Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives

Journal of Hypertension

Volumn 22, Issue 12, 2004, Pages 2363-2369

  Grassi, Guido ^a,b,c   Dell'Oro, Raffaella ^a   Facchini, Annalisa ^a   Trevano, Fosca Quarti ^a   Bolla, Giovanni Battista ^b   Mancia, Giuseppe ^a,b,c,d  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^d SAN GERARDO HOSPITAL   (Italy)

Author keywords

Abdominal fat; Autonomic nervous system; Baroreceptors; Insulin; Obesity; Peripheral fat; Sympathetic nervous system

Indexed keywords

NORADRENALIN; PHENYLEPHRINE;

ADULT; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE; BODY DISTRIBUTION; BODY FAT; CONTROLLED STUDY; FEMALE; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; METABOLISM; OBESITY; PRESSORECEPTOR; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYMPATHETIC FUNCTION;

EID: 10244267463     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200412000-00019     Document Type: Article

References (36)

1. Peterson HR, Rothshild M, Weinberg CR, Fell RD, McLeish KR, Pfeifer MA. Body fat and the activity of the autonomic nervous system. N Engl J Med 1988; 318:1077-1083.
2. Troisi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L. Relation of obesity and diet to sympathetic nervous system activity. Hypertension 1991; 17:669-677.
3. Young JB, Macdonald IA. Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980. Int J Obes 1992; 16:959-967.
4. Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 1997; 96:3423-3429.
5. Coppack SW, Horowitz JF, Paramore DS, Cryer PE, Royal HD, Klein S. Whole body, adipose tissue, and forearm norepinephrine kinetics in lean and obese women. Am J Physiol 1998; 275: E830-E834.
6. Scherrer U, Randin D, Tappy L, Vollenweider P, Jequier E, Nicod P. Body fat and sympathetic nerve activity in healthy subjects. Circulation 1994; 89:2634-2640.
7. Grassi G, Seravalle G, Quarti-Trevano F, Dell'Oro R, Bolla G, Mancia G. Sympathetic activation in obese normotensive subjects. Hypertension 1995; 25:560-563.
8. Grassi G, Seravalle G, Dell'Oro R, Turri C, Bolla GB, Mancia G. Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension 2000; 36:538-542.
9. Grassi G, Seravalle G, Quarti-Trevano F, Dell'Oro R, Bolla G, Mancia G. Effects of hypertension and obesity on the sympathetic activation of heart failure patients. Hypertension 2003; 42:873-877.
10. Jamerson KA, Julius S, Gudbrandsson T, Andersson O, Brant DO. Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 1993; 21:618-623.
11. Landsberg L. Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 2001; 19:523-528.
12. Brook RD, Julius S. Autonomic imbalance, hypertension and cardiovascular risk. Am J Hypertens 2000; 13:112S-122S.
13. Kissebach AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev 1994; 74:761-811.
14. Gasteyger C, Tremblay A. Metabolic impact of body fat distribution. J Endocrinol Invest 2002; 25:876-883.
15. Alvarez GE, Beske SD, Ballard TP, Davy KP. Sympathetic neural activation in visceral obesity. Circulation 2002; 106:2533-2536.
16. Parker PJ, Snitker S, Skinner JS, Ravussin E. Gender differences in muscle sympathetic nerve activity: effect of body fat distribution. Am J Physlol 1996; 270:E363-E366.
17. Grassi G, Esler M. How to assess sympathetic activity in humans. J Hypertens 1999; 17:719-734.
18. Minon CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 2000; 101:862-868.
19. Hjemdahl P, Daleskog M, Kahan T. Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with a radioenzymatic method. Life Sci 1979; 25:131-138.
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419.
21. Anderson EA, Balon TW, Hoffman RP, Sinkey CA, Mark AL. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension 1992; 19:621-627.
22. Huggett RJ, Scott EM, Gilbey SG, Stoker JB, Mackintosh AF, Mary DA. Impact of type-2 diabetes mellitus on sympathetic neural mechanisms in hypertension. Circulation 2003; 108:3097-3101.
23. Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. Effects of insulin and glucose infusion on sympathetic nervous system activity in normal man. Diabetes 1981; 30:219-225.
24. Levinson PD, McGarvey ST, Carlisle CC, Eveloff SE, Herbert PN, Millman RP. Adiposity and cardiovascular risk factors in men with obstructive sleep apnea. Chest 1993; 103:1336-1342.
25. Schafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold HK. Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest 2002; 122:829-839.
26. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME, Somers VK. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 1998; 98:772-776.
27. Narkiewicz K, Kato M, Pesek CA, Somers VK. Human obesity in characterized by a selective potentiation of central chemoreflex sensitivity. Hypertension 1999; 33:1153-1158.
28. Johannsson G, Karlsson C, Lonn L, Marin P, Bjorntorp P, Sjostrom L, et al. Serum leptin concentration and insulin sensitivity in men with abdominal obesity. Obes Res 1998; 6:416-421.
29. Grassi G. Leptin, sympathetic nervous system, and baroreflex function. Curr Hypertens Rep 2004; 6:236-240.
30. Lembo G, Capaido B, Rendina V, Iaccarino G, Napoli R, Guida R, et al. Acute noradrenergic activation induces insulin resistance in human skeletal muscle. Am J Physiol 1994; 266:E242-E247.
31. Grassi G, Vailati S, Bertinieri G, Seravalle G, Stella ML, Dell'Oro R, Mancia G. Heart rate as a marker of sympathetic activity. J Hypertens 1998; 16:1635-1639.
32. Grassi G, Bolla G, Seravale G, Turri C, Lanfranchi A, Mancia G. Comparison between reproducibility and sensitivity of muscle sympathetic nerve traffic and plasma noradrenaline in man. Clin Sci 1997; 92: 285-289.
33. Beske SD, Alvarez GE, Ballard TP, Davy KP. Reduced cardiovagal baroreflex gain in visceral obesity: implication for the metabolic syndrome. Am J Physiol 2003; 282:H630-H635.
34. Mancia G, Bonazzi O, Pozzoni L, Ferrari A, Gardumi M, Gregorini L, Perondi R. Baroreceptor control of atrioventricular conduction in man. Circ Res 1979; 44:752-758.
35. Mancia G, Mark AL. Arterial baroreflexes in humans. In: Shepherd JT, Abboud FM (editors): Handbook of physiology. Section 2: The cardiovascular system. Bethesda, Maryland: American Physiological Society; 1983, pp. 755-793.
36. Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 1999; 34:724-728.