Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate

Experimental Animals

Volumn 55, Issue 2, 2006, Pages 109-115

  Nagata, Mitsunobu ^a,c   Suzuki, Wataru ^a,b   Iizuka, Seiichi ^a   Tabuchi, Masahiro ^a,b   Maruyama, Hirofumi ^a   Takeda, Shuichi ^a,b   Aburada, Masaki ^b   Miyamoto, Ken Ichi ^c  

^a TSUMURA AND CO   (Japan)

^b MUSASHINO UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

Crj:CD 1(1CR) mouse; Experimental obesity; Monosodium glutamate (MSG); Type 2 diabetes mellitus

Indexed keywords

CHOLESTEROL; GLUCOSE; GLUTAMATE SODIUM; INSULIN; TRIACYLGLYCEROL;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BODY MASS; BODY WEIGHT; BULIMIA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUCOSURIA; HISTOPATHOLOGY; HYPERTROPHY; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORGAN WEIGHT; PANCREAS ISLET; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; GLYCOSURIA; MALE; MICE; MICE, INBRED ICR; MICE, OBESE; SODIUM GLUTAMATE;

ANIMALIA;

EID: 33646190929     PISSN: 13411357     EISSN: 13411357     Source Type: Journal    
DOI: 10.1538/expanim.55.109     Document Type: Article

References (12)

1. Cameron, D.P., Poon, K.Y., and Smith, G.C. 1976. Effects of monosodium glutamate administration in the neonatal period on the diabetic syndrome in KK mice. Diabetelogia 12:621-626.
2. Coleman, D.L. 1982. Diabetes-obesity syndromes in mice. Diabetes 31 Suppl 1: 1-6.
3. Iwase, M., Yamamoto, M., Iino, K., Ichikawa, K., Shinohara, N., Yoshinari, M., and Fujishima, M. 1998. Obesity induced by neonatal monosodium glutamate treatment in spontaneously hypertensive rats: An animal model of multiple risk factors. Hypertens. Res. 21: 1-6.
4. Katsuki, S., Hirata,Y., Horino, M., Ito, M., Ishimoto, M., Makino, N., and Hososako, A. 1962. Obesity and hyperglycemia induced in mice by goldthioglucose. Diabetes 3: 209-215.
5. Komeda, K., Yokote, M., and Oki, Y. 1980. Diabetic syndrome in the chinese hamster induced with monosodium glutamate. Experientia 36: 232-234.
6. Liebelt, A.R. and Perry, H.J. 1957. Hypothalamic lesions associated with goldthioglucose-induced obesity. Proc. Soc. Exp. Biol. Med. 95: 774-777.
7. Marshall, B.N., Barrnett, J.R., and Mayer, J. 1955. Hypothalamic lesions in goldthioglucose injected mice. Proc. Soc. Exp. Biol. Med. 90: 240-244.
8. Matsuo, T. and Shino, A. 1972. Induction of diabetic alterations by goldthioglucose-obesity in KK, ICR and C57BL mice. Diabetologia 8: 391-397.
9. Nakajima, H., Tochino, Y., Fujino-Kurihara, H., Yamada, K., Gomi, M., Tajima, K., Kanaya, T., Miyazaki, A., Miyagawa, J., and Hanafusa, T. 1985. Decreased incidence of diabetes mellitus by monosodium glutamate in the nonobese diabetic (NOD) mouse. Res. Commun. Chem. Pathol. Pharmacol. 50: 251-257.
10. Olney, W.J. 1969. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164: 719-721.
11. Shafrir, E. 1992. Animal models of non-insulin-dependent diabetes. Diabetes/Metab. Rev. 8: 179-208.
12. Suzuki, W., Iizuka, S., Tabuchi, M., Funo, S., Yanagisawa, T., Kimura, M., Sato, T., Endo, T., and Kawamura, H. 1999. A new mouse model of spontaneous diabetes derived from ddY strain. Exp. Anim. 48: 181-189.