunodeficiency virus (SIV) proteins in SIV-infected macaques. J. Immunol. 148:2899.
23. + lymphocyte response in acutely infected rhesus macaques. J. Virol. 67:1707.
24. Lohman B. L., M. B. McChesney, C. J. Miller, E. McGowan, S. M. Joye, K. K. A. van Rompay, E. Reay, L. Antipa, N. C. Pdersen, and M. L. Marthas. 1994. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68:7021.
25. Van Herrath M., M. B. A. Oldstone, and H. S. Fox. 1995. Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques. J. Immunol. 154:5582.
26. Venet A, and B. D. Walker. 1993. Cytotoxic T-cell epitopes in HIV/SIV infection. AIDS 7(supp 1):S117.
27. Spira A. I., P. A. Marx, B. K. Patterson, J. Mahoney, R. A. Koup, S. M. Wolinsky, and D. D. Ho. 1996. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J. Exp. Med. 183:215.
28. Bergmeier L. A., L. S. Klavinskis, R. Brookes, E. Mitchell, M. Cranage, G. Hall, M. Dennis, I. Jones, C. Doyle, and T. Lehner. 1995. Characterisation of antigen specific B cells in the peripheral blood and tissues after immunisation with SIV proteins and challenge with live virus. Clin. Immunol. Immunopathol. 76:S107 (Abstract).
29. Harding C. V., and R. Song. 1994. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J. Immunol. 153:4925.
30. Kovacsovics-Bankowski M., and K. L. Rock. 1995. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267:243.
31. Layton G. T., S. J. Harris, A. J. Gearing, M. Hill-Perkins, J. S. Cole, J. C. Griffiths, N. R. Burns, A. J. Kingsman, and S. E. Adams. 1993. Induction of HIV-specific cytotoxic T-lymphocytes in vivo with hybrid HIV-1 V3:Ty-virus-like particles. J. Immunol. 151:1097.
32. Miller M. D., H. Yamamoto, A. L. Hughes, D. I. Watkins, and N. L. Letvin. 1991. Definition of an epitope and an MHC class I molecule recognized by gag-specific CTL in SIVmac infected rhesus monkeys. J. Immunol. 147:320.
33. Yasutomi Y., S. Koenig, R. M. Woods, J. Medsen, N. M. Wassef, C. R. Alving, H. J. Klein, T. E. Nolan, L. J. Boots, J. A. Kessler, E. A. Emini, A. J. Conley, and N. L. Letvin. 1995. A vaccine-elicited, single viral epitopes-specific cytotoxic T lymphocyte response does not protect against intraveneously cell-free simian immunodeficiency virus challenge. J. Virol. 69:2279.
34. + T cells. Science 270:1811.
35. Baier M., A. Werner, N. Bannert, K. Metzner, and R. Kurth. 1995. HIV suppression by Interleukin-16. Nature 378:563.
36. Lehner T., Y. Wang, M. Cranage, L. A. Bergmeier, E. Mitchel, L. Tao, G. Hall, M. Dennis, N. Cook, L. Klavinskis, I. Jones, C. Doyle, and R. Ward. 1996. Protective mucosal immunity elicited by targeted iliac lymph node immunisation with a subunit SIV envelope and core vaccine in macaques. Nature Med. 2:767.