Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia an in silico, in vivo, in vitro study

Circulation

Volumn 119, Issue 1, 2009, Pages 19-27

  Lau, David H ^a   Clausen, Chris ^c   Sosunov, Eugene A ^a   Shlapakova, Iryna N ^a   Anyukhovsky, Evgeny P ^a   Danilo Jr , Peter ^a   Rosen, Tove S ^a   Kelly, Caitlin ^a   Duffy, Heather S ^a   Szabolcs, Matthias J ^b   Chen, Ming ^a   Robinson, Richard B ^a   Lu, Jia ^c   Kumari, Sinhu ^c   Cohen, Ira S ^c   Rosen, Michael R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Stony Brook University ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Arrhythmia; Gene therapy; Ion channels; Myocardial infarction; Tachyarrhythmias

Indexed keywords

SODIUM CHANNEL; SODIUM CHANNEL SKM1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; EPICARDIUM; HEART INFARCTION; HEART STIMULATION; HEART VENTRICLE ARRHYTHMIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACTION POTENTIALS; ADENOVIRIDAE; ANIMALS; CELL LINE; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; DOGS; GENE EXPRESSION; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HEART CONDUCTION SYSTEM; HUMANS; KIDNEY; MALE; MODELS, CARDIOVASCULAR; MUSCLE, SKELETAL; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; PENICILLIN G; PERICARDIUM; SODIUM CHANNELS; TACHYCARDIA, VENTRICULAR;

EID: 59049091825     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.809301     Document Type: Article

References (23)

1. Wit AL, Janse MJ. Experimental models of ventricular tachycardia and fibrillation caused by ischemia and infarction. Circulation. 1992;85: 132-142.
2. Mines GR. On dynamic equilibrium in the heart. J Physiol. 1913;46: 349-383.
3. Mines GR. On circulating excitations in heart muscles and their possible relation to tachycardia and fibrillation. Trans R Soc Can. 1914;4:43-52.
4. Schmitt FO, Erlanger J. Directional differences in the conduction of the impulse through heart muscle and their possible relation to extrasystolic and fibrillary contractions. Am J Physiol. 1928;87:326-346.
5. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. The Sicilian gambit. Circulation. 1991;84: 1831-1851.
6. Trimmer JS, Cooperman SS, Tomiko SA, Zhou J, Crean SM, Boyle MB, Kallen RG, Sheng Z, Barchi RL, Sigworth FJ, Goodman RH, Agnew WS, Mandel G. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron. 1989;3:33-49.
7. Hund TJ, Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine ventricular cell model. Circulation. 2004; 110:3168-3174.
8. Le Marec H, Dangman K, Danilo P, Rosen M. An evaluation of automaticity and triggered activity in the canine heart one to four days after myocardial infarction. Circulation. 1985;71:1224-1236.
9. Sosunov EA, Anyukhovsky EP, Rosen MR. Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium, I: in vitro study. Circulation. 1997;96:4011-4018.
10. Baba S, Dun W, Cabo C, Boyden PA. Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia. Circulation. 2005;112:2386-2396.
11. Hayward LJ, Brown RH Jr, Cannon SC. Inactivation defects caused by myotonia-associated mutations in the sodium IH-IV linker. J Gen Physiol. 1996;107:559-576.
12. 1 subunit in rat skeletal muscle is selectively associated with the tetrodotoxin-sensitive α subunit isoform. Neuron. 1993; 11:915-922.
13. Mayer AG. Rhythmical Pulsation in Scyphomedusae. Publication No. 47. Washington, DC: Carnegie Institution of Washington; 1908:115-131.
14. Garrey W. Auricular fibrillation. Physiol Rev. 1924;2:215-250.
15. Hoffman BF, Cranefield PF. Electrophysiology of the Heart: New York, NY: McGraw-Hill; 1960.
16. Pijnappels D, Schalij M, van Tuyn J, Ypey D, de Vries A, van der Wall E, van der Laarse A, Atsma D. Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling. Cardiovasc Res. 2006;72:282-291.
17. Catterall WA. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron. 2000;26:13-25.
18. Lopreato GF, Lu Y, Southwell A, Atkinson NS, Hillis DM, Wilcox TP, Zakon HH. Evolution and divergence of sodium channel genes in vertebrates. Proc Natl Acad Sci U S A. 2001;98:7588-7592.
19. Baba S, Dun W, Hirose M, Boyden PA. Sodium current function in adult and aged canine atrial cells. Am J Physiol Heart Circ Physiol. 2006;291: H756-H761.
20. Reddy VY, Reynolds MR, Neuzil P, Richardson AW, Taborsky M, Jongnarangsin K, Kralovec S, Sediva L, Ruskin JN, Josephson ME. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med. 2007;357:2657-2665.
21. Sasano T, McDonald AD, Kikuchi K, Donahue JK. Molecular ablation of ventricular tachycardia after myocardial infarction. Nat Med. 2006;12: 1256-1258.
22. Hohnloser SH, Kuck KH, Dorian P, Roberts RS, Hampton JR, Hatala R, Fain E, Gent M, Connolly SJ, for the DINAMIT Investigators. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med. 2004;351:2481-2488.
23. Marban E, Nuss HB, Donahue JK. Gene therapy for cardiac arrhythmias. Cold Spring Harb Symp Quant Biol. 2002;67:527-531.